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12-02-2019 | Original Article

Feasibility and Impact of a Guided Symptom Exposure Augmented Cognitive Behavior Therapy Protocol to Prevent Symptoms of Pharmacologically Induced Depression: A Pilot Study

Auteurs: Lata K. McGinn, Anna Van Meter, Ian Kronish, Jessica Gashin, Karen Burns, Natalie Kil, Thomas G. McGinn

Gepubliceerd in: Cognitive Therapy and Research | Uitgave 4/2019

Abstract

Depression is the leading cause of disability and a major cause of morbidity worldwide, with societal costs now upwards of 1 trillion dollars across the globe. Hence, extending current efforts to augment prevention outcomes is consistent with global public health interests. Although many prevention programs have been developed and have demonstrated efficacy, studies have yet to demonstrate that CBT is effective in preventing symptoms in populations at risk for developing depression induced by pharmacological substances. Using a randomized, controlled design, this pilot study reports on the feasibility and preliminary effects of a novel, guided symptom exposure augmented cognitive behavioral prevention intervention (GSE-CBT) in a sample diagnosed with Hepatitis C at risk for developing medication induced depression. Results demonstrated that the guided symptom exposure augmented CBT (GSE-CBT) was feasible in this population and was delivered with high integrity. Although not statistically different, we observed a pattern of lower depression levels in the GSE-CBT group versus those in the control group throughout. This pilot study demonstrates that a psychosocial prevention intervention is feasible for use in patients at risk for developing pharmacologically induced depression and that a guided symptom exposure augmented CBT protocol has the potential to prevent symptoms of depression that develop as a side effect to taking these medications. Results are preliminary and future studies should use larger samples and test the intervention in other populations.

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Titel: Feasibility and Impact of a Guided Symptom Exposure Augmented Cognitive Behavior Therapy Protocol to Prevent Symptoms of Pharmacologically Induced Depression: A Pilot Study
Auteurs: Lata K. McGinn
Anna Van Meter
Ian Kronish
Jessica Gashin
Karen Burns
Natalie Kil
Thomas G. McGinn
Publicatiedatum: 12-02-2019
Uitgeverij: Springer US
Gepubliceerd in: Cognitive Therapy and Research / Uitgave 4/2019
Print ISSN: 0147-5916
Elektronisch ISSN: 1573-2819
DOI: https://doi.org/10.1007/s10608-018-09990-7

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