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Gepubliceerd in: Child Psychiatry & Human Development 2/2012

01-04-2012 | Original Article

Genetic Risks and ADHD Symptomatology: Exploring the Effects of Parental Antisocial Behaviors in an Adoption-Based Study

Auteurs: Kevin M. Beaver, Joseph L. Nedelec, Meghan W. Rowland, Joseph A. Schwartz

Gepubliceerd in: Child Psychiatry & Human Development | Uitgave 2/2012

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Abstract

A great deal of research has examined the etiology of attention-deficit/hyperactivity disorder (ADHD) and ADHD symptomatologies. Genetic factors are consistently shown to explain a significant proportion of variance in measures of ADHD. The current study adds to this body of research by examining whether genetic liabilities for criminality and alcoholism have effects on the development of ADHD symptomatologies. Analyses based on a sample of adoptees drawn from the National Longitudinal Study of Adolescent Health (Add Health) revealed that ADHD symptomatologies were elevated among adoptees who had biological mothers and fathers who had been arrested or who were alcoholics. These results suggest that part of the covariation between ADHD and antisocial behaviors may be the result of genetic factors that have general effects across a range of maladaptive outcomes.
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1
The race variable was excluded from the equations using the total genetic risk scale score because of unstable parameter estimates stemming from (1) small sample sizes and (2) the lack of variation in race across the different categories on the ADHD scale. Including race in the equations did not affect the statistical significance of the genetic risk measures, but it did generate extremely large standard errors for the race variable. As a result, we opted to exclude this variable from the analyses where the total composite genetic risk scale was used.
 
Literatuur
1.
go back to reference Faraone SV, Doyle AE, Biederman J (2001) Meta-analysis of the association between the 7-repeat allele of the dopamine D4 receptor gene and attention deficit hyperactivity disorder. Am J Psychiatry 158:1052–1057PubMedCrossRef Faraone SV, Doyle AE, Biederman J (2001) Meta-analysis of the association between the 7-repeat allele of the dopamine D4 receptor gene and attention deficit hyperactivity disorder. Am J Psychiatry 158:1052–1057PubMedCrossRef
2.
go back to reference Merikangas KR, He J-P, Brody D, Fisher PW, Bourdon K, Koretz DS (2010) Prevalence and treatment of mental disorders among US children in the 2001–2004 NHANES. Pediatrics 125:75–81PubMedCrossRef Merikangas KR, He J-P, Brody D, Fisher PW, Bourdon K, Koretz DS (2010) Prevalence and treatment of mental disorders among US children in the 2001–2004 NHANES. Pediatrics 125:75–81PubMedCrossRef
3.
go back to reference Visser SN, Bitsko RH, Danielson ML, Perou R, Blumberg SJ (2010) Increasing prevalence of parent-reported attention-deficit/hyperactivity disorder among children—United States, 2003 and 2007. MMWR Morb Mortal Wkly Rep 59:1439–1443 Visser SN, Bitsko RH, Danielson ML, Perou R, Blumberg SJ (2010) Increasing prevalence of parent-reported attention-deficit/hyperactivity disorder among children—United States, 2003 and 2007. MMWR Morb Mortal Wkly Rep 59:1439–1443
4.
go back to reference Jensen PS, Martin D, Cantwell DP (1997) Comorbidity in ADHD: implications for research, practice, and DSM-V. J Am Acad Child Adolesc Psychiatry 36:1065–1079PubMedCrossRef Jensen PS, Martin D, Cantwell DP (1997) Comorbidity in ADHD: implications for research, practice, and DSM-V. J Am Acad Child Adolesc Psychiatry 36:1065–1079PubMedCrossRef
5.
go back to reference Holmes J, Payton A, Barrett J, Harrington R, McGuffin P, Owen M et al (2002) Association of DRD4 in children with ADHD and comorbid conduct problems. Am J Med Genet 114:150–153PubMedCrossRef Holmes J, Payton A, Barrett J, Harrington R, McGuffin P, Owen M et al (2002) Association of DRD4 in children with ADHD and comorbid conduct problems. Am J Med Genet 114:150–153PubMedCrossRef
6.
