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Gepubliceerd in: Quality of Life Research 10/2018

16-06-2018

Fatigue in the general population: German normative values of the EORTC QLQ-FA12

Auteurs: Andreas Hinz, Joachim Weis, Elmar Brähler, Anja Mehnert

Gepubliceerd in: Quality of Life Research | Uitgave 10/2018

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Abstract

Purpose

Fatigue is a frequent symptom in patients suffering from chronic diseases, especially cancer patients. A new fatigue questionnaire was recently developed to better assess this condition, the EORTC QLQ-FA12. The aims of this study were to test the psychometric properties of this fatigue questionnaire and to provide normative values.

Methods

A total of 2411 individuals (53.5% women), representatively selected from the German general population, responded to the EORTC QLQ-FA12 questionnaire.

Results

Women reported more fatigue than men on all three scales of the EORTC QLQ-FA12 with the following effect sizes: d = 0.29 (physical fatigue), d = 0.22 (emotional fatigue), and d = 0.11 (cognitive fatigue). There were no linear age trends. Confirmatory factorial analysis confirmed the latent structure of the questionnaire. The correlations among the latent scales were between 0.71 and 0.84. The internal consistency coefficients were alpha = 0.92 (physical fatigue), 0.86 (emotional fatigue), 0.79 (cognitive fatigue), and 0.94 (sum score).

