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Gepubliceerd in: Journal of Autism and Developmental Disorders 9/2017

07-06-2017 | Original Paper

Frequency of Dendritic Cells and Their Expression of Costimulatory Molecules in Children with Autism Spectrum Disorders

Auteurs: Khaled Saad, Asmaa M. Zahran, Khalid I. Elsayh, Ahmed A. Abdel-Rahman, Abdulrahman A. Al-Atram, Almontaser Hussein, Yasmin G. El-Gendy

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 9/2017

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Abstract

The aim of our study was to evaluate the frequencies of myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs) in children with ASD. Subjects were 32 children with ASD and 30 healthy children as controls. The numbers of mDCs and pDCs and the expression of CD86 and CD80 on the entire DCs were detected by flow cytometry. ASD children had significantly higher percentages of mDCs and pDCs when compared to controls. We found significant inverse relationships between serum 25-hydroxyvitamin D levels and the frequencies of mDCs and pDCs in autistic children. Our data suggested that DCs could play a role in the clinical course of ASD. The relationship of DCs to immune disorders in ASD remains to be determined.
Literatuur
go back to reference Aman, M. G., Singh, N. N., Stewart, A. W., & Field, C. J. (1985). The aberrant behavior checklist: A behavior rating scale for the assessment of treatment effects. American Journal of Mental Deficiency, 89(5), 485–491. PubMed Aman, M. G., Singh, N. N., Stewart, A. W., & Field, C. J. (1985). The aberrant behavior checklist: A behavior rating scale for the assessment of treatment effects. American Journal of Mental Deficiency, 89(5), 485–491. PubMed
go back to reference American Psychiatric Association (2013). Diagnostic and statistical manual of mental disorders 5. Washington, DC: American Psychiatric Association. CrossRef American Psychiatric Association (2013). Diagnostic and statistical manual of mental disorders 5. Washington, DC: American Psychiatric Association. CrossRef
go back to reference Banchereau, J., Briere, F., & Caux, C. (2000). Immunobiology of dendritic cells. Annual Review of Immunology, 18, 767–811. CrossRefPubMed Banchereau, J., Briere, F., & Caux, C. (2000). Immunobiology of dendritic cells. Annual Review of Immunology, 18, 767–811. CrossRefPubMed
go back to reference Bjørklund, G., Saad, K., Chirumbolo, S., Kern, J. K., Geier, D. A., Geier M. R. et al. (2016). Immune dysfunction and neuroinflammation in autism spectrum disorder. Acta Neurobiologiae Experimentalis (Wars), 76(4), 257–268. CrossRef Bjørklund, G., Saad, K., Chirumbolo, S., Kern, J. K., Geier, D. A., Geier M. R. et al. (2016). Immune dysfunction and neuroinflammation in autism spectrum disorder. Acta Neurobiologiae Experimentalis (Wars), 76(4), 257–268. CrossRef
go back to reference Breece, E., Paciotti, B., Nordahl, C. W., Ozonoff, S., Van de Water, J. A., Rogers, S. J., et al. (2013). Myeloid dendritic cells frequencies are increased in children with autism spectrum disorder and associated with amygdala volume and repetitive behaviors. Brain, Behavior, and Immunity, 31, 69–75. CrossRefPubMed Breece, E., Paciotti, B., Nordahl, C. W., Ozonoff, S., Van de Water, J. A., Rogers, S. J., et al. (2013). Myeloid dendritic cells frequencies are increased in children with autism spectrum disorder and associated with amygdala volume and repetitive behaviors. Brain, Behavior, and Immunity, 31, 69–75. CrossRefPubMed
go back to reference Cannell, J. J., & Grant, W. B. (2013). What is the role of vitamin D in autism? Dermatoendocrinology, 5(1), 199–204. CrossRef Cannell, J. J., & Grant, W. B. (2013). What is the role of vitamin D in autism? Dermatoendocrinology, 5(1), 199–204. CrossRef
go back to reference Careaga M, Ashwood P. Autism spectrum disorders: From immunity to behavior. In: Yan Q (ed) Psychoneuroimmunology methods and protocols. New York: Humana Press, pp 219–240. Careaga M, Ashwood P. Autism spectrum disorders: From immunity to behavior. In: Yan Q (ed) Psychoneuroimmunology methods and protocols. New York: Humana Press, pp 219–240.
go back to reference Eyles, D. W., Burne, T. H., McGrath, J. J., & Vitamin, D. (2013). effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease. Frontiers in Neuroendocrinology, 34, 47–64. CrossRefPubMed Eyles, D. W., Burne, T. H., McGrath, J. J., & Vitamin, D. (2013). effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease. Frontiers in Neuroendocrinology, 34, 47–64. CrossRefPubMed
