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Journal of Autism and Developmental Disorders

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13-08-2019 | Origina lPaper

Early Second Trimester Maternal Serum Steroid-Related Biomarkers Associated with Autism Spectrum Disorder

Auteurs: Deborah A. Bilder, M. Sean Esplin, Hilary Coon, Paul Burghardt, Erin A. S. Clark, Alison Fraser, Ken R. Smith, Whitney Worsham, Katlin Chappelle, Thomas Rayner, Amanda V. Bakian

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 11/2019

Abstract

Epidemiologic studies link increased autism spectrum disorder (ASD) risk to obstetrical conditions associated with inflammation and steroid dysregulation, referred to as prenatal metabolic syndrome (PNMS). This pilot study measured steroid-related biomarkers in early second trimester maternal serum collected during the first and second trimester evaluation of risk study. ASD case and PNMS exposure status of index offspring were determined through linkage with autism registries and birth certificate records. ASD case (N = 53) and control (N = 19) groups were enriched for PNMS exposure. Higher estradiol and lower sex hormone binding globulin (SHBG) were significantly associated with increased ASD risk. Study findings provide preliminary evidence to link greater placental estradiol activity with ASD and support future investigations of the prenatal steroid environment in ASD.

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Titel: Early Second Trimester Maternal Serum Steroid-Related Biomarkers Associated with Autism Spectrum Disorder
Auteurs: Deborah A. Bilder
M. Sean Esplin
Hilary Coon
Paul Burghardt
Erin A. S. Clark
Alison Fraser
Ken R. Smith
Whitney Worsham
Katlin Chappelle
Thomas Rayner
Amanda V. Bakian
Publicatiedatum: 13-08-2019
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 11/2019
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-019-04162-2

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