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14-12-2020 | Original Article | Uitgave 4/2021 Open Access

Child Psychiatry & Human Development 4/2021

Effectiveness of Behaviour Therapy for Children and Adolescents with Tourette Syndrome and Chronic Tic Disorder in a Naturalistic Setting

Child Psychiatry & Human Development > Uitgave 4/2021
Per Andrén, Vera Wachtmeister, Julia Franzé, Caroline Speiner, Lorena Fernández de la Cruz, Erik Andersson, Elles de Schipper, Daniel Rautio, Maria Silverberg-Mörse, Eva Serlachius, David Mataix-Cols
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Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s10578-020-01098-y) contains supplementary material, which is available to authorized users.
Preprint: This manuscript has been published as a preprint at the PsyArXiv preprint depository, DOI: https://​doi.​org/​10.​31234/​osf.​io/​hbrm4

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It is unclear if the results of randomised controlled trials (RCTs) of behaviour therapy (BT) for Tourette syndrome (TS) and chronic tic disorder (CTD) can be generalised to naturalistic clinical settings and are durable long-term. In this naturalistic study, 74 young people with TS/CTD received BT at a specialist clinic. Data were collected at baseline, post-treatment, and at 3-, 6-, and 12-month follow-ups. Measures included the Yale Global Tic Severity Scale (YGTSS) and the Clinical Global Impression-Improvement scale (CGI-I), amongst others. Tic severity and tic-related impairment improved after treatment, with large within-group effect sizes. At post-treatment, 57% of the participants were classified as treatment responders according to the CGI-I. Tic severity and tic-related impairment improved further through the follow-up, with 75% treatment responders at the 12-month follow-up. BT is an effective and durable treatment for young people with TS/CTD in a naturalistic specialist clinical setting, with comparable effects to RCTs.

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