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Gepubliceerd in: Mindfulness 8/2022

05-07-2022 | ORIGINAL PAPER

Efficacy of Mindfulness-Based Interventions for Negative Symptoms in Patients Diagnosed with Schizophrenia: a Meta-analysis

Auteurs: Jiabao Chai, Xue Xiao, Ning An, Fuquan Liu, Shijie Liu, Na Hu, Yin Yang, Yonghua Cui, Ying Li

Gepubliceerd in: Mindfulness | Uitgave 8/2022

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Abstract

Objectives

Mindfulness-based interventions (MBIs) can effectively relieve negative symptoms in patients with schizophrenia. However, the effect size of MBIs and their potential influencing factors remain unclear.

Methods

We searched different databases and performed a meta-analysis to determine the efficacy of MBIs for the treatment of negative symptoms in schizophrenia. Standard mean differences (SMDs) with 95% confidence intervals (CIs) were calculated to assess effect sizes of MBIs for negative symptoms. Subgroup analysis and meta-regression analysis were used to explore the potential influencing factors of the pooled SMD of MBIs for negative symptoms.

Results

We identified 26 randomized controlled trials including 1725 individuals with schizophrenia. We observed a small-to-large effect size of MBIs for negative symptoms. The pooled SMD of MBIs for negative symptoms was − 0.59 (95% CI: − 0.87 to − 0.32), with a heterogeneity (I2) of 83.6% (95% CI: 76.9 to 88.4%; p < 0.01) based on a random effects model. In the subgroup analysis, significant differences were found with “Different Geographical Location of Treatment Study” (p < 0.01) and “Different Lengths of MBIs treatment” (p = 0.02). Meta-regression analysis showed that publication year was a significant predictor of the effect size of MBIs for negative symptoms (p < 0.001).

