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Gepubliceerd in: Journal of Abnormal Child Psychology 2/2018

10-03-2017

Gene-Environment Interactions in ADHD: The Roles of SES and Chaos

Auteurs: Karen L. Gould, William L. Coventry, Richard K. Olson, Brian Byrne

Gepubliceerd in: Research on Child and Adolescent Psychopathology | Uitgave 2/2018

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Abstract

Although attention-deficit/hyperactivity disorder (ADHD) is highly heritable, emerging evidence suggests symptoms are associated with interactions between genes and the environment (GxE) during development. This study tested whether heritability of ADHD symptoms is moderated by two environmental factors: socioeconomic status (SES) and chaos (household disorganisation). A population sample of 520 twin pairs (N = 1040, 52.3% female) from 6 to 15 years completed measures of behavior and home environment. Structural equation modelling was then used to test whether environmental factors were associated with a change in the extent to which genes explain variability in ADHD symptoms. Neither chaos nor SES moderated heritability, with consistent contributions from both genes and environment indicated across socioeconomic strata and levels of chaos. This finding contrasts with those of previous research, underlining the need to replicate results in the emerging field of GxE research across different populations and statistical methods. Robust findings may assist in developing targeted interventions for genetically vulnerable individuals.
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Metagegevens
Titel
Gene-Environment Interactions in ADHD: The Roles of SES and Chaos
Auteurs
Karen L. Gould
William L. Coventry
Richard K. Olson
Brian Byrne
Publicatiedatum
10-03-2017
Uitgeverij
Springer US
Gepubliceerd in
Research on Child and Adolescent Psychopathology / Uitgave 2/2018
Print ISSN: 2730-7166
Elektronisch ISSN: 2730-7174
DOI
https://doi.org/10.1007/s10802-017-0268-7