Top

Gepubliceerd in:

05-02-2016

Endocrine dysregulation in women with irritable bowel syndrome according to Rome II criteria

Auteurs: Charlotte Markert, Kerstin Suarez-Hitz, Ulrike Ehlert, Urs M. Nater

Gepubliceerd in: Journal of Behavioral Medicine | Uitgave 3/2016

Abstract

The etiology of the irritable bowel syndrome (IBS) is unexplained: biological, psychological and social factors must be considered. This study examined if differences in HPA-axis activity already exist in those who do not yet fulfill IBS criteria (i.e. “subthreshold IBS”). We also investigated whether there were differences between those who reported clinically relevant (i.e. distressing) IBS symptoms and those who did not. Thirty-six women were subdivided into three groups (IBS group, subthreshold IBS group, control group). Results showed differences in morning cortisol levels (U = 11.58; p < 0.05), with IBS patients showing a lower cortisol response compared to controls. Subthreshold IBS patients were comparable to controls regarding endocrine function. Diurnal cortisol levels did not differ between groups. Group comparisons between distressed subjects and non-distressed subjects regarding cortisol levels did not reach significance. The finding of endocrine abnormalities (at least in a sub-set of patients) is important since these might be associated with deficient pain processing in IBS.

vorige artikel The role of social support in weight loss maintenance: results from the MedWeight study

volgende artikel Identifying when choice helps: clarifying the relationships between choice making, self-construal, and pain

Agreus, L., Svardsudd, K., Talley, N. J., Jones, M. P., & Tibblin, G. (2001). Natural history of gastroesophageal reflux disease and functional abdominal disorders: A population-based study. American Journal of Gastroenterology, 96, 2905–2914.CrossRefPubMed

Bach, D. R., Erdmann, G., Schmidtmann, M., & Monnikes, H. (2006). Emotional stress reactivity in irritable bowel syndrome. European Journal of Gastroenterology and Hepatology, 18, 629–636.CrossRefPubMed

Blanchard, E. B., Lackner, J. M., Jaccard, J., Rowell, D., Carosella, A. M., Powell, C., … Kuhn, E. (2008). The role of stress in symptom exacerbation among IBS patients. Journal of Psychosomatic Research, 64, 119–128.

Bohmelt, A. H., Nater, U. M., Franke, S., Hellhammer, D. H., & Ehlert, U. (2005). Basal and stimulated hypothalamic-pituitary-adrenal axis activity in patients with functional gastrointestinal disorders and healthy controls. Psychosomatic Medicine, 67, 288–294.CrossRefPubMed

Bradford, K., Shih, W., Videlock, E. J., Presson, A. P., Naliboff, B. D., Mayer, E. A., & Chang, L. (2012). Association between early adverse life events and irritable bowel syndrome. Clinical Gastroenterology Hepatology, 10, 385–390.CrossRefPubMedPubMedCentral

Chang, L., Sundaresh, S., Elliott, J., Anton, P. A., Baldi, P., Licudine, A., … Mayer, E. A. (2009). Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis in irritable bowel syndrome. Neurogastroenterology and Motility, 21, 149–159.

Clow, A., Thorn, L., Evans, P., & Hucklebridge, F. (2004). The awakening cortisol response: Methodological issues and significance. Stress, 7, 29–37.CrossRefPubMed

Dang, J., Ardila-Hani, A., Amichai, M. M., Chua, K., & Pimentel, M. (2012). Systematic review of diagnostic criteria for IBS demonstrates poor validity and utilization of Rome III. Neurogastroenterology and Motility, 24, 853–e397.CrossRefPubMed

Dickhaus, B., Mayer, E. A., Firooz, N., Stains, J., Conde, F., Olivas, T. I., … Naliboff, B. D. (2003). Irritable bowel syndrome patients show enhanced modulation of visceral perception by auditory stress. American Journal of Gastroenterology, 98, 135–143.

Dinan, T. G., Quigley, E. M., Ahmed, S. M., Scully, P., O’Brien, S., O’Mahony, L., … Keeling, P. W. (2006). Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: Plasma cytokines as a potential biomarker? Gastroenterology, 130, 304–311.

