Skip to main content
Top
Gepubliceerd in: Journal of Behavioral Medicine 2/2021

08-11-2020

Examining stigma, social support, and gender differences in unsuppressed HIV viral load among participants in HPTN 065

Auteurs: Allysha C. Maragh-Bass, Theresa Gamble, Wafaa M. El-Sadr, Brett Hanscom, Elizabeth E. Tolley

Gepubliceerd in: Journal of Behavioral Medicine | Uitgave 2/2021

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Successful navigation of the HIV care continuum is necessary to maintain viral suppression. We explored gender-stratified correlates of being virally unsuppressed in the Prevention for Positives (P4P) component of HPTN 065. The outcome of interest was unsuppressed viral load (> 40 copies/mL) among individuals already living with HIV. Correlates included medication adherence factors, social support and stigma. Logistic regression models were stratified by gender (N = 673). Men-specific correlates of being virally unsuppressed included opposite-sex partners, older age and HIV disclosure stigma. Women-specific correlates included time since diagnosis, and personal-level barriers to medication adherence. When more individuals knew about their HIV status, women had over twice the likelihood of being virally unsuppressed; no such association was seen among men. Additionally, higher levels of social support were not associated with viral suppression among women. Interventions should consider gender-specific approaches to engaging social support in de-stigmatization of HIV and promotion of medication adherence and subsequent viral suppression.
Literatuur
go back to reference Arnold, E. A., Rebchook, G. M., & Kegeles, S. M. (2014). ‘Triply cursed’: Racism, homophobia and HIV-related stigma are barriers to regular HIV testing, treatment adherence and disclosure among young Black gay men. Culture, Health and Sexuality, 16, 710–722.CrossRef Arnold, E. A., Rebchook, G. M., & Kegeles, S. M. (2014). ‘Triply cursed’: Racism, homophobia and HIV-related stigma are barriers to regular HIV testing, treatment adherence and disclosure among young Black gay men. Culture, Health and Sexuality, 16, 710–722.CrossRef
go back to reference Barbee, A. P., & Cunningham, M. R. (1995). An experimental approach to social support communications: Interactive coping in close relationships. Annals of the International Communication Association, 18, 381–413.CrossRef Barbee, A. P., & Cunningham, M. R. (1995). An experimental approach to social support communications: Interactive coping in close relationships. Annals of the International Communication Association, 18, 381–413.CrossRef
go back to reference Blashill, A. J., Bedoya, C. A., Mayer, K. H., O’Cleirigh, C., Pinkston, M. M., Remmert, J. E., et al. (2015). Psychosocial syndemics are additively associated with worse ART adherence in HIV-infected individuals. AIDS and Behavior, 19, 981–986.CrossRef Blashill, A. J., Bedoya, C. A., Mayer, K. H., O’Cleirigh, C., Pinkston, M. M., Remmert, J. E., et al. (2015). Psychosocial syndemics are additively associated with worse ART adherence in HIV-infected individuals. AIDS and Behavior, 19, 981–986.CrossRef
go back to reference Bluthenthal, R. N., Palar, K., Mendel, P., Kanouse, D. E., Corbin, D. E., & Derose, K. P. (2012). Attitudes and beliefs related to HIV/AIDS in urban religious congregations: Barriers and opportunities for HIV-related interventions. Social Science and Medicine, 74, 1520–1527.CrossRef Bluthenthal, R. N., Palar, K., Mendel, P., Kanouse, D. E., Corbin, D. E., & Derose, K. P. (2012). Attitudes and beliefs related to HIV/AIDS in urban religious congregations: Barriers and opportunities for HIV-related interventions. Social Science and Medicine, 74, 1520–1527.CrossRef
go back to reference Bavinton, B. R., Pinto, A. N., Phanuphak, N., Grinsztejn, B., Prestage, G. P., et al. (2018). Viral suppression and HIV transmission in serodiscordant male couples: An international, prospective, observational, cohort study. The Lancet HIV, 5, e438–e447.CrossRef Bavinton, B. R., Pinto, A. N., Phanuphak, N., Grinsztejn, B., Prestage, G. P., et al. (2018). Viral suppression and HIV transmission in serodiscordant male couples: An international, prospective, observational, cohort study. The Lancet HIV, 5, e438–e447.CrossRef
go back to reference Brown, J. D. (2002). The cronbach alpha reliability estimate. Shiken: JALT Testing and Evaluation SIG Newsletter, 6, 17–18. Brown, J. D. (2002). The cronbach alpha reliability estimate. Shiken: JALT Testing and Evaluation SIG Newsletter, 6, 17–18.
