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Gepubliceerd in: Netherlands Heart Journal 12/2007

01-12-2007 | Original article

Gender disparities in torsade de pointes ventricular tachycardia

Auteurs: A. O. Verkerk, H. L. Tan

Gepubliceerd in: Netherlands Heart Journal | Uitgave 12/2007

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Abstract

Background Gender disparities in the incidence of torsade de pointes (TdP) ventricular tachycardia exist, but the mechanisms in humans are unresolved. We addressed this issue using a mathematical model of a human ventricular cell.
MethodsWe implemented gender differences in the Priebe-Beuckelmann model cell by modifying the amplitudes of the L-type Ca2+ current (ICa,L), transient outward K+ current (Ito), and rapid component of the delayed rectifier K+current (IKr), according to experimental data from animal male and female hearts. Gender disparities in electrical heterogeneity between transmural layers (subepicardium, midmyocardium, subendocardium) were implemented by modifying various ion currents according to experimental data.
ResultsAction potentials in female cells have longer durations and steeper duration versus frequency relationships than male cells. In the female cells, electrical heterogeneity between transmural layers is larger and the susceptibility to early afterdepolarisations is higher than in male cells.
ConclusionGender-related differences in ICa,L, Ito, and IKr may explain the gender disparities in human cardiac electrophysiology. Female cells have an increased susceptibility to early afterdepolarisations following mild reductions in net repolarising forces. Combined with their greater electrical heterogeneity, this renders them more vulnerable to TdP. (Neth Heart J 2007;15:405-11.)
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Metagegevens
Titel
Gender disparities in torsade de pointes ventricular tachycardia
Auteurs
A. O. Verkerk
H. L. Tan
Publicatiedatum
01-12-2007
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Netherlands Heart Journal / Uitgave 12/2007
Print ISSN: 1568-5888
Elektronisch ISSN: 1876-6250
DOI
https://doi.org/10.1007/BF03086040

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