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Gepubliceerd in: Journal of Behavioral Medicine 5/2013

01-10-2013

Functional magnetic resonance imaging study reveals differences in the habituation to psychological stress in patients with Crohn’s disease versus healthy controls

Auteurs: Alessandro Agostini, Nicola Filippini, Francesca Benuzzi, Angela Bertani, Antonella Scarcelli, Chiara Leoni, Valentina Farinelli, Donatella Riso, Rosy Tambasco, Carlo Calabrese, Fernando Rizzello, Paolo Gionchetti, Mauro Ercolani, Paolo Nichelli, Massimo Campieri

Gepubliceerd in: Journal of Behavioral Medicine | Uitgave 5/2013

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Abstract

In patients with Crohn’s disease (CD) stress is believed to increase the incidence of disease relapse. The brain processes stressful stimuli and triggers the stress-evoked responses. Habituation to stress is an adaptive process that allows minimizing these responses. We hypothesized inadequate habituation to stress in CD patients. The aim of this study was to compare the neural habituation between CD patients and controls. Twenty CD patients and eighteen controls underwent a functional magnetic resonance imaging while performing two repeated runs of a stress-evoking task. The task elicited different neural activity between the groups across runs in (1) amygdala, hippocampus, (2) insula, putamen (3) cerebellar regions, suggesting altered habituation to stress in patients. These structures regulate the neuroendocrine and autonomic stress-evoked responses that control the proinflammatory responses. The inadequate habituation to stress that we found in patients could play a role in the relationship between stress and inflammatory exacerbations in CD.
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Metagegevens
Titel
Functional magnetic resonance imaging study reveals differences in the habituation to psychological stress in patients with Crohn’s disease versus healthy controls
Auteurs
Alessandro Agostini
Nicola Filippini
Francesca Benuzzi
Angela Bertani
Antonella Scarcelli
Chiara Leoni
Valentina Farinelli
Donatella Riso
Rosy Tambasco
Carlo Calabrese
Fernando Rizzello
Paolo Gionchetti
Mauro Ercolani
Paolo Nichelli
Massimo Campieri
Publicatiedatum
01-10-2013
Uitgeverij
Springer US
Gepubliceerd in
Journal of Behavioral Medicine / Uitgave 5/2013
Print ISSN: 0160-7715
Elektronisch ISSN: 1573-3521
DOI
https://doi.org/10.1007/s10865-012-9441-1

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