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Journal of Autism and Developmental Disorders

Gepubliceerd in:

01-12-2005

Dysbindin (DTNBP1, 6p22.3) is Associated with Childhood-Onset Psychosis and Endophenotypes Measured by the Premorbid Adjustment Scale (PAS)

Auteurs: M. C. Gornick, A. M. Addington, A. Sporn, N. Gogtay, D. Greenstein, M. Lenane, P. Gochman, A. Ordonez, R. Balkissoon, R. Vakkalanka, D. R. Weinberger, J. L. Rapoport, R. E. Straub

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 6/2005

Abstract

Straub et al. (2002) recently identified the 6p22.3 gene dysbindin (DTNBP1) through positional cloning as a schizophrenia susceptibility gene. We studied a rare cohort of 102 children with onset of psychosis before age 13. Standardized ratings of early development, medication response, neuropsychological and cognitive performance, premorbid dysfunction and clinical follow-up were obtained. Fourteen SNPs were genotyped in the gene DTNBP1. Family-based pairwise and haplotype transmission disequilibrium test (TDT) analysis with the clinical phenotype, and quantitative transmission disequilibrium test (QTDT) explored endophenotype relationships. One SNP was associated with diagnosis (TDT p=.01). The QTDT analyses showed several significant relationships. Four adjacent SNPs were associated (p values=.0009–.003) with poor premorbid functioning. These findings support the hypothesis that this and other schizophrenia susceptibility genes contribute to early neurodevelopmental impairment.

vorige artikel Pre-Linguistic Autism Diagnostic Observation Schedule Adapted for Older Individuals with Severe to Profound Mental Retardation: A Pilot Study

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Titel: Dysbindin (DTNBP1, 6p22.3) is Associated with Childhood-Onset Psychosis and Endophenotypes Measured by the Premorbid Adjustment Scale (PAS)
Auteurs: M. C. Gornick
A. M. Addington
A. Sporn
N. Gogtay
D. Greenstein
M. Lenane
P. Gochman
A. Ordonez
R. Balkissoon
R. Vakkalanka
D. R. Weinberger
J. L. Rapoport
R. E. Straub
Publicatiedatum: 01-12-2005
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 6/2005
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-005-0028-3

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