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Gepubliceerd in: Journal of Autism and Developmental Disorders 8/2014

01-08-2014 | Original Paper

Downregulation of GABAA Receptor Protein Subunits α6, β2, δ, ε, γ2, θ, and ρ2 in Superior Frontal Cortex of Subjects with Autism

Auteurs: S. Hossein Fatemi, Teri J. Reutiman, Timothy D. Folsom, Oyvind G. Rustan, Robert J. Rooney, Paul D. Thuras

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 8/2014

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Abstract

We measured protein and mRNA levels for nine gamma-aminobutyric acid A (GABAA) receptor subunits in three brain regions (cerebellum, superior frontal cortex, and parietal cortex) in subjects with autism versus matched controls. We observed changes in mRNA for a number of GABAA and GABAB subunits and overall reduced protein expression for GABAA receptor alpha 6 (GABRα6), GABAA receptor beta 2 (GABRβ2), GABAA receptor delta (GABRδ), GABAA receptor epsilon (GABRε), GABAA receptor gamma 2 (GABRγ2), GABAA receptor theta (GABRθ), and GABAA receptor rho 2 (GABRρ2) in superior frontal cortex from subjects with autism. Our data demonstrate systematic changes in GABAA&B subunit expression in brains of subjects with autism, which may help explain the presence of cognitive abnormalities in subjects with autism.
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Metagegevens
Titel
Downregulation of GABAA Receptor Protein Subunits α6, β2, δ, ε, γ2, θ, and ρ2 in Superior Frontal Cortex of Subjects with Autism
Auteurs
S. Hossein Fatemi
Teri J. Reutiman
Timothy D. Folsom
Oyvind G. Rustan
Robert J. Rooney
Paul D. Thuras
Publicatiedatum
01-08-2014
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 8/2014
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-014-2078-x

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