go back to reference Mannuzza S, Klein RG, Moulton JL (2008) Lifetime criminality among boys with attention deficit hyperactivity disorder: a prospective follow-up study into adulthood using official arrest records. Psychiatr Res 160:237–246CrossRef Mannuzza S, Klein RG, Moulton JL (2008) Lifetime criminality among boys with attention deficit hyperactivity disorder: a prospective follow-up study into adulthood using official arrest records. Psychiatr Res 160:237–246CrossRef
7.
go back to reference Albayrak Ö, Friedel S, Schimmelmann BG, Hinney A, Hebebrand J (2008) Genetic aspects in attention-deficit/hyperactivity disorder. J Neural Transm 115:305–315PubMedCrossRef Albayrak Ö, Friedel S, Schimmelmann BG, Hinney A, Hebebrand J (2008) Genetic aspects in attention-deficit/hyperactivity disorder. J Neural Transm 115:305–315PubMedCrossRef
8.
go back to reference Schilling CM, Walsh A, Yun I (2011) ADHD and criminality: a primer on the genetic, neurobiological, evolutionary, and treatment literature for criminologists. J Crim Justice 39:3–11CrossRef Schilling CM, Walsh A, Yun I (2011) ADHD and criminality: a primer on the genetic, neurobiological, evolutionary, and treatment literature for criminologists. J Crim Justice 39:3–11CrossRef
9.
go back to reference Biederman J, Wilens T, Mick E, Milberger S, Spencer TJ, Faraone SV (1995) Psychoactive substance use disorders in adults with attention deficit hyperactivity disorder (ADHD): effects of ADHD and psychiatric comorbidity. Am J Psychiatry 152:1652–1658PubMed Biederman J, Wilens T, Mick E, Milberger S, Spencer TJ, Faraone SV (1995) Psychoactive substance use disorders in adults with attention deficit hyperactivity disorder (ADHD): effects of ADHD and psychiatric comorbidity. Am J Psychiatry 152:1652–1658PubMed
10.
go back to reference Chilcoat HD, Breslau N (1999) Pathways from ADHD to early drug use. J Am Acad Child Adolesc Psychiatry 38:1347–1354PubMedCrossRef Chilcoat HD, Breslau N (1999) Pathways from ADHD to early drug use. J Am Acad Child Adolesc Psychiatry 38:1347–1354PubMedCrossRef
11.
go back to reference Rasmussen K, Levander S (2008) Untreated ADHD in adults: are there sex differences in symptoms, comorbidity, and impairment? J Atten Disord 12:353–360PubMedCrossRef Rasmussen K, Levander S (2008) Untreated ADHD in adults: are there sex differences in symptoms, comorbidity, and impairment? J Atten Disord 12:353–360PubMedCrossRef
12.
go back to reference Gudjonsson GH, Sigurdsson JF, Young S, Newton AK, Peersen M (2009) Attention deficit hyperactivity disorder (ADHD). How do ADHD symptoms relate to personality among prisoners? Pers Indiv Differ 47:64–68CrossRef Gudjonsson GH, Sigurdsson JF, Young S, Newton AK, Peersen M (2009) Attention deficit hyperactivity disorder (ADHD). How do ADHD symptoms relate to personality among prisoners? Pers Indiv Differ 47:64–68CrossRef
13.
go back to reference Bobb AJ, Castellanos FX, Addington AM, Rapoport JL (2006) Molecular genetic studies of ADHD: 1991 to 2004. Am J Med Genet 141B:551–565CrossRef Bobb AJ, Castellanos FX, Addington AM, Rapoport JL (2006) Molecular genetic studies of ADHD: 1991 to 2004. Am J Med Genet 141B:551–565CrossRef
14.
go back to reference Thapar A, Holmes J, Poulton K, Harrington R (1999) Genetic basis of attention deficit and hyperactivity. Br J Psychiatry 174:105–111PubMedCrossRef Thapar A, Holmes J, Poulton K, Harrington R (1999) Genetic basis of attention deficit and hyperactivity. Br J Psychiatry 174:105–111PubMedCrossRef
15.
