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Journal of Autism and Developmental Disorders

Gepubliceerd in:

05-02-2019 | Original Paper

EEG Abnormalities as a Neurophysiological Biomarker of Severity in Autism Spectrum Disorder: A Pilot Cohort Study

Auteurs: Antonio Gennaro Nicotera, Randi Jenssen Hagerman, Maria Vincenza Catania, Serafino Buono, Santo Di Nuovo, Elisa Maria Liprino, Emanuela Stracuzzi, Stefania Giusto, Giuseppina Di Vita, Sebastiano Antonino Musumeci

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 6/2019

Abstract

To date, the phenotypic significance of EEG abnormalities in patients with ASD is unclear. In a population affected by ASD we aimed to evaluate: the phenotypic characteristics; the prevalence of EEG abnormalities; the potential correlations between EEG abnormalities and behavioral and cognitive variables. Sixty-nine patients with ASD underwent cognitive or developmental testing, language assessment, and adaptive behavior skills evaluation as well as sleep/wake EEG recording. EEG abnormalities were found in 39.13% of patients. EEG abnormalities correlated with autism severity, hyperactivity, anger outbursts, aggression, negative or destructive behavior, motor stereotypies, intellectual disability, language impairment and self-harm. Our findings confirmed that EEG abnormalities are present in the ASD population and correlate with several associated phenotypic features.

vorige artikel The Experiences of College Students on the Autism Spectrum: A Comparison to Their Neurotypical Peers

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Akshoomoff, N., Farid, N., Courchesne, E., & Haas, R. (2007). Abnormalities on the neurological examination and EEG in young children with pervasive developmental disorders. Journal of Autism and Developmental Disorders, 37(5), 887–893.CrossRefPubMedPubMedCentral

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders firth edition (DSM-5). Washington DC: APA.CrossRef

Archer, T., & Garcia, D. (2016). Attention-Deficit/hyperactivity disorder: Focus upon aberrant N-methyl-d-aspartate receptors systems. Current Topics in Behavioral Neurosciences, 29, 295–311.CrossRefPubMed

Baglietto, M. G., Battaglia, F. M., Nobili, L., et al. (2001). Neuropsychological disorders related to interictal epileptic discharges during sleep in benign epilepsy of childhood with centrotemporal or Rolandic spikes. Developmental Medicine & Child Neurology, 43(6), 407–412.CrossRef

Baird, G., Robinson, R. O., Boyd, S., & Charman, T. (2006). Sleep electroencephalograms in young children with autism with and without regression. Developmental Medicine & Child Neurology, 48(7), 604–608.CrossRef

Bernard, P. B., Castano, A. M., O’Leary, H., Simpson, K., Browning, M. D., & Benke, T. A. (2013). Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures. Neurobiology of Disease, 59, 1–17.CrossRefPubMedPubMedCentral

Canitano, R., Luchetti, A., & Zappella, M. (2005). Epilepsy, electroencephalographic abnormalities, and regression in children with autism. Journal of Child Neurology, 20(1), 27–31.CrossRefPubMed

Capal, J. K., Carosella, C., Corbin, E., Horn, P. S., Caine, R., & Manning-Courtney, P. (2018). EEG endophenotypes in autism spectrum disorder. Epilepsy & Behavior, 88, 341–348.CrossRef

Caselli, M. C., & Casadio, P. (1995). Il primo vocabolario del bambino. Guida all’uso del questionario MacArthur per la valutazione della comunicazione e del linguaggio nei primi anni di vita. Milano: Franco Angeli.

Chez, M. G., Chang, M., Krasne, V., Coughlan, C., Kominsky, M., & Schwartz, A. (2006). Frequency of epileptiform EEG abnormalities in a sequential screening of autistic patients with no known clinical epilepsy from 1996 to 2005. Epilepsy & Behavior, 8(1), 267–271.CrossRef

Cianchetti, C., & Fancello, G. S. (1997) TVL-Test di Valutazione del Linguaggio. Trento: Erickson.

Deonna, T., & Roulet-Perez, E. (2010). Early-onset acquired epileptic aphasia (Landau-Kleffner syndrome, LKS) and regressive autistic disorders with epileptic EEG abnormalities: the continuing debate. Brain & Development, 32(9), 746–752.CrossRef

Deonna, T., Zesiger, P., Davidoff, V., Maeder, M., Mayor, C., & Roulet, E. (2000). Benign partial epilepsy of childhood: A longitudinal neuropsychological and EEG study of cognitive function. Developmental Medicine & Child Neurology, 42(9), 595–603.CrossRef

Dorothy, V., & Bishop, M. (2009). TROG-2 Test for Reception of Grammar-Version 2. Edizione italiana: Silvana Suraniti, Raffaele Ferri, Vincenzo Ferri. OS Giunti Firenze.