go back to reference Cohen, M. S., Chen, Y. Q., McCauley, M., Gamble, T., Hosseinipour, M. C., Kumarasamy, N., et al. (2011). Prevention of HIV-1 infection with early antiretroviral therapy. New England Journal of Medicine, 365, 493–505.CrossRef Cohen, M. S., Chen, Y. Q., McCauley, M., Gamble, T., Hosseinipour, M. C., Kumarasamy, N., et al. (2011). Prevention of HIV-1 infection with early antiretroviral therapy. New England Journal of Medicine, 365, 493–505.CrossRef
go back to reference Cortopassi, A. C., Driver, R., Eaton, L. A., & Kalichman, S. C. (2019). A new Era of HIV risk: It’s not what you know, It's who you know (and how infectious). Annual Review of Psychology, 70, 673–701.CrossRef Cortopassi, A. C., Driver, R., Eaton, L. A., & Kalichman, S. C. (2019). A new Era of HIV risk: It’s not what you know, It's who you know (and how infectious). Annual Review of Psychology, 70, 673–701.CrossRef
go back to reference Derlega, V. J., Winstead, B. A., Oldfield, E. C., & Barbee, A. P. (2003). Close relationships and social support in coping with HIV: A test of sensitive interaction systems theory. AIDS and Behavior, 7, 119–129.CrossRef Derlega, V. J., Winstead, B. A., Oldfield, E. C., & Barbee, A. P. (2003). Close relationships and social support in coping with HIV: A test of sensitive interaction systems theory. AIDS and Behavior, 7, 119–129.CrossRef
go back to reference Dong, Y., & Peng, C. J. (2013). Principled missing data methods for researchers. SpringerPlus, 2, 1–17.CrossRef Dong, Y., & Peng, C. J. (2013). Principled missing data methods for researchers. SpringerPlus, 2, 1–17.CrossRef
go back to reference Dunlap, E., Golub, A., & Johnson, B. D. (2006). The severely-distressed African American family in the crack Era: Empowerment is not enough. Journal of Sociology and Social Welfare, 33, 115–139.PubMedPubMedCentral Dunlap, E., Golub, A., & Johnson, B. D. (2006). The severely-distressed African American family in the crack Era: Empowerment is not enough. Journal of Sociology and Social Welfare, 33, 115–139.PubMedPubMedCentral
go back to reference Emlet, C. A., Brennan, D. J., Brennenstuhl, S., Rueda, S., Hart, T. A., & Rourke, S. B. (2015). The impact of HIV-related stigma on older and younger adults living with HIV disease: Does age matter? AIDS Care, 27, 520–528.CrossRef Emlet, C. A., Brennan, D. J., Brennenstuhl, S., Rueda, S., Hart, T. A., & Rourke, S. B. (2015). The impact of HIV-related stigma on older and younger adults living with HIV disease: Does age matter? AIDS Care, 27, 520–528.CrossRef
go back to reference Fang, X., Vincent, W., Calabrese, S. K., Heckman, T. G., Sikkema, K. J., Humphries, D. L., et al. (2015). Resilience, stress, and life quality in older adults living with HIV/AIDS. Aging and Mental Health, 19, 1015–1021.CrossRef Fang, X., Vincent, W., Calabrese, S. K., Heckman, T. G., Sikkema, K. J., Humphries, D. L., et al. (2015). Resilience, stress, and life quality in older adults living with HIV/AIDS. Aging and Mental Health, 19, 1015–1021.CrossRef
go back to reference Feaster, D. J., Brincks, A. M., Mitrani, V. B., Prado, G., Schwartz, S. J., & Szapocznik, J. (2010). The efficacy of structural ecosystems therapy for HIV Medication adherence with African American women. Journal of Family Psychology, 24, 51–59.CrossRef Feaster, D. J., Brincks, A. M., Mitrani, V. B., Prado, G., Schwartz, S. J., & Szapocznik, J. (2010). The efficacy of structural ecosystems therapy for HIV Medication adherence with African American women. Journal of Family Psychology, 24, 51–59.CrossRef
go back to reference Fleming, P. J., DiClemente, R. J., & Barrington, C. (2016). Masculinity and HIV: Dimensions of masculine norms that contribute to men’s HIV-related sexual behaviors. AIDS and Behavior, 20, 788–798.CrossRef Fleming, P. J., DiClemente, R. J., & Barrington, C. (2016). Masculinity and HIV: Dimensions of masculine norms that contribute to men’s HIV-related sexual behaviors. AIDS and Behavior, 20, 788–798.CrossRef
go back to reference Friedman, M. R., Stall, R., Plankey, M., Wei, C., Shoptaw, S., Herrick, A., et al. (2015). Effects of syndemics on HIV viral load and medication adherence in the multicenter AIDS cohort study. AIDS, 29, 1087.CrossRef Friedman, M. R., Stall, R., Plankey, M., Wei, C., Shoptaw, S., Herrick, A., et al. (2015). Effects of syndemics on HIV viral load and medication adherence in the multicenter AIDS cohort study. AIDS, 29, 1087.CrossRef