go back to reference Stergiakouli E, Thapar A (2010) Fitting the pieces together: current research on the genetic basis of attention-deficit/hyperactivity disorder (ADHD). Neuropsychiatr Dis Treat 6:551–560PubMedCrossRef Stergiakouli E, Thapar A (2010) Fitting the pieces together: current research on the genetic basis of attention-deficit/hyperactivity disorder (ADHD). Neuropsychiatr Dis Treat 6:551–560PubMedCrossRef
17.
go back to reference Sprich S, Biederman J, Crawford MH, Mundy E, Faraone SV (2000) Adoptive and biological families of children and adolescents with ADHD. J Am Acad Child Adolesc Psychiatry 39:1432–1437PubMedCrossRef Sprich S, Biederman J, Crawford MH, Mundy E, Faraone SV (2000) Adoptive and biological families of children and adolescents with ADHD. J Am Acad Child Adolesc Psychiatry 39:1432–1437PubMedCrossRef
18.
go back to reference Bobb AJ, Addington AM, Sidransky E, Gornick MC, Lerch JP, Greenstein DK et al (2005) Support for association between ADHD and two candidate genes: NET1 and DRD1. Am J Med Genet 134B:67–72PubMedCrossRef Bobb AJ, Addington AM, Sidransky E, Gornick MC, Lerch JP, Greenstein DK et al (2005) Support for association between ADHD and two candidate genes: NET1 and DRD1. Am J Med Genet 134B:67–72PubMedCrossRef
19.
go back to reference Gizer IR, Ficks C, Waldman ID (2009) Candidate gene studies of ADHD: a meta-analytic review. Hum Genet 126:51–90PubMedCrossRef Gizer IR, Ficks C, Waldman ID (2009) Candidate gene studies of ADHD: a meta-analytic review. Hum Genet 126:51–90PubMedCrossRef
20.
go back to reference Kebir O, Tabbane K, Sengupta S, Joober R (2009) Candidate genes and neuropsychological phenotypes in children with ADHD: review of association studies. J Psychiatry Neurosci 34:88–101PubMed Kebir O, Tabbane K, Sengupta S, Joober R (2009) Candidate genes and neuropsychological phenotypes in children with ADHD: review of association studies. J Psychiatry Neurosci 34:88–101PubMed
21.
go back to reference Nadder T, Rutter M, Silberg JL, Maes HH, Eaves LJ (2002) Genetic effects on the variation and covariation of attention deficit-hyperactivity disorder (ADHD) and oppositional-defiant disorder/conduct disorder (ODD/CD) symptomatologies across informant and occasion of measurement. Psychol Med 32:39–53PubMedCrossRef Nadder T, Rutter M, Silberg JL, Maes HH, Eaves LJ (2002) Genetic effects on the variation and covariation of attention deficit-hyperactivity disorder (ADHD) and oppositional-defiant disorder/conduct disorder (ODD/CD) symptomatologies across informant and occasion of measurement. Psychol Med 32:39–53PubMedCrossRef
22.
go back to reference Silberg J, Rutter M, Meyer J, Maes H, Hewitt J, Simonoff E et al (1996) Genetic and environmental influences on the covariation between hyperactivity and conduct disturbance in juvenile twins. J Child Psychol Psychiatry 37:803–816PubMedCrossRef Silberg J, Rutter M, Meyer J, Maes H, Hewitt J, Simonoff E et al (1996) Genetic and environmental influences on the covariation between hyperactivity and conduct disturbance in juvenile twins. J Child Psychol Psychiatry 37:803–816PubMedCrossRef
23.
go back to reference Thapar A, Harrington R, McGuffin P (2001) Examining the comorbidity of ADHD-related behaviours and conduct problems using a twin study design. Br J Psychiatry 179:224–229PubMedCrossRef Thapar A, Harrington R, McGuffin P (2001) Examining the comorbidity of ADHD-related behaviours and conduct problems using a twin study design. Br J Psychiatry 179:224–229PubMedCrossRef
24.
