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Gepubliceerd in: Quality of Life Research 9/2021

24-04-2021

Exercise tolerance and quality of life in patients with known or suspected coronary artery disease

Auteurs: Vasiliki Katsi, Georgios Georgiopoulos, Panagiota Mitropoulou, Konstantinos Kontoangelos, Zoi Kollia, Chara Tzavara, Dimitrios Soulis, Konstantinos Toutouzas, Dimitrios Oikonomou, Alberto Aimo, Konstantinos Tsioufis

Gepubliceerd in: Quality of Life Research | Uitgave 9/2021

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Abstract

Background

Coronary artery disease (CAD) is known to impact on patients’ physical and mental health. The relationship between performance on treadmill exercise tolerance test (ETT) and health-related quality of life (HRQL)has never been specifically investigated in the setting of CAD.

Methods

Consecutive patients undergoing an ETT with the Bruce protocol during a diagnostic workup for CAD (n = 1,631, age 55 ± 12 years) were evaluated. Exercise-related indices were recorded. Detailed information on cardiovascular risk factors and past medical history were obtained. HRQLwas assessed with the use of the validated 36-Item Short Form Survey (SF-36) questionnaire.

Results

Increasing age and the presence of cardiovascular risk factors and comorbidities correlated with lower scores on the physical and mental health component of SF-36(all P < 0.05). Subjects with arrhythmias during exercise and slow recovery of systolic blood pressure had lower scores on the physical health indices or the Social Role Functioning component (P < 0.05). Achieved target heart rate and good exercise tolerance were independently associated with better scores of the physical and mental health domains of SF-36 and overall HRQLscores (β = 0.05 for target HR and PCS-36, β = 1.86 and β = 1.66 per increasing stage of exercise tolerance and PCS-36 and MCS-36, respectively, P < 0.001 for all associations). Ischemic ECG changes were associated with worse scores on Physical Functioning (β = − 3.2, P = 0.02) and Bodily Pain (β = − 4.55, P = 0.026).

Conclusion

ETT parameters are associated with HRQL indices in patients evaluated for possible CAD. Physical conditioning may increase patient well-being and could serve as a complementary target in conjunction with cardiovascular drug therapy.
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Metagegevens
Titel
Exercise tolerance and quality of life in patients with known or suspected coronary artery disease
Auteurs
Vasiliki Katsi
Georgios Georgiopoulos
Panagiota Mitropoulou
Konstantinos Kontoangelos
Zoi Kollia
Chara Tzavara
Dimitrios Soulis
Konstantinos Toutouzas
Dimitrios Oikonomou
Alberto Aimo
Konstantinos Tsioufis
Publicatiedatum
24-04-2021
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 9/2021
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-021-02844-y