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Gepubliceerd in: Journal of Autism and Developmental Disorders 2/2021

24-06-2020 | Original Paper

Evaluation of Appetite-Regulating Hormones ın Young Children with Autism Spectrum Disorder

Auteurs: Çağla Çelikkol Sadıç, Ayhan Bilgiç, İbrahim Kılınç, Mehmet Burhan Oflaz, Tamer Baysal

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 2/2021

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Abstract

This study aimed to investigate the role of leptin, ghrelin, neuropeptide Y, and nesfatin-1 in young children with autism spectrum disorder (ASD). A total of 44 children with ASD and 44 healthy controls aged 18–60 months were included. Plasma levels of hormones were measured using commercial enzyme-linked immunosorbent assay kits. Plasma leptin and ghrelin levels were significantly higher in the ASD group than in the control group. However, no significant difference for plasma neuropeptide Y and nesfatin-1 levels was detected between the groups. No relation was found between the severity of ASD symptoms, severity of eating problems, and plasma levels of hormones. Leptin and ghrelin may play a potential role in the pathogenesis of ASD.

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Literatuur
go back to reference Adams, J. B., Audhya, T., McDonough-Means, S., Rubin, R. A., Quig, D., Geis, E., et al. (2011). Nutritional and metabolic status of children with autism vs. neurotypical children, and the association with autism severity. Nutrition & Metabolism, 8(1), 34. Adams, J. B., Audhya, T., McDonough-Means, S., Rubin, R. A., Quig, D., Geis, E., et al. (2011). Nutritional and metabolic status of children with autism vs. neurotypical children, and the association with autism severity. Nutrition & Metabolism, 8(1), 34.
go back to reference Adamsen, D., Ramaekers, H. H. T., Britschgi, C., Rüfenacht, V., Meili, D., et al. (2014). Autism spectrum disorder associated with low serotonin in CSF and mutations in the SLC29A4 plasma membrane monoamine transporter (PMAT) gene. Molecular Autism, 13(5), 43. Adamsen, D., Ramaekers, H. H. T., Britschgi, C., Rüfenacht, V., Meili, D., et al. (2014). Autism spectrum disorder associated with low serotonin in CSF and mutations in the SLC29A4 plasma membrane monoamine transporter (PMAT) gene. Molecular Autism, 13(5), 43.
go back to reference Algul, S., & Ozcelik, O. (2018). Evaluating the levels of nesfatin-1 and ghrelin hormones in patients with moderate and severe major depressive disorders. Psychiatry Investigation, 15(2), 214–218. PubMed Algul, S., & Ozcelik, O. (2018). Evaluating the levels of nesfatin-1 and ghrelin hormones in patients with moderate and severe major depressive disorders. Psychiatry Investigation, 15(2), 214–218. PubMed
go back to reference Al-Zaid, F. S., Alhader, A. A., & Al-Ayadhi, L. Y. (2014). Altered ghrelin levels in boys with autism: A novel finding associated with hormonal dysregulation. Scientific Reports, 26(4), 6478. Al-Zaid, F. S., Alhader, A. A., & Al-Ayadhi, L. Y. (2014). Altered ghrelin levels in boys with autism: A novel finding associated with hormonal dysregulation. Scientific Reports, 26(4), 6478.
go back to reference American Psychiatric Association. (2013). Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5). Philadelphia: American Psychiatric Association. American Psychiatric Association. (2013). Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5). Philadelphia: American Psychiatric Association.
go back to reference Ashwood, P., Anthony, A., Torrente, F., & Wakefield, A. J. (2004). Spontaneous mucosal lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms: Mucosal immune activation and reduced counter regulatory interleukin-10. Journal of Clinical Immunology, 24, 664–673. PubMed Ashwood, P., Anthony, A., Torrente, F., & Wakefield, A. J. (2004). Spontaneous mucosal lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms: Mucosal immune activation and reduced counter regulatory interleukin-10. Journal of Clinical Immunology, 24, 664–673. PubMed
go back to reference Ashwood, P., Kwong, C., Hansen, R., Hertz-Picciotto, I., Croen, L., Krakowiak, P., et al. (2008). Brief report: Plasma leptin levels are elevated in autism: Association with early onset phenotype? Journal of Autism and Developmental Disorders, 38, 169–175. PubMed Ashwood, P., Kwong, C., Hansen, R., Hertz-Picciotto, I., Croen, L., Krakowiak, P., et al. (2008). Brief report: Plasma leptin levels are elevated in autism: Association with early onset phenotype? Journal of Autism and Developmental Disorders, 38, 169–175. PubMed
