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Gepubliceerd in: Journal of Autism and Developmental Disorders 3/2011

01-03-2011 | Original Paper

Early Developmental Regression in Autism Spectrum Disorder: Evidence from an International Multiplex Sample

Auteurs: Jeremy R. Parr, Ann Le Couteur, Gillian Baird, Michael Rutter, Andrew Pickles, Eric Fombonne, Anthony J. Bailey, The International Molecular Genetic Study of Autism Consortium (IMGSAC)

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 3/2011

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Abstract

The characteristics of early developmental regression (EDR) were investigated in individuals with ASD from affected relative pairs recruited to the International Molecular Genetic Study of Autism Consortium (IMGSAC). Four hundred and fifty-eight individuals with ASD were recruited from 226 IMGSAC families. Regression before age 36 months occurred in 23.9% of individuals. The observed concordance rate for EDR within sibling pairs (18.9%) was not significantly above the rate expected under independence (13.5%, p = 0.10). The rate of regression in individuals with ASD from multiplex families was similar to that reported in singleton and epidemiological samples. Regression concordance data were not supportive of a separate familial influence on EDR, other than as a part of autism itself.
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Fifteen individuals lost skills after 36 months of age; eight of these individuals lost language skills, of whom four lost language and non-language skills and four lost language skills only. Seven of the 15 individuals lost non-language skills (most commonly social skills), by comparison with 10/105 individuals with EDR (Table 2), suggesting the possibility that non-language regression may be more common after 36 months. In the 8 individuals who lost language, regression occurred at a mean age of 65.6 months (range 42–144 months); six of these individuals met definite language loss criteria and two individuals lost language that met lower level criteria. At the time of ADI-R administration, twelve of the 15 individuals had a performance IQ > 60 and 9/15 had at least functional phrase speech. Due to the small number of children who lost skills after age 3 years, statistical comparisons with the non-regression group are not possible. Nevertheless, these data suggest that some individuals with ASD do lose language and non-language skills after age 3 years.
 
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Metagegevens
Titel
Early Developmental Regression in Autism Spectrum Disorder: Evidence from an International Multiplex Sample
Auteurs
Jeremy R. Parr
Ann Le Couteur
Gillian Baird
Michael Rutter
Andrew Pickles
Eric Fombonne
Anthony J. Bailey
The International Molecular Genetic Study of Autism Consortium (IMGSAC)
Publicatiedatum
01-03-2011
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 3/2011
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-010-1055-2