go back to reference Tuvblad C, Zheng M, Raine A, Baker LA (2008) A common genetic factor explains the covariation among ADHD ODD and CD symptoms in 9–10 year old boys and girls. J Abnorm Child Psychol 37:153–167CrossRef Tuvblad C, Zheng M, Raine A, Baker LA (2008) A common genetic factor explains the covariation among ADHD ODD and CD symptoms in 9–10 year old boys and girls. J Abnorm Child Psychol 37:153–167CrossRef
25.
go back to reference Cadoret RJ, Stewart MA (1991) An adoption study of attention deficit/hyperactivity/aggression and their relationship to adult antisocial personality. Compr Psychiatry 32:73–82PubMedCrossRef Cadoret RJ, Stewart MA (1991) An adoption study of attention deficit/hyperactivity/aggression and their relationship to adult antisocial personality. Compr Psychiatry 32:73–82PubMedCrossRef
26.
go back to reference Udry JR (2003) The National Longitudinal Study of Adolescent Health (Add Health), Waves I and II, 1994–1996; Wave III, 2002–2002 [machine-readable data file and documentation]. Chapel Hill, NC, Carolina Population Center, University of North Carolina at Chapel Hill Udry JR (2003) The National Longitudinal Study of Adolescent Health (Add Health), Waves I and II, 1994–1996; Wave III, 2002–2002 [machine-readable data file and documentation]. Chapel Hill, NC, Carolina Population Center, University of North Carolina at Chapel Hill
28.
go back to reference Beaver KM (2011) Genetic influences on being processed through the criminal justice system: results from a sample of adoptees. Biol Psychiatry 69:282–287PubMedCrossRef Beaver KM (2011) Genetic influences on being processed through the criminal justice system: results from a sample of adoptees. Biol Psychiatry 69:282–287PubMedCrossRef
29.
go back to reference Haberstick BC, Timberlake D, Hopfer CJ, Lessem JM, Ehringer MA, Hewitt JK (2008) Genetic and environmental contributions to retrospectively reported DSM-IV childhood attention deficit hyperactivity disorder. Psychol Med 38:1057–1066PubMedCrossRef Haberstick BC, Timberlake D, Hopfer CJ, Lessem JM, Ehringer MA, Hewitt JK (2008) Genetic and environmental contributions to retrospectively reported DSM-IV childhood attention deficit hyperactivity disorder. Psychol Med 38:1057–1066PubMedCrossRef
30.
go back to reference McClernon FJ, Fuemmeler BF, Kollins SH, Kail ME, Ashley-Koch AE (2008) Interactions between genotype and retrospective ADHD symptoms predict lifetime smoking risk in a sample of young adults. Nicotine Tob Res 10:117–127PubMedCrossRef McClernon FJ, Fuemmeler BF, Kollins SH, Kail ME, Ashley-Koch AE (2008) Interactions between genotype and retrospective ADHD symptoms predict lifetime smoking risk in a sample of young adults. Nicotine Tob Res 10:117–127PubMedCrossRef
31.
go back to reference Ouyang L, Fang X, Mercy J, Perou R, Grosse SD (2008) Attention-deficit/hyperactivity disorder symptoms and child maltreatment: a population-based study. J Pediatr 153:851–856PubMedCrossRef Ouyang L, Fang X, Mercy J, Perou R, Grosse SD (2008) Attention-deficit/hyperactivity disorder symptoms and child maltreatment: a population-based study. J Pediatr 153:851–856PubMedCrossRef
32.
go back to reference Brookes K-J, Mill J, Guindalini C, Curran S, Xu X, Knight J et al (2006) A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy. Arch Gen Psychiatry 63:74–81PubMedCrossRef Brookes K-J, Mill J, Guindalini C, Curran S, Xu X, Knight J et al (2006) A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy. Arch Gen Psychiatry 63:74–81PubMedCrossRef
33.