Conclusions

The study proved the psychometric quality of the EORTC QLQ-FA12 in the general population. Gender differences should be accounted for when comparing groups of patients. The normative scores can be used to qualify the assessment of the degree of patients’ fatigue.
Literatuur
1.
go back to reference Saligan, L. N., Olson, K., Filler, K., et al. (2015). The biology of cancer-related fatigue: A review of the literature. Supportive Care in Cancer, 23, 2461–2478.CrossRefPubMedPubMedCentral Saligan, L. N., Olson, K., Filler, K., et al. (2015). The biology of cancer-related fatigue: A review of the literature. Supportive Care in Cancer, 23, 2461–2478.CrossRefPubMedPubMedCentral
2.
go back to reference Weis, J. (2011). Cancer-related fatigue: prevalence, assessment and treatment strategies. Expert Review of Pharmacoeconomics & Outcomes Research, 11, 441–446.CrossRef Weis, J. (2011). Cancer-related fatigue: prevalence, assessment and treatment strategies. Expert Review of Pharmacoeconomics & Outcomes Research, 11, 441–446.CrossRef
3.
go back to reference Whitehead, L. C., Unahi, K., Burrell, B., & Crowe, M. T. (2016). The experience of fatigue across long-term conditions: A qualitative meta-synthesis. Journal of Pain and Symptom Management, 52, 131.CrossRefPubMed Whitehead, L. C., Unahi, K., Burrell, B., & Crowe, M. T. (2016). The experience of fatigue across long-term conditions: A qualitative meta-synthesis. Journal of Pain and Symptom Management, 52, 131.CrossRefPubMed
4.
go back to reference Giacalone, A., Quitadamo, D., Zanet, E., Berretta, M., Spina, M., & Tirelli, U. (2013). Cancer-related fatigue in the elderly. Supportive Care in Cancer, 21, 2899–2911.CrossRefPubMed Giacalone, A., Quitadamo, D., Zanet, E., Berretta, M., Spina, M., & Tirelli, U. (2013). Cancer-related fatigue in the elderly. Supportive Care in Cancer, 21, 2899–2911.CrossRefPubMed
5.
go back to reference Mehnert, A., Hartung, T. J., Friedrich, M., et al. (2018). One in two cancer patients is significantly distressed: Prevalence and indicators of distress. Psycho-Oncology, 27, 75–82.CrossRefPubMed Mehnert, A., Hartung, T. J., Friedrich, M., et al. (2018). One in two cancer patients is significantly distressed: Prevalence and indicators of distress. Psycho-Oncology, 27, 75–82.CrossRefPubMed
6.
go back to reference Cella, D., Davis, K., Breitbart, W., & Curt, G. (2001). Cancer-related fatigue: Prevalence of proposed diagnostic criteria in a United States sample of cancer survivors. Journal of Clinical Oncology, 19, 3385–3391.CrossRefPubMed Cella, D., Davis, K., Breitbart, W., & Curt, G. (2001). Cancer-related fatigue: Prevalence of proposed diagnostic criteria in a United States sample of cancer survivors. Journal of Clinical Oncology, 19, 3385–3391.CrossRefPubMed
7.
go back to reference Kuhnt, S., Ernst, J., Singer, S., et al. (2009). Fatigue in cancer survivors—prevalence and predictors. Onkologie, 32, 312–317.CrossRefPubMed Kuhnt, S., Ernst, J., Singer, S., et al. (2009). Fatigue in cancer survivors—prevalence and predictors. Onkologie, 32, 312–317.CrossRefPubMed
8.
go back to reference Cumming, T. B., Packer, M., Kramer, S. F., & English, C. (2016). The prevalence of fatigue after stroke: A systematic review and meta-analysis. International Journal of Stroke, 11, 968–977.CrossRefPubMed Cumming, T. B., Packer, M., Kramer, S. F., & English, C. (2016). The prevalence of fatigue after stroke: A systematic review and meta-analysis. International Journal of Stroke, 11, 968–977.CrossRefPubMed
9.
go back to reference Kentson, M., Tödt, K., Skargren, E., et al. (2016). Factors associated with experience of fatigue, and functional limitations due to fatigue in patients with stable COPD. Therapeutic Advances in Respiratory Disease, 10, 410–424.CrossRefPubMedPubMedCentral Kentson, M., Tödt, K., Skargren, E., et al. (2016). Factors associated with experience of fatigue, and functional limitations due to fatigue in patients with stable COPD. Therapeutic Advances in Respiratory Disease, 10, 410–424.CrossRefPubMedPubMedCentral
10.
go back to reference Katz, P. (2017). Causes and consequences of fatigue in rheumatoid arthritis. Current Opinion in Rheumatology, 29, 269–276.CrossRefPubMed Katz, P. (2017). Causes and consequences of fatigue in rheumatoid arthritis. Current Opinion in Rheumatology, 29, 269–276.CrossRefPubMed
11.
