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Open Access 14-12-2020 | Original Article

Effectiveness of Behaviour Therapy for Children and Adolescents with Tourette Syndrome and Chronic Tic Disorder in a Naturalistic Setting

Auteurs: Per Andrén, Vera Wachtmeister, Julia Franzé, Caroline Speiner, Lorena Fernández de la Cruz, Erik Andersson, Elles de Schipper, Daniel Rautio, Maria Silverberg-Mörse, Eva Serlachius, David Mataix-Cols

Gepubliceerd in: Child Psychiatry & Human Development | Uitgave 4/2021

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Abstract

It is unclear if the results of randomised controlled trials (RCTs) of behaviour therapy (BT) for Tourette syndrome (TS) and chronic tic disorder (CTD) can be generalised to naturalistic clinical settings and are durable long-term. In this naturalistic study, 74 young people with TS/CTD received BT at a specialist clinic. Data were collected at baseline, post-treatment, and at 3-, 6-, and 12-month follow-ups. Measures included the Yale Global Tic Severity Scale (YGTSS) and the Clinical Global Impression-Improvement scale (CGI-I), amongst others. Tic severity and tic-related impairment improved after treatment, with large within-group effect sizes. At post-treatment, 57% of the participants were classified as treatment responders according to the CGI-I. Tic severity and tic-related impairment improved further through the follow-up, with 75% treatment responders at the 12-month follow-up. BT is an effective and durable treatment for young people with TS/CTD in a naturalistic specialist clinical setting, with comparable effects to RCTs.
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Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s10578-020-01098-y) contains supplementary material, which is available to authorized users.
Preprint: This manuscript has been published as a preprint at the PsyArXiv preprint depository, DOI: https://​doi.​org/​10.​31234/​osf.​io/​hbrm4

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Introduction

Tourette syndrome (TS) and chronic (motor or vocal) tic disorder (CTD) are neurodevelopmental disorders characterised by the presence of motor and/or vocal tics lasting for at least 1 year [1]. TS/CTD are associated with functional impairment in multiple domains, including everyday life and activities, social adjustment, and academic performance [2, 3]. Additionally, TS/CTD are also associated with high rates of psychiatric comorbidity, which further add to the patients’ burden [4].
There are several treatment options available for patients with TS/CTD. Treatment guidelines from both Europe and North America recommend behaviour therapy (BT) as the first-line intervention, based on a combination of clinical trial evidence and expert consensus [57]. Out of several available BT modalities, comprehensive behavioural intervention for tics (CBIT) has most evidence to date [8]. CBIT, which includes habit reversal training (HRT) as its primary component, has been successfully evaluated in several randomised controlled trials (RCTs) in both paediatric and adult samples [911]. There is also some evidence for the use of exposure with response prevention (ERP) [12]. European and Canadian treatment guidelines recommend both CBIT/HRT and ERP as first-line interventions for patients with TS/CTD, whilst American treatment guidelines primarily recommend CBIT/HRT [57].
Efficacy trials aim to evaluate treatment effects under extensively controlled conditions, which entail several methodological advantages and generate high internal validity. However, the efforts for achieving high internal validity might result in substantial deviations from regular clinical practice, affecting the external validity and the generalisability of results. Examples of factors contributing to low external validity in efficacy trials include using specific participant eligibility criteria (e.g., excluding participants with certain psychiatric or somatic comorbidities), delivering an intervention in a highly standardised way (e.g., using specific treatment protocols with a pre-determined number of sessions and highly experienced/trained therapists), restricting concurrent interventions (e.g., excluding individuals on psychotropic medications) or using extensive resources to maximize patient compliance with the intervention (e.g., reminding patients about appointments) [13]. For example, the two largest RCTs of BT for TS/CTD excluded participants with comorbid autism and used specific treatment protocols and highly trained therapists, although allowed for the inclusion of participants with most other psychiatric comorbidities and on concurrent tic medication (if stable) [9, 11].
Effectiveness trials (sometimes referred to as pragmatic trials), on the other hand, aim to evaluate treatment effects when delivered in regular clinical practice. To ensure generalisability of the results to the full spectrum of the population to which the treatment might be applied, the treatments are delivered more flexibly, the patients’ compliance may vary, and there are generally no strict inclusion and exclusion criteria [14]. Perhaps unsurprisingly, meta-analyses including studies from a variety of fields indicate that treatment effects are generally larger in efficacy trials, compared to effectiveness trials [15, 16].
To our knowledge, only one study has evaluated the effectiveness of BT for young people with TS/CTD [17]. In a retrospective chart review conducted at a specialised paediatric clinic, CBIT was found to be potentially effective in reducing tic severity in a small sample of patients (N = 10). However, larger studies are needed to more thoroughly evaluate how the results from previous efficacy trials [9, 11, 12] generalise to naturalistic clinical settings.
Another common issue in many studies of BT for TS/CTD is that follow-ups have been relatively short (up to 6 months after the end of treatment) [9, 11, 12] or restricted to initial treatment responders only [9, 11]. The few available long-term follow-up studies have generally been small (N= 23–32) [10, 18]. Long-term follow-ups are especially important in this patient group given that tics are highly influenced by contextual factors and have a natural tendency to wax and wane over time [1].
The aim of this study was two-folded. First, we evaluated the effectiveness of BT in a consecutive sample of youth with TS/CTD referred to a specialist clinic. Second, we investigated whether the treatment gains were maintained at long-term follow-up (12 months after the end of the treatment).

Methods

Study Design and Setting

This was an open longitudinal study in a naturalistic clinical setting. The study was conducted at a single site, a specialist outpatient clinic for obsessive–compulsive and related disorders, including TS/CTD, within the child and adolescent mental health services (CAMHS) in Stockholm, Sweden. The Swedish health care system is mainly government-funded and universal for all citizens. Our specialist clinic primarily receives referrals from local CAMHS services (Stockholm region), but in some cases also from other parts of Sweden. All consecutive patients referred to the clinic with a diagnosis of TS or CTD (together with their parents/legal guardians, henceforth referred to as parents) were invited to participate in the study, and those agreeing provided written informed consent. The study was approved by the Swedish Ethical Review Authority (reference number: 2015/1977-31/4 [2019-02132]).

Procedure

Before their initial assessment at the clinic, all patients and their parents completed multiple standardised self- and parent-reported questionnaires online (see section Time Points and Outcome Measures). The initial assessment consisted of a 3-h evaluation at the clinic, where experienced clinical psychologists conducted a full psychopathological screening using the Mini-International Neuropsychiatric Interview for Children and Adolescents (MINI-KID) [19] and supplementary modules for obsessive–compulsive and related disorders. Each patient was then discussed by a multidisciplinary team of clinical child psychologists, child psychiatrists, and nurses, using all collected information from the interviews and questionnaires to diagnose patients according to the 10th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-10) [20] and the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) [1]. After the initial assessment, patients were either offered treatment at our specialist clinic, referred to more suitable services (e.g., according to other clinical priorities) or discharged (e.g., if symptoms were too mild or in remission). Treatment started as soon as a therapist was available, usually within a few weeks.

Time Points and Outcome Measures

Data were collected at intake for all families. For patients who received treatment at the specialist clinic, data were also collected directly after treatment (post-treatment) and at 3-, 6-, and 12-month follow-up post-treatment. Because this was a naturalistic study, some patients were still in follow-up when the final data extraction was performed on 30 April 2020, which accounted for some of the data missing at later time points.
Data collection included a range of clinician-, self-, and parent-reported measures (see below). All measures were repeatedly collected at all time points. Clinician-rated measures were administered by the clinicians responsible for the initial assessment (baseline) as well as by the therapists providing treatment (all subsequent time points). All self- and parent-reported questionnaires were administered digitally via an online service.