go back to reference Blardi, P., de Lalla, A., Ceccatelli, L., Vanessa, G., Auteri, A., & Hayek, J. (2010). Variations of plasma leptin and adiponectin levels in autistic patients. Neuroscience Letters, 479, 54–57. PubMed Blardi, P., de Lalla, A., Ceccatelli, L., Vanessa, G., Auteri, A., & Hayek, J. (2010). Variations of plasma leptin and adiponectin levels in autistic patients. Neuroscience Letters, 479, 54–57. PubMed
go back to reference Bourgeron, T. (2009). A synaptic trek to autism. Current Opinion in Neurobiology, 19(2), 231–234. PubMed Bourgeron, T. (2009). A synaptic trek to autism. Current Opinion in Neurobiology, 19(2), 231–234. PubMed
go back to reference Breij, L. M., Mulder, M. T., van Vark-van der Zee, L. C., & Hokken-Koelega, A. C. S. (2017). Appetite regulating hormones in early life and relationships with type of feeding and body composition in healthy term infants. European Journal of Nutrition, 56, 1725–1732. PubMed Breij, L. M., Mulder, M. T., van Vark-van der Zee, L. C., & Hokken-Koelega, A. C. S. (2017). Appetite regulating hormones in early life and relationships with type of feeding and body composition in healthy term infants. European Journal of Nutrition, 56, 1725–1732. PubMed
go back to reference Brothers, S. P., & Wahlestedt, C. (2010). Therapeutic potential of neuropeptide Y (NPY) receptor ligands. EMBO Molecular Medicine, 2, 429–439. PubMedPubMedCentral Brothers, S. P., & Wahlestedt, C. (2010). Therapeutic potential of neuropeptide Y (NPY) receptor ligands. EMBO Molecular Medicine, 2, 429–439. PubMedPubMedCentral
go back to reference Cannon, A. M., Kakulas, F., Hepworth, A. R., Lai, C. T., Hartmann, P. E., & Geddes, D. T. (2015). The effects of leptin on breastfeeding behaviour. International Journal of Environmental Research and Public Health, 12(10), 12340–12355. PubMedPubMedCentral Cannon, A. M., Kakulas, F., Hepworth, A. R., Lai, C. T., Hartmann, P. E., & Geddes, D. T. (2015). The effects of leptin on breastfeeding behaviour. International Journal of Environmental Research and Public Health, 12(10), 12340–12355. PubMedPubMedCentral
go back to reference Center for Disease Control and Prevention. (2014). Prevalence of autism spectrum disorders among children age 8 years-Autism and Developmental Disabilities Monitoring Network, 11 sites, United States 2010. MMWR Surveillance Summaries, 63, 1–21. Center for Disease Control and Prevention. (2014). Prevalence of autism spectrum disorders among children age 8 years-Autism and Developmental Disabilities Monitoring Network, 11 sites, United States 2010. MMWR Surveillance Summaries, 63, 1–21.
go back to reference Cheung, C. K., & Wu, J. C. (2013). Role of ghrelin in the pathophysiology of gastrointestinal disease. Gut Liver, 7(5), 505–512. PubMedPubMedCentral Cheung, C. K., & Wu, J. C. (2013). Role of ghrelin in the pathophysiology of gastrointestinal disease. Gut Liver, 7(5), 505–512. PubMedPubMedCentral
go back to reference Chowdhury, E. A., Richardson, J. D., Tsintzas, K., Thompson, D., & Betts, J. A. (2016). Effect of extended morning fasting upon ad libitum lunch intake and associated metabolic and hormonal responses in obese adults. International Journal of Obesity (Lond), 40(2), 305–311. Chowdhury, E. A., Richardson, J. D., Tsintzas, K., Thompson, D., & Betts, J. A. (2016). Effect of extended morning fasting upon ad libitum lunch intake and associated metabolic and hormonal responses in obese adults. International Journal of Obesity (Lond), 40(2), 305–311.
go back to reference Clark, J. T., Kalra, P. S., Crowley, W. R., & Kalra, S. P. (1984). Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology, 115(1), 427–429. PubMed Clark, J. T., Kalra, P. S., Crowley, W. R., & Kalra, S. P. (1984). Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology, 115(1), 427–429. PubMed
go back to reference Considine, R. V., Considine, E. L., Williams, C. J., Nyce, M. R., Magosin, S. A., Bauer, T. L., et al. (1995). Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity. Journal of Clinical Investigation, 95, 2986–2988. PubMedCentral Considine, R. V., Considine, E. L., Williams, C. J., Nyce, M. R., Magosin, S. A., Bauer, T. L., et al. (1995). Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity. Journal of Clinical Investigation, 95, 2986–2988. PubMedCentral
go back to reference Crujeiras, A. B., Carreira, M. C., Cabia, B., Andrade, S., Amil, M., & Casanueva, F. F. (2015). Leptin resistance in obesity: An epigenetic landscape. Life Sciences, 1(140), 57–63. Crujeiras, A. B., Carreira, M. C., Cabia, B., Andrade, S., Amil, M., & Casanueva, F. F. (2015). Leptin resistance in obesity: An epigenetic landscape. Life Sciences, 1(140), 57–63.