go back to reference Fullilove, M. T., & Fullilove, R. E., III. (1999). Stigma as an obstacle to AIDS action: The case of the African American community. American Behavioral Scientist, 42, 1117–1129.CrossRef Fullilove, M. T., & Fullilove, R. E., III. (1999). Stigma as an obstacle to AIDS action: The case of the African American community. American Behavioral Scientist, 42, 1117–1129.CrossRef
go back to reference Geter, A., Sutton, M. Y., & Hubbard McCree, D. (2018). Social and structural determinants of HIV treatment and care among black women living with HIV infection: A systematic review—2005–2016. AIDS Care, 30, 409–416.CrossRef Geter, A., Sutton, M. Y., & Hubbard McCree, D. (2018). Social and structural determinants of HIV treatment and care among black women living with HIV infection: A systematic review—2005–2016. AIDS Care, 30, 409–416.CrossRef
go back to reference Gray, W. N., Denson, L. A., Baldassano, R. N., & Hommel, K. A. (2011). Treatment adherence in adolescents with inflammatory bowel disease: The collective impact of barriers to adherence and anxiety/depressive symptoms. Journal of Pediatric Psychology, 37, 282–291.CrossRef Gray, W. N., Denson, L. A., Baldassano, R. N., & Hommel, K. A. (2011). Treatment adherence in adolescents with inflammatory bowel disease: The collective impact of barriers to adherence and anxiety/depressive symptoms. Journal of Pediatric Psychology, 37, 282–291.CrossRef
go back to reference Hall, H. I., Holtgrave, D. R., Tang, T., & Rhodes, P. (2013). HIV transmission in the United States: considerations of viral load, risk behavior, and health disparities. AIDS and Behavior, 17, 1632–1636.CrossRef Hall, H. I., Holtgrave, D. R., Tang, T., & Rhodes, P. (2013). HIV transmission in the United States: considerations of viral load, risk behavior, and health disparities. AIDS and Behavior, 17, 1632–1636.CrossRef
go back to reference Highstein, G. R., Willey, C., & Mundy, L. M. (2006). Development of stage of readiness and decisional balance instruments: Tools to enhance clinical decision-making for adherence to antiretroviral therapy. AIDS and Behavior, 10, 563–573.CrossRef Highstein, G. R., Willey, C., & Mundy, L. M. (2006). Development of stage of readiness and decisional balance instruments: Tools to enhance clinical decision-making for adherence to antiretroviral therapy. AIDS and Behavior, 10, 563–573.CrossRef
go back to reference Houston, E., Osborn, A., Lyons, T., Masvawure, T., & Raja, S. (2015). Exploring perceived social support from peer facilitators in an HIV treatment adherence intervention for African American patients: A content analysis of participant perspectives. Journal of Community and Applied Social Psychology, 25, 487–501.CrossRef Houston, E., Osborn, A., Lyons, T., Masvawure, T., & Raja, S. (2015). Exploring perceived social support from peer facilitators in an HIV treatment adherence intervention for African American patients: A content analysis of participant perspectives. Journal of Community and Applied Social Psychology, 25, 487–501.CrossRef
go back to reference Jemison, D., Jackson, S., Oni, O., Cats-Baril, D., Thomas-Smith, S., Batchelder, A., et al. (2019). Pilot randomized controlled trial of a syndemics intervention with HIV-positive, cocaine-using women. AIDS and Behavior, 23, 2467–2476.CrossRef Jemison, D., Jackson, S., Oni, O., Cats-Baril, D., Thomas-Smith, S., Batchelder, A., et al. (2019). Pilot randomized controlled trial of a syndemics intervention with HIV-positive, cocaine-using women. AIDS and Behavior, 23, 2467–2476.CrossRef
go back to reference Lichtenstein, B., Laska, M. K., & Clair, J. M. (2002). Chronic sorrow in the HIV-positive patient: Issues of race, gender, and social support. AIDS Patient Care and STDs, 16, 27–38.CrossRef Lichtenstein, B., Laska, M. K., & Clair, J. M. (2002). Chronic sorrow in the HIV-positive patient: Issues of race, gender, and social support. AIDS Patient Care and STDs, 16, 27–38.CrossRef
go back to reference Logie, C. H., James, L., Tharao, W., & Loutfy, M. R. (2011). HIV, gender, race, sexual orientation, and sex work: A qualitative study of intersectional stigma experienced by HIV-positive women in Ontario Canada. PLoS medicine, 8, e1001124.CrossRef Logie, C. H., James, L., Tharao, W., & Loutfy, M. R. (2011). HIV, gender, race, sexual orientation, and sex work: A qualitative study of intersectional stigma experienced by HIV-positive women in Ontario Canada. PLoS medicine, 8, e1001124.CrossRef
go back to reference Long, J.S. (1997). Regression models for categorical and limited dependent variables. Thousand Oaks,103. Long, J.S. (1997). Regression models for categorical and limited dependent variables. Thousand Oaks,103.
