Top

Journal of Autism and Developmental Disorders

Gepubliceerd in:

01-10-2014 | Original Paper

Expression of the Broad Autism Phenotype in Simplex Autism Families from the Simons Simplex Collection

Auteurs: Julie Davidson, Robin P. Goin-Kochel, Lee Anne Green-Snyder, Rachel J. Hundley, Zachary Warren, Sarika U. Peters

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 10/2014

Abstract

The broad autism phenotype (BAP) refers to the phenotypic expression of an underlying genetic liability to autism, manifest in non-autistic relatives. This study examined the relationship among the Broad Autism Phenotype Questionnaire (BAPQ), Social Responsiveness Scale: Adult Research Version (SRS:ARV), and Family History Interview (FHI) in a large, multi-site study of 1,650 simplex families (Simons Simplex Collection). Correlations between the BAPQ and SRS:ARV Total scores were moderate, and correlations between FHI ratings and SRS:ARV and BAPQ were significant but weak. Overall, the results suggested that BAP traits occur at low rates in simplex families, and rates vary significantly depending upon the measure utilized. Implications include the need for multiple informants, and the assessment of distinct BAP traits in large-scale genetic studies of individuals with ASD.

vorige artikel Reactive aggression among children with and without autism spectrum disorder

volgende artikel Standardizing ADOS Domain Scores: Separating Severity of Social Affect and Restricted and Repetitive Behaviors

Abrahams, B. S., & Geschwind, D. H. (2008). Advances in autism genetics: on the threshold of a new neurobiology. Nature Reviews Genetics, 9(5), 341–355.PubMedCrossRefPubMedCentral

Baron-Cohen, S., Wheelwright, S., Skinner, R., Martin, J., & Clubley, E. (2001). The autism-spectrum quotient (AQ): Evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematicians. Journal of Autism and Developmental Disorders, 31(1), 5–17.PubMedCrossRef

Bernier, R., Gerdts, J., Munson, J., Dawson, G., & Estes, A. (2011). Evidence for broader autism phenotype characteristics in parents from multiple-incidence autism families. Autism Research, [Epub ahead of print].

Burmeister, M., McInnis, M. G., & Zollner, S. (2008). Psychiatric genetics: Progress amid controversy. Nature Reviews Genetics, 9(7), 527–540.PubMedCrossRef

Centers for Disease Control (CDC). (2009). Prevalence of autism spectrum disorders: Autism and developmental disabilities monitoring network, United States, 2006. Morbidity and Mortality Weekly Report Surveillance Summaries, 58(10), 1–20.

Constantino, J. N., & Gruber, C. P. (2005). The social responsiveness scale manual. Los Angeles: Western Psychological Services.

Dawson, G., Estes, A., Munson, J., Schellenberg, G., Bernier, R., & Abbott, R. (2007). Quantitative assessment of autism symptom-related traits in probands and parents: Broader phenotype autism symptom scale. Journal of Autism and Developmental Disorders, 37(3), 523–536.PubMedCrossRef

Fischbach, G. D., & Lord, C. (2010). The simons simplex collection: A resource for identification of autism genetic risk factors. Neuron, 68(2), 192–195.PubMedCrossRef

Hurley, R. S., Losh, M., Parlier, M., Reznick, J. S., & Piven, J. (2007). The broad autism phenotype questionnaire. Journal of Autism and Developmental Disorders, 37(9), 1679–1690.PubMedCrossRef

Hyler, S. E., Rieder, R. O., Williams, J. B., Spitzer, R. L., Lyons, M., & Hendler, J. (1989). A comparison of clinical and self-report diagnoses of DSM-III personality disorders in 552 patients. Comprehensive Psychiatry, 30(2), 170–178.PubMedCrossRef

IMGSAC. (2000). Family history interview: Interviewer impressions. Unpublished interviewer impressions for autism.