go back to reference Faraone SV, Biederman J (1998) Neurobiology of attention-deficit hyperactivity disorder. Biol Psychiatry 44:951–958PubMedCrossRef Faraone SV, Biederman J (1998) Neurobiology of attention-deficit hyperactivity disorder. Biol Psychiatry 44:951–958PubMedCrossRef
34.
go back to reference Ficks CA, Waldman ID (2009) Gene-environment interactions in attention-deficit/hyperactivity disorder. Curr Psychiatry Rep 11:387–392PubMedCrossRef Ficks CA, Waldman ID (2009) Gene-environment interactions in attention-deficit/hyperactivity disorder. Curr Psychiatry Rep 11:387–392PubMedCrossRef
35.
go back to reference Kim-Cohen J, Caspi A, Taylor A, Williams B, Newcombe R, Craig IW et al (2006) MAOA, maltreatment, and gene–environment interaction predicting children’s mental health: new evidence and a meta-analysis. Mol Psychiatry 11:903–913PubMedCrossRef Kim-Cohen J, Caspi A, Taylor A, Williams B, Newcombe R, Craig IW et al (2006) MAOA, maltreatment, and gene–environment interaction predicting children’s mental health: new evidence and a meta-analysis. Mol Psychiatry 11:903–913PubMedCrossRef
36.
go back to reference Kirley A, Lowe N, Mullins C, McCarron M, Daly G, Waldman I et al (2004) Phenotype studies of the DRD4 gene polymorphisms in ADHD: association with oppositional defiant disorder and positive family history. Am J Med Genet B Neuropsychiatr Genet 131B:38–42PubMedCrossRef Kirley A, Lowe N, Mullins C, McCarron M, Daly G, Waldman I et al (2004) Phenotype studies of the DRD4 gene polymorphisms in ADHD: association with oppositional defiant disorder and positive family history. Am J Med Genet B Neuropsychiatr Genet 131B:38–42PubMedCrossRef
37.
go back to reference Langley K, Turic D, Rice F, Holmans P, van den Bree MBM, Craddock N et al (2008) Testing for gene × environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behavior. Am J Med Genet 147B:49–53PubMedCrossRef Langley K, Turic D, Rice F, Holmans P, van den Bree MBM, Craddock N et al (2008) Testing for gene × environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behavior. Am J Med Genet 147B:49–53PubMedCrossRef
38.
go back to reference Swanson JM, Kinsbourne M, Nigg J, Lanphear B, Stefanatos GA, Volkow N et al (2007) Etiologic subtypes of attention-deficit/hyperactivity disorder: brain imaging, molecular genetic and environmental factors and the dopamine hypothesis. Neuropsychol Rev 17:39–59PubMedCrossRef Swanson JM, Kinsbourne M, Nigg J, Lanphear B, Stefanatos GA, Volkow N et al (2007) Etiologic subtypes of attention-deficit/hyperactivity disorder: brain imaging, molecular genetic and environmental factors and the dopamine hypothesis. Neuropsychol Rev 17:39–59PubMedCrossRef
39.
go back to reference Thapar A, O’Donovan M, Owen MJ (2005) The genetics of attention deficit hyperactivity disorder. Hum Mol Genet 14:R275–R282PubMedCrossRef Thapar A, O’Donovan M, Owen MJ (2005) The genetics of attention deficit hyperactivity disorder. Hum Mol Genet 14:R275–R282PubMedCrossRef
40.
go back to reference Waldman ID (2007) Gene–environment interactions reexamined: does mother’s marital stability interact with the dopamine receptor D2 gene in the etiology of childhood attention-deficit/hyperactivity disorder? Dev Psychopathol 19:1117–1128PubMedCrossRef Waldman ID (2007) Gene–environment interactions reexamined: does mother’s marital stability interact with the dopamine receptor D2 gene in the etiology of childhood attention-deficit/hyperactivity disorder? Dev Psychopathol 19:1117–1128PubMedCrossRef
41.
