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06-12-2019 | Original Paper

EEG Spectral Features in Sleep of Autism Spectrum Disorders in Children with Tuberous Sclerosis Complex

Auteurs: Ian A. Cook, Andrew C. Wilson, Jurriaan M. Peters, Monisha N. Goyal, E. Martina Bebin, Hope Northrup, Darcy Krueger, Andrew F. Leuchter, Mustafa Sahin, the TACERN Study Group

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 3/2020

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Abstract

Tuberous sclerosis complex (TSC) is a multisystem disorder with increased prevalence of autism spectrum disorders (ASDs). This project aimed to characterize the autism phenotype of TSC and identify biomarkers of risk for ASD. Because abnormalities of EEG during sleep are tied to neurodevelopment in children, we compared electroencephalographic (EEG) measures during Stage II sleep in TSC children who either did (ASD+) or did not (ASD−) exhibit symptoms of ASD over 36-month follow up. Relative alpha band power was significantly elevated in the ASD+ group at 24 months of age with smaller differences at younger ages, suggesting this may arise from differences in brain development. These findings suggest that EEG features could enhance the detection of risk for ASD.
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Metagegevens
Titel
EEG Spectral Features in Sleep of Autism Spectrum Disorders in Children with Tuberous Sclerosis Complex
Auteurs
Ian A. Cook
Andrew C. Wilson
Jurriaan M. Peters
Monisha N. Goyal
E. Martina Bebin
Hope Northrup
Darcy Krueger
Andrew F. Leuchter
Mustafa Sahin
the TACERN Study Group
Publicatiedatum
06-12-2019
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 3/2020
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-019-04326-0