Drossman, D. A., & Dumitrascu, D. L. (2006). Rome III: New standard for functional gastrointestinal disorders. Journal of Gastrointestinal and Liver Diseases, 15, 237–241.PubMed

Drossman, D. A., Leserman, J., Nachman, G., Li, Z. M., Gluck, H., Toomey, T. C., & Mitchell, C. M. (1990). Sexual and physical abuse in women with functional or organic gastrointestinal disorders. Annals of Internal Medicine, 113, 828–833.CrossRefPubMed

Ehlert, U., Nater, U. M., & Bohmelt, A. (2005). High and low unstimulated salivary cortisol levels correspond to different symptoms of functional gastrointestinal disorders. Journal of Psychosomatic Research, 59, 7–10.CrossRefPubMed

FitzGerald, L. Z., Kehoe, P., & Sinha, K. (2009). Hypothalamic–pituitary–adrenal axis dysregulation in women with irritable bowel syndrome in response to acute physical stress. Western Journal of Nursing Research, 31, 818–836.CrossRefPubMed

Halder, S. L., Locke, G. R, 3rd, Schleck, C. D., Zinsmeister, A. R., Melton, L. J, 3rd, & Talley, N. J. (2007). Natural history of functional gastrointestinal disorders: A 12-year longitudinal population-based study. Gastroenterology, 133, 799–807.CrossRefPubMed

Heim, C., Ehlert, U., Hanker, J. P., & Hellhammer, D. H. (1998). Abuse-related posttraumatic stress disorder and alterations of the hypothalamic-pituitary-adrenal axis in women with chronic pelvic pain. Psychosomatic Medicine, 60, 309–318.CrossRefPubMed

Heim, C., Ehlert, U., & Hellhammer, D. H. (2000). The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders. Psychoneuroendocrinology, 25, 1–35.CrossRefPubMed

Hellhammer, J., Fries, E., Schweisthal, O. W., Schlotz, W., Stone, A. A., & Hagemann, D. (2007). Several daily measurements are necessary to reliably assess the cortisol rise after awakening: State- and trait components. Psychoneuroendocrinology, 32, 80–86.CrossRefPubMed

Hungin, A. P., Whorwell, P. J., Tack, J., & Mearin, F. (2003). The prevalence, patterns and impact of irritable bowel syndrome: An international survey of 40,000 subjects. Alimentary Pharmacology and Therapeutics, 17, 643–650.CrossRefPubMed

Kennedy, P. J., Clarke, G., O’Neill, A., Groeger, J. A., Quigley, E. M., Shanahan, F., … Dinan, T. G. (2014a). Cognitive performance in irritable bowel syndrome: Evidence of a stress-related impairment in visuospatial memory. Psychological Medicine, 44, 1553–1566.

Kennedy, P. J., Cryan, J. F., Quigley, E. M., Dinan, T. G., & Clarke, G. (2014b). A sustained hypothalamic-pituitary-adrenal axis response to acute psychosocial stress in irritable bowel syndrome. Psychological Medicine, 44, 3123–3134.CrossRefPubMed

Kuehl, L. K., Michaux, G. P., Richter, S., Schachinger, H., & Anton, F. (2010). Increased basal mechanical pain sensitivity but decreased perceptual wind-up in a human model of relative hypocortisolism. Pain, 149, 539–546.CrossRefPubMed

Lederbogen, F., Kuhner, C., Kirschbaum, C., Meisinger, C., Lammich, J., Holle, R., … Ladwig, K. H. (2010). Salivary cortisol in a middle-aged community sample: Results from 990 men and women of the KORA-F3 Augsburg study. European Journal of Endocrinology, 163, 443–451.

Leibbrand, R., Cuntz, U., & Hiller, W. (2002). Assessment of functional gastrointestinal disorders using the Gastro-Questionnaire. International Journal of Behavioral Medicine, 9, 155–172.CrossRefPubMed

Levy, R. L., Cain, K. C., Jarrett, M., & Heitkemper, M. M. (1997). The relationship between daily life stress and gastrointestinal symptoms in women with irritable bowel syndrome. Journal of Behavioral Medicine, 20, 177–193.CrossRefPubMed

Locke, G. R, 3rd, Weaver, A. L., Melton, L. J, 3rd, & Talley, N. J. (2004). Psychosocial factors are linked to functional gastrointestinal disorders: A population based nested case-control study. American Journal of Gastroenterology, 99, 350–357.CrossRefPubMed

Longstreth, G. F., Thompson, W. G., Chey, W. D., Houghton, L. A., Mearin, F., & Spiller, R. C. (2006). Functional bowel disorders. Gastroenterology, 130, 1480–1491.CrossRefPubMed

Markert, C., Suarez-Hitz, K., Ehlert, U., & Nater, U. M. (2014). Distress criterion influences prevalence rates of functional gastrointestinal disorders. BMC Gastroenterology, 14, 215.CrossRefPubMedPubMedCentral

Mayer, E. A. (2000). The neurobiology of stress and gastrointestinal disease. Gut, 47, 861–869.CrossRefPubMedPubMedCentral

Mearin, F., Badia, X., Balboa, A., Baro, E., Caldwell, E., Cucala, M., … Talley, N. J. (2001). Irritable bowel syndrome prevalence varies enormously depending on the employed diagnostic criteria: comparison of Rome II versus previous criteria in a general population. Scandinavian Journal of Gastroenterology, 36, 1155–1161.