go back to reference Payán, D. D., Flórez, K. R., Bogart, L. M., Kanouse, D. E., Mata, M. A., Oden, C. W., et al. (2019). Promoting health from the pulpit: A process evaluation of HIV sermons to reduce HIV stigma and promote testing in African American and Latino churches. Health Communication, 34, 11–20.CrossRef Payán, D. D., Flórez, K. R., Bogart, L. M., Kanouse, D. E., Mata, M. A., Oden, C. W., et al. (2019). Promoting health from the pulpit: A process evaluation of HIV sermons to reduce HIV stigma and promote testing in African American and Latino churches. Health Communication, 34, 11–20.CrossRef
go back to reference Pellowski, J. A., Price, D. M., Harrison, A. D., Tuthill, E. L., Myer, L., Operario, D., & Lurie, M. N. (2018). A systematic review and meta-analysis of antiretroviral therapy (ART) adherence interventions for women living with HIV. AIDS and Behavior, 1–16. Pellowski, J. A., Price, D. M., Harrison, A. D., Tuthill, E. L., Myer, L., Operario, D., & Lurie, M. N. (2018). A systematic review and meta-analysis of antiretroviral therapy (ART) adherence interventions for women living with HIV. AIDS and Behavior, 1–16.
go back to reference Pristschet, L., Powell, D., & Horne, Z. (2016). Marginally significant effects as evidence for hypotheses: Changing attitudes over four decades. Psychological Science, 27, 1036–1042.CrossRef Pristschet, L., Powell, D., & Horne, Z. (2016). Marginally significant effects as evidence for hypotheses: Changing attitudes over four decades. Psychological Science, 27, 1036–1042.CrossRef
go back to reference Risher, K., Mayer, K., & Beyrer, C. (2015). The HIV treatment cascade in men who have sex with men, people who inject drugs and sex workers. Current Opinion in HIV and AIDS, 10, 420.CrossRef Risher, K., Mayer, K., & Beyrer, C. (2015). The HIV treatment cascade in men who have sex with men, people who inject drugs and sex workers. Current Opinion in HIV and AIDS, 10, 420.CrossRef
go back to reference Robinson, A. C., Knowlton, A. R., Gielen, A. C., & Gallo, J. J. (2016). Substance use, mental illness, and familial conflict non-negotiation among HIV-positive African Americans: latent class regression and a new syndemic framework. Journal of Behavioral Medicine, 39, 1–12.CrossRef Robinson, A. C., Knowlton, A. R., Gielen, A. C., & Gallo, J. J. (2016). Substance use, mental illness, and familial conflict non-negotiation among HIV-positive African Americans: latent class regression and a new syndemic framework. Journal of Behavioral Medicine, 39, 1–12.CrossRef
go back to reference Rodger, A. J., Cambiano, V., Bruun, T., Vernazza, P., Collins, S., et al. (2016). Sexual activity without condoms and risk of HIV transmission in serodifferent couples When the HIV-positive partner is using suppressive antiretroviral therapy. JAMA, 316, 171–181.CrossRef Rodger, A. J., Cambiano, V., Bruun, T., Vernazza, P., Collins, S., et al. (2016). Sexual activity without condoms and risk of HIV transmission in serodifferent couples When the HIV-positive partner is using suppressive antiretroviral therapy. JAMA, 316, 171–181.CrossRef
go back to reference Rossiter, J. R. (2008). Content validity of measures of abstract constructs in management and organizational research. British Journal of Management, 19, 380–388.CrossRef Rossiter, J. R. (2008). Content validity of measures of abstract constructs in management and organizational research. British Journal of Management, 19, 380–388.CrossRef
go back to reference Rueda, S., Mitra, S., Chen, S., Gogolishvili, D., Globerman, J., Chambers, L., et al. (2016). Examining the associations between HIV-related stigma and health outcomes in people living with HIV/AIDS: A series of meta-analyses. British Medical Journal Open, 6, e011453. Rueda, S., Mitra, S., Chen, S., Gogolishvili, D., Globerman, J., Chambers, L., et al. (2016). Examining the associations between HIV-related stigma and health outcomes in people living with HIV/AIDS: A series of meta-analyses. British Medical Journal Open, 6, e011453.
