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Gepubliceerd in: Journal of Autism and Developmental Disorders 2/2015

01-02-2015 | Original Paper

Eyeblink Conditioning: A Non-invasive Biomarker for Neurodevelopmental Disorders

Auteurs: Bethany C. Reeb-Sutherland, Nathan A. Fox

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2015

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Abstract

Eyeblink conditioning (EBC) is a classical conditioning paradigm typically used to study the underlying neural processes of learning and memory. EBC has a well-defined neural circuitry, is non-invasive, and can be employed in human infants shortly after birth making it an ideal tool to use in both developing and special populations. In addition, abnormalities in the cerebellum, a region of the brain highly involved in EBC, have been implicated in a number of neurodevelopmental disorders including autism spectrum disorders (ASDs). In the current paper, we review studies that have employed EBC as a biomarker for several neurodevelopmental disorders including fetal alcohol syndrome, Down syndrome, fragile X syndrome, attention deficit/hyperactivity disorder, dyslexia, specific language impairment, and schizophrenia. In addition, we discuss the benefits of using such a tool in individuals with ASD.
Literatuur
go back to reference Adolphs, R., Sears, L., & Piven, J. (2001). Abnormal processing of social information from faces in autism. Journal of Cognitive Neuroscience, 13, 232–240.PubMed Adolphs, R., Sears, L., & Piven, J. (2001). Abnormal processing of social information from faces in autism. Journal of Cognitive Neuroscience, 13, 232–240.PubMed
go back to reference Allin, M., et al. (2001). Cognitive and motor function and the size of the cerebellum in adolescents born very pre-term. Brain, 124, 60–66.PubMed Allin, M., et al. (2001). Cognitive and motor function and the size of the cerebellum in adolescents born very pre-term. Brain, 124, 60–66.PubMed
go back to reference Amaral, D. G., Schumann, C. M., & Nordahl, C. W. (2008). Neuroanatomy of autism. Trends in Neurosciences, 31, 137–145.PubMed Amaral, D. G., Schumann, C. M., & Nordahl, C. W. (2008). Neuroanatomy of autism. Trends in Neurosciences, 31, 137–145.PubMed
go back to reference Andreasen, N. C., Paradiso, S., & O’Leary, D. S. (1998). “Cognitive dysmetria” as an integrative theory of schizophrenia: A dysfunction in cortical-subcortical-cerebellar circuitry? Schizophrenia Bulletin, 24, 203–218.PubMed Andreasen, N. C., Paradiso, S., & O’Leary, D. S. (1998). “Cognitive dysmetria” as an integrative theory of schizophrenia: A dysfunction in cortical-subcortical-cerebellar circuitry? Schizophrenia Bulletin, 24, 203–218.PubMed
go back to reference Andreasen, N. C., & Pierson, R. (2008). The role of the cerebellum in schizophrenia. Biological Psychiatry, 64, 81–88.PubMedCentralPubMed Andreasen, N. C., & Pierson, R. (2008). The role of the cerebellum in schizophrenia. Biological Psychiatry, 64, 81–88.PubMedCentralPubMed
go back to reference Andreasen, N. C., et al. (1996). Schizophrenia and cognitive dysmetria: a positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry. Proceedings of the National Academy of Sciences of the United States of America, 93, 9985–9990.PubMedCentralPubMed Andreasen, N. C., et al. (1996). Schizophrenia and cognitive dysmetria: a positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry. Proceedings of the National Academy of Sciences of the United States of America, 93, 9985–9990.PubMedCentralPubMed
go back to reference APA. (2000). Diagnostic and statistical manual of mental disorders IV-TR. Washington, DC: American Psychiatric Association. APA. (2000). Diagnostic and statistical manual of mental disorders IV-TR. Washington, DC: American Psychiatric Association.
go back to reference Aylward, G. (2002). Cognitive and neuropsychological outcomes: More than IQ scores. Mental Retardation and Developmental Disabilities Research Reviews, 8, 234–240.PubMed Aylward, G. (2002). Cognitive and neuropsychological outcomes: More than IQ scores. Mental Retardation and Developmental Disabilities Research Reviews, 8, 234–240.PubMed
go back to reference Berquin, P. C., et al. (1998). Cerebellum in attention-deficit hyperactivity disorder: A morphometric MRI study. Neurology, 50, 1087–1093.PubMed Berquin, P. C., et al. (1998). Cerebellum in attention-deficit hyperactivity disorder: A morphometric MRI study. Neurology, 50, 1087–1093.PubMed
go back to reference Berthier, N. E., & Moore, J. W. (1990). Activity of deep cerebellar nuclear cells during classical conditioning of nictitating membrane extension in rabbits. Experimental Brain Research, 63, 44–54. Berthier, N. E., & Moore, J. W. (1990). Activity of deep cerebellar nuclear cells during classical conditioning of nictitating membrane extension in rabbits. Experimental Brain Research, 63, 44–54.
go back to reference Bolbecker, A. R., Mehta, C. S., Edwards, C. R., Steinmetz, J. E., O’Donnell, B. F., & Hetrick, W. P. (2009). Eye-blink conditioning deficits indicate temporal processing abnormalities in schizophrenia. Schizophrenia Research, 111, 182–191.PubMedCentralPubMed Bolbecker, A. R., Mehta, C. S., Edwards, C. R., Steinmetz, J. E., O’Donnell, B. F., & Hetrick, W. P. (2009). Eye-blink conditioning deficits indicate temporal processing abnormalities in schizophrenia. Schizophrenia Research, 111, 182–191.PubMedCentralPubMed
go back to reference Bolbecker, A. R., et al. (2011). Exploration of cerebellar-dependent associative learning in schizophrenia: effects of varying and shifting interstimulus interval on eyeblink conditioning. Behavioral Neuroscience, 125, 687–698.PubMedCentralPubMed Bolbecker, A. R., et al. (2011). Exploration of cerebellar-dependent associative learning in schizophrenia: effects of varying and shifting interstimulus interval on eyeblink conditioning. Behavioral Neuroscience, 125, 687–698.PubMedCentralPubMed
go back to reference Bolduc, M. E., et al. (2011). Spectrum of neurodevelopmental disabilities in children with cerebellar malformations. Developmental Medicine and Child Neurology, 53, 409–416.PubMed Bolduc, M. E., et al. (2011). Spectrum of neurodevelopmental disabilities in children with cerebellar malformations. Developmental Medicine and Child Neurology, 53, 409–416.PubMed
go back to reference Brown, S. M., et al. (2005). Eyeblink conditioning deficits indicate timing and cerebellar abnormalities in schizophrenia. Brain and Cognition, 58, 94–108.PubMed Brown, S. M., et al. (2005). Eyeblink conditioning deficits indicate timing and cerebellar abnormalities in schizophrenia. Brain and Cognition, 58, 94–108.PubMed
go back to reference Brunet, E., Sarfati, Y., Hardy-Bayle, M. C., & Decety, J. (2000). A PET investigation of the attribution of intentions with a nonverbal task. NeuroImage, 11, 157–166.PubMed Brunet, E., Sarfati, Y., Hardy-Bayle, M. C., & Decety, J. (2000). A PET investigation of the attribution of intentions with a nonverbal task. NeuroImage, 11, 157–166.PubMed
go back to reference Calarge, C., Andreasen, N. C., & O’Leary, D. S. (2003). Visualizing how one brain understands another: A PET study of theory of mind. American Journal of Psychiatry, 160, 1954–1964.PubMed Calarge, C., Andreasen, N. C., & O’Leary, D. S. (2003). Visualizing how one brain understands another: A PET study of theory of mind. American Journal of Psychiatry, 160, 1954–1964.PubMed
go back to reference Castellanos, F. X., et al. (2002). Developmental trajectories of brain volume abnormalities in children and adolescents with attention-deficit/hyperactivity disorder. Journal of the American Medical Association, 288, 1740–1748.PubMed Castellanos, F. X., et al. (2002). Developmental trajectories of brain volume abnormalities in children and adolescents with attention-deficit/hyperactivity disorder. Journal of the American Medical Association, 288, 1740–1748.PubMed
go back to reference Catts, H. W. (2004). Language impairments and reading disabilities. In R. D. Kent (Ed.), The MIT Encyclopedia of communication disorders (pp. 329–331). Cambridge, MA: MIT. Catts, H. W. (2004). Language impairments and reading disabilities. In R. D. Kent (Ed.), The MIT Encyclopedia of communication disorders (pp. 329–331). Cambridge, MA: MIT.
