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07-06-2017 | Original Paper | Uitgave 9/2017

Frequency of Dendritic Cells and Their Expression of Costimulatory Molecules in Children with Autism Spectrum Disorders

Tijdschrift:: Journal of Autism and Developmental Disorders > Uitgave 9/2017

Auteurs:: Khaled Saad, Asmaa M. Zahran, Khalid I. Elsayh, Ahmed A. Abdel-Rahman, Abdulrahman A. Al-Atram, Almontaser Hussein, Yasmin G. El-Gendy

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Abstract

The aim of our study was to evaluate the frequencies of myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs) in children with ASD. Subjects were 32 children with ASD and 30 healthy children as controls. The numbers of mDCs and pDCs and the expression of CD86 and CD80 on the entire DCs were detected by flow cytometry. ASD children had significantly higher percentages of mDCs and pDCs when compared to controls. We found significant inverse relationships between serum 25-hydroxyvitamin D levels and the frequencies of mDCs and pDCs in autistic children. Our data suggested that DCs could play a role in the clinical course of ASD. The relationship of DCs to immune disorders in ASD remains to be determined.

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Titel: Frequency of Dendritic Cells and Their Expression of Costimulatory Molecules in Children with Autism Spectrum Disorders
Auteurs:: Khaled Saad
Asmaa M. Zahran
Khalid I. Elsayh
Ahmed A. Abdel-Rahman
Abdulrahman A. Al-Atram
Almontaser Hussein
Yasmin G. El-Gendy
Publicatiedatum: 07-06-2017
DOI: https://doi.org/10.1007/s10803-017-3190-5
Uitgeverij: Springer US
Tijdschrift: Journal of Autism and Developmental Disorders
Uitgave 9/2017
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432

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