Clinician-Rated Measures

The Yale Global Tic Severity Scale (YGTSS) [21] is a clinician-rated semi-structured interview which assesses tic severity and tic-related impairment. It is the most commonly used outcome measure in TS/CTD clinical trials [22]. The interview consists of three major parts: a symptom checklist, a tic severity rating, and a tic-related impairment rating. The total score of 0–100 points can be divided into several subscores, namely the Motor Tic Severity Score (0–25 points), the Vocal Tic Severity Score (0–25 points), the Total Tic Severity Score (YGTSS-TTSS; the two former scores combined, 0–50 points), and the Impairment Score (0–50 points). The YGTSS has demonstrated good psychometric properties [21, 23, 24].
The Clinical Global Impression-Improvement scale (CGI-I) [25] is a single-item clinician rating of symptom improvement. In this study, the CGI-I provided a rating of tic disorder symptom improvement compared to the baseline time point, with a range from 1 (‘very much improved’) to 7 (‘very much worse’). In line with previous TS/CTD trials [9, 11], ratings of 1 (‘very much improved’) and 2 (‘much improved’) were used to define treatment response.
The Children’s Global Assessment Scale (CGAS) [26] was also administered to provide a clinician rating of general functioning (not only restricted to tic disorder symptoms). The CGAS consists of a single item ranging from 1 to 100, where 100 indicates the best possible functioning.

Self-Reported Measures

The Premonitory Urge for Tics Scale (PUTS) is a 9-item (9-36 points) measure of premonitory urges. The questionnaire has shown good psychometric properties [27, 28]. The Gilles de la Tourette Syndrome-Quality of Life scale (GTS-QOL) [29] is a 27-item (0–108 points) disease-specific measure of health-related quality of life. Since the child and adolescent versions of the questionnaire had not yet been published when the data collection started, the adult version was used in this study. The Obsessive Compulsive Inventory-Child Version (OCI-CV) [30] is a 21-item (0–42 points) multi-dimensional measure of obsessive–compulsive symptoms. The questionnaire has demonstrated good psychometric properties [30]. Both the Children’s Depression Inventory-Short version (CDI-S; 10 items, 0–20 points) [31] and the Short Mood and Feelings Questionnaire-Child Version (SMFQ-CV; 13 items, 0–26 points) [32] were used in the study as self-reported measures of depressive symptoms, with the SMFQ-CV gradually replacing the CDI-S over time. For analyses, both depression measures were combined using z-scores. Lastly, the Work and Social Adjustment Scale-Youth version (WSAS-Y) [33], a psychometrically sound, 5-item (0–40 points) measure of functional impairment in several areas, was included.

Parent-Reported Measures

The Parent Tic Questionnaire (PTQ) [34] is a parent-rated measure of tic severity consisting of two separate lists of common motor and vocal tics. For each present tic, parents rate its frequency and intensity, generating a total score ranging from 0 to 224 points. The questionnaire has established psychometric properties [34]. Parents also rated their children’s depressive symptoms with the SMFQ-Parent Version (SMFQ-PV; 13 items, 0–26 points) [32] and global functional impairment with the WSAS-Parent version (WSAS-P; 5 items, 0–40 points) [33].

Interventions

BT was delivered according to published treatment manuals [35, 36] further supplemented by locally developed patient worksheets. The choice of BT modality (HRT or ERP) was primarily according to therapist preference, even though the patient and their family were also invited to express their preference. In HRT, the patients practiced to become more aware of their tics and to perform competing responses (i.e., voluntary behaviours physically incompatible with the tics) aimed at interrupting tic occurrence. In ERP, patients practiced to suppress tics (response prevention) for increased periods of time. In addition, patients intentionally provoked their premonitory urges (i.e., unpleasant sensations typically preceding tic occurrence) to make tic suppression more difficult (exposure), with the aim of increasing their tic suppression abilities. Along with psychoeducation and the core elements of HRT or ERP, additional therapeutic strategies could be added by the therapist, such as relaxation training and interventions based on functional assessment (as included in CBIT) [35]. BT treatments were by default 10 sessions long, but could be tailored (shortened or extended) to each patient’s needs. Each therapy session generally lasted 1 h. Therapists were clinical psychologists (5 years of master level studies and a minimum of 1 year of clinical training) trained in BT with extensive experience in the treatment of obsessive–compulsive and related disorders, including TS/CTD, or trainee psychologists or clinical psychology master students under supervision of a senior clinical psychologist. Throughout the study period, more senior clinical psychologists with extensive experience in delivering BT for TS/CTD were readily available for consultation.
Additionally, some patients were on medication for their tics. This included prescriptions prior to being referred to the clinic, as well as new prescriptions by a child and adolescent psychiatrist at the clinic, according to clinical judgement and treatment guidelines.

Statistical Analyses

Mixed-effects regression models for repeated measures using maximum likelihood estimation (MLE) of parameters were implemented on all continuous outcome measures. The models included fixed effects of time and random intercepts for the participant effects. The primary model included the baseline and post-treatment time points. Furthermore, to investigate the durability of the treatment effects, a second model was fitted which included the post-treatment, 3-, 6-, and 12-month follow-up time points. For graphical representation purposes only, a third model was also fitted including all time points from baseline to the 12-month follow-up. Significance thresholds (two-tailed) were set to p < 0.05. Bootstrapped within-group effect-sizes (d), derived from mixed-effects regression models, were calculated with the m_effectsize command in Stata developed by the Karolinska Institutet Biostatistics Core and available at www.​imm.​ki.​se/​biostatistics/​stata. All analyses were performed using Stata 14.2 (StataCorp LLC). Sample sizes may vary for some of the analyses as a result of missing data. Missing data points are specified for each measure in all tables.

Results

Study Participants and Treatment Completion

Figure 1 shows the study participants’ flow. A total of 110 patients with TS/CTD provided informed consent for the study between 1 January 2015 and 27 January 2020. Seventy-four participants received BT for TS/CTD at the specialist clinic, of which 46 received psychoeducation plus ERP, 14 received psychoeducation plus HRT, and 14 received other BT: psychoeducation plus a combination of ERP and HRT (n = 7) or psychoeducation plus ERP/HRT treatment rationales only (n = 7; when judged sufficient for the participant’s clinical needs). The 74 participants completed an average of 7.07 (SD = 3.01, range = 2–16) BT sessions between baseline and the post-treatment time point. Figure 1 further shows the availability of TS/CTD data for each time point. For the 74 participants, follow-up data continued to be collected until 30 April 2020.
Table 1 shows baseline demographic and clinical characteristics for the total BT sample and by BT modality. Supplementary Table S1 further shows the proportion of specific motor and vocal tics at baseline, according to the YGTSS symptom checklist.
Table 1
Baseline demographic and clinical characteristics of the total BT sample and by BT modality
 
