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Journal of Autism and Developmental Disorders

Gepubliceerd in:

30-01-2021 | Original Paper

Executive Function in Autism: Association with ADHD and ASD Symptoms

Auteurs: Rachel R. Lee, Anthony R. Ward, David M. Lane, Michael G. Aman, Katherine A. Loveland, Rosleen Mansour, Deborah A. Pearson

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2023

Abstract

There is substantial comorbidity between autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD), and there are well-documented executive functioning (EF) deficits in both populations. An important question concerns whether EF deficits in children with ASD are related to severity of ASD, ADHD, or both. We examined ADHD and ASD symptoms in relation to ratings of EF in the home and classroom. The sample comprised 64 children (55 males) diagnosed with ASD (mean age = 9.26 years; mean FSIQ = 92). Analyses indicated that parent and teacher ratings of EF (except Shift and Emotional Control) were consistently related to ADHD symptom severity, but not to ASD severity. Thus, functioning in the domains of Shift and Emotional control appear relatively spared, whereas performance in all other EF was impaired in relation to ADHD symptoms.

vorige artikel “It Defines Who I Am” or “It’s Something I Have”: What Language Do [Autistic] Australian Adults [on the Autism Spectrum] Prefer?

volgende artikel Structural and Pragmatic Language Impairments in Children Evaluated for Autism Spectrum Disorder (ASD)

Alloway, T. P., Gathercole, S. E., Holmes, J., Place, M., Elliott, J. G., & Hilton, K. (2009). The diagnostic utility of behavioral checklists in identifying children with ADHD and children with working memory deficits. Child Psychiatry and Human Development, 40(3), 353–366. https://doi.org/10.1007/s10578-009-0131-3.CrossRefPubMed

Barkley, R. A. (1997). Behavioral inhibition, sustained attention, and executive functions: Constructing a unifying theory of ADHD. Psychological Bulletin, 121(1), 65. https://doi.org/10.1037/0033-2909.121.1.65.CrossRefPubMed

Blijd-Hoogewys, E. M. A., Bezemer, M. L., & van Geert, P. L. C. (2014). Executive functioning in children with ASD: An analysis of the BRIEF. Journal of Autism and Developmental Disabilities, 44, 3089–3100. https://doi.org/10.1007/s10803-014-2176-9.CrossRef

Conners, C. K. (1997). Conners’ Parent Rating Scale-Revised (L). North Tonawanda, NY: Multi-Health Systems.

Corbett, B. A., Constantine, L. J., Hendren, R., Rocke, D., & Ozonoff, S. (2009). Examining executive functioning in children with autism spectrum disorder, attention deficit hyperactivity disorder and typical development. Psychiatry Research, 166(2–3), 210–222. https://doi.org/10.1016/j.psychres.2008.02.005.CrossRefPubMedPubMedCentral

Craig, F., Margari, F., Legrottaglie, A. R., Palumbi, R., De Giambattista, C., & Margari, L. (2016). A review of executive function deficits in autism spectrum disorder and attention-deficit/hyperactivity disorder. Neuropsychiatric Disease and Treatment, 12, 1191–1202. https://doi.org/10.2147/NDT.S104620.CrossRefPubMedPubMedCentral

Danielsson, H., Henry, L., Messer, D., & Rönnberg, J. (2012). Strengths and weaknesses in executive functioning in children with intellectual disability. Journal of Research in Developmental Disabilities, 2(33), 600–607. https://doi.org/10.1016/j.ridd.2011.11.004.CrossRef

Demetriou, E. A., Lampit, A., Quintana, D. S., Naismith, S. L., Song, Y. J. C., Pye, J. E., et al. (2018). Autism spectrum disorders: A meta-analysis of executive function. Molecular Psychiatry, 23, 1198–1204. https://doi.org/10.1038/mp.2017.75.CrossRefPubMed

Everett, J., Thomas, J., Cote, F., Levesque, J., & Michaud, D. (1991). Cognitive effects of psychostimulant medication in hyperactive children. Child Psychiatry and Human Development, 22(2), 79–87. https://doi.org/10.1007/BF00707786.CrossRefPubMed

Gau, S. S. F., & Shang, C. Y. (2010). Improvement of executive functions in boys with attention deficit hyperactivity disorder: An open-label follow-up study with once-daily atomoxetine. International Journal of Neuropsychopharmacology, 13(2), 243–256. https://doi.org/10.1017/S1461145709990836.CrossRefPubMed