Fonseca, L. C., Tedrus, G. M., & Pacheco, E. M. (2007). Epileptiform EEG discharges in benign childhood epilepsy with centrotemporal spikes: Reactivity and transitory cognitive impairment. Epilepsy & Behavior, 11(1), 65–70.CrossRef

Frye, R. E., Rossignol, D., Casanova, M. F., et al. (2013). A review of traditional and novel treatments for seizures in autism spectrum disorder: Findings from a systematic review and expert panel. Frontiers in Public Health, 1, 31.CrossRefPubMedPubMedCentral

Frye, R. E., Sreenivasula, S., & Adams, J. B. (2011). Traditional and non-traditional treatments for autism spectrum disorder with seizures: An on-line survey. BMC Pediatrics, 11, 37.CrossRefPubMedPubMedCentral

Gabis, L., Pomeroy, J., & Andriola, M. R. (2005). Autism and epilepsy: Cause, consequence, comorbidity, or coincidence? Epilepsy & Behavior, 7(4), 652–656.CrossRef

Giovanardi Rossi, P., Posar, A., & Parmeggiani, A. (2000). Epilepsy in adolescents and young adults with autistic disorder. Brain & Development, 22(2), 102–106.CrossRef

Griffiths, R. (1996). GMDS-ER, Griffiths Mental Development Scales-Extended Revised. Giunti OS-Firenze.

Hagerman, R. J. (2013). Epilepsy drives autism in neurodevelopmental disorders. Developmental Medicine & Child Neurology, 55(2), 101–102.CrossRef

Hagerman, R. J., Berry-Kravis, E., Hazlett, H. C., et al. (2017). Fragile X syndrome. Nature Reviews Disease Primers, 3, 17065.CrossRefPubMed

Hancock, E. C., & Cross, J. H. (2013). Treatment of Lennox–Gastaut syndrome. Cochrane Database of Systematic Reviews, 2, CD003277.

Hartley-McAndrew, M., & Weinstock, A. (2010). Autism spectrum disorder: Correlation between aberrant behaviors, EEG abnormalities and seizures. Surgical Neurology International, 2(1), e10.CrossRef

Hernan, A. E., Alexander, A., Jenks, K. R., et al. (2014). Focal epileptiform activity in the prefrontal cortex is associated with long-term attention and sociability deficits. Neurobiology of Disease, 63, 25–34.CrossRefPubMed

Hrdlicka, M., Komarek, V., Propper, L., et al. (2004). Not EEG abnormalities but epilepsy is associated with autistic regression and mental functioning in childhood autism. Eur Child and Adolescent Psychiatry, 13(4), 209–213.CrossRef

Hughes, J. R., & Melyn, M. (2005). EEG and seizures in autistic children and adolescents: Further findings with therapeutic implications. Clinical EEG Neuroscience, 36(1), 15–20.CrossRefPubMed

Kawasaki, Y., Yokota, K., Shinomiya, M., Shimizu, Y., & Niwa, S. (1997). Brief report: Electroencephalographic paroxysmal activities in the frontal area emerged in middle childhood and during adolescence in a follow-up study of autism. Journal of Autism and Developmental Disorders, 27(5), 605–620.CrossRefPubMed

Kim, H. L., Donnelly, J. H., Tournay, A. E., Book, T. M., & Filipek, P. (2006). Absence of seizures despite high prevalence of epileptiform EEG abnormalities in children with autism monitored in a tertiary care center. Epilepsia, 47(2), 394–398.CrossRefPubMed

Lee, C. H., Lim, S. N., Lien, F., & Wu, T. (2013). Duration of electroencephalographic recordings in patients with epilepsy. Seizure, 22(6), 438–442.CrossRefPubMed

Lesch, K. P. (2016). Maturing insights into the genetic architecture of neurodevelopmental disorders—from common and rare variant interplay to precision psychiatry. J Child Psychology Psychiatry, 57(6), 659–661.CrossRef

Lloyd, M. D. (2000). Peabody-Test di vocabolario recettivo. Edizione italiana: G. Stella, C. Pizzioli, Patrizio E. Tressoldi.

Lord, C., Rutter, M., DiLavore, P. C., Risi, S., Gotham, K., & Bishop, S. L. (2013). Autism diagnostic observation schedule (Second edn.). Los Angeles: Western Psychological Services. Edizione Italiana Colombi, Tancredi, Persico e Faggioli, Hogrefe Editore Firenze.

LoRusso, M. P. (2009). Abilità Pragmatiche nel Linguaggio. Giunti OS: APL Medea.