Total BT (N = 74)
ERP (n = 46)
HRT (n = 14)
Other BT (n = 14)
Age, mean (SD); min–max
11.36 (2.81); 6.42-17.83
11.11 (2.55); 6.42-16.83
12.14 (3.34); 7.42-17.50
11.41 (3.07); 6.42-17.83
Males, n (%)
52 (70)
32 (70)
9 (64)
11 (79)
Age of tic onset, mean (SD); min–max (n = 73)
5.79 (2.15); 2-14
5.62 (1.60); 3-9
6.50 (3.63); 2-14
5.64 (1.74); 3-8
Tic disorder, n (%)
 Tourette syndromeA
62 (84)
40 (87)
12 (86)
10 (71)
 Chronic motor tic disorder
10 (14)
4 (9)
2 (14)
4 (29)
 Chronic vocal tic disorder
2 (3)
2 (4)
0 (0)
0 (0)
Comorbidity, n (%)
 Any comorbidity
37 (50)
23 (50)
6 (43)
8 (57)
 Attention-deficit/hyperactivity disorder
17 (23)
12 (26)
2 (14)
3 (21)
 Obsessive-compulsive disorder
10 (14)
8 (17)
0 (0)
2 (14)
 Anxiety disorders
8 (11)
3 (7)
3 (21)
2 (14)
 Autism spectrum disorder
8 (11)
4 (9)
2 (14)
2 (14)
 Depression
2 (3)
1 (2)
0 (0)
1 (7)
 Dyslexia
2 (3)
2 (4)
0 (0)
0 (0)
 Intellectual disability
1 (1)
0 (0)
1 (7)
0 (0)
 Trichotillomania
1 (1)
1 (2)
0 (0)
0 (0)
Previous BT for TS/CTD, n (%)
9 (12)
4 (9)
1 (7)
4 (29)
Medication status, n (%)
 None
53 (72)
34 (74)
11 (79)
8 (57)
 Stimulant
12 (16)
9 (20)
0 (0)
3 (21)
 Melatonin
7 (9)
5 (11)
1 (7)
1 (7)
 SSRI
7 (9)
4 (9)
1 (7)
2 (14)
 Antipsychotic
4 (5)
1 (2)
1 (7)
2 (14)
 Antihistamine
3 (4)
2 (4)
0 (0)
1 (7)
 α2-agonist
1 (1)
1 (2)
0 (0)
0 (0)
Additional support in school, n (%) (n = 67)
25 (37)
18 (42)
3 (23)
4 (36)
Parent educationB, n (%) (n = 54)
 College/University
48 (89)
31 (89)
9 (90)
8 (89)
 Secondary school
5 (9)
3 (9)
1 (10)
1 (11)
 Primary school
1 (2)
1 (3)
0 (0)
0 (0)
Family history of TS/CTD, 1st degree, n (%)
32 (43)
17 (37)
8 (57)
7 (50)
Family history of TS/CTD, 2nd degree, n (%)
17 (23)
12 (26)
1 (7)
4 (29)
BT behaviour therapy, CTD chronic motor or vocal tic disorder, ERP exposure with response prevention, HRT habit reversal training, SD standard deviation, SSRI selective serotonin reuptake inhibitor, TS Tourette syndrome
A This includes two participants who were diagnosed with provisional tic disorder at baseline and eventually fulfilled Tourette syndrome criteria during the follow-up period
B The highest level of education among pairs of parents was selected

Clinician-Rated Measures and Treatment Response

Mixed-effects regression analyses at post-treatment showed a significant reduction on the YGTSS-TTSS for the total BT sample (coefficient [95% CI] − 7.74 [− 9.33 to − 6.16], p < 0.001), as well as for each BT modality (ERP: − 7.90 [− 9.81 to − 5.99], p < 0.001; HRT: − 6.09 [− 9.87 to − 2.31], p = 0.002; other BT: − 8.81 [− 12.72 to − 4.91], p < 0.001). Bootstrapped effect sizes (d) were the following: 1.03 (0.78 to 1.29) for the total sample, 1.09 (0.75 to 1.43) for the ERP group, 0.82 (0.19 to 1.44) for HRT, and 1.13 (0.59 to 1.66) for patients receiving other BT. Table 2 shows detailed statistics for the YGTSS and other TS/CTD-specific measures at post-treatment for the total BT sample. Supplementary Tables S2–S4 show the equivalent information separately for each BT modality.
Table 2
Detailed statistics for TS/CTD-specific measures at post-treatment for the total BT sample
 
Total BT (N = 74)
Mean (SE)A
Within-group difference
Within-group effect sizeB
Coefficient (95% CI); p-value
Bootstrapped d (95% CI)
Yale global tic severity scale
 Total tic severity score
  Baseline (n = 71)
23.43 (0.87)
  
  Post-treatment (n = 71)
15.68 (0.87)
− 7.74 (− 9.33 to − 6.16); p < 0.001*
1.03 (0.78 to 1.29)
 Motor tic severity score
  Baseline (n = 71)
14.26 (0.48)
  
  Post-treatment (n = 71)
9.56 (0.48)
− 4.70 (− 5.69 to − 3.70); p < 0.001*
1.13 (0.78 to 1.48)
 Vocal tic severity score
  Baseline (n = 71)
9.18 (0.59)
  
  Post-treatment (n = 71)
6.11 (0.59)
− 3.07 (− 4.07 to − 2.07); p < 0.001*
0.61 (0.37 to 0.84)
 Impairment score
  Baseline (n = 71)
21.84 (1.07)
  
  Post-treatment (n = 71)
9.27 (1.07)
− 12.57 (− 14.70 to − 10.45); p < 0.001*
1.37 (1.04 to 1.70)
Parent tic questionnaire
  Baseline (n = 69)
37.61 (2.27)
  
  Post-treatment (n = 53)
22.97 (2.49)
− 14.64 (− 19.28 to − 10.01); p < 0.001*
0.76 (0.50 to 1.01)
GTS-quality of life scale
  Baseline (n = 57)
31.24 (2.24)
  
  Post-treatment (n = 40)
16.51 (2.59)
− 14.73 (− 20.01 to − 9.45); p < 0.001*
0.86 (0.57 to 1.14)
Premonitory urge for tics scale
  Baseline (n = 67)
19.95 (0.75)
  
  Post-treatment (n = 46)
20.02 (0.87)
0.74 (− 1.65 to 1.80); p = 0.933
− 0.01 (− 0.36 to 0.34)
BT behaviour therapy, CI confidence interval, CTD chronic motor or vocal tic disorder, GTS Gilles de la Tourette, SE standard error, TS Tourette syndrome
A Estimated means from the mixed-effects regression model
B Bootstrapped effect sizes (d) are derived from the mixed-effects regression model. Effect sizes of 0.2, 0.5, and 0.8 are considered small, moderate, and large, respectively
*Significant at an alpha level of 0.05
At post-treatment, 38 out of 74 participants (57%, available data for n = 67) were classified as treatment responders according to the CGI-I. Numbers were too small to meaningfully report on the specific BT modalities separately.
Between baseline and the post-treatment time point, 8 out of 74 participants (11%) changed their medication (α2-agonists or antipsychotics): 4 participants (5%) either increased their dosage or started medication, 2 participants (3%) switched from one compound to another, and 2 participants (3%) either decreased their dosage or stopped taking medication for their tics. A mixed-effects regression analysis excluding these 8 participants from the total BT sample showed a similarly significant reduction on the YGTSS-TTSS as in the main model (coefficient [95% CI] − 7.60 [− 9.34 to − 5.85], p < 0.001, bootstrapped d = 1.01 [0.76 to 1.26]).
Mixed-effects regression analyses for the YGTSS Impairment Score and the CGAS both showed significant improvements at post-treatment for the total BT sample and each BT modality separately (Table 2 and Supplementary Tables S5–S8).

