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Gepubliceerd in: Quality of Life Research 8/2019

05-04-2019

Factors associated with low health-related quality of life among younger and older Thai patients with non-valvular atrial fibrillation

Auteurs: Varalak Srinonprasert, Kasem Ratanasumawong, Tomon Thongsri, Somchai Dutsadeevettakul, Pongpun Jittham, Weerapan Wiwatworapan, Rungroj Krittayaphong, COOL AF Investigators

Gepubliceerd in: Quality of Life Research | Uitgave 8/2019

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Abstract

Purpose

The aim of this study was to investigate the factors associated with low health-related quality of life (HRQoL) compared between younger and older Thai patients with non-valvular atrial fibrillation (NVAF).

Methods

This is a cross-sectional analysis of baseline data from a prospective NVAF registry from 24 hospitals located across Thailand. Patient demographic, clinical, lifestyle, and medication data were collected at baseline. EuroQOL/EQ-5D-3L was used to assess HRQoL. Health utility was calculated for the entire study population, and low HRQoL was defined as the lowest quartile. Multivariate logistic regression was used to identify factors that significantly predict low HRQoL among younger and older (≥ 65 years) patients with NVAF.

Results

Among the 3218 participants that were enrolled, 61.0% were aged older than 65 years. Mean HRQoL was lower in older than in younger patients (0.72 ± 0.26 vs. 0.84 ± 0.20; p < 0.001). Factors associated with low HRQoL among younger NVAF patients were the treatment-related factors bleeding history (p = 0.006) and taking warfarin (p = 0.001). Among older patients, the NVAF-related complications ischemic stroke or TIA, heart failure (HF), and dementia (all p < 0.001) were all significantly associated with low HRQoL. Dementia is the factor that most adversely influences low HRQoL among older NVAF. Interestingly, symptomatic NVAF was found to be a protective factor for low HRQoL (p < 0.001).

Conclusions

Bleeding history and taking warfarin among younger patients, and ischemic stroke/TIA, HF, and dementia among older patients are significant predictors of low HRQoL. These factors should be taken into consideration when selecting treatment options for patients with NVAF.
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Metagegevens
Titel
Factors associated with low health-related quality of life among younger and older Thai patients with non-valvular atrial fibrillation
Auteurs
Varalak Srinonprasert
Kasem Ratanasumawong
Tomon Thongsri
Somchai Dutsadeevettakul
Pongpun Jittham
Weerapan Wiwatworapan
Rungroj Krittayaphong
COOL AF Investigators
Publicatiedatum
05-04-2019
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 8/2019
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-019-02171-3

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