go back to reference Kratz, A. L., Schilling, S., Goesling, J., & Williams, D. A. (2016). The PROMIS FatigueFM Profile. A self-report measure of fatigue for use in fibromyalgia. Quality of Life Research, 25, 1803–1813.CrossRefPubMedPubMedCentral Kratz, A. L., Schilling, S., Goesling, J., & Williams, D. A. (2016). The PROMIS FatigueFM Profile. A self-report measure of fatigue for use in fibromyalgia. Quality of Life Research, 25, 1803–1813.CrossRefPubMedPubMedCentral
12.
go back to reference Herlofson, K., & Kluger, B. M. (2017). Fatigue in Parkinson’s disease. Journal of the Neurological Sciences, 374, 38–41.CrossRefPubMed Herlofson, K., & Kluger, B. M. (2017). Fatigue in Parkinson’s disease. Journal of the Neurological Sciences, 374, 38–41.CrossRefPubMed
13.
go back to reference van den Akker, L. E., Beckerman, H., Collette, E. H., Eijssen, I. C. J. M., Dekker, J., & Groot, V. (2016). Effectiveness of cognitive behavioral therapy for the treatment of fatigue in patients with multiple sclerosis: A systematic review and meta-analysis. Journal of Psychosomatic Research, 90, 33–42.CrossRefPubMed van den Akker, L. E., Beckerman, H., Collette, E. H., Eijssen, I. C. J. M., Dekker, J., & Groot, V. (2016). Effectiveness of cognitive behavioral therapy for the treatment of fatigue in patients with multiple sclerosis: A systematic review and meta-analysis. Journal of Psychosomatic Research, 90, 33–42.CrossRefPubMed
14.
go back to reference Han, C. J., & Yang, G. S. (2016). Fatigue in irritable bowel syndrome: A systematic review and meta-analysis of pooled frequency and severity of fatigue. Asian Nursing Research, 10, 1–10.CrossRefPubMed Han, C. J., & Yang, G. S. (2016). Fatigue in irritable bowel syndrome: A systematic review and meta-analysis of pooled frequency and severity of fatigue. Asian Nursing Research, 10, 1–10.CrossRefPubMed
15.
go back to reference Agasi-Idenburg, C., Velthuis, M., & Wittink, H. (2010). Quality criteria and user-friendliness in self-reported questionnaires on cancer-related fatigue: A review. Journal of Clinical Epidemiology, 63, 705–711.CrossRefPubMed Agasi-Idenburg, C., Velthuis, M., & Wittink, H. (2010). Quality criteria and user-friendliness in self-reported questionnaires on cancer-related fatigue: A review. Journal of Clinical Epidemiology, 63, 705–711.CrossRefPubMed
16.
go back to reference de Raaf, P. J., de Klerk, C., & van der Rijt, C. C. D. (2013). Elucidating the behavior of physical fatigue and mental fatigue in cancer patients: A review of the literature. Psycho-Oncology, 22, 1919–1929.CrossRefPubMed de Raaf, P. J., de Klerk, C., & van der Rijt, C. C. D. (2013). Elucidating the behavior of physical fatigue and mental fatigue in cancer patients: A review of the literature. Psycho-Oncology, 22, 1919–1929.CrossRefPubMed
17.
go back to reference Seyidova-Khoshknabi, D., Davis, M. P., & Walsh, D. (2011). Review article: A systematic review of cancer-related fatigue measurement questionnaires. American Journal of Hospice and Palliative Medicine, 28, 119–129.CrossRefPubMed Seyidova-Khoshknabi, D., Davis, M. P., & Walsh, D. (2011). Review article: A systematic review of cancer-related fatigue measurement questionnaires. American Journal of Hospice and Palliative Medicine, 28, 119–129.CrossRefPubMed
18.
go back to reference Aaronson, N. K., Ahmedzai, S., Bergman, B., et al. (1993). The European-Organization-for-Research-and-Treatment-of-Cancer QLQ-C30—a quality-of-life instrument for use in international clinical trials in oncology. Journal of the National Cancer Institute, 85, 365–376.CrossRefPubMed Aaronson, N. K., Ahmedzai, S., Bergman, B., et al. (1993). The European-Organization-for-Research-and-Treatment-of-Cancer QLQ-C30—a quality-of-life instrument for use in international clinical trials in oncology. Journal of the National Cancer Institute, 85, 365–376.CrossRefPubMed
19.
go back to reference Weis, J., Tomaszewski, K. A., Hammerlid, E., et al. (2017). International psychometric validation of an EORTC quality of life module measuring cancer related fatigue (EORTC QLQ-FA12). Journal of the National Cancer Institute, 109, djw273.CrossRef Weis, J., Tomaszewski, K. A., Hammerlid, E., et al. (2017). International psychometric validation of an EORTC quality of life module measuring cancer related fatigue (EORTC QLQ-FA12). Journal of the National Cancer Institute, 109, djw273.CrossRef
20.