Self- and Parent-Reported Measures

Mixed-effects regression analyses for the PTQ, the GTS-QOL, the OCI-CV, the CDI-S and the SMFQ-CV combined to z-scores, the SMFQ-PV, the WSAS-Y, and the WSAS-P, showed significant improvements at post-treatment for the total BT sample (Table 2 and Supplementary Table S5). The results for the specific BT modalities are presented in Supplementary Tables S2–S4 and S6–S8, but should be interpreted with caution given the small sample sizes.

Long-Term Follow-Up

Mixed-effects regression analyses showed a significant improvement between post-treatment and the 12-month follow-up on the YGTSS-TTSS for the total BT sample (coefficient [95% CI] − 1.90 [− 3.60 to − 0.20], p = 0.029). Similarly, there was a continued improvement on the YGTSS Impairment Score and the CGAS for the total BT sample (Table 3 and Supplementary Table S9). A third model including all five time points was also implemented in order to obtain a graphical representation of the YGTSS-TTSS for the total BT sample from baseline to the 12-month follow-up (coefficient [95% CI] − 9.60 [− 11.35 to − 7.84], p < 0.001; Fig. 2).
Table 3
Detailed statistics for TS/CTD-specific measures for the long-term follow-up period for the total BT sample
 
Total BT (N = 74)
Mean (SE)A
Within-group differenceB
Within-group effect sizeC
Coefficient (95% CI); p-value
Bootstrapped d (95% CI)
Yale global tic severity scale
 Total tic severity score
  Post-treatment (n = 71)
15.72 (0.88)
  
  3-month follow-up (n = 63)
14.97 (0.91)
− 0.75 (− 2.33 to 0.84); p = 0.356
0.12 (− 0.08 to 0.31)
  6-month follow-up (n = 56)
14.56 (0.94)
− 1.16 (− 2.80 to 0.49); p = 0.169
0.16 (− 0.04 to 0.36)
  12-month follow-up (n = 51)
13.82 (0.97)
− 1.90 (− 3.60 to − 0.20); p = 0.029*
0.24 (0.03 to 0.45)
 Motor tic severity score
  Post-treatment (n = 71)
9.57 (0.50)
  
  3-month follow-up (n = 63)
8.87 (0.52)
− 0.70 (− 1.68 to 0.27); p = 0.159
0.17 (− 0.04 to 0.38)
  6-month follow-up (n = 56)
8.91 (0.54)
− 0.66 (− 1.68 to 0.35); p = 0.200
0.16 (− 0.09 to 0.40)
  12-month follow-up (n = 51)
8.50 (0.56)
− 1.08 (− 2.12 to − 0.03); p = 0.044*
0.23 (− 0.08 to 0.53)
 Vocal tic severity score
  Post-treatment (n = 71)
6.15 (0.55)
  
  3-month follow-up (n = 63)
6.10 (0.57)
− 0.05 (− 1.02 to 0.92); p = 0.920
0.04 (− 0.17 to 0.25)
  6-month follow-up (n = 56)
5.65 (0.58)
− 0.50 (− 1.51 to 0.51); p = 0.332
0.11 (− 0.11 to 0.34)
  12-month follow-up (n = 51)
5.30 (0.60)
− 0.85 (− 1.89 to 0.20); p = 0.111
0.19 (− 0.03 to 0.41)
 Impairment score
  Post-treatment (n = 71)
9.33 (1.02)
  
  3-month follow-up (n = 63)
7.16 (1.07)
− 2.17 (− 4.21 to − 0.13); p = 0.037*
0.23 (0.02 to 0.44)
  6-month follow-up (n = 56)
7.54 (1.11)
− 1.79 (− 3.91 to 0.33); p = 0.098
0.20 (− 0.02 to 0.42)
  12-month follow-up (n = 51)
6.75 (1.14)
− 2.57 (− 4.76 to − 0.38); p = 0.021*
0.27 (0.03 to 0.48)
Parent tic questionnaire
  Post-treatment (n = 53)
22.42 (2.25)
  
  3-month follow-up (n = 45)
21.01 (2.40)
− 1.41 (− 6.46 to 3.63); p = 0.583
0.12 (− 0.18 to 0.41)
  6-month follow-up (n = 40)
22.02 (2.51)
− 0.41 (− 5.64 to 4.83); p = 0.879
0.05 (− 0.28 to 0.38)
  12-month follow-up (n = 35)
19.25 (2.64)
− 3.17 (− 8.66 to 2.31); p = 0.257
0.15 (− 0.17 to 0.46)
GTS-quality of life scale
  Post-treatment (n = 40)
15.01 (2.03)
  
  3-month follow-up (n = 41)
16.30 (2.02)
1.29 (− 2.51 to 5.09); p = 0.506
− 0.12 (− 0.35 to 0.11)
  6-month follow-up (n = 33)
17.08 (2.15)
2.07 (− 2.02 to 6.16); p = 0.321
− 0.16 (− 0.43 to 0.12)
  12-month follow-up (n = 28)
19.37 (2.27)
4.36 (0.01 to 8.70); p = 0.049*
− 0.30 (− 0.60 to 0.00)
Premonitory urge for tics scale
  Post-treatment (n = 46)
20.28 (0.85)
  
  3-month follow-up (n = 45)
20.38 (0.86)
0.10 (− 1.42 to 1.62); p = 0.893
− 0.06 (-0.31 to 0.18)
  6-month follow-up (n = 35)
19.16 (0.92)
− 1.11 (− 2.76 to 0.53); p = 0.185
0.15 (− 0.09 to 0.39)
  12-month follow-up (n = 29)
20.52 (0.97)
0.24 (− 1.48 to 1.96); p = 0.784
0.04 (− 0.25 to 0.33)
BT behaviour therapy, CI confidence interval, CTD chronic motor or vocal tic disorder, GTS Gilles de la Tourette, SE standard error, TS Tourette syndrome
A  Estimated means from the mixed-effects regression model
B  Coefficients at the 3-month, 6-month, and 12-month follow-ups compare with the post-treatment time point
C  Bootstrapped effect sizes (d) are derived from the mixed-effects regression model. Effect sizes of 0.2, 0.5, and 0.8 are considered small, moderate, and large, respectively
*Significant at an alpha level of 0.05
At the time of the data freeze, 11 participants were still active at the clinic and had not yet reached the 12-month follow-up. For the remaining 63 participants, 39 (75%, available data for n = 52) were classified as treatment responders at the 12-month follow-up. Numbers were too small to report on the specific BT modalities. Between the post-treatment and the 12-month follow-up time points, the 63 participants received on average 3.02 additional follow-up sessions (SD = 1.64, range = 0–10, complete data). The follow-up sessions primarily consisted of a YGTSS administration and brief clinical advice to promote the maintenance of the treatment effects. For participants who received more than 3 follow-up sessions, the additional sessions were considered as pure booster sessions focused on improving TS/CTD symptoms.
Additionally, comparing data from the post-treatment and the 12-month follow-up time points, 4 out of 74 participants (5%; available data for n = 53) changed their medication (α2-agonists or antipsychotics): 2 participants (3%) either increased their dosage or started medication, 1 participant (1%) switched from one compound to another, and 1 participant (1%) decreased his dosage. A mixed-effects regression analysis excluding these 4 participants from the total BT sample showed a similar continued improvement between the post-treatment and the 12-month follow-up time points on the YGTSS-TTSS as in the main model (coefficient [95% CI]  − 1.86 [− 3.64 to − 0.07], p = 0.041).
Regarding the self- and parent-reported measures, mixed-effects regression analyses showed that the gains were maintained (i.e., unchanged) between post-treatment and the 12-month follow-up on the PTQ, the PUTS, the OCI-CV, the SMFQ-PV, the WSAS-Y, and the WSAS-P. For the GTS-QOL and the CDI-S and the SMFQ-CV combined to z-scores, mixed-effects regression analyses showed that symptoms significantly deteriorated between the same time points. Full details are presented in Table 3 and Supplementary Table S9. Note that long-term follow-up analyses only were performed for the total BT sample due to an increased amount of missing data in the later time points.