Conclusions

We identified a small-to-large effect size of MBIs to relieve negative symptoms in patients with schizophrenia. The number of sessions and different cultures were associated with the efficacy of MBT for negative symptoms.
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Literatuur
go back to reference *Bhatia, T., Mazumdar, S., Wood, J., He, F., Gur, R. E., Gur, R. C., Nimgaonkar, V. L., & Deshpande, S. N. (2017). A randomised controlled trial of adjunctive yoga and adjunctive physical exercise training for cognitive dysfunction in schizophrenia. Acta Neuropsychiatrica, 29(2), 102–114. https://​doi.​org/​10.​1017/​neu.​2016.​42 *Bhatia, T., Mazumdar, S., Wood, J., He, F., Gur, R. E., Gur, R. C., Nimgaonkar, V. L., & Deshpande, S. N. (2017). A randomised controlled trial of adjunctive yoga and adjunctive physical exercise training for cognitive dysfunction in schizophrenia. Acta Neuropsychiatrica, 29(2), 102–114. https://​doi.​org/​10.​1017/​neu.​2016.​42
go back to reference Borenstein, M., Hedges, L. V., Higgins, J. P., & Rothstein, H. R. (2021). Introduction to meta-analysis. John Wiley & Sons. CrossRef Borenstein, M., Hedges, L. V., Higgins, J. P., & Rothstein, H. R. (2021). Introduction to meta-analysis. John Wiley & Sons. CrossRef
go back to reference Chan, C. M., Cao, T., & Gao, M. T. (2015). Chinese conception of mental illness: A comparative culture analysis. Asian Journal of Pharmacy, Nursing and Medicial Sciences, 3(1), 1–7. Chan, C. M., Cao, T., & Gao, M. T. (2015). Chinese conception of mental illness: A comparative culture analysis. Asian Journal of Pharmacy, Nursing and Medicial Sciences, 3(1), 1–7.
go back to reference Downs, J., Dean, H., Lechler, S., Sears, N., Patel, R., Shetty, H., Hotopf, M., Ford, T., Kyriakopoulos, M., Diaz-Caneja, C. M., Arango, C., MacCabe, J. H., Hayes, R. D., & Pina-Camacho, L. (2019). Negative symptoms in early-onset psychosis and their association with antipsychotic treatment failure. Schizophrenia Bulletin, 45(1), 69–79. https://​doi.​org/​10.​1093/​schbul/​sbx197 CrossRefPubMed Downs, J., Dean, H., Lechler, S., Sears, N., Patel, R., Shetty, H., Hotopf, M., Ford, T., Kyriakopoulos, M., Diaz-Caneja, C. M., Arango, C., MacCabe, J. H., Hayes, R. D., & Pina-Camacho, L. (2019). Negative symptoms in early-onset psychosis and their association with antipsychotic treatment failure. Schizophrenia Bulletin, 45(1), 69–79. https://​doi.​org/​10.​1093/​schbul/​sbx197 CrossRefPubMed
go back to reference Hodann-Caudevilla, R. M., Díaz-Silveira, C., Burgos-Julián, F. A., & Santed, M. A. (2020). Mindfulness-based interventions for people with schizophrenia: A systematic review and meta-analysis. International Journal of Environmental Research and Public Health, 17(13), 4690. https://​doi.​org/​10.​3390/​ijerph17134690 Hodann-Caudevilla, R. M., Díaz-Silveira, C., Burgos-Julián, F. A., & Santed, M. A. (2020). Mindfulness-based interventions for people with schizophrenia: A systematic review and meta-analysis. International Journal of Environmental Research and Public Health, 17(13), 4690. https://​doi.​org/​10.​3390/​ijerph17134690
go back to reference King, A. P., Block, S. R., Sripada, R. K., Rauch, S., Giardino, N., Favorite, T., Angstadt, M., Kessler, D., Welsh, R., & Liberzon, I. (2016). Altered default mode network (DMN) resting state functional connectivity following a mindfulness-based exposure therapy for posttraumatic stress disorder (PTSD) in combat veterans of Afghanistan and Iraq. Depression and Anxiety, 33(4), 289–299. https://​doi.​org/​10.​1002/​da.​22481 CrossRefPubMed King, A. P., Block, S. R., Sripada, R. K., Rauch, S., Giardino, N., Favorite, T., Angstadt, M., Kessler, D., Welsh, R., & Liberzon, I. (2016). Altered default mode network (DMN) resting state functional connectivity following a mindfulness-based exposure therapy for posttraumatic stress disorder (PTSD) in combat veterans of Afghanistan and Iraq. Depression and Anxiety, 33(4), 289–299. https://​doi.​org/​10.​1002/​da.​22481 CrossRefPubMed