go back to reference Cummings, D. E., Purnell, J. Q., Frayo, R. S., Schmidova, K., Wisse, B. E., & Weigle, D. S. (2001). A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes, 50, 1714–1719. PubMed Cummings, D. E., Purnell, J. Q., Frayo, R. S., Schmidova, K., Wisse, B. E., & Weigle, D. S. (2001). A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes, 50, 1714–1719. PubMed
go back to reference Curtin, C., Anderson, S. E., Must, A., & Bandini, L. (2010). The prevalence of obesity in children with autism: A secondary data analysis using nationally representative data from the National Survey of Children's Health. BMC Pediatrics, 23(10), 11. Curtin, C., Anderson, S. E., Must, A., & Bandini, L. (2010). The prevalence of obesity in children with autism: A secondary data analysis using nationally representative data from the National Survey of Children's Health. BMC Pediatrics, 23(10), 11.
go back to reference DeLong, G. R. (1992). Autism, amnesia, hippocampus, and learning. Neuroscience and Biobehavioral Reviews, 16, 63–70. PubMed DeLong, G. R. (1992). Autism, amnesia, hippocampus, and learning. Neuroscience and Biobehavioral Reviews, 16, 63–70. PubMed
go back to reference Diano, S., Farr, S. A., Benoit, S. C., McNay, E. C., da Silva, I., Horvath, B., et al. (2006). Ghrelin controls hippocampal spine synapse density and memory performance. Nature Neuroscience, 9(3), 381–388. PubMed Diano, S., Farr, S. A., Benoit, S. C., McNay, E. C., da Silva, I., Horvath, B., et al. (2006). Ghrelin controls hippocampal spine synapse density and memory performance. Nature Neuroscience, 9(3), 381–388. PubMed
go back to reference Dixit, V. D., Schaffer, E. M., Pyle, R. S., Collins, G. D., Sakthivel, S. K., Palaniappan, R., et al. (2004). Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells. Journal of Clinical Investigation, 114(1), 57–66. PubMedCentral Dixit, V. D., Schaffer, E. M., Pyle, R. S., Collins, G. D., Sakthivel, S. K., Palaniappan, R., et al. (2004). Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells. Journal of Clinical Investigation, 114(1), 57–66. PubMedCentral
go back to reference Dodd, G. T., Worth, A. A., Nunn, N., Korpal, A. K., Bechtold, D. A., Allison, M. B., et al. (2014). The thermogenic effect of leptin is dependent on a distinct population of prolactin releasing peptide neurons in the dorsomedial hypothalamus. Cell Metabolism, 20, 639–649. PubMedPubMedCentral Dodd, G. T., Worth, A. A., Nunn, N., Korpal, A. K., Bechtold, D. A., Allison, M. B., et al. (2014). The thermogenic effect of leptin is dependent on a distinct population of prolactin releasing peptide neurons in the dorsomedial hypothalamus. Cell Metabolism, 20, 639–649. PubMedPubMedCentral
go back to reference Doenyas, C. (2018). Gut microbiota, inflammation, and probiotics on neural development in autism spectrum disorder. Neuroscience, 15(374), 271–286. Doenyas, C. (2018). Gut microbiota, inflammation, and probiotics on neural development in autism spectrum disorder. Neuroscience, 15(374), 271–286.
go back to reference Dore, R., Levata, L., Lehnert, H., & Schulz, C. (2017). Nesfatin-1: Functions and physiology of a novel regulatory peptide. Journal of Endocrinology, 232(1), R45–R65. Dore, R., Levata, L., Lehnert, H., & Schulz, C. (2017). Nesfatin-1: Functions and physiology of a novel regulatory peptide. Journal of Endocrinology, 232(1), R45–R65.
go back to reference Dzaja, A., Dalal, M. A., Himmerich, H., Uhr, M., Pollmächer, T., & Schuld, A. (2004). Sleep enhances nocturnal plasma ghrelin levels in healthy subjects. American Journal of Physiology, Endocrinology and Metabolism, 286(6), E963–E967. PubMed Dzaja, A., Dalal, M. A., Himmerich, H., Uhr, M., Pollmächer, T., & Schuld, A. (2004). Sleep enhances nocturnal plasma ghrelin levels in healthy subjects. American Journal of Physiology, Endocrinology and Metabolism, 286(6), E963–E967. PubMed
go back to reference Emmerzaal, T. L., & Kozicz, T. (2013). Nesfatin-1; Implication in stress and stress-associated anxiety and depression. Current Pharmaceutical Design, 19, 6941–6948. PubMed Emmerzaal, T. L., & Kozicz, T. (2013). Nesfatin-1; Implication in stress and stress-associated anxiety and depression. Current Pharmaceutical Design, 19, 6941–6948. PubMed
go back to reference Ghozy, S., Tran, L., Naveed, S., Quynh, T. T. H., Helmy Zayan, A., Waqas, A., et al. (2020). Association of breastfeeding status with risk of autism spectrum disorder: A systematic review, dose-response analysis and meta-analysis. Asian Journal of Psychiatry, 48, 101916. PubMed Ghozy, S., Tran, L., Naveed, S., Quynh, T. T. H., Helmy Zayan, A., Waqas, A., et al. (2020). Association of breastfeeding status with risk of autism spectrum disorder: A systematic review, dose-response analysis and meta-analysis. Asian Journal of Psychiatry, 48, 101916. PubMed
go back to reference Gibson, L. A., Alava, M. H., Kelly, M. P., & Campbell, M. J. (2017). The effects of breastfeeding on childhood BMI: A propensity score matching approach. Journal of Public Health (Oxf), 39(4), e152–e160. Gibson, L. A., Alava, M. H., Kelly, M. P., & Campbell, M. J. (2017). The effects of breastfeeding on childhood BMI: A propensity score matching approach. Journal of Public Health (Oxf), 39(4), e152–e160.