go back to reference Shin, T., Davison, M. L., & Long, J. D. (2017). Maximum likelihood versus multiple imputation for missing data in small longitudinal samples with nonnormality. Psychological Methods, 22, 426–449.CrossRef Shin, T., Davison, M. L., & Long, J. D. (2017). Maximum likelihood versus multiple imputation for missing data in small longitudinal samples with nonnormality. Psychological Methods, 22, 426–449.CrossRef
go back to reference Spieldenner, A. (2016). PrEP whores and HIV prevention: The queer communication of HIV pre-exposure prophylaxis (PrEP). Journal of Homosexuality, 63, 1685–1697.CrossRef Spieldenner, A. (2016). PrEP whores and HIV prevention: The queer communication of HIV pre-exposure prophylaxis (PrEP). Journal of Homosexuality, 63, 1685–1697.CrossRef
go back to reference StataCorp. (2015). STATA statistical software for windows, release 14.0. college station, TX: StataCorp LP. StataCorp. (2015). STATA statistical software for windows, release 14.0. college station, TX: StataCorp LP.
go back to reference Sutton, M. Y., & Parks, C. P. (2013). HIV/AIDS prevention, faith, and spirituality among Black/African American and Latino communities in the United States: Strengthening scientific faith-based efforts to shift the course of the epidemic and reduce HIV-related health disparities. Journal of Religion and Health, 52, 514–530.CrossRef Sutton, M. Y., & Parks, C. P. (2013). HIV/AIDS prevention, faith, and spirituality among Black/African American and Latino communities in the United States: Strengthening scientific faith-based efforts to shift the course of the epidemic and reduce HIV-related health disparities. Journal of Religion and Health, 52, 514–530.CrossRef
go back to reference Tavakol, M., & Dennick, R. (2011). Making sense of Cronbach's alpha. International Journal of Medical Education, 2, 53.CrossRef Tavakol, M., & Dennick, R. (2011). Making sense of Cronbach's alpha. International Journal of Medical Education, 2, 53.CrossRef
go back to reference Turan, B., Smith, W., Cohen, M. H., Wilson, T. E., Adimora, A. A., Merenstein, D., et al. (2016). Mechanisms for the negative effects of internalized HIV-related stigma on antiretroviral therapy adherence in women: the mediating roles of social isolation and depression. Journal of acquired immune deficiency syndromes, 72, 198.CrossRef Turan, B., Smith, W., Cohen, M. H., Wilson, T. E., Adimora, A. A., Merenstein, D., et al. (2016). Mechanisms for the negative effects of internalized HIV-related stigma on antiretroviral therapy adherence in women: the mediating roles of social isolation and depression. Journal of acquired immune deficiency syndromes, 72, 198.CrossRef
Metagegevens
Titel
Examining stigma, social support, and gender differences in unsuppressed HIV viral load among participants in HPTN 065
Auteurs
Allysha C. Maragh-Bass
Theresa Gamble
Wafaa M. El-Sadr
Brett Hanscom
Elizabeth E. Tolley
Publicatiedatum
08-11-2020
Uitgeverij
Springer US
Gepubliceerd in
Journal of Behavioral Medicine / Uitgave 2/2021
Print ISSN: 0160-7715
Elektronisch ISSN: 1573-3521
DOI
https://doi.org/10.1007/s10865-020-00186-7

Andere artikelen Uitgave 2/2021

Journal of Behavioral Medicine 2/2021 Naar de uitgave