Skip to main content
Top
Gepubliceerd in: Child Psychiatry & Human Development 4/2010

01-08-2010 | Original Article

Effects of Zinc and Ferritin Levels on Parent and Teacher Reported Symptom Scores in Attention Deficit Hyperactivity Disorder

Auteurs: Ozgur Oner, Pinar Oner, Ozlem Hekim Bozkurt, Elif Odabas, Nilufer Keser, Hasan Karadag, Murat Kızılgün

Gepubliceerd in: Child Psychiatry & Human Development | Uitgave 4/2010

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

Objective: It has been suggested that both low iron and zinc levels might be associated with Attention Deficit Hyperactivity Disorder (ADHD) symptoms. However, the association of zinc and iron levels with ADHD symptoms has not been investigated at the same time in a single sample. Method: 118 subjects with ADHD (age = 7–14 years, mean = 9.8, median = 10) were included in the study. The relationship between age, gender, ferritin, zinc, hemoglobin, mean corpuscular volume and reticulosite distribution width and behavioral symptoms of children and adolescents with ADHD were investigated with multiple linear regression analysis. Results: Results showed that subjects with lower zinc level had higher Conners Parent Rating Scale (CPRS) Total, Conduct Problems and Anxiety scores, indicating more severe problems. CPRS Hyperactivity score was associated both with zinc and ferritin levels. Conners Teacher Rating Scale (CTRS) scores were not significantly associated with zinc or ferritin levels. Conclusions: Results indicated that both low zinc and ferritin levels were associated with higher hyperactivity symptoms. Zinc level was also associated with anxiety and conduct problems. Since both zinc and iron are associated with dopamine metabolism, it can be speculated that low zinc and iron levels might be associated with more significant impairment in dopaminergic transmission in subjects with ADHD.
Literatuur
1.
go back to reference American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, IVth edn. Washington DC American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, IVth edn. Washington DC
2.
go back to reference Konofal E, Lecendreux M, Arnulf I, Mouren MC (2004) Iron deficiency in children with attention deficit hyperactivity disorder. Arch Pediatr Adolesc Med 158:1113–1115CrossRefPubMed Konofal E, Lecendreux M, Arnulf I, Mouren MC (2004) Iron deficiency in children with attention deficit hyperactivity disorder. Arch Pediatr Adolesc Med 158:1113–1115CrossRefPubMed
3.
go back to reference Oner O, Alkar O, Oner P (2008) Relation of ferritin levels with symptom ratings and cognitive performance in children with ADHD. Ped Int 50:40–44CrossRef Oner O, Alkar O, Oner P (2008) Relation of ferritin levels with symptom ratings and cognitive performance in children with ADHD. Ped Int 50:40–44CrossRef
4.
go back to reference Millichap JG, Yee MM, Davidson SI (2006) Serum ferritin in children with attention-deficit hyperactivity disorder. Pediatr Neurol 34:200–203CrossRefPubMed Millichap JG, Yee MM, Davidson SI (2006) Serum ferritin in children with attention-deficit hyperactivity disorder. Pediatr Neurol 34:200–203CrossRefPubMed
5.
go back to reference Sever Y, Ashkenazi A, Tyrano S, Weizman A (1997) Iron treatment in children with attention deficit hyperactivity disorder. Neuropsychobiology 35:178–180CrossRefPubMed Sever Y, Ashkenazi A, Tyrano S, Weizman A (1997) Iron treatment in children with attention deficit hyperactivity disorder. Neuropsychobiology 35:178–180CrossRefPubMed
6.
go back to reference Konofal E, Lecendreux M, Deron J, Marchand M, Cortese S, Zaïm M, Mouren MC, Arnulf I (2008) Effects of iron supplementation on attention deficit hyperactivity disorder in children. Pediatr Neurol 38:20–26CrossRefPubMed Konofal E, Lecendreux M, Deron J, Marchand M, Cortese S, Zaïm M, Mouren MC, Arnulf I (2008) Effects of iron supplementation on attention deficit hyperactivity disorder in children. Pediatr Neurol 38:20–26CrossRefPubMed
