Skip to main content
main-content
Top

Tip

Swipe om te navigeren naar een ander artikel

Gepubliceerd in: Journal of Autism and Developmental Disorders 1/2012

01-01-2012 | Original paper

Enhanced Cortisol Response to Stress in Children in Autism

Auteurs: Eve G. Spratt, Joyce S. Nicholas, Kathleen T. Brady, Laura A. Carpenter, Charles R. Hatcher, Kirk A. Meekins, Richard W. Furlanetto, Jane M. Charles

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 1/2012

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Children with Autism often show difficulties in adapting to change. Previous studies of cortisol, a neurobiologic stress hormone reflecting hypothalamic–pituitary–adrenal (HPA) axis activity, in children with autism have demonstrated variable results. This study measured cortisol levels in children with and without Autism: (1) at rest; (2) in a novel environment; and (3) in response to a blood draw stressor. A significantly higher serum cortisol response was found in the group of children with autism. Analysis showed significantly higher peak cortisol levels and prolonged duration and recovery of cortisol elevation following the blood-stick stressor in children with autism. This study suggests increased reactivity of the HPA axis to stress and novel stimuli in children with autism.

Met onderstaand(e) abonnement(en) heeft u direct toegang:

BSL Psychologie Totaal

Met BSL Psychologie Totaal blijf je als professional steeds op de hoogte van de nieuwste ontwikkelingen binnen jouw vak. Met het online abonnement heb je toegang tot een groot aantal boeken, protocollen, vaktijdschriften en e-learnings op het gebied van psychologie en psychiatrie. Zo kun je op je gemak en wanneer het jou het beste uitkomt verdiepen in jouw vakgebied.

