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07-08-2017 | Original Article | Uitgave 10/2017 Open Access

Netherlands Heart Journal 10/2017

Dutch outcome in implantable cardioverter-defibrillator therapy (DO-IT): registry design and baseline characteristics of a prospective observational cohort study to predict appropriate indication for implantable cardioverter-defibrillator

Netherlands Heart Journal > Uitgave 10/2017
M. van Barreveld, M. G. W. Dijkgraaf, M. Hulleman, L. V. A. Boersma, P. P. H. M. Delnoy, M. Meine, A. E. Tuinenburg, D. A. M. J. Theuns, P. H. van der Voort, G. P. Kimman, E. Buskens, J. P. G. Tijssen, N. Bruinsma, T. E. Verstraelen, A. H. Zwinderman, P. H. F. M. van Dessel, A. A. M. Wilde, on behalf of the DO-IT investigators
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Electronic supplementary material

The online version of this article (doi: 10.​1007/​s12471-017-1016-x) contains supplementary material, which is available to authorized users.
A complete list of investigators in the DO-IT Registry is provided in the online supplementary material.



Implantable cardioverter-defibrillators (ICDs) are widely used for the prevention of sudden cardiac death. At present, both clinical benefit and cost-effectiveness of ICD therapy in primary prevention patients are topics of discussion, as only a minority of these patients will eventually receive appropriate ICD therapy.


The DO-IT Registry is a nationwide prospective cohort with a target enrolment of 1,500 primary prevention ICD patients with reduced left ventricular function in a setting of structural heart disease. The primary outcome measures are death and appropriate ICD therapy for ventricular tachyarrhythmias. Secondary outcome measures are inappropriate ICD therapy, death of any cause, hospitalisation for ICD related complications and for cardiovascular reasons. As of December 2016, data on demographic, clinical, and ICD characteristics of 1,468 patients have been collected. Follow-up will continue up to 24 months after inclusion of the last patient. During follow-up, clinical and ICD data are collected based on the normal follow-up of these patients, assuming ICD interrogations take place every six months and clinical follow-up is once a year. At baseline, the mean age was 66 (standard deviation [SD] 10) years and 27% were women.


The DO-IT Registry represents a real-world nationwide cohort of patients receiving ICDs for primary prevention of sudden cardiac death with reduced left ventricular function in a setting of structural heart disease. The registry investigates the efficacy of the current practice and aims to develop prediction rules to identify subgroups who will not (sufficiently) benefit from ICD implantation and to provide results regarding costs and budget impact of targeted supply of primary preventions ICDs.

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Netherlands Heart Journal

Het Netherlands Heart Journal wordt uitgegeven in samenwerking met de Nederlandse Vereniging voor Cardiologie en de Nederlandse Hartstichting. Het tijdschrift is Engelstalig en wordt gratis beschikbaa ...

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