Discussion

This study evaluated the effectiveness of BT for young people with TS/CTD in a naturalistic setting, a TS/CTD specialist outpatient clinic in Stockholm, Sweden. Additionally, the study examined the long-term maintenance (up to 1 year after the end of treatment) of the treatment effects, regardless of whether the participants had initially responded to treatment.
Baseline participant characteristics were in many respects consistent with existing literature [9, 11, 12, 37], including the age of tic onset, mean age, sex ratio, type of tic disorder ratio, and the mean baseline YGTSS-TTSS score. A majority of the participants received ERP (62%) compared to HRT (19%) and other BT (19%). The therapists’ preference for ERP may have been influenced by various factors, including their participation in an ERP training workshop during the study period, their familiarity with ERP from treating other related disorders (primarily obsessive–compulsive disorder), and that in Europe ERP is generally more frequently used than HRT/CBIT.
Tic severity and tic-related impairment (as measured by the YGTSS) improved significantly for both the total BT sample and each separate BT modality, with within-group effect sizes consistently in the large range. The estimated reduction of 7.7 raw points on the YGTSS-TTSS for the total BT sample at post-treatment was in line with several major RCTs of BT for TS/CTD (range = 3.4-8.5 raw points) [9, 11, 12]. Further, the 7.7 raw points equals an average tic severity reduction of 33%, which is well above the proposed 25% reduction corresponding to a clinically meaningful change [38]. The treatment response rate of 57% at post-treatment was comparable to the 53% reported for CBIT/HRT in the largest RCT to date [9]. Thus, we did not observe worse outcomes in a naturalistic setting, compared to controlled settings, as reported for other common psychiatric disorders [15, 16].
Results from self- and parent-reported measures were also generally positive, with significant improvements on measures of tic severity, TS/CTD-specific health-related quality of life, obsessive–compulsive symptoms, depression, and global functional impairment. More specifically, the estimated reduction of 14.6 raw points on the PTQ was above the proposed 10-point reduction indicative for positive clinical change [39]. Percentage wise, however, the 39% reduction on the PTQ was below the proposed 45% to 55% range for positive treatment response [39]. Similarly to previous trials of BT for TS/CTD [18, 40, 41], we did not observe significant improvements on the PUTS, suggesting that premonitory urges are not amenable to modification with BT.
Regarding long-term durability of the treatment effects, tic severity and tic-related impairment (as measured by the YGTSS) improved further between post-treatment and the 12-month follow-up. The treatment response rate for the total BT sample increased from 57% at post-treatment to 75% at the 12-month follow-up. Taken together, these results indicate that the effects of BT delivered in a naturalistic specialist clinical setting are maintained for at least 1 year after the end of treatment. Thus, this study provides important new information, as published RCTs have typically not followed patients for longer than 6 months after the end of treatment and have only followed treatment responders [9, 11].
This study had several strengths, primarily related to its naturalistic design and the inclusion of a long-term follow-up. External validity was arguably higher than in the typical RCT given that treatment was provided in a naturalistic setting, no specific eligibility criteria were used (e.g., 11% of the sample had comorbid autism spectrum disorder), and concurrent interventions (such as medication) were allowed. However, this study also had limitations. By definition, the naturalistic design did not control for the natural passage of time, meaning that participants could potentially have improved due to reasons unrelated to the interventions provided, such as ‘regression to the mean’ or the natural waxing and waning of tics. The study is further limited by missing data, especially for self- and parent-reported measures and later follow-up time points. Clinician-rated measures (including the YGTSS) were administered by the therapists providing treatment, rather than independent assessors. A small proportion of participants were on TS/CTD medication or changed their medication during the study period, but sensitivity analyses excluding these participants did not modify the results. We recruited a consecutive sample of patients referred to our clinic but the proportion of individuals who did not consent to participation is unknown because we did not have ethical approval to save their data. However, in our experience, the vast majority of families agreed to be included in the study. Lastly, it is important to note that, even if the study design was naturalistic, the patients were still seen in a specialist setting and treated by trained therapists using evidence-based treatment manuals. The results might therefore not be generalisable to general CAMHS or other healthcare settings.

Summary

To our knowledge, the current study is the largest to date evaluating BT for young people with TS/CTD in a naturalistic setting. The results confirmed that BT is an effective and durable treatment for young people with TS/CTD in a specialist clinical context, with effects comparable to those reported in RCTs.

Acknowledgements

This work used services from the eHealth Core Facility at Karolinska Institutet, which is supported by the Strategic Research Area Healthcare Science (SFO-V).

Compliance with Ethical Standards

Conflict of interest

LFC receives royalties for contributing articles to UpToDate, Wolters Kluwer Health. DM-C receives royalties for contributing articles to UpToDate, Wolters Kluwer Health and for editorial work from Elsevier. The other authors report no biomedical financial interests or potential conflicts of interest.

Ethical Approval

All procedures performed in the study were in accordance with the ethical standards of the national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the Swedish Ethical Review Authority (reference number: 2015/1977-31/4 [2019-02132]).
Informed consent was obtained from all individual participants (and their parents/legal guardians) included in the study.
Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://​creativecommons.​org/​licenses/​by/​4.​0/​.