Literatuur
go back to reference Achenbach, T. M. (1991). Manual for the child behavior checklist/4- 18. Burlington, VT: University of Vermont, Department of Psychiatry. Achenbach, T. M. (1991). Manual for the child behavior checklist/4- 18. Burlington, VT: University of Vermont, Department of Psychiatry.
go back to reference Aihara, R., & Hashimoto, T. (1989). Neuroendocrinologic studies on autism. No To Hattatsu, 21, 154–162. PubMed Aihara, R., & Hashimoto, T. (1989). Neuroendocrinologic studies on autism. No To Hattatsu, 21, 154–162. PubMed
go back to reference Bourgeron, T. (2010). The possible interplay of synaptic and clock genes in autism spectrum disorders. Cold Spring harbor symposia on quantitative biology, Vol. 72. Cold Spring Harbor Laboratory Press. Bourgeron, T. (2010). The possible interplay of synaptic and clock genes in autism spectrum disorders. Cold Spring harbor symposia on quantitative biology, Vol. 72. Cold Spring Harbor Laboratory Press.
go back to reference Brosnan, M., Turner-Cobb, J., Munro-Naan, Z., & Jessop, D. (2009). Absence of a normal cortisol awakening response (CAR) in adolescent males with Asperger syndrome (AS). Psychoneuroendocrinology, 34(7), 1095–1100. PubMedCrossRef Brosnan, M., Turner-Cobb, J., Munro-Naan, Z., & Jessop, D. (2009). Absence of a normal cortisol awakening response (CAR) in adolescent males with Asperger syndrome (AS). Psychoneuroendocrinology, 34(7), 1095–1100. PubMedCrossRef
go back to reference Corbett, B. A., Mendoza, S., Abdullah, M., Wegelin, J. A., & Levine, S. (2006). Cortisol circadian rhythms and response to stress in children with autism. Psychoneuroendocrinology, 31, 59–68. PubMedCrossRef Corbett, B. A., Mendoza, S., Abdullah, M., Wegelin, J. A., & Levine, S. (2006). Cortisol circadian rhythms and response to stress in children with autism. Psychoneuroendocrinology, 31, 59–68. PubMedCrossRef
go back to reference Corbett, B. A., Schupp, C. W., Levine, S., & Mendoza, S. (2009). Comparing cortisol, stress, and sensory sensitivity in children with autism. Autism Research, 2(1), 39–49. PubMedCrossRef Corbett, B. A., Schupp, C. W., Levine, S., & Mendoza, S. (2009). Comparing cortisol, stress, and sensory sensitivity in children with autism. Autism Research, 2(1), 39–49. PubMedCrossRef
go back to reference Corbett, B. A., Schupp, C. W., Simon, D., Ryan, N., & Mendoza, S. (2010). Elevated cortisol during play is associated with age and social engagement in children with autism. Molecular Autism, 1(13). Corbett, B. A., Schupp, C. W., Simon, D., Ryan, N., & Mendoza, S. (2010). Elevated cortisol during play is associated with age and social engagement in children with autism. Molecular Autism, 1(13).
go back to reference Curin, J. M., Terzic, J., Petkovic, Z. B., Zekan, L., Terzic, I. M., & Susnjara, I. M. (2003). Lower cortisol and higher ACTH levels in individuals with autism. Journal of Autism and Developmental Disorders, 33, 443–448. PubMedCrossRef Curin, J. M., Terzic, J., Petkovic, Z. B., Zekan, L., Terzic, I. M., & Susnjara, I. M. (2003). Lower cortisol and higher ACTH levels in individuals with autism. Journal of Autism and Developmental Disorders, 33, 443–448. PubMedCrossRef
go back to reference Dettling, A. C., Parker, S. W., Lane, S., Sebanc, A., & Gunnar, M. R. (2000). Quality of care and temperament determine changes in cortisol concentrations over the day for young children in child care. Psychoneuroendocrinology, 25, 819–836. PubMedCrossRef Dettling, A. C., Parker, S. W., Lane, S., Sebanc, A., & Gunnar, M. R. (2000). Quality of care and temperament determine changes in cortisol concentrations over the day for young children in child care. Psychoneuroendocrinology, 25, 819–836. PubMedCrossRef
go back to reference DiLalla, D. L., & Rogers, S. J. (1994). Domains of the childhood autism rating scale: Revelance for diagnosis and treatment. Journal of Autism and Developmental Disorders, 24, 115–128. PubMedCrossRef DiLalla, D. L., & Rogers, S. J. (1994). Domains of the childhood autism rating scale: Revelance for diagnosis and treatment. Journal of Autism and Developmental Disorders, 24, 115–128. PubMedCrossRef
go back to reference Gillespie, C. F., Phifer, J., Bradley, B., & Ressler, K. J. (2009). Risk and resilience: Genetic and environmental influences on development of the stress response. Depression and Anxiety, 26, 984–992. PubMedCrossRef Gillespie, C. F., Phifer, J., Bradley, B., & Ressler, K. J. (2009). Risk and resilience: Genetic and environmental influences on development of the stress response. Depression and Anxiety, 26, 984–992. PubMedCrossRef
go back to reference Gomez, M. T., Malozowski, S., Winterer, J., Vamvakopoulos, N. C., & Chrousos, G. P. (1991). Urinary free cortisol values in normal children and adolescents. The Journal of Pediatrics, 118, 256–258. PubMedCrossRef Gomez, M. T., Malozowski, S., Winterer, J., Vamvakopoulos, N. C., & Chrousos, G. P. (1991). Urinary free cortisol values in normal children and adolescents. The Journal of Pediatrics, 118, 256–258. PubMedCrossRef
