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Journal of Autism and Developmental Disorders

Gepubliceerd in:

04-01-2021 | Letter to the Editor

Electroconvulsive Therapy for Catatonia with mTOR Mutation

Auteurs: Charles B. Mormando, DO, John C. Garman, BS, Cezary Mikoluk, BS, Andrew Francis, PhD MD

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 10/2021

Excerpt

Catatonia is being increasingly recognized in autism spectrum and other neurodevelopmental disorders. Several studies show that 12–20% of adolescents with autism have comorbid catatonia, which may be an underestimate of true prevalence (Mormando and Francis 2020). Catatonia may be under-recognized, as repetitive speech and behavior, purposeless agitation, and stereotyped self-injury are misinterpreted as intrinsic signs of ASD or other neurodevelopmental disorders (Wachtel et al. 2018; Mormando and Francis 2020). A recent research and clinical focus has led to viewing some repetitious movements, intractable self-injurious behavior, and purposeless agitation as recognizable signs of catatonia that may respond to benzodiazepines or electroconvulsive therapy (ECT) (Wachtel et al. 2018). …

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Gordo, G., Tenorio, J., Arias, P., Santos-Simarro, F., Garcia-Minaur, S., Moreno, J. C., et al. (2018). mTOR mutations in Smith-Kingsmore syndrome: Four additional patients and a review. Clinical Genetics, 93(4), 762–775.CrossRef

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Mormando, C., & Francis, A. (2020). Catatonia revived: A unique syndrome updated. International Review of Psychiatry, 32(5–6), 403–411.CrossRef

Smith, L. D., Saunders, C. J., Dinwiddie, D. L., Atherton, A., Miller, N. A., Soden, S., et al. (2013). Exome sequencing reveals de novo germline mutation of mammalian target of rapamycin (MTOR) in a patient with megalencephaly and intractable seizures. Genomes Exomes, 2, 63–72.CrossRef

Wachtel, L. E., Shorter, E., & Fink, M. (2018). Electroconvulsive therapy for self-injurious behavior in autism spectrum disorders: Recognizing catatonia is key. Current Opinion in Psychiatry, 31(2), 116–122.CrossRef

Titel: Electroconvulsive Therapy for Catatonia with mTOR Mutation
Auteurs: Charles B. Mormando, DO
John C. Garman, BS
Cezary Mikoluk, BS
Andrew Francis, PhD MD
Publicatiedatum: 04-01-2021
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 10/2021
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-020-04815-7

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