Nicholl, B. I., Halder, S. L., Macfarlane, G. J., Thompson, D. G., O’Brien, S., Musleh, M., & McBeth, J. (2008). Psychosocial risk markers for new onset irritable bowel syndrome-results of a large prospective population-based study. Pain, 137, 147–155.CrossRefPubMedPubMedCentral

O’Donnell, K., Badrick, E., Kumari, M., & Steptoe, A. (2008). Psychological coping styles and cortisol over the day in healthy older adults. Psychoneuroendocrinology, 33, 601–611.CrossRefPubMed

Olafsdottir, L. B., Gudjonsson, H., Jonsdottir, H. H., Bjornsson, E., & Thjodleifsson, B. (2012). Natural history of functional gastrointestinal disorders: Comparison of two longitudinal population-based studies. Digestive and Liver Disease, 44, 211–217.CrossRefPubMed

Patacchioli, F. R., Angelucci, L., Dellerba, G., Monnazzi, P., & Leri, O. (2001). Actual stress, psychopathology and salivary cortisol levels in the irritable bowel syndrome (IBS). Journal of Endocrinological Investigation, 24, 173–177.CrossRefPubMed

Posserud, I., Agerforz, P., Ekman, R., Bjornsson, E. S., Abrahamsson, H., & Simren, M. (2004). Altered visceral perceptual and neuroendocrine response in patients with irritable bowel syndrome during mental stress. Gut, 53, 1102–1108.CrossRefPubMedPubMedCentral

Pruessner, J. C., Kirschbaum, C., Meinlschmid, G., & Hellhammer, D. H. (2003). Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendocrinology, 28, 916–931.CrossRefPubMed

Schulz, P., Jansen, L., & Schlotz, W. (2005). Stressreaktivität: Theoretisches Konzept und Messung [Stress reactivity: Theoretical concept and measurement]. Diagnostica, 51, 124–133.CrossRef

Schulz, P., Schlotz, W., & Becker, P. (2004). TICS Trierer Inventar zum chronischen Stress [Trier Inventory for the Assessment of Chronic Stress]. Manual. Göttingen: Hogrefe.

Suarez, K., Mayer, C., Ehlert, U., & Nater, U. M. (2010). Psychological stress and self-reported functional gastrointestinal disorders. The Journal of Nervous and Mental Disease, 198, 226–229.CrossRefPubMed

Suarez-Hitz, K. A., Otto, B., Bidlingmaier, M., Schwizer, W., Fried, M., & Ehlert, U. (2012). Altered psychobiological responsiveness in women with irritable bowel syndrome. Psychosomatic Medicine, 74, 221–231.CrossRefPubMed

Thompson, W. G., Longstreth, G. F., Drossman, D. A., Heaton, K. W., Irvine, E. J., & Muller-Lissner, S. A. (1999). Functional bowel disorders and functional abdominal pain. Gut, 45, II43–II47.PubMedPubMedCentral

Whitehead, W. E., Crowell, M. D., Robinson, J. C., Heller, B. R., & Schuster, M. M. (1992). Effects of stressful life events on bowel symptoms: Subjects with irritable bowel syndrome compared with subjects without bowel dysfunction. Gut, 33, 825–830.CrossRefPubMedPubMedCentral

Whitehead, W. E., & Drossman, D. A. (2010). Validation of symptom-based diagnostic criteria for irritable bowel syndrome: A critical review. American Journal of Gastroenterology, 105, 814–820.CrossRefPubMed

Titel: Endocrine dysregulation in women with irritable bowel syndrome according to Rome II criteria
Auteurs: Charlotte Markert
Kerstin Suarez-Hitz
Ulrike Ehlert
Urs M. Nater
Publicatiedatum: 05-02-2016
Uitgeverij: Springer US
Gepubliceerd in: Journal of Behavioral Medicine / Uitgave 3/2016
Print ISSN: 0160-7715
Elektronisch ISSN: 1573-3521
DOI: https://doi.org/10.1007/s10865-016-9718-x

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Log in om toegang te krijgen

Andere artikelen Uitgave 3/2016

Successful weight loss maintenance associated with morning chronotype and better sleep quality

A synthesis of meta-analytic evidence of behavioral interventions to reduce HIV/STIs

Effects of stress, health competence, and social support on depressive symptoms after cardiac hospitalization

High perceived social standing is associated with better health in HIV-infected Ugandan adults on highly active antiretroviral therapy

Gender, BMI, and eating regulation in the context of same-sex and heterosexual couples

Sleep and health-related factors in overweight and obese rural women in a randomized controlled trial