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01-02-2009 | Original Paper | Uitgave 2/2009

GABA_A Receptor Downregulation in Brains of Subjects with Autism

Tijdschrift:: Journal of Autism and Developmental Disorders > Uitgave 2/2009

Auteurs:: S. Hossein Fatemi, Teri J. Reutiman, Timothy D. Folsom, Paul D. Thuras

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Abstract

Gamma-aminobutyric acid A (GABA_A) receptors are ligand-gated ion channels responsible for mediation of fast inhibitory action of GABA in the brain. Preliminary reports have demonstrated altered expression of GABA receptors in the brains of subjects with autism suggesting GABA/glutamate system dysregulation. We investigated the expression of four GABA_A receptor subunits and observed significant reductions in GABRA1, GABRA2, GABRA3, and GABRB3 in parietal cortex (Brodmann’s Area 40 (BA40)), while GABRA1 and GABRB3 were significantly altered in cerebellum, and GABRA1 was significantly altered in superior frontal cortex (BA9). The presence of seizure disorder did not have a significant impact on GABA_A receptor subunit expression in the three brain areas. Our results demonstrate that GABA_A receptors are reduced in three brain regions that have previously been implicated in the pathogenesis of autism, suggesting widespread GABAergic dysfunction in the brains of subjects with autism.

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Titel: GABAA Receptor Downregulation in Brains of Subjects with Autism
Auteurs:: S. Hossein Fatemi
Teri J. Reutiman
Timothy D. Folsom
Paul D. Thuras
Publicatiedatum: 01-02-2009
DOI: https://doi.org/10.1007/s10803-008-0646-7
Uitgeverij: Springer US
Tijdschrift: Journal of Autism and Developmental Disorders
Uitgave 2/2009
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432

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