go back to reference Gunay, H., Tutuncu, R., Aydin, S., Dag, E., & Abasli, D. (2012). Decreased plasma nesfatin-1 levels in patients with generalized anxiety disorder. Psychoneuroendocrinology., 37, 1949–1953. PubMed Gunay, H., Tutuncu, R., Aydin, S., Dag, E., & Abasli, D. (2012). Decreased plasma nesfatin-1 levels in patients with generalized anxiety disorder. Psychoneuroendocrinology., 37, 1949–1953. PubMed
go back to reference Hahn-Holbrook, J., Saxbe, D., Bixby, C., Steele, C., & Glynn, L. (2019). Human milk as "Chrononutrition": Implications for child health and development. Pediatric Research, 85(7), 936–942. PubMed Hahn-Holbrook, J., Saxbe, D., Bixby, C., Steele, C., & Glynn, L. (2019). Human milk as "Chrononutrition": Implications for child health and development. Pediatric Research, 85(7), 936–942. PubMed
go back to reference Hasan, Z. A., Al-Kafaji, G., Al-Sherawi, M. I., Razzak, R. A., Eltayeb, D., Skrypnk, C., et al. (2019). Investigation of serum levels of leptin, ghrelin and growth hormone in bahraini children with autism. International Archives of Translational Medicine, 5, 007. Hasan, Z. A., Al-Kafaji, G., Al-Sherawi, M. I., Razzak, R. A., Eltayeb, D., Skrypnk, C., et al. (2019). Investigation of serum levels of leptin, ghrelin and growth hormone in bahraini children with autism. International Archives of Translational Medicine, 5, 007.
go back to reference Heilig, M. (2004). The NPY system in stress, anxiety and depression. Neuropeptides, 38(4), 213–224. PubMed Heilig, M. (2004). The NPY system in stress, anxiety and depression. Neuropeptides, 38(4), 213–224. PubMed
go back to reference Illnerova, H., Buresova, M., & Presl, J. (1993). Melatonin rhythm in human milk. Journal of Clinical Endocrinology and Metabolism, 77, 838–841. PubMed Illnerova, H., Buresova, M., & Presl, J. (1993). Melatonin rhythm in human milk. Journal of Clinical Endocrinology and Metabolism, 77, 838–841. PubMed
go back to reference Jyonouchi, H., Sun, S., & Itokazu, N. (2002). Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder. Neuropsychobiology, 46, 76–84. PubMed Jyonouchi, H., Sun, S., & Itokazu, N. (2002). Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder. Neuropsychobiology, 46, 76–84. PubMed
go back to reference Kalies, H., Heinrich, J., Borte, M., Schaaf, B., Berg, A. V., Kries, R. V., et al. (2005). The effect of breastfeeding on weight gain in infants: Results of a birth cohort study. European Journal of Medical Research, 10(1), 36–42. PubMed Kalies, H., Heinrich, J., Borte, M., Schaaf, B., Berg, A. V., Kries, R. V., et al. (2005). The effect of breastfeeding on weight gain in infants: Results of a birth cohort study. European Journal of Medical Research, 10(1), 36–42. PubMed
go back to reference Kim, T. W., Jeong, J. H., & Hong, S. C. (2015). The impact of sleep and circadian disturbance on hormones and metabolism. International Journal of Endocrinology, 2015, 591729. PubMedPubMedCentral Kim, T. W., Jeong, J. H., & Hong, S. C. (2015). The impact of sleep and circadian disturbance on hormones and metabolism. International Journal of Endocrinology, 2015, 591729. PubMedPubMedCentral
go back to reference Krug, D. A., Arick, J., & Almond, P. (1980). Behavior checklist for identifying severely handicapped individuals with high levels of autistic behavior. Journal of Child Psychology and Psychiatry, 21, 221–229. PubMed Krug, D. A., Arick, J., & Almond, P. (1980). Behavior checklist for identifying severely handicapped individuals with high levels of autistic behavior. Journal of Child Psychology and Psychiatry, 21, 221–229. PubMed
go back to reference La Cava, A., & Matarese, G. (2004). The weight of leptin in immunity. Nature Reviews Immunology, 4(5), 371–379. PubMed La Cava, A., & Matarese, G. (2004). The weight of leptin in immunity. Nature Reviews Immunology, 4(5), 371–379. PubMed