go back to reference Chapman, R. S., & Hesketh, L. J. (2000). Behavioral phenotype of individuals with Down syndrome. Mental Retardation and Developmental Disabilities Research Reviews, 6, 84–95.PubMed Chapman, R. S., & Hesketh, L. J. (2000). Behavioral phenotype of individuals with Down syndrome. Mental Retardation and Developmental Disabilities Research Reviews, 6, 84–95.PubMed
go back to reference Cheng, D. T., Disterhoft, J. F., Power, J. M., Ellis, D. A., & Desmond, J. E. (2008). Neural substrates underlying human delay and trace eyeblink conditioning. Proceedings of the National Academy of Sciences of the United States of America, 105, 8108–8113.PubMedCentralPubMed Cheng, D. T., Disterhoft, J. F., Power, J. M., Ellis, D. A., & Desmond, J. E. (2008). Neural substrates underlying human delay and trace eyeblink conditioning. Proceedings of the National Academy of Sciences of the United States of America, 105, 8108–8113.PubMedCentralPubMed
go back to reference Christian, K. M., & Thompson, R. F. (2003). Neural substrates of eyeblink conditioning: acquisition and retention. Learning & Memory, 11, 427–455. Christian, K. M., & Thompson, R. F. (2003). Neural substrates of eyeblink conditioning: acquisition and retention. Learning & Memory, 11, 427–455.
go back to reference Claflin, D. I., Stanton, M. E., Herbert, J. S., Greer, J., & Eckerman, C. O. (2002). Effect of delay interval on classical eyeblink conditioning in 5-month-old human infants. Developmental Psychobiology, 41, 329–340.PubMed Claflin, D. I., Stanton, M. E., Herbert, J. S., Greer, J., & Eckerman, C. O. (2002). Effect of delay interval on classical eyeblink conditioning in 5-month-old human infants. Developmental Psychobiology, 41, 329–340.PubMed
go back to reference Coffin, J. M., Baroody, S., Schneider, K., & O’Neill, J. (2005). Impaired cerebellar learning in children with prenatal alcohol exposure: A comparative study of eyeblink conditioning in children with ADHD and dyslexia. Cortex, 41, 389–398.PubMed Coffin, J. M., Baroody, S., Schneider, K., & O’Neill, J. (2005). Impaired cerebellar learning in children with prenatal alcohol exposure: A comparative study of eyeblink conditioning in children with ADHD and dyslexia. Cortex, 41, 389–398.PubMed
go back to reference Courchesne, E. (1997). Brainstem, cerebellar and limbic neuroanatomical abnormalities in autism. Current Opinion in Neurobiology, 7, 269–278.PubMed Courchesne, E. (1997). Brainstem, cerebellar and limbic neuroanatomical abnormalities in autism. Current Opinion in Neurobiology, 7, 269–278.PubMed
go back to reference Courchesne, E., Redcay, E., Morgan, J. T., & Kennedy, D. P. (2005). Autism at the beginning: Microstructural and growth abnormalities underlying the cognitive and behavioral phenotype of autism. Development and Psychopathology, 17, 577–597.PubMed Courchesne, E., Redcay, E., Morgan, J. T., & Kennedy, D. P. (2005). Autism at the beginning: Microstructural and growth abnormalities underlying the cognitive and behavioral phenotype of autism. Development and Psychopathology, 17, 577–597.PubMed
go back to reference Courchesne, E., et al. (2007). Mapping early brain development in autism. Neuron, 56, 1–15. Courchesne, E., et al. (2007). Mapping early brain development in autism. Neuron, 56, 1–15.
go back to reference Cromwell, R., Palk, B., & Folshee, J. (1961). Studies in activity level: The relationships among eyelid conditioning, intelligence, activity level, and age. American Journal of Mental Deficiency, 65, 744–748.PubMed Cromwell, R., Palk, B., & Folshee, J. (1961). Studies in activity level: The relationships among eyelid conditioning, intelligence, activity level, and age. American Journal of Mental Deficiency, 65, 744–748.PubMed
go back to reference D’Agata, F., et al. (2011). The recognition of facial emotions in spinocerebellar ataxia patients. Cerebellum, 10, 600–610.PubMed D’Agata, F., et al. (2011). The recognition of facial emotions in spinocerebellar ataxia patients. Cerebellum, 10, 600–610.PubMed
go back to reference Dawson, G., et al. (2010). Randomized, controlled trial of an intervention for toddlers with autism: The Early Start Denver Model. Pediatrics, 125, e17–e23.PubMed Dawson, G., et al. (2010). Randomized, controlled trial of an intervention for toddlers with autism: The Early Start Denver Model. Pediatrics, 125, e17–e23.PubMed
go back to reference Dawson, G., et al. (2012). Early behavioral intervention is associated with normalized brain activity in young children with autism. Journal of the American Academy of Child and Adolescent Psychiatry, 51, 1150–1159.PubMedCentralPubMed Dawson, G., et al. (2012). Early behavioral intervention is associated with normalized brain activity in young children with autism. Journal of the American Academy of Child and Adolescent Psychiatry, 51, 1150–1159.PubMedCentralPubMed
go back to reference de Kieviet, J. F., Zoetebier, L., van Elburg, R. M., Vermeulen, R. J., & Oosterlaan, J. (2012). Brain development of very preterm and very low-birthweight children in childhood and adolescence: A meta-analysis. Developmental Medicine and Child Neurology, 54, 313–323.PubMed de Kieviet, J. F., Zoetebier, L., van Elburg, R. M., Vermeulen, R. J., & Oosterlaan, J. (2012). Brain development of very preterm and very low-birthweight children in childhood and adolescence: A meta-analysis. Developmental Medicine and Child Neurology, 54, 313–323.PubMed
go back to reference De Vries, B. B., et al. (1997). Screening and diagnosis for the fragile X syndrome among the mentally retarded: an epidemiological and psychological survey. Collaborative Fragile X Study Group. American Journal of Human Genetics, 61, 660–667.PubMedCentralPubMed De Vries, B. B., et al. (1997). Screening and diagnosis for the fragile X syndrome among the mentally retarded: an epidemiological and psychological survey. Collaborative Fragile X Study Group. American Journal of Human Genetics, 61, 660–667.PubMedCentralPubMed
go back to reference DeCasper, A. J., & Fifer, W. P. (1980). Of human bonding: Newborns prefer their mothers’ voices. Science, 208, 1174–1176.PubMed DeCasper, A. J., & Fifer, W. P. (1980). Of human bonding: Newborns prefer their mothers’ voices. Science, 208, 1174–1176.PubMed
go back to reference Edwards, C. R., et al. (2008). Cerebellum volume and eyeblink conditioning in schizophrenia. Psychiatry Research: Neuroimaging, 162, 185–194.PubMedCentralPubMed Edwards, C. R., et al. (2008). Cerebellum volume and eyeblink conditioning in schizophrenia. Psychiatry Research: Neuroimaging, 162, 185–194.PubMedCentralPubMed
go back to reference Eigsti, I. M., & Shapiro, T. (2003). A systems neuroscience approach to autism: Biological, cognitive, and clinical perspectives. Mental Retardation and Developmental Disabilities, 9, 205–215. Eigsti, I. M., & Shapiro, T. (2003). A systems neuroscience approach to autism: Biological, cognitive, and clinical perspectives. Mental Retardation and Developmental Disabilities, 9, 205–215.
