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Gepubliceerd in: Journal of Abnormal Child Psychology 2/2013

01-02-2013

Early Negative Affect Predicts Anxiety, not Autism, in Preschool Boys with Fragile X Syndrome

Auteurs: Bridgette L. Tonnsen, Patrick S. Malone, Deborah D. Hatton, Jane E. Roberts

Gepubliceerd in: Research on Child and Adolescent Psychopathology | Uitgave 2/2013

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Abstract

Children with fragile X syndrome (FXS) face high risk for anxiety disorders, yet no studies have explored FXS as a high-risk sample for investigating early manifestations of anxiety outcomes. Negative affect is one of the most salient predictors of problem behaviors and has been associated with both anxiety and autistic outcomes in clinical and non-clinical pediatric samples. In light of the high comorbidity between autism and anxiety within FXS, the present study investigates the relationship between longitudinal trajectories of negative affect (between 8 and 71 months) and severity of anxiety and autistic outcomes in young males with FXS (n = 25). Multilevel models indicated associations between elevated anxiety and higher fear and sadness, lower soothability, and steeper longitudinal increases in approach. Autistic outcomes were unrelated to negative affect. These findings suggest early negative affect differentially predicts anxiety, not autistic symptoms, within FXS. Future research is warranted to determine the specificity of the relationship between negative affect and anxiety, as well as to explore potential moderators. Characterizing the relationship between early negative affect and anxiety within FXS may inform etiology and treatment considerations specific to children with FXS, as well as lend insight into precursors of anxiety disorders in other clinical groups and community samples.
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Metagegevens
Titel
Early Negative Affect Predicts Anxiety, not Autism, in Preschool Boys with Fragile X Syndrome
Auteurs
Bridgette L. Tonnsen
Patrick S. Malone
Deborah D. Hatton
Jane E. Roberts
Publicatiedatum
01-02-2013
Uitgeverij
Springer US
Gepubliceerd in
Research on Child and Adolescent Psychopathology / Uitgave 2/2013
Print ISSN: 2730-7166
Elektronisch ISSN: 2730-7174
DOI
https://doi.org/10.1007/s10802-012-9671-2