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08-12-2017 | Uitgave 3/2018

Quality of Life Research 3/2018

Evaluating cognition in individuals with Huntington disease: Neuro-QoL cognitive functioning measures

Tijdschrift:
Quality of Life Research > Uitgave 3/2018
Auteurs:
Jin-Shei Lai, Siera Goodnight, Nancy R. Downing, Rebecca E. Ready, Jane S. Paulsen, Anna L. Kratz, Julie C. Stout, Michael K. McCormack, David Cella, Christopher Ross, Jenna Russell, Noelle E. Carlozzi
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Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s11136-017-1755-6) contains supplementary material, which is available to authorized users.

Abstract

Purpose

Cognitive functioning impacts health-related quality of life (HRQOL) for individuals with Huntington disease (HD). The Neuro-QoL includes two patient-reported outcome (PRO) measures of cognition—Executive Function (EF) and General Concerns (GC). These measures have not previously been validated for use in HD. The purpose of this analysis is to evaluate the reliability and validity of the Neuro-QoL Cognitive Function measures for use in HD.

Methods

Five hundred ten individuals with prodromal or manifest HD completed the Neuro-QoL Cognition measures, two other PRO measures of HRQOL (WHODAS 2.0 and EQ5D), and a depression measure (PROMIS Depression). Measures of functioning The Total Functional Capacity and behavior (Problem Behaviors Assessment) were completed by clinician interview. Objective measures of cognition were obtained using clinician-administered Symbol Digit Modalities Test and the Stroop Test (Word, Color, and Interference). Self-rated, clinician-rated, and objective composite scores were developed. We examined the Neuro-QoL measures for reliability, convergent validity, discriminant validity, and known-groups validity.

Results

Excellent reliabilities (Cronbach’s alphas ≥ 0.94) were found. Convergent validity was supported, with strong relationships between self-reported measures of cognition. Discriminant validity was supported by less robust correlations between self-reported cognition and other constructs. Prodromal participants reported fewer cognitive problems than manifest groups, and early-stage HD participants reported fewer problems than late-stage HD participants.

Conclusions

The Neuro-QoL Cognition measures provide reliable and valid assessments of self-reported cognitive functioning for individuals with HD. Findings support the utility of these measures for assessing self-reported cognition.

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Extra materiaal
Supplementary material 1 (DOCX 42 KB)
11136_2017_1755_MOESM1_ESM.docx
Supplementary material 2 (DOCX 35 KB)
11136_2017_1755_MOESM2_ESM.docx
Literatuur
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