go back to reference Fifer, W. P., et al. (2010). Newborn infants learn during sleep. Proceedings of the National Academy of Sciences of the United States of America, 107, 10320–10323.PubMedCentralPubMed Fifer, W. P., et al. (2010). Newborn infants learn during sleep. Proceedings of the National Academy of Sciences of the United States of America, 107, 10320–10323.PubMedCentralPubMed
go back to reference Fitzgerald, H. E., & Brackbill, Y. (1976). Classical conditioning in infancy: Development and constraints. Psychological Bulletin, 83, 353–376.PubMed Fitzgerald, H. E., & Brackbill, Y. (1976). Classical conditioning in infancy: Development and constraints. Psychological Bulletin, 83, 353–376.PubMed
go back to reference Foroud, T., et al. (2012). Relation over time between facial measurements and cognitive outcomes in fetal alcohol-exposed children. Alcoholism: Clinical and Experimental Research, 36, 1634–1646. Foroud, T., et al. (2012). Relation over time between facial measurements and cognitive outcomes in fetal alcohol-exposed children. Alcoholism: Clinical and Experimental Research, 36, 1634–1646.
go back to reference Forsyth, J. K., et al. (2012). Cerebellar-dependent eyeblink conditioning deficits in schizophrenia spectrum disorders. Schizophrenia Bulletin, 38, 751–759.PubMedCentralPubMed Forsyth, J. K., et al. (2012). Cerebellar-dependent eyeblink conditioning deficits in schizophrenia spectrum disorders. Schizophrenia Bulletin, 38, 751–759.PubMedCentralPubMed
go back to reference Frings, M., et al. (2010). Timing of conditioned eyeblink responses is impaired in children with attention-deficit/hyperactivity disorder. Experimental Brain Research, 201, 167–176.PubMed Frings, M., et al. (2010). Timing of conditioned eyeblink responses is impaired in children with attention-deficit/hyperactivity disorder. Experimental Brain Research, 201, 167–176.PubMed
go back to reference Garcia, K. S., & Mauk, M. D. (1998). Pharmacological analysis of cerebellar contributions to the timing and expression of conditioned eyelid responses. Neuropharmacology, 37, 471–480.PubMed Garcia, K. S., & Mauk, M. D. (1998). Pharmacological analysis of cerebellar contributions to the timing and expression of conditioned eyelid responses. Neuropharmacology, 37, 471–480.PubMed
go back to reference Garcia, K. S., Steele, P. M., & Mauk, M. D. (1999). Cerebellar cortex lesions prevent acquisition of conditioned eyelid responses. Journal of Neuroscience, 19, 1940–10947. Garcia, K. S., Steele, P. M., & Mauk, M. D. (1999). Cerebellar cortex lesions prevent acquisition of conditioned eyelid responses. Journal of Neuroscience, 19, 1940–10947.
go back to reference Gergely, G., & Watson, J. S. (1996). The social biofeedback theory of parental affect-mirroring: The development of emotional self-awareness and self-control in infancy. International Journal of Psychoanalysis, 77, 1181–1212.PubMed Gergely, G., & Watson, J. S. (1996). The social biofeedback theory of parental affect-mirroring: The development of emotional self-awareness and self-control in infancy. International Journal of Psychoanalysis, 77, 1181–1212.PubMed
go back to reference Gerwig, M., Kolb, F. P., & Timmann, D. (2007). The involvement of the human cerebellum in eyeblink conditioning. Cerebellum, 6, 38–57.PubMed Gerwig, M., Kolb, F. P., & Timmann, D. (2007). The involvement of the human cerebellum in eyeblink conditioning. Cerebellum, 6, 38–57.PubMed
go back to reference Gleichgerrcht, E., Torralva, T., Rattazzi, A., Marenco, V., Roca, M., & Manes, F. (2012). Selective impairment of cognitive empathy for moral judgment in adults with high functioning autism. Social Cognitive and Affective Neuroscience, in press. Gleichgerrcht, E., Torralva, T., Rattazzi, A., Marenco, V., Roca, M., & Manes, F. (2012). Selective impairment of cognitive empathy for moral judgment in adults with high functioning autism. Social Cognitive and Affective Neuroscience, in press.
go back to reference Green, J. T. (2004). The effects of ethanol on the developing cerebellum and eyeblink conditioning. Cerebellum, 3, 178–187. Green, J. T. (2004). The effects of ethanol on the developing cerebellum and eyeblink conditioning. Cerebellum, 3, 178–187.
go back to reference Green, J. T., Rogers, R. F., Goodlett, C. R., & Steinmetz, J. E. (2000). Impairment in eyeblink conditioning in adult rats exposed to ethanol as neonates. Alcoholism, Clinical and Experimental Research, 24, 438–447.PubMed Green, J. T., Rogers, R. F., Goodlett, C. R., & Steinmetz, J. E. (2000). Impairment in eyeblink conditioning in adult rats exposed to ethanol as neonates. Alcoholism, Clinical and Experimental Research, 24, 438–447.PubMed
go back to reference Hagerman, R. J., & Hagerman, P. J. (2002). The fragile X premutation: Into the phenotypic fold. Current Opinion in Genetics & Development, 12, 278–283. Hagerman, R. J., & Hagerman, P. J. (2002). The fragile X premutation: Into the phenotypic fold. Current Opinion in Genetics & Development, 12, 278–283.
go back to reference Hammock, E. A., & Levitt, P. (2006). The discipline of neurobehavioral development: The emerging interface that builds processes and skills. Human Development, 49, 294–309. Hammock, E. A., & Levitt, P. (2006). The discipline of neurobehavioral development: The emerging interface that builds processes and skills. Human Development, 49, 294–309.