go back to reference Loh, K., Herzog, H., & Shi, Y. C. (2015). Regulation of energy homeostasis by the NPY system. Trends in Endocrinology and Metabolism, 26(3), 125–135. PubMed Loh, K., Herzog, H., & Shi, Y. C. (2015). Regulation of energy homeostasis by the NPY system. Trends in Endocrinology and Metabolism, 26(3), 125–135. PubMed
go back to reference Maffei, M., Halaas, J., Ravussin, E., Pratley, R. E., Lee, G. H., Zhang, Y., et al. (1995). Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Medicine, 1, 1155–1161. PubMed Maffei, M., Halaas, J., Ravussin, E., Pratley, R. E., Lee, G. H., Zhang, Y., et al. (1995). Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Medicine, 1, 1155–1161. PubMed
go back to reference Morin, L. P. (2013). Neuroanatomy of the extended circadian rhythm system. Experimental Neurology, 243, 4–20. PubMed Morin, L. P. (2013). Neuroanatomy of the extended circadian rhythm system. Experimental Neurology, 243, 4–20. PubMed
go back to reference Nozhenko, Y., Asnani-Kishnani, M., Rodríguez, A. M., & Palou, A. (2015). Milk leptin surge and biological rhythms of leptin and other regulatory proteins in breastmilk. PLoS ONE, 10(12), e0145376. PubMedPubMedCentral Nozhenko, Y., Asnani-Kishnani, M., Rodríguez, A. M., & Palou, A. (2015). Milk leptin surge and biological rhythms of leptin and other regulatory proteins in breastmilk. PLoS ONE, 10(12), e0145376. PubMedPubMedCentral
go back to reference Obermann-Borst, S. A., Eilers, P. H., Tobi, E. W., de Jong, F. H., Slagboom, P. E., Heijmans, B. T., et al. (2013). Duration of breastfeeding and gender are associated with methylation of the LEPTIN gene in very young children. Pediatric Research, 74(3), 344–349. PubMed Obermann-Borst, S. A., Eilers, P. H., Tobi, E. W., de Jong, F. H., Slagboom, P. E., Heijmans, B. T., et al. (2013). Duration of breastfeeding and gender are associated with methylation of the LEPTIN gene in very young children. Pediatric Research, 74(3), 344–349. PubMed
go back to reference Oh-I, S., Shimizu, H., Satoh, T., Okada, S., Adachi, S., Inoue, K., et al. (2006). Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature, 443, 709–712. PubMed Oh-I, S., Shimizu, H., Satoh, T., Okada, S., Adachi, S., Inoue, K., et al. (2006). Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature, 443, 709–712. PubMed
go back to reference Oury, F., & Karsenty, G. (2011). Towards a serotonin-dependent leptin roadmap in the brain. Trends in Endocrinology and Metabolism, 22(9), 382–387. PubMed Oury, F., & Karsenty, G. (2011). Towards a serotonin-dependent leptin roadmap in the brain. Trends in Endocrinology and Metabolism, 22(9), 382–387. PubMed
go back to reference Ozsavci, D., Ersahin, M., Sener, A., et al. (2011). The novel function of nesfatin-1 as an anti-inflammatory and antiapoptotic peptide in subarachnoid hemorrhage-induced oxidative brain damage in rats. Neurosurgery., 68, 1699–1708. PubMed Ozsavci, D., Ersahin, M., Sener, A., et al. (2011). The novel function of nesfatin-1 as an anti-inflammatory and antiapoptotic peptide in subarachnoid hemorrhage-induced oxidative brain damage in rats. Neurosurgery., 68, 1699–1708. PubMed
go back to reference Ozturk, C. C., Oktay, S., Yuksel, M., Akakin, D., Yarat, A., & Kasimay, C. O. (2015). Anti-inflammatory effects of nesfatin-1 in rats with acetic acid—Induced colitis and underlying mechanisms. Journal of Physiology and Pharmacology, 66(5), 741–750. PubMed Ozturk, C. C., Oktay, S., Yuksel, M., Akakin, D., Yarat, A., & Kasimay, C. O. (2015). Anti-inflammatory effects of nesfatin-1 in rats with acetic acid—Induced colitis and underlying mechanisms. Journal of Physiology and Pharmacology, 66(5), 741–750. PubMed
