Skip to main content


Swipe om te navigeren naar een ander artikel

01-12-2017 | ORIGINAL PAPER | Uitgave 4/2018

Mindfulness 4/2018

Epigenetic Response to Mindfulness in Peripheral Blood Leukocytes Involves Genes Linked to Common Human Diseases

Mindfulness > Uitgave 4/2018
Javier García-Campayo, Marta Puebla-Guedea, Alberto Labarga, Amaya Urdánoz, Miren Roldán, Laura Pulido, Xabier Martínez de Morentin, Álvaro Perdones-Montero, Jesús Montero-Marín, Maite Mendioroz
Belangrijke opmerkingen

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s12671-017-0851-6) contains supplementary material, which is available to authorized users.


The benefits of mindfulness on human health are well-documented, but the mechanisms underlying these effects are not well-understood. Our aim was to identify molecular alterations related to mindfulness by profiling the epigenetic response in long-term meditators. We performed a genome-wide screen of DNA methylation by using the Illumina HumanMethylation450 platform in peripheral blood leukocytes from 17 long-term meditators and 17 matched controls. Top-ranked genes were validated by bisulfite cloning sequencing. Database for Annotation, Visualization, and Integrated Discovery and Ingenuity Pathways Analysis bioinformatic tools were used to characterize key processes underling the methylation changes. We found 64 differentially methylated regions (DMRs) in meditators compared to controls, corresponding to 43 genes. Most of the mindfulness-related DMRs (70.3%) were hypomethylated in meditators, and 23.4% of mindfulness-related DMRs clustered in telomeric chromosomal regions. Notably, almost half of the mindfulness-related DMRs (48.4%) involved genes linked to common human diseases, such as neurological and psychiatric disorders, cardiovascular diseases, and cancer. Lipid metabolism and atherosclerosis signaling pathway were significantly enriched in our set of DMRs. Functional in silico analysis also revealed tumor necrosis factor (TNF) and NF-κB signaling as crucial regulators of the mindfulness-related genes. Our study suggests that there is a consistent epigenetic response to long-term meditation practice in blood leukocytes with predominant loss of cytosine-phosphate-guanine methylation in distinct genomic regions, such as telomeres. Further research is warranted to confirm that the molecular response to mindfulness practice involves crucial transcriptional regulators related to a wide range of human common diseases, such as TNF and NF-κB.

Log in om toegang te krijgen

Met onderstaand(e) abonnement(en) heeft u direct toegang:

BSL Psychologie Totaal

Met BSL Psychologie Totaal blijf je als professional steeds op de hoogte van de nieuwste ontwikkelingen binnen jouw vak. Met het online abonnement heb je toegang tot een groot aantal boeken, protocollen, vaktijdschriften en e-learnings op het gebied van psychologie en psychiatrie. Zo kun je op je gemak en wanneer het jou het beste uitkomt verdiepen in jouw vakgebied.

Extra materiaal
Alleen toegankelijk voor geautoriseerde gebruikers
Over dit artikel

Andere artikelen Uitgave 4/2018

Mindfulness 4/2018 Naar de uitgave


Orthogonal Institutions