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07-06-2017 | Original Paper | Uitgave 9/2017

Frequency of Dendritic Cells and Their Expression of Costimulatory Molecules in Children with Autism Spectrum Disorders

Tijdschrift:: Journal of Autism and Developmental Disorders > Uitgave 9/2017

Auteurs:: Khaled Saad, Asmaa M. Zahran, Khalid I. Elsayh, Ahmed A. Abdel-Rahman, Abdulrahman A. Al-Atram, Almontaser Hussein, Yasmin G. El-Gendy

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Abstract

The aim of our study was to evaluate the frequencies of myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs) in children with ASD. Subjects were 32 children with ASD and 30 healthy children as controls. The numbers of mDCs and pDCs and the expression of CD86 and CD80 on the entire DCs were detected by flow cytometry. ASD children had significantly higher percentages of mDCs and pDCs when compared to controls. We found significant inverse relationships between serum 25-hydroxyvitamin D levels and the frequencies of mDCs and pDCs in autistic children. Our data suggested that DCs could play a role in the clinical course of ASD. The relationship of DCs to immune disorders in ASD remains to be determined.

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Meer informatie

Aman, M. G., Singh, N. N., Stewart, A. W., & Field, C. J. (1985). The aberrant behavior checklist: A behavior rating scale for the assessment of treatment effects. American Journal of Mental Deficiency, 89(5), 485–491. PubMed

American Psychiatric Association (2013). Diagnostic and statistical manual of mental disorders 5. Washington, DC: American Psychiatric Association. CrossRef

Banchereau, J., Briere, F., & Caux, C. (2000). Immunobiology of dendritic cells. Annual Review of Immunology, 18, 767–811. CrossRefPubMed

Bjørklund, G., Saad, K., Chirumbolo, S., Kern, J. K., Geier, D. A., Geier M. R. et al. (2016). Immune dysfunction and neuroinflammation in autism spectrum disorder. Acta Neurobiologiae Experimentalis (Wars), 76(4), 257–268. CrossRef

Breece, E., Paciotti, B., Nordahl, C. W., Ozonoff, S., Van de Water, J. A., Rogers, S. J., et al. (2013). Myeloid dendritic cells frequencies are increased in children with autism spectrum disorder and associated with amygdala volume and repetitive behaviors. Brain, Behavior, and Immunity, 31, 69–75. CrossRefPubMed

Cannell, J. J., & Grant, W. B. (2013). What is the role of vitamin D in autism? Dermatoendocrinology, 5(1), 199–204. CrossRef

Careaga M, Ashwood P. Autism spectrum disorders: From immunity to behavior. In: Yan Q (ed) Psychoneuroimmunology methods and protocols. New York: Humana Press, pp 219–240.

Eyles, D. W., Burne, T. H., McGrath, J. J., & Vitamin, D. (2013). effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease. Frontiers in Neuroendocrinology, 34, 47–64. CrossRefPubMed

Ferreira, G. B., Gysemans, C. A., Demengeot, J., da Cunha, J. P., Vanherwegen, A. S., Overbergh, L., et al. (2014). 1,25-Dihydroxyvitamin D3 promotes tolerogenic dendritic cells with functional migratory properties in NOD mice. Journal of immunology (Baltimore, Md.: 1950), 1, 192.

Ferreira, G. B., Vanherwegen, A. S., Eelen, G., Gutiérrez, A. C., Van Lommel, L., Marchal, K., et al. (2015). Vitamin D3 induces tolerance in human dendritic cells by activation of intracellular metabolic pathways. Cell Reports, S2211–1247(15), 711–725. CrossRef

Geier, D. A., Kern, J. K., & Geier, M. R. (2013). A comparison of the autism treatment evaluation checklist (ATEC) and the childhood autism rating scale (CARS) for the quantitative evaluation of autism. Journal of Mental Health Research in Intellectual Disabilities, 6(4), 255–267. CrossRefPubMedPubMedCentral

Gurney, J. G., McPheeters, M. L., & Davis, M. M. (2006). Parental report of health conditions and health care use among children with and without autism: National Survey of Children’s Health. Archives of Pediatrics and Adolescent Medicine, 160, 825–830. CrossRefPubMed

Kern, J. K., Geier, D. A., Sykes, L. K., Homme, K. G., & Geier, M. R. (2014). Medical conditions in autism and events associated with initial onset of autism. OA. Autism: The International Journal of Research and Practice, 2(1), 9.

