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Quality of Life Research
Gepubliceerd in: Quality of Life Research 8/2021

10-03-2021

Gender differences in factors associated with low quality of life and depression in Korean patients with ankylosing spondylitis

Auteurs: Bora Nam, Bon San Koo, Seoung Wan Nam, Ji-Hui Shin, Yoonah Song, Soo-Kyung Cho, Yoon-Kyoung Sung, Tae-Hwan Kim

Gepubliceerd in: Quality of Life Research | Uitgave 8/2021

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Abstract

Purpose

To identify predictors of low health-related quality of life (HRQoL) and depression in ankylosing spondylitis (AS) patients with a focus on gender differences.

Methods

We conducted a cross-sectional cohort study. Both AS-related clinical data and contextual factors were obtained. HRQoL and depressive mood were assessed by EuroQol-5 dimension (EQ-5D) and the Center for Epidemiological Studies Depression Scale (CES-D), respectively. Gender-stratified multivariable logistic regression analyses were performed.

Results

Among 211 patients, 161 were males. Males had similar disease activity and higher radiographic damage compared with females. There was no significant difference in EQ-5D index score between genders. CES-D score was higher in females. Higher ASDAS-C-reactive protein (CRP) was associated with low HRQoL in both males (Odds ratio [OR] 4.25, 95% confidence interval [CI] 2.42–7.46) and females (OR 2.94, 95% CI 1.02–8.48). Being employed was associated with decreased possibility of having low HRQoL in males (OR 0.39, 95% CI 0.16–0.95). Regarding depression, higher ASDAS-CRP (OR 1.87, 95% CI 1.03–3.40), current smoking (OR 2.98, 95% CI 1.09–8.15), and being employed (OR 0.17, 95% CI 0.06–0.46) were associated with depression in males. For females, living with a partner was related to depression (OR 0.08, 95% CI 0.01–0.93).

Conclusion

AS patients with high disease activity are likely to be suffering from low HRQoL. Both disease-related factors and contextual factors were associated with depression, and predictors showed some differences between genders. Awareness of gender differences in comprehensive assessment can lead us to better personalized management in AS patients.
vorige artikel Health-related quality of life in refugee youth and the mediating role of mental distress and post-migration stressors
volgende artikel Prevalence and 11-year incidence of common eye diseases and their relation to health-related quality of life, mental health, and visual impairment
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Metagegevens
Titel
Gender differences in factors associated with low quality of life and depression in Korean patients with ankylosing spondylitis
Auteurs
Bora Nam
Bon San Koo
Seoung Wan Nam
Ji-Hui Shin
Yoonah Song
Soo-Kyung Cho
Yoon-Kyoung Sung
Tae-Hwan Kim
Publicatiedatum
10-03-2021
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 8/2021
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-021-02800-w

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