go back to reference Hardiman, M. J., Ramnani, N., & Yeo, C. H. (1996). Reversible inactivations of the cerebellum with muscimol prevent the acquisition and extinction of conditioned nictitating membrane responses in the rabbit. Experimental Brain Research, 110, 235–247.PubMed Hardiman, M. J., Ramnani, N., & Yeo, C. H. (1996). Reversible inactivations of the cerebellum with muscimol prevent the acquisition and extinction of conditioned nictitating membrane responses in the rabbit. Experimental Brain Research, 110, 235–247.PubMed
go back to reference Hart, A. R., Whitby, E. W., Griffiths, P. D., & Smith, M. F. (2008). Magnetic resonance imaging and developmental outcome following preterm birth: Review of current evidence. Developmental Medicine and Child Neurology, 50, 655–663.PubMed Hart, A. R., Whitby, E. W., Griffiths, P. D., & Smith, M. F. (2008). Magnetic resonance imaging and developmental outcome following preterm birth: Review of current evidence. Developmental Medicine and Child Neurology, 50, 655–663.PubMed
go back to reference Herbert, J. S., Eckerman, C. O., Goldstein, R. F., & Stanton, M. E. (2004). Contrasts in infant classical eyeblink conditioning as a function of premature birth. Infancy, 5, 367–383. Herbert, J. S., Eckerman, C. O., Goldstein, R. F., & Stanton, M. E. (2004). Contrasts in infant classical eyeblink conditioning as a function of premature birth. Infancy, 5, 367–383.
go back to reference Herbert, J. S., Eckerman, C. O., & Stanton, M. E. (2003). The ontogeny of human learning in delay, long-delay, and trace eyeblink conditioning. Behavioral Neuroscience, 117, 1196–1210.PubMed Herbert, J. S., Eckerman, C. O., & Stanton, M. E. (2003). The ontogeny of human learning in delay, long-delay, and trace eyeblink conditioning. Behavioral Neuroscience, 117, 1196–1210.PubMed
go back to reference Hessl, D., Rivera, S. M., & Reiss, A. L. (2004). The neuroanatomy and neuroendocrinology of fragile x syndrome. Mental Retardation and Developmental Disabilities Research Review, 10, 17–24. Hessl, D., Rivera, S. M., & Reiss, A. L. (2004). The neuroanatomy and neuroendocrinology of fragile x syndrome. Mental Retardation and Developmental Disabilities Research Review, 10, 17–24.
go back to reference Hill, E. L. (2001). Non-specific nature of specific language impairment: A review of the literature with regard to concomitant motor impairments. International Journal of Language and Communication Disorders, 36, 149–171.PubMed Hill, E. L. (2001). Non-specific nature of specific language impairment: A review of the literature with regard to concomitant motor impairments. International Journal of Language and Communication Disorders, 36, 149–171.PubMed
go back to reference Hinds, H. L., et al. (1993). Tissue specific expression of FMR-1 provides evidence for a functional role in fragile x syndrome. Nature Genetics, 3, 36–43. doi:10.1038/ng0193-36.PubMed Hinds, H. L., et al. (1993). Tissue specific expression of FMR-1 provides evidence for a functional role in fragile x syndrome. Nature Genetics, 3, 36–43. doi:10.​1038/​ng0193-36.PubMed
go back to reference Hofer, E., Doby, D., Anderer, P., & Dantendorfer, K. (2001). Impaired conditional discrimination learning in schizophrenia. Schizophrenia Research, 51, 127–136.PubMed Hofer, E., Doby, D., Anderer, P., & Dantendorfer, K. (2001). Impaired conditional discrimination learning in schizophrenia. Schizophrenia Research, 51, 127–136.PubMed
go back to reference Hoffman, H. S., Cohen, M. E., & DeVido, C. J. (1985). A comparison of classical eyelid conditioning in adults and infants. Infant Behavior and Development, 8, 247–254. Hoffman, H. S., Cohen, M. E., & DeVido, C. J. (1985). A comparison of classical eyelid conditioning in adults and infants. Infant Behavior and Development, 8, 247–254.
go back to reference Hoyme, H. E., et al. (2005). A practical clinical approach to diagnosis of fetal alcohol spectrum disorders: Clarification of the 1996 Institute of Medicine criteria. Pediatrics, 115, 39–47.PubMed Hoyme, H. E., et al. (2005). A practical clinical approach to diagnosis of fetal alcohol spectrum disorders: Clarification of the 1996 Institute of Medicine criteria. Pediatrics, 115, 39–47.PubMed
go back to reference Insel, T. R. (2010). Rethinking schizophrenia. Nature, 468, 187–193.PubMed Insel, T. R. (2010). Rethinking schizophrenia. Nature, 468, 187–193.PubMed
go back to reference Ivkovich, D., Collins, K. L., Eckerman, C. O., Krasnegor, N. A., & Stanton, M. E. (1999). Classical delay eyeblink conditioning in 4- and 5-month-old human infants. Psychological Science, 10, 4–8. Ivkovich, D., Collins, K. L., Eckerman, C. O., Krasnegor, N. A., & Stanton, M. E. (1999). Classical delay eyeblink conditioning in 4- and 5-month-old human infants. Psychological Science, 10, 4–8.
go back to reference Ivkovich, D., Eckman, C. O., Krasnegor, N. A., & Stanton, M. E. (2000). Using eyeblink conditioning to assess neurocognitive development in human infants. In D. S. Woodruff-Pak, & J. E. Steinmetz (Eds.), Eyeblink classical conditioning: Volume 1 applications in humans (pp. 119–142). Norwell, MA: Kluwer Academic Publishers. Ivkovich, D., Eckman, C. O., Krasnegor, N. A., & Stanton, M. E. (2000). Using eyeblink conditioning to assess neurocognitive development in human infants. In D. S. Woodruff-Pak, & J. E. Steinmetz (Eds.), Eyeblink classical conditioning: Volume 1 applications in humans (pp. 119–142). Norwell, MA: Kluwer Academic Publishers.
go back to reference Jacobson, S. W., et al. (2008). Impaired eyeblink conditioning in children with fetal alcohol syndrome. Alcoholism, Clinical and Experimental Research, 32, 365–372.PubMed Jacobson, S. W., et al. (2008). Impaired eyeblink conditioning in children with fetal alcohol syndrome. Alcoholism, Clinical and Experimental Research, 32, 365–372.PubMed
go back to reference Jacobson, S. W., et al. (2011). Impaired delay and trace eyeblink conditioning in school-age children with fetal alcohol syndrome. Alcoholism, Clinical and Experimental Research, 35, 1–15. Jacobson, S. W., et al. (2011). Impaired delay and trace eyeblink conditioning in school-age children with fetal alcohol syndrome. Alcoholism, Clinical and Experimental Research, 35, 1–15.