go back to reference Pinato, L., Galina Spilla, C. S., Markus, R. P., & da Silveira, C.-M. (2019). Dysregulation of circadian rhythms in autism spectrum disorders. Current Pharmaceutical Design, 25(41), 4379–4393. PubMed Pinato, L., Galina Spilla, C. S., Markus, R. P., & da Silveira, C.-M. (2019). Dysregulation of circadian rhythms in autism spectrum disorders. Current Pharmaceutical Design, 25(41), 4379–4393. PubMed
go back to reference Pinsky, M., Rauch, M., Abbas, A., Sharabi-Nov, A., Tamir, S., & Gutman, R. (2017). Long-lived weight-reduced αMUPA mice show higher and longer maternal-dependent postnatal leptin surge. PLoS ONE, 12(11), e0188658. PubMedPubMedCentral Pinsky, M., Rauch, M., Abbas, A., Sharabi-Nov, A., Tamir, S., & Gutman, R. (2017). Long-lived weight-reduced αMUPA mice show higher and longer maternal-dependent postnatal leptin surge. PLoS ONE, 12(11), e0188658. PubMedPubMedCentral
go back to reference Raghavan, R., Zuckerman, B., Hong, X., Wang, G., Ji, Y., Paige, D., et al. (2018). Fetal and infancy growth pattern, cord and early childhood plasma leptin, and development of autism spectrum disorder in the Boston birth cohort. Autism Research, 11(10), 1416–1431. PubMedPubMedCentral Raghavan, R., Zuckerman, B., Hong, X., Wang, G., Ji, Y., Paige, D., et al. (2018). Fetal and infancy growth pattern, cord and early childhood plasma leptin, and development of autism spectrum disorder in the Boston birth cohort. Autism Research, 11(10), 1416–1431. PubMedPubMedCentral
go back to reference Rodrigues, D. H., Rocha, N. P., Sousa, L. F., Barbosa, I. G., Kummer, A., & Teixeira, A. L. (2014). Changes in adipokine levels in autism spectrum disorders. Neuropsychobiology., 69(1), 6–10. PubMed Rodrigues, D. H., Rocha, N. P., Sousa, L. F., Barbosa, I. G., Kummer, A., & Teixeira, A. L. (2014). Changes in adipokine levels in autism spectrum disorders. Neuropsychobiology., 69(1), 6–10. PubMed
go back to reference Sah, R., Ekhator, N. N., Strawn, J. R., Sallee, F. R., Baker, D. G., Horn, P. S., et al. (2009). Low cerebrospinal fluid neuropeptide Y concentrations in posttraumatic stress disorder. Biological Psychiatry, 66(7), 705–707. PubMedPubMedCentral Sah, R., Ekhator, N. N., Strawn, J. R., Sallee, F. R., Baker, D. G., Horn, P. S., et al. (2009). Low cerebrospinal fluid neuropeptide Y concentrations in posttraumatic stress disorder. Biological Psychiatry, 66(7), 705–707. PubMedPubMedCentral
go back to reference Sajdyk, T. J., Shekhar, A., & Gehlert, D. R. (2004). Interactions between NPY and CRF in the amygdala to regulate emotionality. Neuropeptides., 38(4), 225–234. PubMed Sajdyk, T. J., Shekhar, A., & Gehlert, D. R. (2004). Interactions between NPY and CRF in the amygdala to regulate emotionality. Neuropeptides., 38(4), 225–234. PubMed
go back to reference Sato, T., Fukue, Y., Teranishi, H., Yoshida, Y., & Kojima, M. (2005). Molecular forms of hypothalamic ghrelin and its regulation by fasting and 2-deoxy-d-glucose administration. Endocrinology, 146, 2510–2516. PubMed Sato, T., Fukue, Y., Teranishi, H., Yoshida, Y., & Kojima, M. (2005). Molecular forms of hypothalamic ghrelin and its regulation by fasting and 2-deoxy-d-glucose administration. Endocrinology, 146, 2510–2516. PubMed
go back to reference Schopler, E., Reichler, R. J., DeVellis, R. F., & Daly, K. (1980). Toward objective classification of childhood autism: Childhood Autism Rating Scale (CARS). Journal of Autism and Developmental Disorders, 10, 91–103. PubMed Schopler, E., Reichler, R. J., DeVellis, R. F., & Daly, K. (1980). Toward objective classification of childhood autism: Childhood Autism Rating Scale (CARS). Journal of Autism and Developmental Disorders, 10, 91–103. PubMed
