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Gepubliceerd in: Quality of Life Research 4/2011

01-05-2011

EuroQol (EQ-5D) health utility scores for patients with migraine

Auteurs: Ruifeng Xu, Ralph P. Insinga, Wendy Golden, X. Henry Hu

Gepubliceerd in: Quality of Life Research | Uitgave 4/2011

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Abstract

Purpose

Previous studies have reported health utilities for migraine patients as generally measured between migraine attacks, but health utility data for within a migraine attack are unavailable. We evaluated within-attack health utilities among acute migraine patients experiencing different grades of headache severity.

Methods

We examined data for 330 20–65-year-old adults, in good physical health, who had 1–6 moderate/severe migraine attacks per month in the 2 months prior to the screening visit. Data were collected from a multicenter, double-blind study of a treatment for acute migraine in the United States. The EQ-5D system was used to measure generic health status at baseline and 24 h post-treatment within an acute migraine attack, and patients were also asked to rate their pain level at these time points (no, mild, moderate, or severe pain). The D1 time-trade-off scoring algorithm for the U.S. population was applied. Confidence intervals were estimated by bootstrap methods.

Results

The study population was 88% women and 78% white ethnicity, with 60% of subjects over age 40. The disutility of mild migraine pain was estimated to be 0.140 (95% CI: 0.0848, 0.1940), with a disutility for moderate migraine pain of 0.186 (95% CI: 0.1645, 0.2053) and for severe migraine pain of 0.493 (95% CI: 0.4100, 0.5654).

Conclusions

Within-attack disutilities estimated for migraine in this study are much greater than those reported for migraine when evaluated as a chronic health condition (e.g., valuations collected at random time points). These data can be of value in adapting results from clinical trials of migraine interventions to cost-utility policy analyses.

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Metagegevens
Titel
EuroQol (EQ-5D) health utility scores for patients with migraine
Auteurs
Ruifeng Xu
Ralph P. Insinga
Wendy Golden
X. Henry Hu
Publicatiedatum
01-05-2011
Uitgeverij
Springer Netherlands
Gepubliceerd in
Quality of Life Research / Uitgave 4/2011
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-010-9783-5