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Literatuur
1.
go back to reference American Psychiatric Association (2013) Diagnostic and Statistical manual of mental disorders: DSM-5, 5th edn. American Psychiatric Publishing, Washington, DCCrossRef American Psychiatric Association (2013) Diagnostic and Statistical manual of mental disorders: DSM-5, 5th edn. American Psychiatric Publishing, Washington, DCCrossRef
2.
go back to reference Eapen V, Cavanna AE, Robertson MM (2016) Comorbidities, social impact, and quality of life in tourette syndrome. Front Psychiatry 7:97CrossRef Eapen V, Cavanna AE, Robertson MM (2016) Comorbidities, social impact, and quality of life in tourette syndrome. Front Psychiatry 7:97CrossRef
3.
go back to reference Pérez-Vigil A, Fernández de la Cruz L, Brander G, Isomura K, Jangmo A, Kuja-Halkola R, Hesselmark E, D’Onofrio BM, Larsson H, Mataix-Cols D (2018) Association of Tourette syndrome and chronic tic disorders with objective indicators of educational attainment: a population-based sibling comparison study. JAMA Neurol 75:1098–1105 Pérez-Vigil A, Fernández de la Cruz L, Brander G, Isomura K, Jangmo A, Kuja-Halkola R, Hesselmark E, D’Onofrio BM, Larsson H, Mataix-Cols D (2018) Association of Tourette syndrome and chronic tic disorders with objective indicators of educational attainment: a population-based sibling comparison study. JAMA Neurol 75:1098–1105
4.
go back to reference Hollis C, Pennant M, Cuenca J, Glazebrook C, Kendall T, Whittington C, Stockton S, Larsson L, Bunton P, Dobson S, Groom M, Hedderly T, Heyman I, Jackson GM, Jackson S, Murphy T, Rickards H, Robertson M, Stern J (2016) Clinical effectiveness and patient perspectives of different treatment strategies for tics in children and adolescents with Tourette syndrome: a systematic review and qualitative analysis. Health Technol Assess 20:1–450CrossRef Hollis C, Pennant M, Cuenca J, Glazebrook C, Kendall T, Whittington C, Stockton S, Larsson L, Bunton P, Dobson S, Groom M, Hedderly T, Heyman I, Jackson GM, Jackson S, Murphy T, Rickards H, Robertson M, Stern J (2016) Clinical effectiveness and patient perspectives of different treatment strategies for tics in children and adolescents with Tourette syndrome: a systematic review and qualitative analysis. Health Technol Assess 20:1–450CrossRef
5.
go back to reference Pringsheim T, Okun MS, Muller-Vahl K, Martino D, Jankovic J, Cavanna AE, Woods DW, Robinson M, Jarvie E, Roessner V, Oskoui M, Holler-Managan Y, Piacentini J (2019) Practice guideline recommendations summary: treatment of tics in people with Tourette syndrome and chronic tic disorders. Neurology 92:896–906CrossRef Pringsheim T, Okun MS, Muller-Vahl K, Martino D, Jankovic J, Cavanna AE, Woods DW, Robinson M, Jarvie E, Roessner V, Oskoui M, Holler-Managan Y, Piacentini J (2019) Practice guideline recommendations summary: treatment of tics in people with Tourette syndrome and chronic tic disorders. Neurology 92:896–906CrossRef
6.
go back to reference Verdellen CW, van de Griendt J, Hartmann A, Murphy T (2011) European clinical guidelines for Tourette syndrome and other tic disorders. Part III: behavioural and psychosocial interventions. Eur Child Adolesc Psychiatry 20:197–207CrossRef Verdellen CW, van de Griendt J, Hartmann A, Murphy T (2011) European clinical guidelines for Tourette syndrome and other tic disorders. Part III: behavioural and psychosocial interventions. Eur Child Adolesc Psychiatry 20:197–207CrossRef
7.
go back to reference Steeves T, McKinlay BD, Gorman D, Billinghurst L, Day L, Carroll A, Dion Y, Doja A, Luscombe S, Sandor P, Pringsheim T (2012) Canadian guidelines for the evidence-based treatment of tic disorders: behavioural therapy, deep brain stimulation, and transcranial magnetic stimulation. Can J Psychiatry 57:144–151CrossRef Steeves T, McKinlay BD, Gorman D, Billinghurst L, Day L, Carroll A, Dion Y, Doja A, Luscombe S, Sandor P, Pringsheim T (2012) Canadian guidelines for the evidence-based treatment of tic disorders: behavioural therapy, deep brain stimulation, and transcranial magnetic stimulation. Can J Psychiatry 57:144–151CrossRef
8.
go back to reference Pringsheim T, Holler-Managan Y, Okun MS, Jankovic J, Piacentini J, Cavanna AE, Martino D, Muller-Vahl K, Woods DW, Robinson M, Jarvie E, Roessner V, Oskoui M (2019) Comprehensive systematic review summary: treatment of tics in people with Tourette syndrome and chronic tic disorders. Neurology 92:907–915CrossRef Pringsheim T, Holler-Managan Y, Okun MS, Jankovic J, Piacentini J, Cavanna AE, Martino D, Muller-Vahl K, Woods DW, Robinson M, Jarvie E, Roessner V, Oskoui M (2019) Comprehensive systematic review summary: treatment of tics in people with Tourette syndrome and chronic tic disorders. Neurology 92:907–915CrossRef
9.
go back to reference Piacentini J, Woods DW, Scahill L, Wilhelm S, Peterson AL, Chang S, Ginsburg GS, Deckersbach T, Dziura J, Levi-Pearl S, Walkup JT (2010) Behavior therapy for children with Tourette disorder: a randomized controlled trial. JAMA 303:1929–1937CrossRef Piacentini J, Woods DW, Scahill L, Wilhelm S, Peterson AL, Chang S, Ginsburg GS, Deckersbach T, Dziura J, Levi-Pearl S, Walkup JT (2010) Behavior therapy for children with Tourette disorder: a randomized controlled trial. JAMA 303:1929–1937CrossRef
10.
go back to reference Wilhelm S, Deckersbach T, Coffey BJ, Bohne A, Peterson AL, Baer L (2003) Habit reversal versus supportive psychotherapy for Tourette’s disorder: a randomized controlled trial. Am J Psychiatry 160:1175–1177CrossRef Wilhelm S, Deckersbach T, Coffey BJ, Bohne A, Peterson AL, Baer L (2003) Habit reversal versus supportive psychotherapy for Tourette’s disorder: a randomized controlled trial. Am J Psychiatry 160:1175–1177CrossRef
11.
go back to reference Wilhelm S, Peterson AL, Piacentini J, Woods DW, Deckersbach T, Sukhodolsky DG, Chang S, Liu H, Dziura J, Walkup JT, Scahill L (2012) Randomized trial of behavior therapy for adults with Tourette syndrome. Arch Gen Psychiatry 69:795–803CrossRef Wilhelm S, Peterson AL, Piacentini J, Woods DW, Deckersbach T, Sukhodolsky DG, Chang S, Liu H, Dziura J, Walkup JT, Scahill L (2012) Randomized trial of behavior therapy for adults with Tourette syndrome. Arch Gen Psychiatry 69:795–803CrossRef
12.
go back to reference Verdellen CW, Keijsers GP, Cath DC, Hoogduin CA (2004) Exposure with response prevention versus habit reversal in Tourettes’s syndrome: a controlled study. Behav Res Ther 42:501–511CrossRef Verdellen CW, Keijsers GP, Cath DC, Hoogduin CA (2004) Exposure with response prevention versus habit reversal in Tourettes’s syndrome: a controlled study. Behav Res Ther 42:501–511CrossRef
13.
go back to reference Singal AG, Higgins PD, Waljee AK (2014) A primer on effectiveness and efficacy trials. Clin Transl Gastroenterol 5:e45CrossRef Singal AG, Higgins PD, Waljee AK (2014) A primer on effectiveness and efficacy trials. Clin Transl Gastroenterol 5:e45CrossRef