go back to reference Gonzalez-Bono, E., Rohleder, N., Hellhammer, D. H., Salvador, A., & Kirschbaum, C. (2002). Glucose but not protein or fat load amplifies the cortisol response to psychosocial stress. Hormones and Behavior, 41, 328–333. PubMedCrossRef Gonzalez-Bono, E., Rohleder, N., Hellhammer, D. H., Salvador, A., & Kirschbaum, C. (2002). Glucose but not protein or fat load amplifies the cortisol response to psychosocial stress. Hormones and Behavior, 41, 328–333. PubMedCrossRef
go back to reference Gunnar, M. R., & Donzella, B. (2002). Social regulation of the cortisol levels in early human development. Psychoneuroendocrinology, 27, 199–220. PubMedCrossRef Gunnar, M. R., & Donzella, B. (2002). Social regulation of the cortisol levels in early human development. Psychoneuroendocrinology, 27, 199–220. PubMedCrossRef
go back to reference Hahn, W. E., Van Ness, J., & Chaudhar, N. (1992). Overview of the molecular genetics of mouse brain. Molecular Genetic Neuroscience, 332. Hahn, W. E., Van Ness, J., & Chaudhar, N. (1992). Overview of the molecular genetics of mouse brain. Molecular Genetic Neuroscience, 332.
go back to reference Heinrichs, S. C., & Koob, G. F. (2004). Corticotropin-releasing factor in brain: A role in activation, arousal, and affect regulation. Journal of Pharmacology and Experimental Therapeutics, 311, 427–440. PubMedCrossRef Heinrichs, S. C., & Koob, G. F. (2004). Corticotropin-releasing factor in brain: A role in activation, arousal, and affect regulation. Journal of Pharmacology and Experimental Therapeutics, 311, 427–440. PubMedCrossRef
go back to reference Hill, S. D., Wagner, E. A., Shedlarski, J. G., & Sears, S. P. (1977). Diurnal cortisol and temperature variation of normal and autistic children. Developmental Psychobiology, 10, 579–583. PubMedCrossRef Hill, S. D., Wagner, E. A., Shedlarski, J. G., & Sears, S. P. (1977). Diurnal cortisol and temperature variation of normal and autistic children. Developmental Psychobiology, 10, 579–583. PubMedCrossRef
go back to reference Hoshino, Y., Yokoyama, F., Watanabe, M., Murata, S., Kaneko, M., & Kumashiro, H. (1987). The diurnal variation and response to dexamethasone suppression test of saliva cortisol level in autistic children. Japanese Journal of Psychiatry and Neurology, 41, 227–235. PubMed Hoshino, Y., Yokoyama, F., Watanabe, M., Murata, S., Kaneko, M., & Kumashiro, H. (1987). The diurnal variation and response to dexamethasone suppression test of saliva cortisol level in autistic children. Japanese Journal of Psychiatry and Neurology, 41, 227–235. PubMed
go back to reference Jansen, L. M. C., Gispen-de Wied, C. C., & van der Gaag, R.-J. (2003). Differentiation between Autism and multiple complex developmental disorder in response to psychosocial stress. Neuropsychopharmacology, 28, 582–590. PubMedCrossRef Jansen, L. M. C., Gispen-de Wied, C. C., & van der Gaag, R.-J. (2003). Differentiation between Autism and multiple complex developmental disorder in response to psychosocial stress. Neuropsychopharmacology, 28, 582–590. PubMedCrossRef
go back to reference Jansen, L. M. C., Gispen-de Wied, C. C., Wiegant, V. M., Westenberg, H. G. M., Lahuis, B., & van Engeland, H. (2006). Autonimic and neuroendocrine responses to a psychosocial stressor in adults with Autistic Spectrum Disorder. Journal of Autism and Developmental Disorders, 36, 891–899. PubMedCrossRef Jansen, L. M. C., Gispen-de Wied, C. C., Wiegant, V. M., Westenberg, H. G. M., Lahuis, B., & van Engeland, H. (2006). Autonimic and neuroendocrine responses to a psychosocial stressor in adults with Autistic Spectrum Disorder. Journal of Autism and Developmental Disorders, 36, 891–899. PubMedCrossRef
go back to reference Karten, Y. J., Olariu, A., & Cameron, H. A. (2005). Stress in early life inhibits neurogenesis in adulthood. Trends in Neuroscience, 28, 171–172. CrossRef Karten, Y. J., Olariu, A., & Cameron, H. A. (2005). Stress in early life inhibits neurogenesis in adulthood. Trends in Neuroscience, 28, 171–172. CrossRef
go back to reference Lam, K. S., Aman, M. G., & Arnold, L. E. (2006). Neurochemical correlates of autistic disorder: A review of the literature. Research in Developmental Disabilities, 27, 254–289. PubMedCrossRef Lam, K. S., Aman, M. G., & Arnold, L. E. (2006). Neurochemical correlates of autistic disorder: A review of the literature. Research in Developmental Disabilities, 27, 254–289. PubMedCrossRef
go back to reference Lopata, C., Volker, M. A., Putnam, S. K., Thomeer, M. L., & Nida, R. E. (2008). Effect of social familiarity on salivary cortisol and self-reports of social anxiety and stress in children with high functioning Autism spectrum disorders. Journal of Autism and Developmental Disorders, 38(10), 1866–1877. PubMedCrossRef Lopata, C., Volker, M. A., Putnam, S. K., Thomeer, M. L., & Nida, R. E. (2008). Effect of social familiarity on salivary cortisol and self-reports of social anxiety and stress in children with high functioning Autism spectrum disorders. Journal of Autism and Developmental Disorders, 38(10), 1866–1877. PubMedCrossRef