go back to reference Ferreira, G. B., Gysemans, C. A., Demengeot, J., da Cunha, J. P., Vanherwegen, A. S., Overbergh, L., et al. (2014). 1,25-Dihydroxyvitamin D3 promotes tolerogenic dendritic cells with functional migratory properties in NOD mice. Journal of immunology (Baltimore, Md.: 1950), 1, 192. Ferreira, G. B., Gysemans, C. A., Demengeot, J., da Cunha, J. P., Vanherwegen, A. S., Overbergh, L., et al. (2014). 1,25-Dihydroxyvitamin D3 promotes tolerogenic dendritic cells with functional migratory properties in NOD mice. Journal of immunology (Baltimore, Md.: 1950), 1, 192.
go back to reference Ferreira, G. B., Vanherwegen, A. S., Eelen, G., Gutiérrez, A. C., Van Lommel, L., Marchal, K., et al. (2015). Vitamin D3 induces tolerance in human dendritic cells by activation of intracellular metabolic pathways. Cell Reports, S2211–1247(15), 711–725. CrossRef Ferreira, G. B., Vanherwegen, A. S., Eelen, G., Gutiérrez, A. C., Van Lommel, L., Marchal, K., et al. (2015). Vitamin D3 induces tolerance in human dendritic cells by activation of intracellular metabolic pathways. Cell Reports, S2211–1247(15), 711–725. CrossRef
go back to reference Geier, D. A., Kern, J. K., & Geier, M. R. (2013). A comparison of the autism treatment evaluation checklist (ATEC) and the childhood autism rating scale (CARS) for the quantitative evaluation of autism. Journal of Mental Health Research in Intellectual Disabilities, 6(4), 255–267. CrossRefPubMedPubMedCentral Geier, D. A., Kern, J. K., & Geier, M. R. (2013). A comparison of the autism treatment evaluation checklist (ATEC) and the childhood autism rating scale (CARS) for the quantitative evaluation of autism. Journal of Mental Health Research in Intellectual Disabilities, 6(4), 255–267. CrossRefPubMedPubMedCentral
go back to reference Gurney, J. G., McPheeters, M. L., & Davis, M. M. (2006). Parental report of health conditions and health care use among children with and without autism: National Survey of Children’s Health. Archives of Pediatrics and Adolescent Medicine, 160, 825–830. CrossRefPubMed Gurney, J. G., McPheeters, M. L., & Davis, M. M. (2006). Parental report of health conditions and health care use among children with and without autism: National Survey of Children’s Health. Archives of Pediatrics and Adolescent Medicine, 160, 825–830. CrossRefPubMed
go back to reference Kern, J. K., Geier, D. A., Sykes, L. K., Homme, K. G., & Geier, M. R. (2014). Medical conditions in autism and events associated with initial onset of autism. OA. Autism: The International Journal of Research and Practice, 2(1), 9. Kern, J. K., Geier, D. A., Sykes, L. K., Homme, K. G., & Geier, M. R. (2014). Medical conditions in autism and events associated with initial onset of autism. OA. Autism: The International Journal of Research and Practice, 2(1), 9.
go back to reference Mead, J., & Ashwood, P. (2015). Evidence supporting an altered immune response in ASD. Immunology Letters, 163(1), 49–55. CrossRefPubMed Mead, J., & Ashwood, P. (2015). Evidence supporting an altered immune response in ASD. Immunology Letters, 163(1), 49–55. CrossRefPubMed
go back to reference Ruggeri, B., Sarkans, U., Schumann, G., & Persico, A. M. (2014). Biomarkers in autism spectrum disorder: the old and the new. Psychopharmacology, 231(6), 1201–1216. CrossRefPubMed Ruggeri, B., Sarkans, U., Schumann, G., & Persico, A. M. (2014). Biomarkers in autism spectrum disorder: the old and the new. Psychopharmacology, 231(6), 1201–1216. CrossRefPubMed
go back to reference Saad K, Abdel-Rahman AA, Elserogy YM, Al-Atram AA, Cannell JJ, Bjørklund G et al. (2016a) Vitamin D status in autism spectrum disorders and the efficacy of vitamin D supplementation in autistic children. Nutrition Neuroscience, 19(8):346–351. CrossRef Saad K, Abdel-Rahman AA, Elserogy YM, Al-Atram AA, Cannell JJ, Bjørklund G et al. (2016a) Vitamin D status in autism spectrum disorders and the efficacy of vitamin D supplementation in autistic children. Nutrition Neuroscience, 19(8):346–351. CrossRef
go back to reference Saad K, Abdel-rahman AA, Elserogy Y, Al-Atram AA, El-Houfey AA, Othman HA et al. (2016b). Randomized-controlled trial of vitamin d supplementation in children with autism spectrum disorder. Journal of Child Psychology and Psychiatry. doi: 10.​1111/​jcpp.​12652. PubMed Saad K, Abdel-rahman AA, Elserogy Y, Al-Atram AA, El-Houfey AA, Othman HA et al. (2016b). Randomized-controlled trial of vitamin d supplementation in children with autism spectrum disorder. Journal of Child Psychology and Psychiatry. doi: 10.​1111/​jcpp.​12652. PubMed