14.
go back to reference Godwin M, Ruhland L, Casson I, MacDonald S, Delva D, Birtwhistle R, Lam M, Seguin R (2003) Pragmatic controlled clinical trials in primary care: the struggle between external and internal validity. BMC Med Res Methodol 3:28CrossRef Godwin M, Ruhland L, Casson I, MacDonald S, Delva D, Birtwhistle R, Lam M, Seguin R (2003) Pragmatic controlled clinical trials in primary care: the struggle between external and internal validity. BMC Med Res Methodol 3:28CrossRef
15.
go back to reference Weisz JR, Jensen-Doss A, Hawley KM (2006) Evidence-based youth psychotherapies versus usual clinical care: a meta-analysis of direct comparisons. Am Psychol 61:671–689CrossRef Weisz JR, Jensen-Doss A, Hawley KM (2006) Evidence-based youth psychotherapies versus usual clinical care: a meta-analysis of direct comparisons. Am Psychol 61:671–689CrossRef
16.
go back to reference Weisz JR, Kuppens S, Eckshtain D, Ugueto AM, Hawley KM, Jensen-Doss A (2013) Performance of evidence-based youth psychotherapies compared with usual clinical care: a multilevel meta-analysis. JAMA Psychiatry 70:750–761CrossRef Weisz JR, Kuppens S, Eckshtain D, Ugueto AM, Hawley KM, Jensen-Doss A (2013) Performance of evidence-based youth psychotherapies compared with usual clinical care: a multilevel meta-analysis. JAMA Psychiatry 70:750–761CrossRef
17.
go back to reference Dreison KC, Lagges AM (2017) Effectiveness of the Comprehensive Behavioral Intervention for Tics (CBIT) in a Pediatric Psychiatry Clinic: a Retrospective Chart Review. Clin Pract Pediatr Psychol 2:180–185CrossRef Dreison KC, Lagges AM (2017) Effectiveness of the Comprehensive Behavioral Intervention for Tics (CBIT) in a Pediatric Psychiatry Clinic: a Retrospective Chart Review. Clin Pract Pediatr Psychol 2:180–185CrossRef
18.
go back to reference Andrén P, Aspvall K, Fernández de la Cruz L, Wiktor P, Romano S, Andersson E, Murphy T, Isomura K, Serlachius E, Mataix-Cols D (2019) Therapist-guided and parent-guided internet-delivered behaviour therapy for paediatric Tourette’s disorder: a pilot randomised controlled trial with long-term follow-up. BMJ Open 9:e024685CrossRef Andrén P, Aspvall K, Fernández de la Cruz L, Wiktor P, Romano S, Andersson E, Murphy T, Isomura K, Serlachius E, Mataix-Cols D (2019) Therapist-guided and parent-guided internet-delivered behaviour therapy for paediatric Tourette’s disorder: a pilot randomised controlled trial with long-term follow-up. BMJ Open 9:e024685CrossRef
19.
go back to reference Sheehan DV, Sheehan KH, Shytle RD, Janavs J, Bannon Y, Rogers JE, Milo KM, Stock SL, Wilkinson B (2010) Reliability and validity of the Mini International Neuropsychiatric Interview for Children and Adolescents (MINI-KID). J Clin Psychiatry 71:313–326CrossRef Sheehan DV, Sheehan KH, Shytle RD, Janavs J, Bannon Y, Rogers JE, Milo KM, Stock SL, Wilkinson B (2010) Reliability and validity of the Mini International Neuropsychiatric Interview for Children and Adolescents (MINI-KID). J Clin Psychiatry 71:313–326CrossRef
20.
go back to reference World Health Organization (1992) International statistical classification of diseases and related health problems. 10th revision. edn. World Health Organization, Geneva World Health Organization (1992) International statistical classification of diseases and related health problems. 10th revision. edn. World Health Organization, Geneva
21.
go back to reference Leckman JF, Riddle MA, Hardin MT, Ort SI, Swartz KL, Stevenson J, Cohen DJ (1989) The Yale Global Tic Severity Scale: initial testing of a clinician-rated scale of tic severity. J Am Acad Child Adolesc Psychiatry 28:566–573CrossRef Leckman JF, Riddle MA, Hardin MT, Ort SI, Swartz KL, Stevenson J, Cohen DJ (1989) The Yale Global Tic Severity Scale: initial testing of a clinician-rated scale of tic severity. J Am Acad Child Adolesc Psychiatry 28:566–573CrossRef
22.
go back to reference Pietracupa S, Bruno E, Cavanna AE, Falla M, Zappia M, Colosimo C (2015) Scales for hyperkinetic disorders: a systematic review. J Neurol Sci 358:9–21CrossRef Pietracupa S, Bruno E, Cavanna AE, Falla M, Zappia M, Colosimo C (2015) Scales for hyperkinetic disorders: a systematic review. J Neurol Sci 358:9–21CrossRef
23.
go back to reference Storch EA, Murphy TK, Geffken GR, Sajid M, Allen P, Roberti JW, Goodman WK (2005) Reliability and validity of the Yale Global Tic Severity Scale. Psychol Assess 17:486–491CrossRef Storch EA, Murphy TK, Geffken GR, Sajid M, Allen P, Roberti JW, Goodman WK (2005) Reliability and validity of the Yale Global Tic Severity Scale. Psychol Assess 17:486–491CrossRef
24.
go back to reference Storch EA, Murphy TK, Fernandez M, Krishnan M, Geffken GR, Kellgren AR, Goodman WK (2007) Factor-analytic study of the Yale Global Tic Severity Scale. Psychiatry Res 149:231–237CrossRef Storch EA, Murphy TK, Fernandez M, Krishnan M, Geffken GR, Kellgren AR, Goodman WK (2007) Factor-analytic study of the Yale Global Tic Severity Scale. Psychiatry Res 149:231–237CrossRef
25.
go back to reference Guy W (1976) Clinical Global Impression Scales (CGI). ECDEU Assessment Manual for Psychopharmacology (Publication 76-338) Washington, DC: Department of Health, Education, and Welfare Guy W (1976) Clinical Global Impression Scales (CGI). ECDEU Assessment Manual for Psychopharmacology (Publication 76-338) Washington, DC: Department of Health, Education, and Welfare
26.
go back to reference Shaffer D, Gould MS, Brasic J, Ambrosini P, Fisher P, Bird H, Aluwahlia S (1983) A children’s global assessment scale (CGAS). Arch Gen Psychiatry 40:1228–1231CrossRef Shaffer D, Gould MS, Brasic J, Ambrosini P, Fisher P, Bird H, Aluwahlia S (1983) A children’s global assessment scale (CGAS). Arch Gen Psychiatry 40:1228–1231CrossRef
27.
go back to reference Woods DW, Piacentini J, Himle MB, Chang S (2005) Premonitory Urge for Tics Scale (PUTS): initial psychometric results and examination of the premonitory urge phenomenon in youths with Tic disorders. J Dev Behav Pediatr 26:397–403CrossRef Woods DW, Piacentini J, Himle MB, Chang S (2005) Premonitory Urge for Tics Scale (PUTS): initial psychometric results and examination of the premonitory urge phenomenon in youths with Tic disorders. J Dev Behav Pediatr 26:397–403CrossRef
28.
go back to reference Raines JM, Edwards KR, Sherman MF, Higginson CI, Winnick JB, Navin K, Gettings JM, Conteh F, Bennett SM, Specht MW (2018) Premonitory Urge for Tics Scale (PUTS): replication and extension of psychometric properties in youth with chronic tic disorders (CTDs). J Neural Transm (Vienna) 125:727–734CrossRef Raines JM, Edwards KR, Sherman MF, Higginson CI, Winnick JB, Navin K, Gettings JM, Conteh F, Bennett SM, Specht MW (2018) Premonitory Urge for Tics Scale (PUTS): replication and extension of psychometric properties in youth with chronic tic disorders (CTDs). J Neural Transm (Vienna) 125:727–734CrossRef