Geurts, H. M., Verté, S., Oosterlaan, J., Roeyers, H., & Sergeant, J. A. (2004). How specific are executive functioning deficits in attention deficit hyperactivity disorder and autism? Journal of Child Psychology and Psychiatry, 45(4), 836–854. https://doi.org/10.1111/j.1469-7610.2004.00276.x.CrossRefPubMed

Gioia, G. A., Isquith, P. K., Guy, S. C., & Kenworthy, L. (2000a). TEST REVIEW behavior rating inventory of executive function. Child Neuropsychology, 6, 235–238. https://doi.org/10.1076/chin.6.3.235.3152.CrossRef

Gioia, G. A., Isquith, P. K., Guy, S. C., & Kenworthy, L. (2000b). BRIEF Behavior rating inventory of executive function: Professional manual. Lutz: Psychological Assessment Resources.

Gioia, G. A., Isquith, P. K., Kenworthy, L., & Barton, R. M. (2002). Profiles of everyday executive function in acquired and developmental disorders. Child Neuropsychology, 8(2), 121–137. https://doi.org/10.1076/chin.8.2.121.8727.CrossRefPubMed

Goldberg, M. C., Mostofsky, S. H., Cutting, L. E., Mahone, E. M., Astor, B. C., Denckla, M. B., et al. (2005). Subtle executive impairment in children with autism and children with ADHD. Journal of Autism and Developmental Disorders, 35(3), 279–293. https://doi.org/10.1007/s10803-005-3291-4.CrossRefPubMed

Granader, Y., Wallace, G. L., Hardey, K. K., Yerys, B. E., Lawson, R. A., Rosenthal, M., et al. (2014). Characterizing the factor structure of parent reported executive function in autism spectrum disorders: The impact of cognitive inflexibility. Journal of Autism and Developmental Disorder, 44(12), 3056–3062. https://doi.org/10.1007/s10803-014-2169-8.CrossRef

Hale, J. B., Reddy, L. A., Semrud-Clikeman, M., Hain, L. A., Whitaker, J., Morley, J., et al. (2011). Executive impairment determines ADHD medication response: Implications for academic achievement. Journal of Learning Disabilities, 44(2), 196–212. https://doi.org/10.1177/0022219410391191.CrossRefPubMed

Happe, F., Booth, R., Charlton, R., & Hughes, C. (2006). Executive function deficits in autism spectrum disorders and attention-deficit/hyperactivity disorder: Examining profiles across domains and ages. Brain and Cognition, 61(1), 25–39. https://doi.org/10.1016/j.bandc.2006.03.004.CrossRefPubMed

Hovik, K. T., Egeland, J., Isquith, P. K., Gioia, G., Skogli, E. W., Andersen, P. N., et al. (2017). Distinct patterns of everyday executive function problems distinguish children with Tourette syndrome from children with ADHD or autism spectrum disorders. Journal of Attention Disorders, 21(10), 811–823. https://doi.org/10.1177/1087054714550336.CrossRefPubMed

Howes, O. D., Rogdaki, M., Findon, J. L., Wichers, R. H., Charman, T., King, B. H., et al. (2018). Autism spectrum disorder: Consensus guidelines on assessment, treatment, and research from the British Association for Psychopharmacology. Journal of Psychopharmacology, 32(1), 3–29. https://doi.org/10.1177/0269881117741766.CrossRefPubMed

John, T. S., Dawson, G., & Estes, A. (2018). Brief report: Executive function as a predictor of academic achievement in school-age children with ASD. Journal of Autism and Developmental Disabilities, 48(1), 276–283. https://doi.org/10.1007/s10803-017-3296-9.CrossRef

Johnson, K., Murray, K., Spain, D., Walker, I., & Russell, A. (2019). Executive function: Cognition and behaviour in adults with autism spectrum disorders (ASD). Journal of Autism and Developmental Disorders, 49(10), 4181–4192. https://doi.org/10.1007/s10803-019-04133-7.CrossRef

Kempton, S., Vance, A., Maruff, P., Luk, E., Costin, J., & Pantelis, C. (1999). Executive function and attention deficit hyperactivity disorder: Stimulant medication and better executive function performance in children. Psychological Medicine, 29(3), 527–538. https://doi.org/10.1017/S0033291799008338.CrossRefPubMed

