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11-12-2017

Elevated inflammation in association with alcohol abuse among Blacks but not Whites: results from the MIDUS biomarker study

Auteurs: Yusuf Ransome, Natalie Slopen, Oskar Karlsson, David R. Williams

Gepubliceerd in: Journal of Behavioral Medicine | Uitgave 3/2018

Abstract

Some studies document racial disparities in self-reported health associated with alcohol use and abuse. However, few studies examined biomarkers that underlie the onset of alcohol-related chronic diseases. We investigated whether the association between alcohol abuse and five biomarkers of inflammation (CRP, IL-6, fibrinogen, E-selectin, sICAM-1) vary between Black and White Americans aged 35 to 84 (n = 1173) from the Midlife in the United States Biomarker Study. Multivariable Ordinary Least Squares regressions were used to assess Black–White differences in the association between alcohol abuse and the biomarkers. Race moderated the association between alcohol abuse and CRP (b = 0.56, SE = 0.28, p = 0.048), IL-6 (b = 0.65, SE = 0.22, p = 0.004), and a composite inflammation score (b = 0.014, SE = 0.07, p = 0.041). These findings potentially shed light for why alcohol has a stronger negative association with poorer health for Blacks compared to Whites. Analysis should be replicated in larger prospective cohorts.

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Titel: Elevated inflammation in association with alcohol abuse among Blacks but not Whites: results from the MIDUS biomarker study
Auteurs: Yusuf Ransome
Natalie Slopen
Oskar Karlsson
David R. Williams
Publicatiedatum: 11-12-2017
Uitgeverij: Springer US
Gepubliceerd in: Journal of Behavioral Medicine / Uitgave 3/2018
Print ISSN: 0160-7715
Elektronisch ISSN: 1573-3521
DOI: https://doi.org/10.1007/s10865-017-9905-4

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