go back to reference Mill J, Petronis A (2008) Pre- and peri-natal environmental risks for attention-deficit hyperactivity disorder (ADHD): the potential role of epigenetic processes in mediating susceptibility. J Child Psychol Psychiatry 49:1020–1030PubMedCrossRef Mill J, Petronis A (2008) Pre- and peri-natal environmental risks for attention-deficit hyperactivity disorder (ADHD): the potential role of epigenetic processes in mediating susceptibility. J Child Psychol Psychiatry 49:1020–1030PubMedCrossRef
42.
go back to reference Farrington DP, Ttofi MM, Coid JW (2009) Development of adolescence-limited, late-onset, and persistent offenders from age 8 to age 48. Aggress Behav 35:150–163PubMedCrossRef Farrington DP, Ttofi MM, Coid JW (2009) Development of adolescence-limited, late-onset, and persistent offenders from age 8 to age 48. Aggress Behav 35:150–163PubMedCrossRef
43.
go back to reference Harpin VA (2005) The effect of ADHD on the life of an individual, their family, and community from preschool to adult life. Arch Dis Child 90:i2–i7PubMedCrossRef Harpin VA (2005) The effect of ADHD on the life of an individual, their family, and community from preschool to adult life. Arch Dis Child 90:i2–i7PubMedCrossRef
44.
go back to reference Matza LS, Paramore C, Prasad M (2005) A review of the economic burden of ADHD. Cost Eff Resour Alloc 3:5–13PubMedCrossRef Matza LS, Paramore C, Prasad M (2005) A review of the economic burden of ADHD. Cost Eff Resour Alloc 3:5–13PubMedCrossRef
45.
go back to reference Piquero AR, Farrington DP, Nagin DS, Moffitt TE (2010) Trajectories of offending and their relation to life failure in late middle age: findings from the Cambridge study in delinquent development. J Res Crime Del 47:151–173CrossRef Piquero AR, Farrington DP, Nagin DS, Moffitt TE (2010) Trajectories of offending and their relation to life failure in late middle age: findings from the Cambridge study in delinquent development. J Res Crime Del 47:151–173CrossRef
46.
go back to reference Fuemmeler BF, Kollins SH, McClernon FJ (2007) Attention deficit hyperactivity disorder symptoms predict nicotine dependence and progression to regular smoking from adolescence to young adulthood. J Pediatr Psychol 32:1203–1213PubMedCrossRef Fuemmeler BF, Kollins SH, McClernon FJ (2007) Attention deficit hyperactivity disorder symptoms predict nicotine dependence and progression to regular smoking from adolescence to young adulthood. J Pediatr Psychol 32:1203–1213PubMedCrossRef
47.
go back to reference Kollins SH, McClernon FJ, Fuemmeler BF (2005) Association between smoking and attention-deficit/hyperactivity disorder symptoms in a population-based sample of young adults. Arch Gen Psychiatry 62:1142–1147PubMedCrossRef Kollins SH, McClernon FJ, Fuemmeler BF (2005) Association between smoking and attention-deficit/hyperactivity disorder symptoms in a population-based sample of young adults. Arch Gen Psychiatry 62:1142–1147PubMedCrossRef
48.
go back to reference Vaughn MG, Beaver KM, Delisi M, Perron BE, Schelbe L (2009) Gene-environment interplay and the importance of self-control in predicting polydrug use and substance-related problems. Addict Behav 34:112–116PubMedCrossRef Vaughn MG, Beaver KM, Delisi M, Perron BE, Schelbe L (2009) Gene-environment interplay and the importance of self-control in predicting polydrug use and substance-related problems. Addict Behav 34:112–116PubMedCrossRef
Metagegevens
Titel
Genetic Risks and ADHD Symptomatology: Exploring the Effects of Parental Antisocial Behaviors in an Adoption-Based Study
Auteurs
Kevin M. Beaver
Joseph L. Nedelec
Meghan W. Rowland
Joseph A. Schwartz
Publicatiedatum
01-04-2012
Uitgeverij
Springer US
Gepubliceerd in
Child Psychiatry & Human Development / Uitgave 2/2012
Print ISSN: 0009-398X
Elektronisch ISSN: 1573-3327
DOI
https://doi.org/10.1007/s10578-011-0263-0

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