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01-08-2011 | Brief Communication

Estimation of the impact of diabetes-related complications on health utilities for patients with type 2 diabetes in Ontario, Canada

Auteurs: Daria J. O’Reilly, Feng Xie, Eleanor Pullenayegum, Hertzel C. Gerstein, Janet Greb, Gord K. Blackhouse, Jean-Eric Tarride, Jim Bowen, Ron A. Goeree

Gepubliceerd in: Quality of Life Research | Uitgave 6/2011

Abstract

Objectives

The goal of this study was to analyze health-related quality of life (HRQL) data from a Canadian population with type 2 diabetes in order to estimate the disutility associated with experiencing a diabetes-related complication.

Methods

The EQ-5D, a standardized instrument for use as a measure of health outcome, was administered to 1,147 patients in Hamilton, Ontario, with type 2 diabetes. After controlling for age, gender, and duration of diabetes, changes in utility values were estimated by regressing the EQ-5D scores onto binary indicators for the presence of an event. The primary method of analysis was Ordinary Least Squares (OLS) and due to concerns over non-Normality, bootstrap standard errors (SE) were calculated.

Results

The analysis included 1,143 participants. Based on the OLS model, reductions in HRQL were associated with duration of diabetes (−0.0015, SE = 0.0006), experiencing a myocardial infarction (MI) (−0.059, SE = 0.017), amputation (−0.063, SE = 0.059), stroke (−0.046, SE = 0.023), and kidney failure (−0.102, SE = 0.047).

Conclusion

This study estimated the reductions in HRQL associated with several important complications commonly experienced in patients with diabetes. The greatest impacts on HRQL were associated with kidney failure and MI. The utility values calculated here can be used to assess the outcome of interventions that reduce these diabetes-related complications and will have a useful impact on future economic evaluations of diabetes management strategies in Canada.

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Titel: Estimation of the impact of diabetes-related complications on health utilities for patients with type 2 diabetes in Ontario, Canada
Auteurs: Daria J. O’Reilly
Feng Xie
Eleanor Pullenayegum
Hertzel C. Gerstein
Janet Greb
Gord K. Blackhouse
Jean-Eric Tarride
Jim Bowen
Ron A. Goeree
Publicatiedatum: 01-08-2011
Uitgeverij: Springer Netherlands
Gepubliceerd in: Quality of Life Research / Uitgave 6/2011
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-010-9828-9

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Abstract

Objectives

Methods

Results

Conclusion

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