Lainhart, J. E., Ozonoff, S., Coon, H., Krasny, L., Dinh, E., Nice, J., et al. (2002). Autism, regression, and the broader autism phenotype. American Journal of Medical Genetics, 113(3), 231–237.PubMedCrossRef

Landa, R., Piven, J., Wzorek, M. M., Gayle, J. O., Chase, G. A., & Folstein, S. E. (1992). Social language use in parents of autistic individuals. Psychological Medicine, 22(1), 245–254.PubMedCrossRef

Losh, M., Childress, D., Lam, K., & Piven, J. (2008). Defining key features of the broad autism phenotype: A comparison across parents of multiple- and single-incidence autism families. American Journal of Medical Genetics Part B Neuropsychiatric Genetics, 147B(4), 424–433.CrossRef

Losh, M., & Piven, J. (2007). Social-cognition and the broad autism phenotype: Identifying genetically meaningful phenotypes. Journal of Child Psychology and Psychiatry, 48(1), 105–112.PubMedCrossRef

Murphy, M., Bolton, P. F., Pickles, A., Fombonne, E., Piven, J., & Rutter, M. (2000). Personality traits of the relatives of autistic probands. Psychological Medicine, 30(6), 1411–1424.PubMedCrossRef

Ozonoff, S., Young, G. S., Carter, A., Messinger, D., Yirmiya, N., Zwaigenbaum, L., et al. (2011). Recurrence risk for autism spectrum disorders: A baby siblings research consortium study. Pediatrics. doi:10.1542/peds.2010-2825.

Piven, J. (2001). The broad autism phenotype: A complementary strategy for molecular genetic studies of autism. American Journal of Medical Genetics, 105(1), 34–35.PubMedCrossRef

Piven, J., Gayle, J., Chase, G. A., Fink, B., Landa, R., Wzorek, M. M., et al. (1990). A family history study of neuropsychiatric disorders in the adult siblings of autistic individuals. Journal of the American Academy of Child and Adolescent Psychiatry, 29(2), 177–183.PubMedCrossRef

Piven, J., Palmer, P., Landa, R., Santangelo, S., Jacobi, D., & Childress, D. (1997). Personality and language characteristics in parents from multiple-incidence autism families. American Journal of Medical Genetics, 74(4), 398–411.PubMedCrossRef

Piven, J., Wzorek, M., Landa, R., Lainhart, J., Bolton, P., Chase, G. A., et al. (1994). Personality characteristics of the parents of autistic individuals. Psychological Medicine, 24(3), 783–795.PubMedCrossRef

Rogers, S. J. (2009). What are infant siblings teaching us about autism in infancy? Autism Research, 2(3), 125–137.PubMedCrossRefPubMedCentral

Seidman, I., Yirmiya, N., Milshtein, S., Ebstein, R. P., & Levi, S. (2011). The broad autism phenotype questionnaire: Mothers versus fathers of children with an autism spectrum disorder. Journal of Autism and Developmental Disorders, [Epub ahead of print].

Sucksmith, E., Roth, I., & Hoekstra, R. A. (2011). Autistic traits below the clinical threshold: Re-examining the broader autism phenotype in the 21st century. Neuropsychology Review, 21(4), 360–389.PubMedCrossRef

Virkud, Y. V., Todd, R. D., Abbacchi, A. M., Zhang, Y., & Constantino, J. N. (2009). Familial aggregation of quantitative autistic traits in multiplex versus simplex autism. American Journal of Medical Genetics Part B Neuropsychiatric Genetics, 150B(3), 328–334.CrossRef

Yirmiya, N., & Charman, T. (2010). The prodrome of autism: Early behavioral and biological signs, regression, peri- and post-natal development and genetics. Journal of Child Psychology and Psychiatry, 51(4), 432–458.PubMedCrossRef

Titel: Expression of the Broad Autism Phenotype in Simplex Autism Families from the Simons Simplex Collection
Auteurs: Julie Davidson
Robin P. Goin-Kochel
Lee Anne Green-Snyder
Rachel J. Hundley
Zachary Warren
Sarika U. Peters
Publicatiedatum: 01-10-2014
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 10/2014
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-012-1492-1

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Log in om toegang te krijgen

Andere artikelen Uitgave 10/2014

Comparing Acquisition of AAC-Based Mands in Three Young Children with Autism Spectrum Disorder Using iPad® Applications with Different Display and Design Elements

Brief Report: Emotion Regulation and Respiratory Sinus Arrhythmia in Autism Spectrum Disorder

Employment Activities and Experiences of Adults with High-Functioning Autism and Asperger’s Disorder

Virtual Reality Job Interview Training in Adults with Autism Spectrum Disorder

Rudy Simone Forwarded By Liane Holliday Willey, Aspergirls: Empowering Females With Asperger Syndrome

Ethics and Autism: Where is the Autistic Voice? Commentary on Post et al.