go back to reference Luchterhand, C., Rakel, D., Haq, C., Grant, L., Byars-Winston, A., Tyska, S., & Engles, K. (2015). Creating a culture of mindfulness in medicine. WMJ, 114(3), 105–109. PubMed Luchterhand, C., Rakel, D., Haq, C., Grant, L., Byars-Winston, A., Tyska, S., & Engles, K. (2015). Creating a culture of mindfulness in medicine. WMJ, 114(3), 105–109. PubMed
go back to reference *Rao, N. P., Ramachandran, P., Jacob, A., Joseph, A., Thonse, U., Nagendra, B., Chako, D. M., Shiri, S., Hassan, H., Sreenivas, V., Maran, S., Durgam, D., Nandakumar, K., Varambally, S., & Gangadhar, B. N. (2021). Add on yoga treatment for negative symptoms of schizophrenia: A multi-centric, randomized controlled trial. Schizophrenia Research, 231, 90–97. https://​doi.​org/​10.​1016/​j.​schres.​2021.​03.​021 *Rao, N. P., Ramachandran, P., Jacob, A., Joseph, A., Thonse, U., Nagendra, B., Chako, D. M., Shiri, S., Hassan, H., Sreenivas, V., Maran, S., Durgam, D., Nandakumar, K., Varambally, S., & Gangadhar, B. N. (2021). Add on yoga treatment for negative symptoms of schizophrenia: A multi-centric, randomized controlled trial. Schizophrenia Research, 231, 90–97. https://​doi.​org/​10.​1016/​j.​schres.​2021.​03.​021
go back to reference Schonert-Reichl, K. A., Oberle, E., Lawlor, M. S., Abbott, D., Thomson, K., Oberlander, T. F., & Diamond, A. (2015). Enhancing cognitive and social-emotional development through a simple-to-administer mindfulness-based school program for elementary school children: A randomized controlled trial. Developmental Psychology, 51(1), 52–66. https://​doi.​org/​10.​1037/​a0038454 CrossRefPubMedPubMedCentral Schonert-Reichl, K. A., Oberle, E., Lawlor, M. S., Abbott, D., Thomson, K., Oberlander, T. F., & Diamond, A. (2015). Enhancing cognitive and social-emotional development through a simple-to-administer mindfulness-based school program for elementary school children: A randomized controlled trial. Developmental Psychology, 51(1), 52–66. https://​doi.​org/​10.​1037/​a0038454 CrossRefPubMedPubMedCentral
go back to reference *Shawyer, F., Farhall, J., Mackinnon, A., Trauer, T., Sims, E., Ratcliff, K., Larner, C., Thomas, N., Castle, D., Mullen, P., & Copolov, D. (2012). A randomised controlled trial of acceptance-based cognitive behavioural therapy for command hallucinations in psychotic disorders. Behaviour Research and Therapy, 50(2), 110–121. https://​doi.​org/​10.​1016/​j.​brat.​2011.​11.​007 *Shawyer, F., Farhall, J., Mackinnon, A., Trauer, T., Sims, E., Ratcliff, K., Larner, C., Thomas, N., Castle, D., Mullen, P., & Copolov, D. (2012). A randomised controlled trial of acceptance-based cognitive behavioural therapy for command hallucinations in psychotic disorders. Behaviour Research and Therapy, 50(2), 110–121. https://​doi.​org/​10.​1016/​j.​brat.​2011.​11.​007
go back to reference Xu, W., & Liu, X. (2013). Mindfulness training enhances individual’s well-being: A review. Chinese Mental Health Journal, 27(3), 197–202. Xu, W., & Liu, X. (2013). Mindfulness training enhances individual’s well-being: A review. Chinese Mental Health Journal, 27(3), 197–202.
go back to reference Zou, L., Yeung, A., Quan, X., Hui, S. S., Hu, X., Chan, J. S. M., Wang, C., Boyden, S. D., Sun, L., & Wang, H. (2018). Mindfulness-based Baduanjin exercise for depression and anxiety in people with physical or mental illnesses: A systematic review and meta-analysis. International Journal of Environmental Research and Public Health, 15(2), 321. https://​doi.​org/​10.​3390/​ijerph15020321 CrossRefPubMedCentral Zou, L., Yeung, A., Quan, X., Hui, S. S., Hu, X., Chan, J. S. M., Wang, C., Boyden, S. D., Sun, L., & Wang, H. (2018). Mindfulness-based Baduanjin exercise for depression and anxiety in people with physical or mental illnesses: A systematic review and meta-analysis. International Journal of Environmental Research and Public Health, 15(2), 321. https://​doi.​org/​10.​3390/​ijerph15020321 CrossRefPubMedCentral
go back to reference Wang, L., Mao, Y., & Ye, D. (2021). Mindfulness-based therapy combined with risperidone treatment for emotional disorder in schizophrenic patients during the recovery period. Chinese Journal of Primary Medicine and Pharmacy, 28(5), 686–689. Wang, L., Mao, Y., & Ye, D. (2021). Mindfulness-based therapy combined with risperidone treatment for emotional disorder in schizophrenic patients during the recovery period. Chinese Journal of Primary Medicine and Pharmacy, 28(5), 686–689.