go back to reference Kaufmann, W. E., et al. (2004). Autism spectrum disorder in fragile X syndrome: Communication, social interaction, and specific behaviors. American Journal of Medical Genetics Part A, 129A, 225–234.PubMed Kaufmann, W. E., et al. (2004). Autism spectrum disorder in fragile X syndrome: Communication, social interaction, and specific behaviors. American Journal of Medical Genetics Part A, 129A, 225–234.PubMed
go back to reference Kim, J. J., Clark, R. E., & Thompson, R. F. (1995). Hippocampectomy impairs the memory of recent, but not remotely, acquired trace eyeblink conditioned responses. Behavioral Neuroscience, 109, 195–203.PubMed Kim, J. J., Clark, R. E., & Thompson, R. F. (1995). Hippocampectomy impairs the memory of recent, but not remotely, acquired trace eyeblink conditioned responses. Behavioral Neuroscience, 109, 195–203.PubMed
go back to reference Klin, A., Lin, D. J., Gorrindo, P., Ramsay, G., & Jones, W. (2009). Two-year-olds with autism orient to non-social contingencies rather than biological motion. Nature, 459, 257–263.PubMedCentralPubMed Klin, A., Lin, D. J., Gorrindo, P., Ramsay, G., & Jones, W. (2009). Two-year-olds with autism orient to non-social contingencies rather than biological motion. Nature, 459, 257–263.PubMedCentralPubMed
go back to reference Koekkoek, S. K. E., et al. (2005). Deletion of FMR1 in Purkinje cells enhances parallel fiber LTD, enlarges spines, and attenuates cerebellar eyelid conditioning in Fragile X syndrome. Neuron, 47, 339–352.PubMed Koekkoek, S. K. E., et al. (2005). Deletion of FMR1 in Purkinje cells enhances parallel fiber LTD, enlarges spines, and attenuates cerebellar eyelid conditioning in Fragile X syndrome. Neuron, 47, 339–352.PubMed
go back to reference Krain, A. L., & Castellanos, F. X. (2006). Brain development and ADHD. Clinical Psychology Review, 26, 433–444.PubMed Krain, A. L., & Castellanos, F. X. (2006). Brain development and ADHD. Clinical Psychology Review, 26, 433–444.PubMed
go back to reference Laasonen, M., et al. (2012). Project DyAdd: Classical eyeblink conditioning in adults with dyslexia and ADHD. Experimental Brain Research, 223, 19–32.PubMed Laasonen, M., et al. (2012). Project DyAdd: Classical eyeblink conditioning in adults with dyslexia and ADHD. Experimental Brain Research, 223, 19–32.PubMed
go back to reference Lai, F., & Williams, R. S. (1989). A prospective study of Alzheimer disease in Down syndrome. Archives of Neurology, 46, 849–853.PubMed Lai, F., & Williams, R. S. (1989). A prospective study of Alzheimer disease in Down syndrome. Archives of Neurology, 46, 849–853.PubMed
go back to reference LeJeune, J., Gautier, M., & Turpin, R. (1959). Study of somatic chromosomes from 9 mongoloid children. Comptes Renus de l’Academic les Sciences, 248, 1721–1722. LeJeune, J., Gautier, M., & Turpin, R. (1959). Study of somatic chromosomes from 9 mongoloid children. Comptes Renus de l’Academic les Sciences, 248, 1721–1722.
go back to reference Lewis, D. A., & Levitt, P. (2002). Schizophrenia as a disorder of neurodevelopment. Annual Review of Neuroscience, 25, 409–432.PubMed Lewis, D. A., & Levitt, P. (2002). Schizophrenia as a disorder of neurodevelopment. Annual Review of Neuroscience, 25, 409–432.PubMed
go back to reference Limperopoulos, C., et al. (2007). Does cerebellar injury in premature infants contribute to the high prevalence of long-term cognitive, learning, and behavioral disability in survivors? Pediatrics, 120, 584–593.PubMed Limperopoulos, C., et al. (2007). Does cerebellar injury in premature infants contribute to the high prevalence of long-term cognitive, learning, and behavioral disability in survivors? Pediatrics, 120, 584–593.PubMed
go back to reference Linkersdorfer, J., Lonnemann, J., Lindberg, S., Hasselhorn, M., & Fiebach, C. J. (2012). Grey matter alterations co-localize with functional abnormalities in developmental dyslexia: An ALE meta-analysis. PLoS ONE, 7, e43122.PubMedCentralPubMed Linkersdorfer, J., Lonnemann, J., Lindberg, S., Hasselhorn, M., & Fiebach, C. J. (2012). Grey matter alterations co-localize with functional abnormalities in developmental dyslexia: An ALE meta-analysis. PLoS ONE, 7, e43122.PubMedCentralPubMed
go back to reference Lintz, L. M., Fitzgerald, H. E., & Brackbill, Y. (1967). Conditioning the eyeblink response to sound in infants. Psychonomic Science, 7, 405–406. Lintz, L. M., Fitzgerald, H. E., & Brackbill, Y. (1967). Conditioning the eyeblink response to sound in infants. Psychonomic Science, 7, 405–406.
go back to reference Little, A. H., Lipsitt, L. P., & Rovee-Collier, C. (1984). Classical conditioning and retention of the infant’s eyelid response: Effects of age and interstimulus interval. Journal of Experimental Child Psychology, 37, 512–524.PubMed Little, A. H., Lipsitt, L. P., & Rovee-Collier, C. (1984). Classical conditioning and retention of the infant’s eyelid response: Effects of age and interstimulus interval. Journal of Experimental Child Psychology, 37, 512–524.PubMed
go back to reference Marenco, S., Weinberger, D. R., & Schreurs, B. G. (2003). Single-cue delay and trace classical conditioning in schizophrenia. Biological Psychiatry, 53, 390–402.PubMed Marenco, S., Weinberger, D. R., & Schreurs, B. G. (2003). Single-cue delay and trace classical conditioning in schizophrenia. Biological Psychiatry, 53, 390–402.PubMed
go back to reference McCormick, D. A., Steinmetz, J. E., & Thompson, R. F. (1985). Lesions of the inferior olivary complex cause extinction of the classically conditioned eyeblink response. Brain Research, 271, 73–88. McCormick, D. A., Steinmetz, J. E., & Thompson, R. F. (1985). Lesions of the inferior olivary complex cause extinction of the classically conditioned eyeblink response. Brain Research, 271, 73–88.
go back to reference McCormick, D. A., & Thompson, R. F. (1984). Neuronal responses of the rabbit cerebellum during acquisition and performance of a classically conditioned nictitating membrane-eyelid response. Journal of Neuroscience, 4, 2811–2822.PubMed McCormick, D. A., & Thompson, R. F. (1984). Neuronal responses of the rabbit cerebellum during acquisition and performance of a classically conditioned nictitating membrane-eyelid response. Journal of Neuroscience, 4, 2811–2822.PubMed
go back to reference Morgan, J. J. B., & Morgan, S. S. (1944). Infant learning as a developmental index. Journal of Genetic Psychology, 65, 281–289. Morgan, J. J. B., & Morgan, S. S. (1944). Infant learning as a developmental index. Journal of Genetic Psychology, 65, 281–289.
go back to reference Moyer, J. F., Deyo, R. A., & Disterhoft, J. F. (1990). Hippocampectomy disrupts trace eye-blink conditioning in rabbits. Behavioral Neuroscience, 104, 243–252.PubMed Moyer, J. F., Deyo, R. A., & Disterhoft, J. F. (1990). Hippocampectomy disrupts trace eye-blink conditioning in rabbits. Behavioral Neuroscience, 104, 243–252.PubMed
go back to reference Naito, T., & Lipsitt, L. P. (1969). Two attempts to condition eyelid responses in human infants. Journal of Experimental Child Psychology, 8, 263–270.PubMed Naito, T., & Lipsitt, L. P. (1969). Two attempts to condition eyelid responses in human infants. Journal of Experimental Child Psychology, 8, 263–270.PubMed
go back to reference Nicolson, R. I., Daum, I., Schugens, M. M., Fawcett, A. J., & Schulz, A. (2002). Eyeblink conditioning indicates cerebellar abnormality in dyslexia. Experimental Brain Research, 143, 42–50.PubMed Nicolson, R. I., Daum, I., Schugens, M. M., Fawcett, A. J., & Schulz, A. (2002). Eyeblink conditioning indicates cerebellar abnormality in dyslexia. Experimental Brain Research, 143, 42–50.PubMed
go back to reference Nicolson, R. I., Fawcett, A. J., Berry, E. L., Jenkins, I. H., Dean, P., & Brooks, D. J. (1999). Association of abnormal cerebellar activation with motor learning difficulties in dyslexic adults. Lancet, 353, 1662–1667.PubMed Nicolson, R. I., Fawcett, A. J., Berry, E. L., Jenkins, I. H., Dean, P., & Brooks, D. J. (1999). Association of abnormal cerebellar activation with motor learning difficulties in dyslexic adults. Lancet, 353, 1662–1667.PubMed
go back to reference Nicolson, R. I., Fawcett, A. J., & Dean, P. (2001). Developmental dyslexia: The cerebellar deficit hypothesis. Trends in Neurosciences, 24, 508–511.PubMed Nicolson, R. I., Fawcett, A. J., & Dean, P. (2001). Developmental dyslexia: The cerebellar deficit hypothesis. Trends in Neurosciences, 24, 508–511.PubMed
go back to reference O’Connor, N., & Rawnsley, K. (1959). Two types of conditioning in psychotics and normals. Journal of Abnormal and Social Psychology, 58, 157–161. O’Connor, N., & Rawnsley, K. (1959). Two types of conditioning in psychotics and normals. Journal of Abnormal and Social Psychology, 58, 157–161.
