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Attention deficit hyperactivity disorder (ADHD) is a common, complex and highly heritable disorder, characterised by inattentive, impulsive and overactive behaviour. Evidence for the heritability of ADHD measures in twin population samples has come from the analysis of total scores that combine inattentive and hyperactive–impulsive symptoms subscales. This study investigated, in a community sample, the aetiology of ADHD-like traits and the aetiological overlap between the two dimensions that define the ADHD disorder.
Parents of 6,222 approximately 8-year-old twin pairs from the Twins Early Development Study (TEDS) population sample completed the two subscales of the Conners’ 18-item DSMIV checklist, a screening instrument for ADHD symptoms.
Both subscales were highly heritable (hyperactive–impulsive: 88%; inattentive: 79%). Bivariate genetic modelling indicated substantial genetic overlap between the two components; however, there were significant independent genetic effects.
These findings suggest that many genes associated with the hyperactivity–impulsivity dimension will also be associated with the inattentive dimension but that there is significant genetic heterogeneity as well. These results provide genetic support for combining the two behavioural dimensions that define ADHD, but also suggest that some symptom-specific genes will also be identified.
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Akaike, H. (1987). Factor analysis and AIC. Psychometrika, 52, 317–332. CrossRef
American Psychiatric Association (APA) (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: American Psychiatric Association.
Lahey, B. B., Applegate, B., McBurnett, K., Biederman, J., Greenhill, L., Hynd, G. W., et al. (1994). DSM-IV field trials for attention deficit hyperactivity disorder in children and adolescents. American Journal of Psychiatry, 151, 1673–1685. PubMed
Lahey, B. B., Schaughency, E. A., Hynd, G. W., Carlson, C. L., & Nieves, N. (1987). Attention deficit disorder with and without hyperactivity: Comparison of behavioral characteristics of clinic-referred children. Journal of the American Academy of Child and Adolescent Psychiatry, 26, 718–723. PubMedCrossRef
Levy, F., McStephen, M., & Hay, D. A. (2001). The diagnostic genetics of ADHD symptoms and subtypes. In F. Levy & D. Hay (Eds.), Attention, genes and ADHD (pp. 35–37). Philadelphia: Taylor & Francis.
Lowe, N., Kirley, A., Hawi, Z., Sham, P., Wickham, H., Kratochvil, C. J., et al. (2004). Joint analysis of the DRD5 marker concludes association with attention-deficit/hyperactivity disorder confined to the predominantly inattentive and combined subtypes. American Journal of Human Genetics, 74, 348–356. PubMedCrossRef
Neale, M. C. (1997) Mx: Statistical modelling. Richmond, VA: Department of Psychiatry, Medical College of Virginia.
Neale, M. C., & Cardon, L. R. (1992) Methodology for genetic studies of twins and families. Dordrecht: Kluwer.
Neale, M. C., Roysamb, E., Jacobson, K. (2006). Multivariate genetic analysis of sex limitation and G × E interaction. Twin Research and Human Genetics, 9, 481–489.
Office for National Statistics (2002). Living in Britain: Results from the 2000/01 General Household Survey. Anonymous.
Plomin, R., DeFries, J. C., McClearn, G. E., & McGuffin, P. (2001). Behavioural genetics. New York: Worth.
Smalley, S. L., McGough, J. J., Del’Homme, M., NewDelman, J., Gordon, E., Kim, T., et al. (2000). Familial clustering of symptoms and disruptive behaviors in multiplex families with attention-deficit/hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 39, 1135–1143. PubMedCrossRef
Spinath, F. M., Ronald, A., Harlaar, N., Price, T. S., & Plomin, R. (2004). Phenotypic ‘g’ early in life: On the etiology of general cognitive ability in a large population sample of twin children aged 2 to 4 years. Intelligence, 31, 195–210. CrossRef
Stata Corporation. (1997). Stata statistical software (Release 9.0), College Station, TX: Stata Corp.
Todd, R. D., Rasmussen, E. R., Neuman, R. J., Reich, W., Hudziak, J. J., Bucholz, K. K., et al. (2001). Familiality and heritability of subtypes of attention deficit hyperactivity disorder in a population sample of adolescent female twins. American Journal of Psychiatry, 158, 1891–1898. PubMedCrossRef
- Genetic Support for the Dual Nature of Attention Deficit Hyperactivity Disorder: Substantial Genetic Overlap Between the Inattentive and Hyperactive–impulsive Components
- Springer US