Losey, T. E., & Uber-Zak, L. (2008). Time to first interictal epileptiform discharge in extended recording EEGs. Journal of Clinical Neurophysiology, 25(6), 357–360.CrossRefPubMed

McVicar, K. A., Ballaban-Gil, K., Rapin, I., Moshé, S. L., & Shinnar, S. (2005). Epileptiform EEG abnormalities in children with language regression. Neurology, 65(1), 129–131.CrossRefPubMed

Millichap, J. G., & Millichap, J. J. (2015). Indications for an EEG in a Child with ADHD. Pediatric Neurology Briefs, 29(5), 39.CrossRefPubMedPubMedCentral

Mulligan, C. K., & Trauner, D. A. (2014). Incidence and behavioral correlates of epileptiform abnormalities in autism spectrum disorders. Journal of Autism and Developmental Disorders, 44(2), 452–458.CrossRefPubMed

Narayanan, J. T., Labar, D. R., & Schaul, N. (2008). Latency to first spike in the EEG of epilepsy patients. Seizure, 17(1), 34–41.CrossRefPubMed

Parmeggiani, A., Posar, A., Antolini, C., Scaduto, M. C., Santucci, M., & Giovanardi-Rossi, P. (2007). Epilepsy in patients with pervasive developmental disorder not otherwise specified. J Child Neurol, 22(10), 1198–1203.CrossRefPubMed

Roid, H. G., & Miller, J. (1997) Leiter international performance scale-revised. Giunti OS: Firenze.

Rossi, P. G., Parmeggiani, A., Bach, V., Santucci, M., & Visconti, P. (1995). EEG features and epilepsy in patients with autism. Brain & Development, 17(3), 169–174.CrossRef

Rutter, M., Bailey, A., & Lord, C. (2003). ADI-R: The autism diagnostic interview-revied. Los Angeles, CA: Western Psychological Services. Edizione italiana a cura di Faggioli, Saccani, Persico, Tancredi, Parrini e Igliozzi. Organizzazioni Speciali-Firenze.

Saemundsen, E., Ludvigsson, P., & Rafnsson, V. (2007). Autism spectrum disorders in children with a history of infantile spasms: A population-based study. Journal of Child Neurology, 22(9), 1102–1107.CrossRefPubMed

Schopler, E., VanBourgondien, M. E., Wellman, G., & Love, S. R. (2014). CARS2. Childhood autism rating scale. Giunti, OS: Firenze.

Sidenvall, R., & Eeg-Olofsson, O. (1995). Epidemiology of infantile spasms in Sweden. Epilepsia, 36(6), 572–574.CrossRefPubMed

Sparrow, S. S., Balla, D. A., & Cicchetti, D. V. (2003). Vineland adaptive behavior scales. Giunti, OS: Firenze.

Spence, S. J., & Schneider, M. T. (2009). The role of epilepsy and epileptiform EEGs in autism spectrum disorders. Pediatric Research, 65(6), 599–606.CrossRefPubMedPubMedCentral

Stefanatos, G. (2011). Changing perspectives on Landau-Kleffner syndrome. The Clinical Neuropsychologist, 25(6), 963–988.CrossRefPubMed

Trauner, D. A. (2015). Behavioral correlates of epileptiform abnormalities in autism. Epilepsy & Behavior, 47, 163–166.CrossRef

Tuchman, R., & Rapin, I. (2002). Epilepsy in autism. The Lancet Neurology, 1(6), 352–358.CrossRefPubMed

van Eeghen, A. M., Pulsifer, M. B., Merker, V. L., et al. (2013). Understanding relationships between autism, intelligence, and epilepsy: a cross-disorder approach. Developmental Medicine & Child Neurology, 55(2), 146–153.CrossRef

Veerappan, V. D., Sweetha, B., Kavitha, H. R., Sivalingam, B., Nambi, S., & Pauline, L. (2018). Two-Year follow-up of isolated epileptiform discharges in autism: An endophenotypic biomarker? Indian Journal of Psychological Medicine, 40, 219–224.CrossRefPubMedPubMedCentral

Volkmar, F. R., & Nelson, D. S. (1990). Seizure disorders in autism. Journal of the American Academy of Child and Adolescent Psychiatry, 29(1), 127–129.CrossRefPubMed

Wechsler, D. (2008). WAIS-IV: Administration and scoring manual. New York: The Psychological Corporation.

Wechsler, D. (2008). WPPSI-III, Wechsler preschool and primary scale of intelligence-III. Giunti OS: Firenze.

Wechsler, D. (2012). WISC-IV, Wechsler intelligence scale for children. Giunti OS: Firenze .

Yasuhara, A. (2010). Correlation between EEG abnormalities and symptoms of autism spectrum disorder (ASD). Brain & Development, 32(10), 791–798.CrossRef

Titel: EEG Abnormalities as a Neurophysiological Biomarker of Severity in Autism Spectrum Disorder: A Pilot Cohort Study
Auteurs: Antonio Gennaro Nicotera
Randi Jenssen Hagerman
Maria Vincenza Catania
Serafino Buono
Santo Di Nuovo
Elisa Maria Liprino
Emanuela Stracuzzi
Stefania Giusto
Giuseppina Di Vita
Sebastiano Antonino Musumeci
Publicatiedatum: 05-02-2019
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 6/2019
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-019-03908-2

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