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The aim of our study was to evaluate the frequencies of myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs) in children with ASD. Subjects were 32 children with ASD and 30 healthy children as controls. The numbers of mDCs and pDCs and the expression of CD86 and CD80 on the entire DCs were detected by flow cytometry. ASD children had significantly higher percentages of mDCs and pDCs when compared to controls. We found significant inverse relationships between serum 25-hydroxyvitamin D levels and the frequencies of mDCs and pDCs in autistic children. Our data suggested that DCs could play a role in the clinical course of ASD. The relationship of DCs to immune disorders in ASD remains to be determined.
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Aman, M. G., Singh, N. N., Stewart, A. W., & Field, C. J. (1985). The aberrant behavior checklist: A behavior rating scale for the assessment of treatment effects. American Journal of Mental Deficiency, 89(5), 485–491. PubMed
American Psychiatric Association (2013). Diagnostic and statistical manual of mental disorders 5. Washington, DC: American Psychiatric Association. CrossRef
Bjørklund, G., Saad, K., Chirumbolo, S., Kern, J. K., Geier, D. A., Geier M. R. et al. (2016). Immune dysfunction and neuroinflammation in autism spectrum disorder. Acta Neurobiologiae Experimentalis (Wars), 76(4), 257–268. CrossRef
Breece, E., Paciotti, B., Nordahl, C. W., Ozonoff, S., Van de Water, J. A., Rogers, S. J., et al. (2013). Myeloid dendritic cells frequencies are increased in children with autism spectrum disorder and associated with amygdala volume and repetitive behaviors. Brain, Behavior, and Immunity, 31, 69–75. CrossRefPubMed
Cannell, J. J., & Grant, W. B. (2013). What is the role of vitamin D in autism? Dermatoendocrinology, 5(1), 199–204. CrossRef
Careaga M, Ashwood P. Autism spectrum disorders: From immunity to behavior. In: Yan Q (ed) Psychoneuroimmunology methods and protocols. New York: Humana Press, pp 219–240.
Ferreira, G. B., Gysemans, C. A., Demengeot, J., da Cunha, J. P., Vanherwegen, A. S., Overbergh, L., et al. (2014). 1,25-Dihydroxyvitamin D3 promotes tolerogenic dendritic cells with functional migratory properties in NOD mice. Journal of immunology (Baltimore, Md.: 1950), 1, 192.
Ferreira, G. B., Vanherwegen, A. S., Eelen, G., Gutiérrez, A. C., Van Lommel, L., Marchal, K., et al. (2015). Vitamin D3 induces tolerance in human dendritic cells by activation of intracellular metabolic pathways. Cell Reports, S2211–1247(15), 711–725. CrossRef
Geier, D. A., Kern, J. K., & Geier, M. R. (2013). A comparison of the autism treatment evaluation checklist (ATEC) and the childhood autism rating scale (CARS) for the quantitative evaluation of autism. Journal of Mental Health Research in Intellectual Disabilities, 6(4), 255–267. CrossRefPubMedPubMedCentral
Kern, J. K., Geier, D. A., Sykes, L. K., Homme, K. G., & Geier, M. R. (2014). Medical conditions in autism and events associated with initial onset of autism. OA. Autism: The International Journal of Research and Practice, 2(1), 9.
Saad K, Abdel-Rahman AA, Elserogy YM, Al-Atram AA, Cannell JJ, Bjørklund G et al. (2016a) Vitamin D status in autism spectrum disorders and the efficacy of vitamin D supplementation in autistic children. Nutrition Neuroscience, 19(8):346–351. CrossRef
Schieve, L. A., Gonzalez, V., Boulet, S. L., Visser, S. N., Rice, C. E., Van Naarden Braun K, & Boyle, C. A. (2011). Concurrent medical conditions and health care use and needs among children with learning and behavioral developmental disabilities, National Health Interview Survey, 2006–2010. Research in Developmental Disabilities, 33, 467–476. CrossRefPubMed
Schopler E, Van Bourgondien M E, Wellman GJ. (2010) Childhood autism rating scale. 2nd. CARS-2. Los Angeles, CA: Western Psychological Services.
Steinman, R. M., Lasker Basic Medical Research Award (2007). Dendritic cells: versatile controllers of the immune system. Natural Medicines, 13(10), 1155–1159. CrossRef
Wang, T. T., DU, L., Shan, L., & Jia, F. Y. (2014). Research advances in immunological dysfunction in children with autism spectrum disorders. Zhongguo Dang Dai Er Ke Za Zhi, 16(12), 1289–1293. PubMed
- Frequency of Dendritic Cells and Their Expression of Costimulatory Molecules in Children with Autism Spectrum Disorders
Asmaa M. Zahran
Khalid I. Elsayh
Ahmed A. Abdel-Rahman
Abdulrahman A. Al-Atram
Yasmin G. El-Gendy
- Springer US