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Gepubliceerd in: Journal of Autism and Developmental Disorders 10/2014

01-10-2014 | Original Paper

Expression of the Broad Autism Phenotype in Simplex Autism Families from the Simons Simplex Collection

Auteurs: Julie Davidson, Robin P. Goin-Kochel, Lee Anne Green-Snyder, Rachel J. Hundley, Zachary Warren, Sarika U. Peters

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 10/2014

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Abstract

The broad autism phenotype (BAP) refers to the phenotypic expression of an underlying genetic liability to autism, manifest in non-autistic relatives. This study examined the relationship among the Broad Autism Phenotype Questionnaire (BAPQ), Social Responsiveness Scale: Adult Research Version (SRS:ARV), and Family History Interview (FHI) in a large, multi-site study of 1,650 simplex families (Simons Simplex Collection). Correlations between the BAPQ and SRS:ARV Total scores were moderate, and correlations between FHI ratings and SRS:ARV and BAPQ were significant but weak. Overall, the results suggested that BAP traits occur at low rates in simplex families, and rates vary significantly depending upon the measure utilized. Implications include the need for multiple informants, and the assessment of distinct BAP traits in large-scale genetic studies of individuals with ASD.
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Metagegevens
Titel
Expression of the Broad Autism Phenotype in Simplex Autism Families from the Simons Simplex Collection
Auteurs
Julie Davidson
Robin P. Goin-Kochel
Lee Anne Green-Snyder
Rachel J. Hundley
Zachary Warren
Sarika U. Peters
Publicatiedatum
01-10-2014
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 10/2014
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-012-1492-1