7.
go back to reference Oner P, Dirik EB, Taner Y, Caykoylu A, Anlar O (2007) Association between low serum ferritin and restless legs syndrome in patients with attention deficit hyperactivity disorder. Tohoku J Exp Med 213:269–276CrossRefPubMed Oner P, Dirik EB, Taner Y, Caykoylu A, Anlar O (2007) Association between low serum ferritin and restless legs syndrome in patients with attention deficit hyperactivity disorder. Tohoku J Exp Med 213:269–276CrossRefPubMed
8.
go back to reference Cortese S, Konofal E, Bernardina BD, Mouren MC, Lecendreux M (2009) Sleep disturbances and serum ferritin levels in children with attention-deficit/hyperactivity disorder. Eur Child Adolesc Psychiatry 18:393–399CrossRefPubMed Cortese S, Konofal E, Bernardina BD, Mouren MC, Lecendreux M (2009) Sleep disturbances and serum ferritin levels in children with attention-deficit/hyperactivity disorder. Eur Child Adolesc Psychiatry 18:393–399CrossRefPubMed
9.
go back to reference Oner P, Oner O (2008) Relationship of ferritin to symptom ratings children with attention deficit hyperactivity disorder, effect of comorbidity. Child Psychiatry Hum Dev 39:323–330CrossRefPubMed Oner P, Oner O (2008) Relationship of ferritin to symptom ratings children with attention deficit hyperactivity disorder, effect of comorbidity. Child Psychiatry Hum Dev 39:323–330CrossRefPubMed
10.
go back to reference Arnold LE, Bozzolo H, Hollway J, Cook A, DiSilvestro RA, Bozzolo DR, Crowl L, Ramadan Y, Williams C (2005) Serum zinc correlates with parent- and teacher- rated inattention in children with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol 15:628–636CrossRefPubMed Arnold LE, Bozzolo H, Hollway J, Cook A, DiSilvestro RA, Bozzolo DR, Crowl L, Ramadan Y, Williams C (2005) Serum zinc correlates with parent- and teacher- rated inattention in children with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol 15:628–636CrossRefPubMed
11.
go back to reference Uçkardeş Y, Ozmert EN, Unal F, Yurdakök K (2009) Effects of zinc supplementation on parent and teacher behaviour rating scores in low socioeconomic level Turkish primary school children. Acta Paediatr 98:731–736CrossRefPubMed Uçkardeş Y, Ozmert EN, Unal F, Yurdakök K (2009) Effects of zinc supplementation on parent and teacher behaviour rating scores in low socioeconomic level Turkish primary school children. Acta Paediatr 98:731–736CrossRefPubMed
12.
go back to reference Krause J (2008) SPECT and PET of the dopamine transporter in attention-deficit/hyperactivity disorder. Expert Rev Neurother 8:611–625CrossRefPubMed Krause J (2008) SPECT and PET of the dopamine transporter in attention-deficit/hyperactivity disorder. Expert Rev Neurother 8:611–625CrossRefPubMed
13.
go back to reference Yorbik O, Ozdag MF, Olgun A, Senol MG, Bek S, Akman S (2008) Potential effects of zinc on information processing in boys with attention deficit hyperactivity disorder. Prog Neuropsychopharmacol Biol Psychiatry 32:662–667CrossRefPubMed Yorbik O, Ozdag MF, Olgun A, Senol MG, Bek S, Akman S (2008) Potential effects of zinc on information processing in boys with attention deficit hyperactivity disorder. Prog Neuropsychopharmacol Biol Psychiatry 32:662–667CrossRefPubMed
14.
go back to reference Erikson K, Pinero D, Connor J, Beard J (1997) Iron status and distribution on iron in the brains of the developing rats. J Nutr 127:2030–2038PubMed Erikson K, Pinero D, Connor J, Beard J (1997) Iron status and distribution on iron in the brains of the developing rats. J Nutr 127:2030–2038PubMed
15.
go back to reference Conners CK (1997) Conners’ rating scales- revised. Multi-Health Systems Publishing, North Tonawada Conners CK (1997) Conners’ rating scales- revised. Multi-Health Systems Publishing, North Tonawada
16.