go back to reference Wang, X., Wen, M., Huang, H., & Jiang, Y. (2019). Effect of mindfulness psychological intervention on medication compliance and relapse in convalescent schizophrenia. China Medicine and Pharmacy, 9(23), 278–281. Wang, X., Wen, M., Huang, H., & Jiang, Y. (2019). Effect of mindfulness psychological intervention on medication compliance and relapse in convalescent schizophrenia. China Medicine and Pharmacy, 9(23), 278–281.
go back to reference Ni, L., Ye, C., Qian, X., & Ma, K. (2019). Effect of yoga therapy on mental symptoms of inpatients with schizophrenia. Journal of International Psychiatry, 46(3), 463–466. Ni, L., Ye, C., Qian, X., & Ma, K. (2019). Effect of yoga therapy on mental symptoms of inpatients with schizophrenia. Journal of International Psychiatry, 46(3), 463–466.
go back to reference Huang, S., Cao, X., & Shen, C. (2018). The influence of mindfulness training on social function of inpatients with schizophrenia. Shanghai Nursing, 18(6), 21–24. Huang, S., Cao, X., & Shen, C. (2018). The influence of mindfulness training on social function of inpatients with schizophrenia. Shanghai Nursing, 18(6), 21–24.
go back to reference Xu, S., Xie, J., Peng, L., Fu, C., Li, M., & Xiong, J. (2018). Effects of mindfulness psychological intervention on emotional experience and attentional control of convalescent soldiers with schizophrenia. Journal of the Third Military Medical University, 40(17), 1527–1532. Xu, S., Xie, J., Peng, L., Fu, C., Li, M., & Xiong, J. (2018). Effects of mindfulness psychological intervention on emotional experience and attentional control of convalescent soldiers with schizophrenia. Journal of the Third Military Medical University, 40(17), 1527–1532.
go back to reference Li, L., & Wang, B. (2017). Intervention study of group acceptance and commitment therapy on quality of life in patients with schizophrenia during rehabilitation. Master’ s thesis Shanxi Medical University. Li, L., & Wang, B. (2017). Intervention study of group acceptance and commitment therapy on quality of life in patients with schizophrenia during rehabilitation. Masters thesis Shanxi Medical University.
go back to reference Isuru, L. L., Dahanayake, D. M. A., de Alwis, A., Weerasinghe, A., Hewage, S. N., & Ranasinghe, C. K. (2015). Impact of dance, drama, yoga and music therapy workshops on symptom reduction in patients with schizophrenia: A randomized controlled study. South Asian Journal of Psychiatry, 3(2), 3–9. Isuru, L. L., Dahanayake, D. M. A., de Alwis, A., Weerasinghe, A., Hewage, S. N., & Ranasinghe, C. K. (2015). Impact of dance, drama, yoga and music therapy workshops on symptom reduction in patients with schizophrenia: A randomized controlled study. South Asian Journal of Psychiatry, 3(2), 3–9.
go back to reference Ikai, S., Suzuki, T., Uchida, H., Saruta, J., Tsukinoki, K., Fujii, Y., & Mimura, M. (2014). Effects of weekly one-hour Hatha yoga therapy on resilience and stress levels in patients with schizophrenia-spectrum disorders: An eight-week randomized controlled trial. Journal of Alternative and Complementary Medicine, 20(11), 823–830. https://​doi.​org/​10.​1089/​acm.​2014.​0205 CrossRefPubMed Ikai, S., Suzuki, T., Uchida, H., Saruta, J., Tsukinoki, K., Fujii, Y., & Mimura, M. (2014). Effects of weekly one-hour Hatha yoga therapy on resilience and stress levels in patients with schizophrenia-spectrum disorders: An eight-week randomized controlled trial. Journal of Alternative and Complementary Medicine, 20(11), 823–830. https://​doi.​org/​10.​1089/​acm.​2014.​0205 CrossRefPubMed
Metagegevens
Titel
Efficacy of Mindfulness-Based Interventions for Negative Symptoms in Patients Diagnosed with Schizophrenia: a Meta-analysis
Auteurs
Jiabao Chai
Xue Xiao
Ning An
Fuquan Liu
Shijie Liu
Na Hu
Yin Yang
Yonghua Cui
Ying Li
Publicatiedatum
05-07-2022
Uitgeverij
Springer US
Gepubliceerd in
Mindfulness / Uitgave 8/2022
Print ISSN: 1868-8527
Elektronisch ISSN: 1868-8535
DOI
https://doi.org/10.1007/s12671-022-01942-3

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