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Journal of Autism and Developmental Disorders

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03-06-2021 | Original Paper

Early Life Antibiotic Exposure and the Subsequent Risk of Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder: A Systematic Review and Meta-Analysis

Auteurs: Hai-ying Yu, Yuan-yue Zhou, Li-ya Pan, Xue Zhang, Hai-yin Jiang

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 5/2022

Abstract

This study was conducted to assess this association between early life antibiotic exposure and the risk of autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) in later life. The results showed that early life antibiotic exposure was associated with an increased risk of ASD (OR = 1.13, 95% confidence interval (CI): 1.07–1.21) or ADHD (OR = 1.18, 95% CI: 1.1–1.27). However, this association for ASD (OR = 1.04, 95% CI: 0.97–1.11) or ADHD (OR = 0.98, 95% CI: 0.94–1.02) disappeared when data from sibling-matched studies were pooled. The statistically significant association between early life antibiotic exposure and ASD or ADHD in later life can be partially explained by unmeasured genetic and familial confounding factors.

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Titel: Early Life Antibiotic Exposure and the Subsequent Risk of Autism Spectrum Disorder and Attention Deficit Hyperactivity Disorder: A Systematic Review and Meta-Analysis
Auteurs: Hai-ying Yu
Yuan-yue Zhou
Li-ya Pan
Xue Zhang
Hai-yin Jiang
Publicatiedatum: 03-06-2021
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 5/2022
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-021-05121-6

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