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Journal of Autism and Developmental Disorders

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01-04-2009 | Original Paper

Effects of Low Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) on Gamma Frequency Oscillations and Event-Related Potentials During Processing of Illusory Figures in Autism

Auteurs: Estate M. Sokhadze, Ayman El-Baz, Joshua Baruth, Grace Mathai, Lonnie Sears, Manuel F. Casanova

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 4/2009

Abstract

Previous studies by our group suggest that the neuropathology of autism is characterized by a disturbance of cortical modularity. In this model a decrease in the peripheral neuropil space of affected minicolumns provides for an inhibitory deficit and a readjustment in their signal to noise bias during information processing. In this study we proposed using low frequency transcranial magnetic stimulation (rTMS) as a way increasing the surround inhibition of minicolumns in autism. Thirteen patients (ADOS and ADI-R diagnized) and equal number of controls participated in the study. Repetitive TMS was delivered at 0.5 Hz, 2 times per week for 3 weeks. Outcome measures based on event-related potentials (ERP), induced gamma activity, and behavioral measures showed significant post-TMS improvement. The results suggest that rTMS offers a potential therapeutic intervention for autism.

vorige artikel Pragmatic Inferences in High-Functioning Adults with Autism and Asperger Syndrome

volgende artikel Restricted and Repetitive Behaviours, Sensory Processing and Cognitive Style in Children with Autism Spectrum Disorders

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Titel: Effects of Low Frequency Repetitive Transcranial Magnetic Stimulation (rTMS) on Gamma Frequency Oscillations and Event-Related Potentials During Processing of Illusory Figures in Autism
Auteurs: Estate M. Sokhadze
Ayman El-Baz
Joshua Baruth
Grace Mathai
Lonnie Sears
Manuel F. Casanova
Publicatiedatum: 01-04-2009
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 4/2009
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-008-0662-7

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