go back to reference Sakamoto, A., Moriuchi, H., Matsuzaki, J., Motoyama, K., & Moriuchi, M. (2015). Retrospective diagnosis of congenital cytomegalovirus infection in children with autism spectrum disorder but no other major neurologic deficit. Brain and Development, 37, 200–205. CrossRefPubMed Sakamoto, A., Moriuchi, H., Matsuzaki, J., Motoyama, K., & Moriuchi, M. (2015). Retrospective diagnosis of congenital cytomegalovirus infection in children with autism spectrum disorder but no other major neurologic deficit. Brain and Development, 37, 200–205. CrossRefPubMed
go back to reference Schieve, L. A., Gonzalez, V., Boulet, S. L., Visser, S. N., Rice, C. E., Van Naarden Braun K, & Boyle, C. A. (2011). Concurrent medical conditions and health care use and needs among children with learning and behavioral developmental disabilities, National Health Interview Survey, 2006–2010. Research in Developmental Disabilities, 33, 467–476. CrossRefPubMed Schieve, L. A., Gonzalez, V., Boulet, S. L., Visser, S. N., Rice, C. E., Van Naarden Braun K, & Boyle, C. A. (2011). Concurrent medical conditions and health care use and needs among children with learning and behavioral developmental disabilities, National Health Interview Survey, 2006–2010. Research in Developmental Disabilities, 33, 467–476. CrossRefPubMed
go back to reference Schopler E, Van Bourgondien M E, Wellman GJ. (2010) Childhood autism rating scale. 2nd. CARS-2. Los Angeles, CA: Western Psychological Services. Schopler E, Van Bourgondien M E, Wellman GJ. (2010) Childhood autism rating scale. 2nd. CARS-2. Los Angeles, CA: Western Psychological Services.
go back to reference Steinman, R. M., Lasker Basic Medical Research Award (2007). Dendritic cells: versatile controllers of the immune system. Natural Medicines, 13(10), 1155–1159. CrossRef Steinman, R. M., Lasker Basic Medical Research Award (2007). Dendritic cells: versatile controllers of the immune system. Natural Medicines, 13(10), 1155–1159. CrossRef
go back to reference Ueno, H., Klechevsky, E., Morita, R., Aspord, C., Cao, T., Matsui, T., et al. (2007). Dendritic cell subsets in health and disease. Immunological Reviews, 219, 118–142. CrossRefPubMed Ueno, H., Klechevsky, E., Morita, R., Aspord, C., Cao, T., Matsui, T., et al. (2007). Dendritic cell subsets in health and disease. Immunological Reviews, 219, 118–142. CrossRefPubMed
go back to reference van Halteren, A. G., van Etten, E., de Jong, E. C., Bouillon, R., Roep, B. O., & Mathieu, C. (2002). Redirection of human autoreactive T-cells Upon interaction with dendritic cells modulated by TX527, an analog of 1,25 dihydroxyvitamin D (3). Diabetes, 51(7), 2119–2125. CrossRefPubMed van Halteren, A. G., van Etten, E., de Jong, E. C., Bouillon, R., Roep, B. O., & Mathieu, C. (2002). Redirection of human autoreactive T-cells Upon interaction with dendritic cells modulated by TX527, an analog of 1,25 dihydroxyvitamin D (3). Diabetes, 51(7), 2119–2125. CrossRefPubMed
go back to reference Voineagu, I., Wang, X., Johnston, P., Lowe, J. K., Tian, Y., Horvath, S., et al. (2011). Transcriptomic analysis of autistic brain reveals convergent molecular pathology. Nature, 474, 380–384. CrossRefPubMedPubMedCentral Voineagu, I., Wang, X., Johnston, P., Lowe, J. K., Tian, Y., Horvath, S., et al. (2011). Transcriptomic analysis of autistic brain reveals convergent molecular pathology. Nature, 474, 380–384. CrossRefPubMedPubMedCentral
go back to reference Wang, T. T., DU, L., Shan, L., & Jia, F. Y. (2014). Research advances in immunological dysfunction in children with autism spectrum disorders. Zhongguo Dang Dai Er Ke Za Zhi, 16(12), 1289–1293. PubMed Wang, T. T., DU, L., Shan, L., & Jia, F. Y. (2014). Research advances in immunological dysfunction in children with autism spectrum disorders. Zhongguo Dang Dai Er Ke Za Zhi, 16(12), 1289–1293. PubMed
go back to reference Wilson, E. H., Weninger, W., & Hunter, C. A. (2010). Trafficking of immune cells in the central nervous system. The Journal of Clinical Investigation, 120, 1368–1379. CrossRefPubMedPubMedCentral Wilson, E. H., Weninger, W., & Hunter, C. A. (2010). Trafficking of immune cells in the central nervous system. The Journal of Clinical Investigation, 120, 1368–1379. CrossRefPubMedPubMedCentral
Metagegevens
Titel
Frequency of Dendritic Cells and Their Expression of Costimulatory Molecules in Children with Autism Spectrum Disorders
Auteurs
Khaled Saad
Asmaa M. Zahran
Khalid I. Elsayh
Ahmed A. Abdel-Rahman
Abdulrahman A. Al-Atram
Almontaser Hussein
Yasmin G. El-Gendy
Publicatiedatum
07-06-2017
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 9/2017
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-017-3190-5