Gepubliceerd in:

01-02-2013

Effect of oxidative stress on respiratory epithelium from children with Down syndrome

Auteurs: Martijn Bruijn, René Lutter, Eric Eldering, Albert P. Bos, Job B.M. van Woensel

Gepubliceerd in: Tijdschrift voor Kindergeneeskunde | bijlage 1/2013

Extract

Children with Down syndrome (DS) are at high risk for ARDS. In DS, both regulation of inflammation and apoptosis, important in ARDS pathophysiology, are abnormal. This has been linked to an imbalance in free radical scavengers. We investigated the expression of free radical scavengers and the effect of oxidative stress in terms of apoptosis and inflammation in respiratory epithelium from children with DS compared to controls. …

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