go back to reference Sharp, W. G., Berry, R. C., McCracken, C., Nuhu, N. N., Marvel, E., Saulnier, C. A., et al. (2013). Feeding problems and nutrient intake in children with autism spectrum disorders: A meta-analysis and comprehensive review of the literature. Journal of Autism and Developmental Disorders, 43(9), 2159–2173. PubMed Sharp, W. G., Berry, R. C., McCracken, C., Nuhu, N. N., Marvel, E., Saulnier, C. A., et al. (2013). Feeding problems and nutrient intake in children with autism spectrum disorders: A meta-analysis and comprehensive review of the literature. Journal of Autism and Developmental Disorders, 43(9), 2159–2173. PubMed
go back to reference Sherwood, W. B., Bion, V., Lockett, G. A., Ziyab, A. H., Soto-Ramírez, N., Mukherjee, N., et al. (2019). Duration of breastfeeding is associated with leptin (LEP) DNA methylation profiles and BMI in 10-year-old children. Clinical Epigenetics, 11(1), 128. PubMedPubMedCentral Sherwood, W. B., Bion, V., Lockett, G. A., Ziyab, A. H., Soto-Ramírez, N., Mukherjee, N., et al. (2019). Duration of breastfeeding is associated with leptin (LEP) DNA methylation profiles and BMI in 10-year-old children. Clinical Epigenetics, 11(1), 128. PubMedPubMedCentral
go back to reference Shimmura, C., Suda, S., Tsuchiya, K. J., Hashimoto, K., Ohno, K., Matsuzaki, H., et al. (2011). Alteration of plasma glutamate and glutamine levels in children with high-functioning autism. PLoS ONE, 6, e25340. PubMedPubMedCentral Shimmura, C., Suda, S., Tsuchiya, K. J., Hashimoto, K., Ohno, K., Matsuzaki, H., et al. (2011). Alteration of plasma glutamate and glutamine levels in children with high-functioning autism. PLoS ONE, 6, e25340. PubMedPubMedCentral
go back to reference Silva, A. P., Pinheiro, P. S., Carvalho, A. P., Carvalho, C. M., Jakobsen, B., Zimmer, J., et al. (2003). Activation of neuropeptide Y receptors is neuroprotective against excitotoxicity in organotypic hippocampal slice cultures. The FASEB Journal, 17(9), 1118–1120. PubMed Silva, A. P., Pinheiro, P. S., Carvalho, A. P., Carvalho, C. M., Jakobsen, B., Zimmer, J., et al. (2003). Activation of neuropeptide Y receptors is neuroprotective against excitotoxicity in organotypic hippocampal slice cultures. The FASEB Journal, 17(9), 1118–1120. PubMed
go back to reference Singh, K., & Zimmerman, A. W. (2015). Sleep in autism spectrum disorder and attention deficit hyperactivity disorder. Seminars in Pediatric Neurology, 22(2), 113–125. PubMed Singh, K., & Zimmerman, A. W. (2015). Sleep in autism spectrum disorder and attention deficit hyperactivity disorder. Seminars in Pediatric Neurology, 22(2), 113–125. PubMed
go back to reference Soke, G. N., Maenner, M., Windham, G., Moody, E., Kaczaniuk, J., DiGuiseppi, C., et al. (2019). Association between breastfeeding initiation and duration and autism spectrum disorder in preschool children enrolled in the study to explore early development. Autism Research, 12(5), 816–829. PubMedPubMedCentral Soke, G. N., Maenner, M., Windham, G., Moody, E., Kaczaniuk, J., DiGuiseppi, C., et al. (2019). Association between breastfeeding initiation and duration and autism spectrum disorder in preschool children enrolled in the study to explore early development. Autism Research, 12(5), 816–829. PubMedPubMedCentral
go back to reference Stengel, A., Mori, M., & Tache, Y. (2013). The role of nesfatin-1 in the regulation of food intake and body weight: Recent developments and future endeavors. Obesity Reviews, 14, 859–870. PubMed Stengel, A., Mori, M., & Tache, Y. (2013). The role of nesfatin-1 in the regulation of food intake and body weight: Recent developments and future endeavors. Obesity Reviews, 14, 859–870. PubMed
go back to reference Sucuoğlu, B., Öktem, F., & Gökler, B. (1996). Otistik çocukların değerlendirilmesinde kullanılan ölçeklere ilişkin bir çalışma. Psikiyatri Psikoloji Psikofarmakoloji (3P) Dergisi, 4(2), 116–121. Sucuoğlu, B., Öktem, F., & Gökler, B. (1996). Otistik çocukların değerlendirilmesinde kullanılan ölçeklere ilişkin bir çalışma. Psikiyatri Psikoloji Psikofarmakoloji (3P) Dergisi, 4(2), 116–121.