Lawson, R. A., Papadakis, A. A., Higginson, C. I., Barnett, J. E., Wills, M. C., Strang, J. F., et al. (2015). Everyday executive function impairments predict comorbid psychopathology in autism spectrum and attention deficit hyperactivity disorders. Neuropsychology, 29(3), 445. https://doi.org/10.1037/neu0000145.CrossRefPubMed

Lefort-Besnard, J., Vogeley, K., Schilbach, L., Varoquaux, G., Thirion, B., Dumas, G., et al. (2020). Patterns of autism symptoms: Hidden structure in the ADOS and ADI-R instruments. Translational Psychiatry, 10, 257. https://doi.org/10.1038/s41398-020-00946-8.CrossRefPubMedPubMedCentral

Leitner, Y. (2014). The co-occurrence of autism and attention deficit hyperactivity disorder in children—What do we know? Frontiers in Human Neuroscience, 8, 268. https://doi.org/10.3389/fnhum.2014.00268.CrossRefPubMedPubMedCentral

Lord, C., Rutter, M., DiLavore, P., & Risi, S. (2001). Autism Diagnostic Observation Schedule-WPS Edition (ADOS-WPS). Los Angeles: Western Psychological Services.

Loveland, K. (2005). Social-emotional impairment and self-regulation in autism spectrum disorders. In J. Nadel & D. Muir (Eds.), Typical and impaired emotional development (pp. 365–382). Oxford: Oxford University Press.

Mansour, R., Dovi, A. T., Lane, D. M., Loveland, K. A., & Pearson, D. A. (2017a). ADHD severity as it relates to comorbid psychiatric symptomatology in children with autism spectrum disorders (ASD). Research in Developmental Disabilities, 60, 52–64.CrossRefPubMed

Mansour, R, Ward A. R., Lane, D. M, Loveland, K. A, Aman, M. G., Jerger, S., et al. ADHD Severity as a predictor of cognitive task performance in children with autism spectrum disorder. Research in Developmental Disabilities (in press).

Ng, R., Heinrich, K., & Hodges, E. K. (2019). Brief report: Neuropsychological testing and informant-ratings of children with autism spectrum disorder, attention-deficit/hyperactivity disorder, or comorbid diagnosis. Journal of Autism and Developmental Disorders, 49, 2589–2596. https://doi.org/10.1007/s10803-019-03986-2.CrossRefPubMed

Ozonoff, S., & Jensen, J. (1999). Brief report: Specific executive function profiles in three neurodevelopmental disorders. Journal of Autism Developmental Disorders, 29, 171–177. https://doi.org/10.1023/A:1023052913110.CrossRefPubMed

Pearson, D. A., Aman, M. G., Arnold , L. E., Lane, D. M., Loveland, K. A., Santos, C. W., et al. (2012). High concordance of parent and teacher ADHD ratings in medicated and unmedicated children with autism spectrum disorders. Journal of Child and Adolescent Psychopharmacology, 22, 284–291. https://doi.org/10.1089/cap.2011.0067.CrossRefPubMedPubMedCentral

Pearson, D. A., Loveland, K. A., Lachar, D., Lane, D. M., Reddoch, S. L., Mansour, R., et al. ( (2006). A comparison of behavioral and emotional functioning in children and adolescents with autistic disorder and PDD-NOS. Child Neuropsychology, 12, 321–333. https://doi.org/10.1080/09297040600646847.CrossRefPubMed

Pearson, D. A., Santos, C. W., Aman, M. G., Arnold, L. E., Casat, C. D., Mansour, R., et al. (2013). Effects of extended release methylphenidate treatment on ratings of attention-deficit/hyperactivity disorder (ADHD) and associated behavior in children with autism spectrum disorders and ADHD symptoms. Journal of Child and Adolescent Psychopharmacology, 23(5), 337–351. https://doi.org/10.1089/cap.2012.0096.CrossRefPubMedPubMedCentral

Pearson, D. A., Santos, C. W., Aman, M. G., Arnold, L. E., Lane, D. M., Loveland, K. A., et al. (2020). Effects of extended release methylphenidate treatment on cognitive task performance in children with autism spectrum disorder and ADHD. Journal of Child and Adolescent Psychopharmacology, 30(7), 414–426. https://doi.org/10.1089/cap.2020.0004CrossRefPubMedPubMedCentral

Podsakoff, P. M., MacKenzie, S. B., Lee, J.-Y., & Podsakoff, N. P. (October 2003). Common method biases in behavioral research: A critical review of the literature and recommended remedies. Journal of Applied Psychology., 88(5), 879–903. https://doi.org/10.1037/0021-9010.88.5.879.CrossRefPubMed