go back to reference Lord, C., & Risi, S. (2000). A standard measure of social and communication deficits associated with the spectrum of Autism. The Autism Diagnostic Observation Schedule- Generic, 30, 205–223. Lord, C., & Risi, S. (2000). A standard measure of social and communication deficits associated with the spectrum of Autism. The Autism Diagnostic Observation Schedule- Generic, 30, 205–223.
go back to reference Maher, K. R., Harper, J. F., Macleay, A., & King, M. G. (1975). Peculiarities in the endocrine response to insulin stress in early infantile Autism. Journal of Nervous and Mental Disease, 161, 180–184. PubMedCrossRef Maher, K. R., Harper, J. F., Macleay, A., & King, M. G. (1975). Peculiarities in the endocrine response to insulin stress in early infantile Autism. Journal of Nervous and Mental Disease, 161, 180–184. PubMedCrossRef
go back to reference Naber, F. B., Swinkels, S. H., Buitelaar, J. K., Bakermans-Kranenburg, M. J., van IJzendoorn, M. H., Dietz, C., et al. (2007). Attachment in toddlers with autism and other developmental disorders. Journal of Autism and Developmental Disorders, 37(6), 1123–1138. PubMedCrossRef Naber, F. B., Swinkels, S. H., Buitelaar, J. K., Bakermans-Kranenburg, M. J., van IJzendoorn, M. H., Dietz, C., et al. (2007). Attachment in toddlers with autism and other developmental disorders. Journal of Autism and Developmental Disorders, 37(6), 1123–1138. PubMedCrossRef
go back to reference Nir, I., Meir, D., Zilber, N., Knobler, H., Hadjez, J., & Lerner, Y. (1995). Brief report: Circadian melatonin, thyroid-stimulating hormone, prolactin, and cortisol levels in serum of young adults with autism. Journal of Autism and Developmental Disorders, 25, 641–654. PubMedCrossRef Nir, I., Meir, D., Zilber, N., Knobler, H., Hadjez, J., & Lerner, Y. (1995). Brief report: Circadian melatonin, thyroid-stimulating hormone, prolactin, and cortisol levels in serum of young adults with autism. Journal of Autism and Developmental Disorders, 25, 641–654. PubMedCrossRef
go back to reference Richdale, A. L., & Prior, M. R. (1992). Urinary cortisol circadian rhythm in a group of high-functioning children with Autism. Journal of Autism and Developmental Disorders, 22, 433–447. PubMedCrossRef Richdale, A. L., & Prior, M. R. (1992). Urinary cortisol circadian rhythm in a group of high-functioning children with Autism. Journal of Autism and Developmental Disorders, 22, 433–447. PubMedCrossRef
go back to reference Schopler, E., Reichler, R., & DeVellis, R. (1980). Toward objective classification of childhood autism: Childhood autism rating scale (CARS). Journal of Autism and Developmental Disorders, 10, 91–103. PubMedCrossRef Schopler, E., Reichler, R., & DeVellis, R. (1980). Toward objective classification of childhood autism: Childhood autism rating scale (CARS). Journal of Autism and Developmental Disorders, 10, 91–103. PubMedCrossRef
go back to reference Squire, L. R. (1992). Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans. Psychological Review, 99, 195–231. PubMedCrossRef Squire, L. R. (1992). Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans. Psychological Review, 99, 195–231. PubMedCrossRef
go back to reference Tordjman, S., Anderson, G. M., McBride, P. A., Hertzig, M. E., Snow, M. E., & Hall, L. M. (1997). Plasma beta-endorphin, adrenocorticotropin hormone, and cortisol. Journal of Child Psychology and Psychiatry, 38, 705–715. PubMedCrossRef Tordjman, S., Anderson, G. M., McBride, P. A., Hertzig, M. E., Snow, M. E., & Hall, L. M. (1997). Plasma beta-endorphin, adrenocorticotropin hormone, and cortisol. Journal of Child Psychology and Psychiatry, 38, 705–715. PubMedCrossRef
go back to reference Yamazaki, K., Saito, Y., Okada, F., Fujieda, T., & Yamashita, I. (1975). An application of neuroendocrinological studies in autistic children and Heller’s syndrome. Journal of Autism and Childhood Schizophrenia, 5, 323–332. PubMedCrossRef Yamazaki, K., Saito, Y., Okada, F., Fujieda, T., & Yamashita, I. (1975). An application of neuroendocrinological studies in autistic children and Heller’s syndrome. Journal of Autism and Childhood Schizophrenia, 5, 323–332. PubMedCrossRef
go back to reference Zinke, K., Fries, E., Kliegel, M., Kirschbaum C., & Dettenborn, L. (2010). Children with high-functioning autism show a normal cortisol awakening response (CAR). Psychoneuroendocrinology. Epub April 19 2010. Zinke, K., Fries, E., Kliegel, M., Kirschbaum C., & Dettenborn, L. (2010). Children with high-functioning autism show a normal cortisol awakening response (CAR). Psychoneuroendocrinology. Epub April 19 2010.
Metagegevens
Titel
Enhanced Cortisol Response to Stress in Children in Autism
Auteurs
Eve G. Spratt
Joyce S. Nicholas
Kathleen T. Brady
Laura A. Carpenter
Charles R. Hatcher
Kirk A. Meekins
Richard W. Furlanetto
Jane M. Charles
Publicatiedatum
01-01-2012
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 1/2012
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-011-1214-0