go back to reference Tseng, P. T., Chen, Y. W., Stubbs, B., Carvalho, A. F., Whiteley, P., Tang, C. H., et al. (2019). Maternal breastfeeding and autism spectrum disorder in children: A systematic review and meta-analysis. Nutritional Neuroscience, 22(5), 354–362. PubMed Tseng, P. T., Chen, Y. W., Stubbs, B., Carvalho, A. F., Whiteley, P., Tang, C. H., et al. (2019). Maternal breastfeeding and autism spectrum disorder in children: A systematic review and meta-analysis. Nutritional Neuroscience, 22(5), 354–362. PubMed
go back to reference Vaisse, C., Halaas, J. L., Horvath, C. M., Darnell, J. E., Jr., Stoffel, M., & Friedman, J. M. (1996). Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nature Genetics, 14, 95–97. PubMed Vaisse, C., Halaas, J. L., Horvath, C. M., Darnell, J. E., Jr., Stoffel, M., & Friedman, J. M. (1996). Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nature Genetics, 14, 95–97. PubMed
go back to reference Weibert, E., Hofmann, T., & Stengel, A. (2019). Role of nesfatin-1 in anxiety, depression and the response to stress. Psychoneuroendocrinology., 100, 58–66. PubMed Weibert, E., Hofmann, T., & Stengel, A. (2019). Role of nesfatin-1 in anxiety, depression and the response to stress. Psychoneuroendocrinology., 100, 58–66. PubMed
go back to reference Weibert, E., & Stengel, A. (2017). The X/A-like cell revisited—Spotlight on the peripheral effects of NUCB2/nesfatin-1 and ghrelin. Journal of Physiology and Pharmacology, 68, 497–520. PubMed Weibert, E., & Stengel, A. (2017). The X/A-like cell revisited—Spotlight on the peripheral effects of NUCB2/nesfatin-1 and ghrelin. Journal of Physiology and Pharmacology, 68, 497–520. PubMed
go back to reference White, J. D. (1993). Neuropeptide Y: A central regulator of energy homeostasis. Regulatory Peptides, 49(2), 93–107. PubMed White, J. D. (1993). Neuropeptide Y: A central regulator of energy homeostasis. Regulatory Peptides, 49(2), 93–107. PubMed
go back to reference Wu, G., Feder, A., Wegener, G., Bailey, C., Saxena, S., Charney, D., et al. (2011). Central functions of neuropeptide Y in mood and anxiety disorders. Expert Opinion on Therapeutic Targets, 15(11), 1317–1331. PubMed Wu, G., Feder, A., Wegener, G., Bailey, C., Saxena, S., Charney, D., et al. (2011). Central functions of neuropeptide Y in mood and anxiety disorders. Expert Opinion on Therapeutic Targets, 15(11), 1317–1331. PubMed
go back to reference Wu, Y. Y., Lye, S., & Briollais, L. (2017). The role of early life growth development, the FTO gene and exclusive breastfeeding on child BMI trajectories. International Journal of Epidemiology, 46(5), 1512–1522. PubMedPubMedCentral Wu, Y. Y., Lye, S., & Briollais, L. (2017). The role of early life growth development, the FTO gene and exclusive breastfeeding on child BMI trajectories. International Journal of Epidemiology, 46(5), 1512–1522. PubMedPubMedCentral
go back to reference Yamashita, Y., Makinodan, M., Toritsuka, M., Yamauchi, T., Ikawa, D., Kimoto, S., et al. (2019). Anti-inflammatory effect of ghrelin in lymphoblastoid cell lines from children with autism spectrum disorder. Front Psychiatry, 26(10), 152. Yamashita, Y., Makinodan, M., Toritsuka, M., Yamauchi, T., Ikawa, D., Kimoto, S., et al. (2019). Anti-inflammatory effect of ghrelin in lymphoblastoid cell lines from children with autism spectrum disorder. Front Psychiatry, 26(10), 152.
go back to reference Yilmaz, R., Haluk, E., & Erkorkmaz, U. (2011). Adaptation study of the Turkish Children’s Eating Behavior Questionnaire. Anadolu Psikiyatri Derg (in Turkish), 12(4), 287–294. Yilmaz, R., Haluk, E., & Erkorkmaz, U. (2011). Adaptation study of the Turkish Children’s Eating Behavior Questionnaire. Anadolu Psikiyatri Derg (in Turkish), 12(4), 287–294.
go back to reference Yilmaz-Irmak, T., Tekinsav-Sutcu, S., Aydin, A., & Sorias, O. (2007). An investigation of validity and reliability of Autism Behavior Checklist (ABC). Turkish Journal of Child and Adolescent Mental Health (in Turkish)., 14(1), 13–23. Yilmaz-Irmak, T., Tekinsav-Sutcu, S., Aydin, A., & Sorias, O. (2007). An investigation of validity and reliability of Autism Behavior Checklist (ABC). Turkish Journal of Child and Adolescent Mental Health (in Turkish)., 14(1), 13–23.
go back to reference Zheng, Z., Zhang, L., Li, S., Zhao, F., Wang, Y., Huang, L., et al. (2017). Association among obesity, overweight and autism spectrum disorder: A systematic review and meta-analysis. Scientific Reports, 7(1), 11697. PubMedPubMedCentral Zheng, Z., Zhang, L., Li, S., Zhao, F., Wang, Y., Huang, L., et al. (2017). Association among obesity, overweight and autism spectrum disorder: A systematic review and meta-analysis. Scientific Reports, 7(1), 11697. PubMedPubMedCentral
Metagegevens
Titel
Evaluation of Appetite-Regulating Hormones ın Young Children with Autism Spectrum Disorder
Auteurs
Çağla Çelikkol Sadıç
Ayhan Bilgiç
İbrahim Kılınç
Mehmet Burhan Oflaz
Tamer Baysal
Publicatiedatum
24-06-2020
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 2/2021
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-020-04579-0