go back to reference O’Halloran, C. J., Kinsella, G. J., & Storey, E. (2012). The cerebellum and neuropsychological functioning: A critical review. Journal of Clinical and Experimental Neuropsychology, 34, 35–56.PubMed O’Halloran, C. J., Kinsella, G. J., & Storey, E. (2012). The cerebellum and neuropsychological functioning: A critical review. Journal of Clinical and Experimental Neuropsychology, 34, 35–56.PubMed
go back to reference Ohlrich, E. S., & Ross, L. E. (1968). Acquisition and differential conditioning of the eyelid response in normal and retarded children. Journal of Experimental Child Psychology, 6, 181–193.PubMed Ohlrich, E. S., & Ross, L. E. (1968). Acquisition and differential conditioning of the eyelid response in normal and retarded children. Journal of Experimental Child Psychology, 6, 181–193.PubMed
go back to reference Pennington, B. F., Moon, J., Edgin, J., Stedron, J., & Nadel, L. (2003). The neuropsychology of Down syndrome: Evidence for hippocampal dysfunction. Child Development, 74, 75–93.PubMed Pennington, B. F., Moon, J., Edgin, J., Stedron, J., & Nadel, L. (2003). The neuropsychology of Down syndrome: Evidence for hippocampal dysfunction. Child Development, 74, 75–93.PubMed
go back to reference Perrett, S. P., & Mauk, M. D. (1995). Extinction of conditioned eyelid responses requires the anterior lobe of the cerebellar cortex. Journal of Neuroscience, 15, 2074–2080.PubMed Perrett, S. P., & Mauk, M. D. (1995). Extinction of conditioned eyelid responses requires the anterior lobe of the cerebellar cortex. Journal of Neuroscience, 15, 2074–2080.PubMed
go back to reference Perrett, S. P., Ruiz, B. P., & Mauk, M. D. (1993). Cerebellar cortex lesions disrupt learning-dependent timing of conditioned eyelid responses. Journal of Neuroscience, 13, 1708–1718.PubMed Perrett, S. P., Ruiz, B. P., & Mauk, M. D. (1993). Cerebellar cortex lesions disrupt learning-dependent timing of conditioned eyelid responses. Journal of Neuroscience, 13, 1708–1718.PubMed
go back to reference Ramnani, N., & Yeo, C. H. (1996). Reversible inactivations of the cerebellum prevent the extinction of conditioned nictitating membrane responses in rabbits. Journal of Physiology, 495, 159–168.PubMedCentralPubMed Ramnani, N., & Yeo, C. H. (1996). Reversible inactivations of the cerebellum prevent the extinction of conditioned nictitating membrane responses in rabbits. Journal of Physiology, 495, 159–168.PubMedCentralPubMed
go back to reference Rapoport, J. (2001). The cerebellum in psychiatric disorders. International Review of Psychiatry, 13, 295–301. Rapoport, J. (2001). The cerebellum in psychiatric disorders. International Review of Psychiatry, 13, 295–301.
go back to reference Reeb-Sutherland, B. C., Fifer, W. P., Byrd, D. L., Hammock, E. A. D., Levitt, P., & Fox, N. A. (2011). One-month-old human infants learn about the social world while they sleep. Developmental Science, 14, 1134–1141.PubMedCentralPubMed Reeb-Sutherland, B. C., Fifer, W. P., Byrd, D. L., Hammock, E. A. D., Levitt, P., & Fox, N. A. (2011). One-month-old human infants learn about the social world while they sleep. Developmental Science, 14, 1134–1141.PubMedCentralPubMed
go back to reference Reeb-Sutherland, B. C., Levitt, P., & Fox, N. A. (2012). The predictive nature of individual differences in early associative learning and emerging social behavior. PLoS ONE, 7, e30511.PubMedCentralPubMed Reeb-Sutherland, B. C., Levitt, P., & Fox, N. A. (2012). The predictive nature of individual differences in early associative learning and emerging social behavior. PLoS ONE, 7, e30511.PubMedCentralPubMed
go back to reference Rendle-Short, J. (1961). The puff test: An attempt to assess the intelligence of young children by use of a conditioned reflex. Archives of Diseases of Childhood, 36, 50–57. Rendle-Short, J. (1961). The puff test: An attempt to assess the intelligence of young children by use of a conditioned reflex. Archives of Diseases of Childhood, 36, 50–57.
go back to reference Rochat, P., & Striano, T. (1999). Social-cognitive development in the first year. In P. Rochat (Ed.), Early social cognition: Understanding others in the first months of life (pp. 3–34). Mahwah: Lawrence Erlbaum Associates. Rochat, P., & Striano, T. (1999). Social-cognitive development in the first year. In P. Rochat (Ed.), Early social cognition: Understanding others in the first months of life (pp. 3–34). Mahwah: Lawrence Erlbaum Associates.
go back to reference Ross, L. E., Headrick, M. W., & MacKay, P. B. (1967). Classical eyelid conditioning in young mongoloid children. Journal of Mental Deficiency, 72, 21–29. Ross, L. E., Headrick, M. W., & MacKay, P. B. (1967). Classical eyelid conditioning in young mongoloid children. Journal of Mental Deficiency, 72, 21–29.
go back to reference Ross, L. E., Koski, C. H., & Yeager, J. (1964). Classical eyelid conditioning of the severely retarded: Partial reinforcement effects. Psychonomic Science, 1, 253–254. Ross, L. E., Koski, C. H., & Yeager, J. (1964). Classical eyelid conditioning of the severely retarded: Partial reinforcement effects. Psychonomic Science, 1, 253–254.
go back to reference Rovee-Collier, C., & Lipsitt, L. P. (1982). Learning, adaptation, and memory in the newborn. In P. Stratton (Ed.), Psychobiology of the human newborn (pp. 147–190). Chichester: Wiley. Rovee-Collier, C., & Lipsitt, L. P. (1982). Learning, adaptation, and memory in the newborn. In P. Stratton (Ed.), Psychobiology of the human newborn (pp. 147–190). Chichester: Wiley.
