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10-03-2017 | Uitgave 2/2018

Gene-Environment Interactions in ADHD: The Roles of SES and Chaos

Tijdschrift:: Journal of Abnormal Child Psychology > Uitgave 2/2018

Auteurs:: Karen L. Gould, William L. Coventry, Richard K. Olson, Brian Byrne

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Abstract

Although attention-deficit/hyperactivity disorder (ADHD) is highly heritable, emerging evidence suggests symptoms are associated with interactions between genes and the environment (GxE) during development. This study tested whether heritability of ADHD symptoms is moderated by two environmental factors: socioeconomic status (SES) and chaos (household disorganisation). A population sample of 520 twin pairs (N = 1040, 52.3% female) from 6 to 15 years completed measures of behavior and home environment. Structural equation modelling was then used to test whether environmental factors were associated with a change in the extent to which genes explain variability in ADHD symptoms. Neither chaos nor SES moderated heritability, with consistent contributions from both genes and environment indicated across socioeconomic strata and levels of chaos. This finding contrasts with those of previous research, underlining the need to replicate results in the emerging field of GxE research across different populations and statistical methods. Robust findings may assist in developing targeted interventions for genetically vulnerable individuals.

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Titel: Gene-Environment Interactions in ADHD: The Roles of SES and Chaos
Auteurs:: Karen L. Gould
William L. Coventry
Richard K. Olson
Brian Byrne
Publicatiedatum: 10-03-2017
DOI: https://doi.org/10.1007/s10802-017-0268-7
Uitgeverij: Springer US
Tijdschrift: Journal of Abnormal Child Psychology An official publication of the International Society for Research in Child and Adolescent Psychopathology
Uitgave 2/2018
Print ISSN: 0091-0627
Elektronisch ISSN: 1573-2835

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