go back to reference Dereboy C, Senol S, Sener S (1998) Adaptation of Conners’ parent rating scale in Turkish. In: Proceedings 10th National Congress of Psychology, Ankara Dereboy C, Senol S, Sener S (1998) Adaptation of Conners’ parent rating scale in Turkish. In: Proceedings 10th National Congress of Psychology, Ankara
17.
go back to reference Goyette CH, Conners CK, Ulrich RF (1978) Normative data on revised Conners’ parent and teacher rating scales. J Abnorm Child Psychol 6:221–236CrossRefPubMed Goyette CH, Conners CK, Ulrich RF (1978) Normative data on revised Conners’ parent and teacher rating scales. J Abnorm Child Psychol 6:221–236CrossRefPubMed
18.
go back to reference Sener S, Dereboy C, Dereboy IF, Sertcan Y (1995) Conners’ teacher rating scale Turkish version-I. Tr J Child Adolesc Ment Health 2:131–141 Sener S, Dereboy C, Dereboy IF, Sertcan Y (1995) Conners’ teacher rating scale Turkish version-I. Tr J Child Adolesc Ment Health 2:131–141
19.
go back to reference Wigglesworth JM, Baum H (1988) Iron dependent enzymes in the brain. In: Youdim MBH (ed) Brain ıron: neurochemical and behavioral aspects. Taylor and Francis, New York, pp 25–66 Wigglesworth JM, Baum H (1988) Iron dependent enzymes in the brain. In: Youdim MBH (ed) Brain ıron: neurochemical and behavioral aspects. Taylor and Francis, New York, pp 25–66
20.
go back to reference Ashkenazi R, Ben-Shachar D, Youdim MBH (1982) Nutritional iron deficiency and dopamine binding sites in the rat brain. Pharmacol Biochem Behav 17:43–47CrossRefPubMed Ashkenazi R, Ben-Shachar D, Youdim MBH (1982) Nutritional iron deficiency and dopamine binding sites in the rat brain. Pharmacol Biochem Behav 17:43–47CrossRefPubMed
21.
go back to reference Swanson JM, Kinsbourne M, Nigg J, Lanphear B, Stefanatos GA, Volkow N, Taylor E, Casey BJ, Castellanos FX, Wadwha PD (2007) Etiological subtypes of attention deficit hyperactivity disorder: brain imaging, molecular genetics and environmental factors and the dopamine hypothesis. Neuropsychol Rev 17:39–59CrossRefPubMed Swanson JM, Kinsbourne M, Nigg J, Lanphear B, Stefanatos GA, Volkow N, Taylor E, Casey BJ, Castellanos FX, Wadwha PD (2007) Etiological subtypes of attention deficit hyperactivity disorder: brain imaging, molecular genetics and environmental factors and the dopamine hypothesis. Neuropsychol Rev 17:39–59CrossRefPubMed
22.
go back to reference Volkow N, Wang J, Newcorn J, Telang F, Solanto MV, Fowler JS, Logan J, Ma Y, Schulz K, Pradhan K, Wong J, Swanson JM (2007) Depressed dopamine activity in caudate and preliminary evidince of limbic involvement in adults with attention deficit hyperactivity disorder. Arch Gen Psychiatry 64:932–940CrossRefPubMed Volkow N, Wang J, Newcorn J, Telang F, Solanto MV, Fowler JS, Logan J, Ma Y, Schulz K, Pradhan K, Wong J, Swanson JM (2007) Depressed dopamine activity in caudate and preliminary evidince of limbic involvement in adults with attention deficit hyperactivity disorder. Arch Gen Psychiatry 64:932–940CrossRefPubMed
23.
go back to reference Whittle N, Lubec G, Singewald N (2009) Zinc deficiency induces enhanced depression-like behaviour and altered limbic activation reversed by antidepressant treatment in mice. Amino Acids 36:147–158CrossRefPubMed Whittle N, Lubec G, Singewald N (2009) Zinc deficiency induces enhanced depression-like behaviour and altered limbic activation reversed by antidepressant treatment in mice. Amino Acids 36:147–158CrossRefPubMed
Metagegevens
Titel
Effects of Zinc and Ferritin Levels on Parent and Teacher Reported Symptom Scores in Attention Deficit Hyperactivity Disorder
Auteurs
Ozgur Oner
Pinar Oner
Ozlem Hekim Bozkurt
Elif Odabas
Nilufer Keser
Hasan Karadag
Murat Kızılgün
Publicatiedatum
01-08-2010
Uitgeverij
Springer US
Gepubliceerd in
Child Psychiatry & Human Development / Uitgave 4/2010
Print ISSN: 0009-398X
Elektronisch ISSN: 1573-3327
DOI
https://doi.org/10.1007/s10578-010-0178-1

Andere artikelen Uitgave 4/2010

Child Psychiatry & Human Development 4/2010 Naar de uitgave