Rapoport, J. L., Buchsbaum, M. S., Weingartner, H., Zahn, T. P., Ludlow, C., & Mikkelsen, E. J. (1980). Dextroamphetamine: Its cognitive and behavioral effects in normal and hyperactive boys and normal men. Archives of General Psychiatry, 37(8), 933–943. https://doi.org/10.1001/archpsyc.1980.01780210091010.CrossRefPubMed

Reich, W. (2000). Diagnostic interview for children and adolescents (DICA). Journal of the American Academy of Child & Adolescent Psychiatry, 39(1), 59–66. https://doi.org/10.1097/00004583-200001000-00017.CrossRef

Reich, W., Welner, Z., & Herjanic, B. (1997). Diagnostic interview for children and adolescents-IV (DICA-IV). New York: Multi-Health Systems Incorporated.

Roid, G. H. (2003). Stanford-Binet Intelligence Scales, fifth edition (SB:V). Itasca: Riverside Publishing.

Rosenthal, M., Wallace, G. L., Lawson, R., Will, M. C., Dixon, E., Yerys, B. F., et al. (2013). Impairments in real world executive function increase from childhood to adolescence in autism spectrum disorders. Neuropsychology, 27(1), 13–18. https://doi.org/10.1037/a0031299.CrossRefPubMedPubMedCentral

Rutter, M., Bailey, A., & Lord, C. (2003a). Manual for the social communication questionnaire. Los Angeles: Psychological Services.

Rutter, M., Le Couteur, A., & Lord, C. (2003b). ADI-R: Autism diagnostic interview revised. Manual. Los Angeles: Western Psychological Services.

Semrud-Clikeman, M., Walkowiak, J., Wilkinson, A., & Butcher, B. (2010). Executive functioning in children with Asperger syndrome, ADHD-combined type, ADHD-predominately inattentive type, and controls. Journal of Autism and Developmental Disorders, 40(8), 1017–1027. https://doi.org/10.1007/s10803-010-0951-9.CrossRefPubMed

Sergeant, J. A., Geurts, H., & Oosterlaan, J. (2002). How specific is a deficit of executive functioning for attention-deficit/hyperactivity disorder? Behavioral Brain Research, 130, 3–28. https://doi.org/10.1016/S0166-4328(01)00430-2.CrossRef

Sturman, N., Deckx, L., & van Driel, M. L. (2017). Methylphenidate for children and adolescents with autism spectrum disorder. Cochrane Database of Systematic Reviews, 11(11), CD011144. https://doi.org/10.1002/14651858.CD011144.pub2.CrossRefPubMed

Tannock, R., Ickowicz, A., & Schachar, R. (1995). Differential effects of methylphenidate on working memory in ADHD children with and without comorbid anxiety. Journal of the American Academy of Child & Adolescent Psychiatry, 34(7), 886–896. https://doi.org/10.1097/00004583-199507000-00012.CrossRef

Van Eylen, L., Boets, B., Steyaert, J., Wagemans, J., & Noems, I. (2015). Executive functioning in autism spectrum disorders: Influence of task and sample characteristics and relation to symptom severity. European Child and Adolescent Psychiatry, 24(11), 1399–1417. https://doi.org/10.1007/s00787-015-0689-1.CrossRefPubMed

van Stralen, J. P. M. (2020). A controlled trial of extended-release guanfacine and psychostimulants on executive function and ADHD. Journal of Attention Disorders, 24(2), 318–325. https://doi.org/10.1177/1087054717751197.CrossRefPubMed

Vance, A. L., Maruff, P., & Barnett, R. (2003). Attention deficit hyperactivity disorder, combined type: Better executive function performance with longer-term psychostimulant medication. Australian & New Zealand Journal of Psychiatry, 37(5), 570–576. https://doi.org/10.1046/j.1440-1614.2003.01238.x.CrossRef

Velleman, P. F., & Welsch, R. E. (1981). Efficient computing of regression diagnostics. The American Statistician, 35, 234–242.

Titel: Executive Function in Autism: Association with ADHD and ASD Symptoms
Auteurs: Rachel R. Lee
Anthony R. Ward
David M. Lane
Michael G. Aman
Katherine A. Loveland
Rosleen Mansour
Deborah A. Pearson
Publicatiedatum: 30-01-2021
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 2/2023
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-020-04852-2

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