go back to reference Schmahmann, J. D., Weilburg, J. B., & Sherman, J. C. (2007). The neuropsychiatry of the cerebellum—insights from the clinic. Cerebellum, 6, 254–267.PubMed Schmahmann, J. D., Weilburg, J. B., & Sherman, J. C. (2007). The neuropsychiatry of the cerebellum—insights from the clinic. Cerebellum, 6, 254–267.PubMed
go back to reference Schmajuk, N. A., & DiCarlo, J. J. (1991). A neural network approach to hippocampal function in classical conditioning. Behavioral Neuroscience, 105, 82–110.PubMed Schmajuk, N. A., & DiCarlo, J. J. (1991). A neural network approach to hippocampal function in classical conditioning. Behavioral Neuroscience, 105, 82–110.PubMed
go back to reference Sears, L. L., Andreasen, N. C., & O’Leary, D. S. (2000). Cerebellar functional abnormalities in schizophrenia are suggested by classical eyeblink conditioning. Biological Psychiatry, 48, 204–209.PubMed Sears, L. L., Andreasen, N. C., & O’Leary, D. S. (2000). Cerebellar functional abnormalities in schizophrenia are suggested by classical eyeblink conditioning. Biological Psychiatry, 48, 204–209.PubMed
go back to reference Sears, L. L., Finn, P. R., & Steinmetz, J. E. (1994). Abnormal classical eye-blink conditioning in autism. Journal of Autism and Developmental Disorders, 24, 737–751.PubMed Sears, L. L., Finn, P. R., & Steinmetz, J. E. (1994). Abnormal classical eye-blink conditioning in autism. Journal of Autism and Developmental Disorders, 24, 737–751.PubMed
go back to reference Sears, L. L., & Steinmetz, J. E. (1990). Haloperidol impairs classically conditioned nictitating membrane responses and conditioning-related cerebellar interpositus nucleus activity in rabbits. Pharmacology, Biochemistry and Behavior, 36, 821–830.PubMed Sears, L. L., & Steinmetz, J. E. (1990). Haloperidol impairs classically conditioned nictitating membrane responses and conditioning-related cerebellar interpositus nucleus activity in rabbits. Pharmacology, Biochemistry and Behavior, 36, 821–830.PubMed
go back to reference Senju, A., Southgate, V., White, S., & Frith, U. (2009). Mindblind eyes: An absence of spontaneous theory of mind in Asperger syndrome. Science, 325, 883–885.PubMed Senju, A., Southgate, V., White, S., & Frith, U. (2009). Mindblind eyes: An absence of spontaneous theory of mind in Asperger syndrome. Science, 325, 883–885.PubMed
go back to reference Shamay-Tsoory, S. G., et al. (2005). The neural correlates of understanding the other’s distress: A positron emission tomography investigation of accurate empathy. NeuroImage, 27, 468–472.PubMed Shamay-Tsoory, S. G., et al. (2005). The neural correlates of understanding the other’s distress: A positron emission tomography investigation of accurate empathy. NeuroImage, 27, 468–472.PubMed
go back to reference Shaywitz, S., & Shaywitz, B. (2003). Dyslexia: specific reading disability. Pediatric Review, 24, 147–153. Shaywitz, S., & Shaywitz, B. (2003). Dyslexia: specific reading disability. Pediatric Review, 24, 147–153.
go back to reference Smit, A. E., et al. (2008). Savings and extinction of conditioned eyeblink responses in fragile X syndrome. Genes, Brain and Behavior, 7, 770–777. Smit, A. E., et al. (2008). Savings and extinction of conditioned eyeblink responses in fragile X syndrome. Genes, Brain and Behavior, 7, 770–777.
go back to reference Sokolov, A. A., Erb, M., Gharabaghi, A., Grodd, W., Tatagiba, M. S., & Pavlova, M. (2012). Biological motion processing: The left cerebellum communicates with the right superior temporal sulcus. NeuroImage, 59, 2824–2830.PubMed Sokolov, A. A., Erb, M., Gharabaghi, A., Grodd, W., Tatagiba, M. S., & Pavlova, M. (2012). Biological motion processing: The left cerebellum communicates with the right superior temporal sulcus. NeuroImage, 59, 2824–2830.PubMed
go back to reference Sokolov, A. A., Gharabaghi, A., Tatagiba, M. S., & Pavlova, M. (2010). Cerebellar engagement in an action observation network. Cerebral Cortex, 20, 486–491.PubMed Sokolov, A. A., Gharabaghi, A., Tatagiba, M. S., & Pavlova, M. (2010). Cerebellar engagement in an action observation network. Cerebral Cortex, 20, 486–491.PubMed
go back to reference Solomon, P. R., Vander Shaaf, E. R., Thompson, R. F., & Weisz, D. J. (1986). Hippocampus and trace conditioning of the rabbit’s classically conditioned nictitating membrane response. Behavioral Neuroscience, 100, 729–744.PubMed Solomon, P. R., Vander Shaaf, E. R., Thompson, R. F., & Weisz, D. J. (1986). Hippocampus and trace conditioning of the rabbit’s classically conditioned nictitating membrane response. Behavioral Neuroscience, 100, 729–744.PubMed
go back to reference Spain, B. (1966). Eyelid conditioning and arousal in schizophrenic and normal subjects. Journal of Abnormal Psychology, 71, 260–266.PubMed Spain, B. (1966). Eyelid conditioning and arousal in schizophrenic and normal subjects. Journal of Abnormal Psychology, 71, 260–266.PubMed
go back to reference Spottiswoode, B. S., et al. (2011). Diffusion tensor imaging of the cerebellum and eyeblink conditioning in fetal alcohol spectrum disorder. Alcoholism, Clinical and Experimental Research, 35, 2174–2183.PubMedCentralPubMed Spottiswoode, B. S., et al. (2011). Diffusion tensor imaging of the cerebellum and eyeblink conditioning in fetal alcohol spectrum disorder. Alcoholism, Clinical and Experimental Research, 35, 2174–2183.PubMedCentralPubMed
go back to reference Stanfield, A. C., McIntosh, A. M., Spencer, M. D., Philip, R., Gaur, S., & Lawrie, S. M. (2008). Towards a neuroanatomy of autism: A systematic review and meta-analysis of structural magnetic resonance imaging studies. European Psychiatry, 23, 289–299.PubMed Stanfield, A. C., McIntosh, A. M., Spencer, M. D., Philip, R., Gaur, S., & Lawrie, S. M. (2008). Towards a neuroanatomy of autism: A systematic review and meta-analysis of structural magnetic resonance imaging studies. European Psychiatry, 23, 289–299.PubMed
go back to reference Stanton, M. E., Claflin, D. I., & Herbert, J. S. (2010). Ontogeny of multiple memory systems: Eyeblink conditioning in rodents and humans. In M. S. Blumberg, J. H. Freeman, & Robinson, S. R. (Eds.), Oxford handbook of developmental behavioral neuroscience (pp. 501–526). New York: Oxford University Publishing. Stanton, M. E., Claflin, D. I., & Herbert, J. S. (2010). Ontogeny of multiple memory systems: Eyeblink conditioning in rodents and humans. In M. S. Blumberg, J. H. Freeman, & Robinson, S. R. (Eds.), Oxford handbook of developmental behavioral neuroscience (pp. 501–526). New York: Oxford University Publishing.
