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05-07-2022 | ORIGINAL PAPER

Efficacy of Mindfulness-Based Interventions for Negative Symptoms in Patients Diagnosed with Schizophrenia: a Meta-analysis

Auteurs: Jiabao Chai, Xue Xiao, Ning An, Fuquan Liu, Shijie Liu, Na Hu, Yin Yang, Yonghua Cui, Ying Li

Gepubliceerd in: Mindfulness | Uitgave 8/2022

Abstract

Objectives

Mindfulness-based interventions (MBIs) can effectively relieve negative symptoms in patients with schizophrenia. However, the effect size of MBIs and their potential influencing factors remain unclear.

Methods

We searched different databases and performed a meta-analysis to determine the efficacy of MBIs for the treatment of negative symptoms in schizophrenia. Standard mean differences (SMDs) with 95% confidence intervals (CIs) were calculated to assess effect sizes of MBIs for negative symptoms. Subgroup analysis and meta-regression analysis were used to explore the potential influencing factors of the pooled SMD of MBIs for negative symptoms.

Results

We identified 26 randomized controlled trials including 1725 individuals with schizophrenia. We observed a small-to-large effect size of MBIs for negative symptoms. The pooled SMD of MBIs for negative symptoms was − 0.59 (95% CI: − 0.87 to − 0.32), with a heterogeneity (I²) of 83.6% (95% CI: 76.9 to 88.4%; p < 0.01) based on a random effects model. In the subgroup analysis, significant differences were found with “Different Geographical Location of Treatment Study” (p < 0.01) and “Different Lengths of MBIs treatment” (p = 0.02). Meta-regression analysis showed that publication year was a significant predictor of the effect size of MBIs for negative symptoms (p < 0.001).

Conclusions

We identified a small-to-large effect size of MBIs to relieve negative symptoms in patients with schizophrenia. The number of sessions and different cultures were associated with the efficacy of MBT for negative symptoms.

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Titel: Efficacy of Mindfulness-Based Interventions for Negative Symptoms in Patients Diagnosed with Schizophrenia: a Meta-analysis
Auteurs: Jiabao Chai
Xue Xiao
Ning An
Fuquan Liu
Shijie Liu
Na Hu
Yin Yang
Yonghua Cui
Ying Li
Publicatiedatum: 05-07-2022
Uitgeverij: Springer US
Gepubliceerd in: Mindfulness / Uitgave 8/2022
Print ISSN: 1868-8527
Elektronisch ISSN: 1868-8535
DOI: https://doi.org/10.1007/s12671-022-01942-3

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Objectives

Methods

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