Mead, J., & Ashwood, P. (2015). Evidence supporting an altered immune response in ASD. Immunology Letters, 163(1), 49–55. CrossRefPubMed

Ruggeri, B., Sarkans, U., Schumann, G., & Persico, A. M. (2014). Biomarkers in autism spectrum disorder: the old and the new. Psychopharmacology, 231(6), 1201–1216. CrossRefPubMed

Saad K, Abdel-Rahman AA, Elserogy YM, Al-Atram AA, Cannell JJ, Bjørklund G et al. (2016a) Vitamin D status in autism spectrum disorders and the efficacy of vitamin D supplementation in autistic children. Nutrition Neuroscience, 19(8):346–351. CrossRef

Saad K, Abdel-rahman AA, Elserogy Y, Al-Atram AA, El-Houfey AA, Othman HA et al. (2016b). Randomized-controlled trial of vitamin d supplementation in children with autism spectrum disorder. Journal of Child Psychology and Psychiatry. doi: 10.1111/jcpp.12652. PubMed

Sakamoto, A., Moriuchi, H., Matsuzaki, J., Motoyama, K., & Moriuchi, M. (2015). Retrospective diagnosis of congenital cytomegalovirus infection in children with autism spectrum disorder but no other major neurologic deficit. Brain and Development, 37, 200–205. CrossRefPubMed

Schieve, L. A., Gonzalez, V., Boulet, S. L., Visser, S. N., Rice, C. E., Van Naarden Braun K, & Boyle, C. A. (2011). Concurrent medical conditions and health care use and needs among children with learning and behavioral developmental disabilities, National Health Interview Survey, 2006–2010. Research in Developmental Disabilities, 33, 467–476. CrossRefPubMed

Schopler E, Van Bourgondien M E, Wellman GJ. (2010) Childhood autism rating scale. 2nd. CARS-2. Los Angeles, CA: Western Psychological Services.

Steinman, R. M., Lasker Basic Medical Research Award (2007). Dendritic cells: versatile controllers of the immune system. Natural Medicines, 13(10), 1155–1159. CrossRef

Ueno, H., Klechevsky, E., Morita, R., Aspord, C., Cao, T., Matsui, T., et al. (2007). Dendritic cell subsets in health and disease. Immunological Reviews, 219, 118–142. CrossRefPubMed

van Halteren, A. G., van Etten, E., de Jong, E. C., Bouillon, R., Roep, B. O., & Mathieu, C. (2002). Redirection of human autoreactive T-cells Upon interaction with dendritic cells modulated by TX527, an analog of 1,25 dihydroxyvitamin D (3). Diabetes, 51(7), 2119–2125. CrossRefPubMed

Voineagu, I., Wang, X., Johnston, P., Lowe, J. K., Tian, Y., Horvath, S., et al. (2011). Transcriptomic analysis of autistic brain reveals convergent molecular pathology. Nature, 474, 380–384. CrossRefPubMedPubMedCentral

Wang, T. T., DU, L., Shan, L., & Jia, F. Y. (2014). Research advances in immunological dysfunction in children with autism spectrum disorders. Zhongguo Dang Dai Er Ke Za Zhi, 16(12), 1289–1293. PubMed

Wilson, E. H., Weninger, W., & Hunter, C. A. (2010). Trafficking of immune cells in the central nervous system. The Journal of Clinical Investigation, 120, 1368–1379. CrossRefPubMedPubMedCentral

Titel: Frequency of Dendritic Cells and Their Expression of Costimulatory Molecules in Children with Autism Spectrum Disorders
Auteurs:: Khaled Saad
Asmaa M. Zahran
Khalid I. Elsayh
Ahmed A. Abdel-Rahman
Abdulrahman A. Al-Atram
Almontaser Hussein
Yasmin G. El-Gendy
Publicatiedatum: 07-06-2017
DOI: https://doi.org/10.1007/s10803-017-3190-5
Uitgeverij: Springer US
Tijdschrift: Journal of Autism and Developmental Disorders
Uitgave 9/2017
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432

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