go back to reference Scott, J. A., Lasch, K. E., Barsevick, A. M., & Piault-Louis, E. (2011). Patients’ experiences with cancer-related fatigue. A review and synthesis of qualitative research. Oncology Nursing Forum, 38, E191–E203.CrossRef Scott, J. A., Lasch, K. E., Barsevick, A. M., & Piault-Louis, E. (2011). Patients’ experiences with cancer-related fatigue. A review and synthesis of qualitative research. Oncology Nursing Forum, 38, E191–E203.CrossRef
21.
go back to reference Weis, J., Arraras, J. I., Conroy, T., et al. (2012). Development of an EORTC quality of life phase III module measuring cancer-related fatigue (EORTC QLQ-FA13). Psycho-Oncology, 22, 1002–1007.CrossRefPubMed Weis, J., Arraras, J. I., Conroy, T., et al. (2012). Development of an EORTC quality of life phase III module measuring cancer-related fatigue (EORTC QLQ-FA13). Psycho-Oncology, 22, 1002–1007.CrossRefPubMed
22.
go back to reference Rief, H., Akbar, M., Keller, M., et al. (2014). Quality of life and fatigue of patients with spinal bone metastases under combined treatment with resistance training and radiation therapy—a randomized pilot trial. Radiation Oncology, 9, 151.CrossRefPubMed Rief, H., Akbar, M., Keller, M., et al. (2014). Quality of life and fatigue of patients with spinal bone metastases under combined treatment with resistance training and radiation therapy—a randomized pilot trial. Radiation Oncology, 9, 151.CrossRefPubMed
23.
go back to reference Rief, H., Heinhold, M., Bruckner, T., et al. (2014). Quality of life, fatigue and local response of patients with unstable spinal bone metastases under radiation therapy—a prospective trial. Radiation Oncology, 9, 133.CrossRefPubMed Rief, H., Heinhold, M., Bruckner, T., et al. (2014). Quality of life, fatigue and local response of patients with unstable spinal bone metastases under radiation therapy—a prospective trial. Radiation Oncology, 9, 133.CrossRefPubMed
24.
go back to reference Fuhrmann, K., Mehnert, A., Geue, K., & Hinz, A. (2015). Fatigue in breast cancer patients: Psychometric evaluation of the fatigue questionnaire EORTC QLQ-FA13. Breast Cancer, 22, 608–614.CrossRefPubMed Fuhrmann, K., Mehnert, A., Geue, K., & Hinz, A. (2015). Fatigue in breast cancer patients: Psychometric evaluation of the fatigue questionnaire EORTC QLQ-FA13. Breast Cancer, 22, 608–614.CrossRefPubMed
25.
go back to reference Nashan, D., Reuter, K., Mohr, P., & Agarwala, S. S. (2012). Understanding and managing interferon-alpha-related fatigue in patients with melanoma. Melanoma Research, 22, 415–423.CrossRefPubMed Nashan, D., Reuter, K., Mohr, P., & Agarwala, S. S. (2012). Understanding and managing interferon-alpha-related fatigue in patients with melanoma. Melanoma Research, 22, 415–423.CrossRefPubMed
26.
go back to reference Kecke, S., Ernst, J., Einenkel, J., Singer, S., & Hinz, A. (2017). Psychometric properties of the fatigue questionnaire EORTC QLQ-FA12 in a sample of female cancer patients. Journal of Pain and Symptom Management, 54, 922–928.CrossRefPubMed Kecke, S., Ernst, J., Einenkel, J., Singer, S., & Hinz, A. (2017). Psychometric properties of the fatigue questionnaire EORTC QLQ-FA12 in a sample of female cancer patients. Journal of Pain and Symptom Management, 54, 922–928.CrossRefPubMed
27.
go back to reference Löwe, B., Wahl, I., Rose, M., et al. (2010). A 4-item measure of depression and anxiety: Validation and standardization of the Patient Health Questionnaire-4 (PHQ-4) in the general population. Journal of Affective Disorders, 122, 86–95.CrossRefPubMed Löwe, B., Wahl, I., Rose, M., et al. (2010). A 4-item measure of depression and anxiety: Validation and standardization of the Patient Health Questionnaire-4 (PHQ-4) in the general population. Journal of Affective Disorders, 122, 86–95.CrossRefPubMed
28.
go back to reference Hu, L. T., & Bentler, P. M. (1999). Cutoff criteria for fit indexes in covariance structure analysis: Conventional criteria versus new alternatives. Structural Equation Modeling, 6, 1–55.CrossRef Hu, L. T., & Bentler, P. M. (1999). Cutoff criteria for fit indexes in covariance structure analysis: Conventional criteria versus new alternatives. Structural Equation Modeling, 6, 1–55.CrossRef
29.
go back to reference Cella, D., Lai, J.-S., & Stone, A. (2011). Self-reported fatigue: One dimension or more? Lessons from the functional assessment of chronic illness therapy—fatigue (FACIT-F) questionnaire. Supportive Care in Cancer, 19, 1441–1450.CrossRefPubMed Cella, D., Lai, J.-S., & Stone, A. (2011). Self-reported fatigue: One dimension or more? Lessons from the functional assessment of chronic illness therapy—fatigue (FACIT-F) questionnaire. Supportive Care in Cancer, 19, 1441–1450.CrossRefPubMed