go back to reference Stanton, M. E., & Goodlett, C. R. (1998). Neonatal ethanol exposure impairs eyeblink conditioning. Alcoholism, Clinical and Experimental Research, 22, 270–275.PubMed Stanton, M. E., & Goodlett, C. R. (1998). Neonatal ethanol exposure impairs eyeblink conditioning. Alcoholism, Clinical and Experimental Research, 22, 270–275.PubMed
go back to reference Steinmetz, J. E., & Rice, M. L. (2010). Cerebellar-dependent delay eyeblink conditioning in adoloscents with Specific Language Impairment. Journal of Neurodevelopmental Disorders, 2, 243–251.PubMedCentralPubMed Steinmetz, J. E., & Rice, M. L. (2010). Cerebellar-dependent delay eyeblink conditioning in adoloscents with Specific Language Impairment. Journal of Neurodevelopmental Disorders, 2, 243–251.PubMedCentralPubMed
go back to reference Stern, D. N. (2000). The interpersonal world of the infant. New York: Basic Books. Stern, D. N. (2000). The interpersonal world of the infant. New York: Basic Books.
go back to reference Tarabulsy, G. M., Tessier, R., & Kappas, A. (1996). Contingency detection and the contingent organization of behavior in interactions: Implications for socioemotional development in infancy. Psychological Bulletin, 120, 25–41.PubMed Tarabulsy, G. M., Tessier, R., & Kappas, A. (1996). Contingency detection and the contingent organization of behavior in interactions: Implications for socioemotional development in infancy. Psychological Bulletin, 120, 25–41.PubMed
go back to reference Taylor, J. A., & Spence, K. W. (1954). Conditioning level in the behavior disorders. Journal of Abnormal and Social Psychology, 49, 497–503. Taylor, J. A., & Spence, K. W. (1954). Conditioning level in the behavior disorders. Journal of Abnormal and Social Psychology, 49, 497–503.
go back to reference Tobia, M. J., & Woodruff-Pak, D. S. (2009). Delay eyeblink classical conditioning is impaired in fragile X syndrome. Behavioral Neuroscience, 123, 665–676.PubMedCentralPubMed Tobia, M. J., & Woodruff-Pak, D. S. (2009). Delay eyeblink classical conditioning is impaired in fragile X syndrome. Behavioral Neuroscience, 123, 665–676.PubMedCentralPubMed
go back to reference Trevarthen, C. (1979). The foundations of intersubjectivity: development of interpersonal and cooperative understanding in infants. In D. Olson (Ed.), The social foundations of language and thought (pp. 316–342). New York: W.W. Norton & Co. Trevarthen, C. (1979). The foundations of intersubjectivity: development of interpersonal and cooperative understanding in infants. In D. Olson (Ed.), The social foundations of language and thought (pp. 316–342). New York: W.W. Norton & Co.
go back to reference Verkerk, A., et al. (1991). Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome. Cell, 65, 905–914. doi:10.1016/0092-8674(91)90397-h.PubMed Verkerk, A., et al. (1991). Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome. Cell, 65, 905–914. doi:10.​1016/​0092-8674(91)90397-h.PubMed
go back to reference Watson, J. S. (1966). The development of generalization of “contingency awareness” in early infancy: some hypotheses. Merril Palmer Quarterly, 12, 123–155. Watson, J. S. (1966). The development of generalization of “contingency awareness” in early infancy: some hypotheses. Merril Palmer Quarterly, 12, 123–155.
go back to reference Wenger, M. A. (1936). An investigation of conditioned responses in human infants. University of Iowa Studies in Child Welfare, 12, 9–90. Wenger, M. A. (1936). An investigation of conditioned responses in human infants. University of Iowa Studies in Child Welfare, 12, 9–90.
go back to reference Werden, D., & Ross, L. E. (1972). A comparison of the trace and delay classical conditioning performance of normal children. Journal of Experimental Child Psychology, 14, 126–132.PubMed Werden, D., & Ross, L. E. (1972). A comparison of the trace and delay classical conditioning performance of normal children. Journal of Experimental Child Psychology, 14, 126–132.PubMed
go back to reference Wisniewski, K. E., Wisniewski, H. M., & Wen, G. Y. (1985). Occurence of neuropathological changes and dementia of Alzheimer’s disease in Down’s syndrome. Annals of Neurology, 17, 278–282.PubMed Wisniewski, K. E., Wisniewski, H. M., & Wen, G. Y. (1985). Occurence of neuropathological changes and dementia of Alzheimer’s disease in Down’s syndrome. Annals of Neurology, 17, 278–282.PubMed
go back to reference Woodruff-Pak, D. S., & Disterhoft, J. F. (2008). Where is the trace in trace conditioning? Trends in Neurosciences, 31, 105–112.PubMed Woodruff-Pak, D. S., & Disterhoft, J. F. (2008). Where is the trace in trace conditioning? Trends in Neurosciences, 31, 105–112.PubMed
go back to reference Woodruff-Pak, D. S., Papka, M., & Simon, E. W. (1994). Eyeblink classical conditioning in Down’s syndrome, Fragile X syndrome, and normal adults over and under age 35. Neuropsychology, 8, 14–24. Woodruff-Pak, D. S., Papka, M., & Simon, E. W. (1994). Eyeblink classical conditioning in Down’s syndrome, Fragile X syndrome, and normal adults over and under age 35. Neuropsychology, 8, 14–24.
go back to reference Woodruff-Pak, D. S., Romano, S., & Papka, M. (1996). Training to criterion in eyeblink classical conditioning in Alzheimer’s disease, Down’s syndrome with Alzheimer’s disease, and healthy elderly. Behavioral Neuroscience, 110, 22–29.PubMed Woodruff-Pak, D. S., Romano, S., & Papka, M. (1996). Training to criterion in eyeblink classical conditioning in Alzheimer’s disease, Down’s syndrome with Alzheimer’s disease, and healthy elderly. Behavioral Neuroscience, 110, 22–29.PubMed
go back to reference Woodruff-Pak, D. S., & Steinmetz, J. E. (Eds.). (2000a). Eyeblink classical conditioning: Volume 1 applications in humans. Norwell, MA: Kluwer Academic Publishers. Woodruff-Pak, D. S., & Steinmetz, J. E. (Eds.). (2000a). Eyeblink classical conditioning: Volume 1 applications in humans. Norwell, MA: Kluwer Academic Publishers.
go back to reference Woodruff-Pak, D. S., & Steinmetz, J. E. (Eds.). (2000b). Eyeblink classical conditioning: Volume 2 animal models. Norwell, MA: Kluwer Academic Publishers. Woodruff-Pak, D. S., & Steinmetz, J. E. (Eds.). (2000b). Eyeblink classical conditioning: Volume 2 animal models. Norwell, MA: Kluwer Academic Publishers.
go back to reference Yung, A. R., McGorry, P. D., McFarlane, C. A., Jackson, H. J., Patton, G. C., & Rakkar, A. (1996). Monitoring and care of young people at incipient risk of psychosis. Schizophrenia Bulletin, 22, 283–303.PubMed Yung, A. R., McGorry, P. D., McFarlane, C. A., Jackson, H. J., Patton, G. C., & Rakkar, A. (1996). Monitoring and care of young people at incipient risk of psychosis. Schizophrenia Bulletin, 22, 283–303.PubMed
go back to reference Yung, A. R., et al. (2003). Psychosis prediction: 12-month follow up of a high-risk (“prodromal”) group. Schizophrenia Research, 60, 21–32.PubMed Yung, A. R., et al. (2003). Psychosis prediction: 12-month follow up of a high-risk (“prodromal”) group. Schizophrenia Research, 60, 21–32.PubMed
Metagegevens
Titel
Eyeblink Conditioning: A Non-invasive Biomarker for Neurodevelopmental Disorders
Auteurs
Bethany C. Reeb-Sutherland
Nathan A. Fox
Publicatiedatum
01-02-2015
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 2/2015
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-013-1905-9

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