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Netherlands Heart Journal
Gepubliceerd in: Netherlands Heart Journal 4/2010

01-04-2010 | Original article

Effects of high-dose insulin infusion on left ventricular function in normal subjects

Auteurs: L. J. Klein, C. M. C. van Campen, O. Kamp, F.C. Visser

Gepubliceerd in: Netherlands Heart Journal | Uitgave 4/2010

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Abstract

Background. Only a few studies have reported on the effect of high-dose insulin (HDI) infusion on cardiac function in healthy volunteers.
Methods. We studied ten healthy volunteers with low-dose dobutamine (LDD, 10 µg/kg/min) echo­cardio­graphy and HDI echocardiography (insulin administration for one hour) by volume and Doppler analysis.
Results. During LDD, cardiac output increased from 5.7±1.3 l/min to 9.0±2.1 l/min (p<0.001) and during HDI from 5.5±1.2 l/min to 6.2±1.1 l/min (p=0.048). Increase was not only due to increase in frequency, which was only present in the LDD study, but also due to increase in stroke volume (from 82±15 ml to 110±23 ml, p<0.001 during LDD and from 82±16 ml to 93±24 ml, p=0.014 during HDI). The increase in stroke volume was the result of a decrease in end-systolic volume with an unchanged end-diastolic volume.
Conclusion. High-dose insulin infusion results in increased cardiac output by improving systolic myocardial function. (Neth Heart J 2010;18:183-9.)
vorige artikel Application of NHG guidelines in patients referred for stable chest pain syndromes
volgende artikel Neurohormonal profile of patients with heart failure and diabetes
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Metagegevens
Titel
Effects of high-dose insulin infusion on left ventricular function in normal subjects
Auteurs
L. J. Klein
C. M. C. van Campen
O. Kamp
F.C. Visser
Publicatiedatum
01-04-2010
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Netherlands Heart Journal / Uitgave 4/2010
Print ISSN: 1568-5888
Elektronisch ISSN: 1876-6250
DOI
https://doi.org/10.1007/BF03091759

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