29.
go back to reference Cavanna AE, Schrag A, Morley D, Orth M, Robertson MM, Joyce E, Critchley HD, Selai C (2008) The Gilles de la Tourette syndrome-quality of life scale (GTS-QOL): development and validation. Neurology 71:1410–1416CrossRef Cavanna AE, Schrag A, Morley D, Orth M, Robertson MM, Joyce E, Critchley HD, Selai C (2008) The Gilles de la Tourette syndrome-quality of life scale (GTS-QOL): development and validation. Neurology 71:1410–1416CrossRef
30.
go back to reference Foa EB, Coles M, Huppert JD, Pasupuleti RV, Franklin ME, March J (2010) Development and validation of a child version of the obsessive compulsive inventory. Behav Ther 41:121–132CrossRef Foa EB, Coles M, Huppert JD, Pasupuleti RV, Franklin ME, March J (2010) Development and validation of a child version of the obsessive compulsive inventory. Behav Ther 41:121–132CrossRef
31.
go back to reference Allgaier AK, Fruhe B, Pietsch K, Saravo B, Baethmann M, Schulte-Korne G (2012) Is the Children’s Depression Inventory Short version a valid screening tool in pediatric care? A comparison to its full-length version. J Psychosom Res 73:369–374CrossRef Allgaier AK, Fruhe B, Pietsch K, Saravo B, Baethmann M, Schulte-Korne G (2012) Is the Children’s Depression Inventory Short version a valid screening tool in pediatric care? A comparison to its full-length version. J Psychosom Res 73:369–374CrossRef
32.
go back to reference Angold A, Costello E, Messer S, Pickles A, Winder F, Silver D (1995) The development of a questionnaire for use in epidemiological studies of depression in children and adolescents. Int J Methods Psychiatr Res 5:237–249 Angold A, Costello E, Messer S, Pickles A, Winder F, Silver D (1995) The development of a questionnaire for use in epidemiological studies of depression in children and adolescents. Int J Methods Psychiatr Res 5:237–249
33.
go back to reference Jassi A, Lenhard F, Krebs G, Gumpert M, Jolstedt M, Andrén P, Nord M, Aspvall K, Wahlund T, Volz C, Mataix-Cols D (2020) The work and social adjustment scale, youth and parent versions: psychometric evaluation of a brief measure of functional impairment in young people. Child Psychiatry Hum Dev 51:453–460CrossRef Jassi A, Lenhard F, Krebs G, Gumpert M, Jolstedt M, Andrén P, Nord M, Aspvall K, Wahlund T, Volz C, Mataix-Cols D (2020) The work and social adjustment scale, youth and parent versions: psychometric evaluation of a brief measure of functional impairment in young people. Child Psychiatry Hum Dev 51:453–460CrossRef
34.
go back to reference Chang S, Himle MB, Tucker BTP, Woods DW, Piacentini J (2009) Initial psychometric properties of a brief parent-report instrument for assessing tic severity in children with chronic tic disorders. Child Fam Behav Ther 31:181–191CrossRef Chang S, Himle MB, Tucker BTP, Woods DW, Piacentini J (2009) Initial psychometric properties of a brief parent-report instrument for assessing tic severity in children with chronic tic disorders. Child Fam Behav Ther 31:181–191CrossRef
35.
go back to reference Woods DW, Piacentini JC, Chang SW, Deckersbach T, Ginsburg GS, Peterson AL, Scahill LD, Walkup JT, Wilhelm S (2008) Managing Tourette syndrome : a behavioral intervention for children and adults : therapist guide. Treatments that work. Oxford University Press, Oxford Woods DW, Piacentini JC, Chang SW, Deckersbach T, Ginsburg GS, Peterson AL, Scahill LD, Walkup JT, Wilhelm S (2008) Managing Tourette syndrome : a behavioral intervention for children and adults : therapist guide. Treatments that work. Oxford University Press, Oxford
36.
go back to reference Verdellen CW, van de Griendt J, Kriens S, van Oostrum I (2011) Tics-therapist manual. Boom Publishers, Amsterdam Verdellen CW, van de Griendt J, Kriens S, van Oostrum I (2011) Tics-therapist manual. Boom Publishers, Amsterdam
37.
go back to reference Bloch MH, Leckman JF (2009) Clinical course of Tourette syndrome. J Psychosom Res 67:497–501CrossRef Bloch MH, Leckman JF (2009) Clinical course of Tourette syndrome. J Psychosom Res 67:497–501CrossRef
38.
go back to reference Jeon S, Walkup JT, Woods DW, Peterson A, Piacentini J, Wilhelm S, Katsovich L, McGuire JF, Dziura J, Scahill L (2013) Detecting a clinically meaningful change in tic severity in Tourette syndrome: a comparison of three methods. Contemp Clin Trials 36:414–420CrossRef Jeon S, Walkup JT, Woods DW, Peterson A, Piacentini J, Wilhelm S, Katsovich L, McGuire JF, Dziura J, Scahill L (2013) Detecting a clinically meaningful change in tic severity in Tourette syndrome: a comparison of three methods. Contemp Clin Trials 36:414–420CrossRef
39.
go back to reference Ricketts EJ, McGuire JF, Chang S, Bose D, Rasch MM, Woods DW, Specht MW, Walkup JT, Scahill L, Wilhelm S, Peterson AL, Piacentini J (2018) Benchmarking treatment response in Tourette’s disorder: a psychometric evaluation and signal detection analysis of the parent tic questionnaire. Behav Ther 49:46–56CrossRef Ricketts EJ, McGuire JF, Chang S, Bose D, Rasch MM, Woods DW, Specht MW, Walkup JT, Scahill L, Wilhelm S, Peterson AL, Piacentini J (2018) Benchmarking treatment response in Tourette’s disorder: a psychometric evaluation and signal detection analysis of the parent tic questionnaire. Behav Ther 49:46–56CrossRef
40.
go back to reference Nissen JB, Kaergaard M, Laursen L, Parner E, Thomsen PH (2019) Combined habit reversal training and exposure response prevention in a group setting compared to individual training: a randomized controlled clinical trial. Eur Child Adolesc Psychiatry 28:57–68CrossRef Nissen JB, Kaergaard M, Laursen L, Parner E, Thomsen PH (2019) Combined habit reversal training and exposure response prevention in a group setting compared to individual training: a randomized controlled clinical trial. Eur Child Adolesc Psychiatry 28:57–68CrossRef
41.
go back to reference Houghton DC, Capriotti MR, Scahill LD, Wilhelm S, Peterson AL, Walkup JT, Piacentini J, Woods DW (2017) Investigating habituation to premonitory urges in behavior therapy for tic disorders. Behav Ther 48:834–846CrossRef Houghton DC, Capriotti MR, Scahill LD, Wilhelm S, Peterson AL, Walkup JT, Piacentini J, Woods DW (2017) Investigating habituation to premonitory urges in behavior therapy for tic disorders. Behav Ther 48:834–846CrossRef
Metagegevens
Titel
Effectiveness of Behaviour Therapy for Children and Adolescents with Tourette Syndrome and Chronic Tic Disorder in a Naturalistic Setting
Auteurs
Per Andrén
Vera Wachtmeister
Julia Franzé
Caroline Speiner
Lorena Fernández de la Cruz
Erik Andersson
Elles de Schipper
Daniel Rautio
Maria Silverberg-Mörse
Eva Serlachius
David Mataix-Cols
Publicatiedatum
14-12-2020
Uitgeverij
Springer US
Gepubliceerd in
Child Psychiatry & Human Development / Uitgave 4/2021
Print ISSN: 0009-398X
Elektronisch ISSN: 1573-3327
DOI
https://doi.org/10.1007/s10578-020-01098-y

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