30.
go back to reference Yost, K. J., Waller, N. G., Lee, M. K., & Vincent, A. (2017). The PROMIS fatigue item bank has good measurement properties in patients with fibromyalgia and severe fatigue. Quality of Life Research, 26, 1417–1426.CrossRefPubMed Yost, K. J., Waller, N. G., Lee, M. K., & Vincent, A. (2017). The PROMIS fatigue item bank has good measurement properties in patients with fibromyalgia and severe fatigue. Quality of Life Research, 26, 1417–1426.CrossRefPubMed
31.
go back to reference Smets, E. M. A., Garssen, B., Bonke, B., & Dehaes, J. C. J. M. (1995). The multidimensional fatigue inventory (MFI): Psychometric qualities of an instrument to assess fatigue. Journal of Psychosomatic Research, 39, 315–325.CrossRefPubMed Smets, E. M. A., Garssen, B., Bonke, B., & Dehaes, J. C. J. M. (1995). The multidimensional fatigue inventory (MFI): Psychometric qualities of an instrument to assess fatigue. Journal of Psychosomatic Research, 39, 315–325.CrossRefPubMed
32.
go back to reference de Vries, J., Michielsen, H., van Heck, G. L., & Drent, M. (2004). Measuring fatigue in sarcoidosis: The Fatigue Assessment Scale (FAS). British Journal of Health Psychology, 9, 279–291.CrossRefPubMed de Vries, J., Michielsen, H., van Heck, G. L., & Drent, M. (2004). Measuring fatigue in sarcoidosis: The Fatigue Assessment Scale (FAS). British Journal of Health Psychology, 9, 279–291.CrossRefPubMed
33.
go back to reference Lai, J.-S., Cella, D., Yanez, B., & Stone, A. (2014). Linking fatigue measures on a common reporting metric. Journal of Pain and Symptom Management, 48, 639–648.CrossRefPubMedPubMedCentral Lai, J.-S., Cella, D., Yanez, B., & Stone, A. (2014). Linking fatigue measures on a common reporting metric. Journal of Pain and Symptom Management, 48, 639–648.CrossRefPubMedPubMedCentral
34.
go back to reference Beutel, M. E., Hinz, A., Albani, C., & Brähler, E. (2006). Fatigue Assessment Questionnaire: Standardization of a cancer-specific instrument based on the general population. Oncology, 70, 351–357.CrossRefPubMed Beutel, M. E., Hinz, A., Albani, C., & Brähler, E. (2006). Fatigue Assessment Questionnaire: Standardization of a cancer-specific instrument based on the general population. Oncology, 70, 351–357.CrossRefPubMed
35.
go back to reference Schwarz, R., Krauss, O., & Hinz, A. (2003). Fatigue in the general population. Onkologie, 26, 140–144.PubMed Schwarz, R., Krauss, O., & Hinz, A. (2003). Fatigue in the general population. Onkologie, 26, 140–144.PubMed
36.
go back to reference Nordin, Å, Taft, C., Lundgren-Nilsson, Å, & Dencker, A. (2016). Minimal important differences for fatigue patient reported outcome measures-a systematic review. BMC Medical Research Methodology, 16, 62.CrossRefPubMedPubMedCentral Nordin, Å, Taft, C., Lundgren-Nilsson, Å, & Dencker, A. (2016). Minimal important differences for fatigue patient reported outcome measures-a systematic review. BMC Medical Research Methodology, 16, 62.CrossRefPubMedPubMedCentral
37.
go back to reference Hinz, A., Singer, S., & Brähler, E. (2014). European reference values for the quality of life questionnaire EORTC QLQ-C30: Results of a German investigation and a summarizing analysis of six European general population normative studies. Acta Oncologica, 53, 958–965.CrossRefPubMed Hinz, A., Singer, S., & Brähler, E. (2014). European reference values for the quality of life questionnaire EORTC QLQ-C30: Results of a German investigation and a summarizing analysis of six European general population normative studies. Acta Oncologica, 53, 958–965.CrossRefPubMed
38.
go back to reference Fischer, F., Gibbons, C., Coste, J., Valderas, J. M., Rose, M., & Leplège, A. (2018). Measurement invariance and general population reference values of the PROMIS Profile 29 in the UK, France, and Germany. Quality of Life Research, 27, 999–1014.CrossRefPubMed Fischer, F., Gibbons, C., Coste, J., Valderas, J. M., Rose, M., & Leplège, A. (2018). Measurement invariance and general population reference values of the PROMIS Profile 29 in the UK, France, and Germany. Quality of Life Research, 27, 999–1014.CrossRefPubMed
Metagegevens
Titel
Fatigue in the general population: German normative values of the EORTC QLQ-FA12
Auteurs
Andreas Hinz
Joachim Weis
Elmar Brähler
Anja Mehnert
Publicatiedatum
16-06-2018
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 10/2018
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-018-1918-0

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