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Journal of Autism and Developmental Disorders

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05-05-2017 | Original Paper

Dose-Response Effects of Long-Acting Liquid Methylphenidate in Children with Attention Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD): A Pilot Study

Auteurs: Soo-Jeong Kim, Sophia Shonka, William P. French, Jennifer Strickland, Lindsey Miller, Mark A. Stein

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 8/2017

Abstract

Attention deficit/hyperactivity disorder (ADHD) symptoms are common in youth with autism spectrum disorders (ASD) and are frequently treated with stimulant medications. Twenty-seven children were randomized to different dose titration schedules, and ADHD symptoms, tolerability, and aberrant behaviors were assessed weekly during a 6-week trial with long-acting liquid methylphenidate (MPH). MPH at low to moderate doses was effective in reducing ADHD symptoms and was well tolerated in young children with ASD and ADHD. Future studies are needed to assess generalization and maintenance of efficacy.

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Aman, M. G., Singh, N. N., Stewart, A. W., & Field, C. J. (1985). The aberrant behavior checklist: A behavior rating scale for the assessment of treatment effects. American Journal of Mental Deficiency, 89, 485–491.PubMed

APA. (2000). Diagnostic and statistical manual of mental disorders, text revision (DSM-IV-TR), (4th ed.). Washington, DC: American Psychiatric Publishing.

APA. (2013). Diagnostic and statistical manual of mental disorders, Fifth Edition (DSM-5). Washington, DC: American Psychiatric Publishing.

Barkley, R. A., McMurray, M. B., Edelbrock, C. S., & Robbins, K. (1990). Side effects of methylphenidate in children with attention deficit hyperactivity disorder: A systemic, placebo-controlled evaluation. Pediatrics, 86, 184–192.PubMed

Campbell, M., Fish, B., David, R., Shapiro, T., Collins, P., & Koh, C. (1972). Response to triiodothyronine and dextroamphetamine: A study of preschool schizophrenic children. Journal of Autism and Developmental Disorders, 2(4), 343–358.CrossRef

Frazier, T. W., Shattuck, P. T., Narendorf, S. C., Cooper, B. P., Wagner, M., & Spitznagel, E. L. (2011). Prevalence and correlates of psychotropic medication use in adolescents with an autism spectrum disorder with and without caregiver-reported attention-deficit/hyperactivity disorder. Journal of Child and Adolescent Psychopharmacology, 21, 571–579.CrossRefPubMedPubMedCentral

Gadow, K. D., DeVincent, C. J., & Pomeroy, J. (2006). ADHD symptom subtypes in children with pervasive developmental disorder. Journal of Autism and Developmental Disorders, 36, 271–283.CrossRefPubMed

Goldstein, S., & Schwebach, A. J. (2004). The comorbidity of pervasive developmental disorder and attention deficit hyperactivity disorder: Results of a retrospective chart review. Journal of Autism and Developmental Disorders, 34, 329–339.CrossRefPubMed

Greenhill, L., Kollins, S., Abikoff, H., McCracken, J., Riddle, M., Swanson, J., et al. (2006). Efficacy and safety of immediate-release methylphenidate treatment for preschoolers with ADHD. Journal of the American Academy of Child and Adolescent Psychiatry, 45, 1284–1293.CrossRefPubMed

Handen, B. L., Johnson, C. R., & Lubetsky, M. (2000). Efficacy of methylphenidate among children with autism and symptoms of attention-deficit hyperactivity disorder. Journal of Autism and Developmental Disorders, 30, 245–255. doi:10.1023/A:1005548619694.CrossRefPubMed

Kaufman, J., Birmaher, B., Brent, D., Rao, U., Flynn, C., Moreci, P., et al. (1997). Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): Initial reliability and validity data. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 980–988.CrossRefPubMed

Lee, D. O., & Ousley, O. Y. (2006). Attention-deficit hyperactivity disorder symptoms in a clinic sample of children and adolescents with pervasive developmental disorders. Journal of Child and Adolescent Psychopharmacology, 16, 737–746.CrossRefPubMed

Pearson, D. A., Santos, C. W., Aman, M. G., Arnold, L. E., Casat, C. D., Mansour, R., … Cleveland, L. A. (2013). Effects of extended release methylphenidate treatment on ratings of attention-deficit/hyperactivity disorder (ADHD) and associated behavior in children with autism spectrum disorders and ADHD symptoms. Journal of Child and Adolescent Psychopharmacology, 23(5), 337–351. doi:10.1089/cap.2012.0096.

Quintana, H., Birmaher, B., Stedge, D., Lennon, S., Freed, J., Bridge, J., & Greenhill, L. (1995). Use of methylphenidate in the treatment of children with autistic disorder. Journal of Autism and Developmental Disorders, 25(3), 283–294.CrossRefPubMed

Rao, P. A., Landa, R. J. (2013). Association between severity of behavioral phenotype and comorbid attention deficit hyperactivity disorder symptoms in children with autism spectrum disorders. Autism, 18, 272–280.CrossRef

Robb, A. S., Findling, R .L., Childress, A. C., Berry, S. A., Belden, H. W., Wigal, S. B. (2014). Efficacy, safety, and tolerability of a novel methylphenidate extended-release oral suspension (MEROS) in ADHD. Journal of Attention Disorders. doi:10.1177/1087054714533191.PubMed

Santosh, P. J., Baird, G., Pityaratstian, N., Tavare, E., Gringas, P. (2006). Impact of comorbid autism spectrum disorders on stimulant response in children with attention deficit hyperactivity disorder: A retrospective and prospective effectiveness study. Child: Care, Health, and Development, 32, 575–583. doi:10.1111/j.1365-2214.2006.00631.x.

Stein, M. A., Mendelsohn, J., Obermeyer, W. H., Amromin, J., & Benca, R. (2001). Sleep and behavior problems in school-aged children. Pediatrics, 107, E60.CrossRefPubMed

Stein, M. A., Sarampote, C. S., Waldman, I. D., Robb, A. S., Conlon, C., Pearl, P. L., et al. (2003). A dose-response study of OROS methylphenidate in children with attention-deficit/hyperactivity disorder. Pediatrics, 112, e404.CrossRefPubMed

Schmidt, K. (1982). The effect of stimulant medication in childhood-onset pervasive developmental disorder—a case report. Journal of Developmental & Behavioral Pediatrics, 3(4), 244–246.CrossRef

Stigler, K. A., Desmond, L. A., Posey, D. J., Wiegand, R. E., & McDougle, C. J. (2004). A naturalistic retrospective analysis of psychostimulants in pervasive developmental disorders. Journal of Child and Adolescent Psychopharmacology, 14, 49–56.CrossRefPubMed

Volkmar, F. R., Hoder, E. L., Cohen, D. J. (1985). Inappropriate uses of stimulant medications. Clinical Pediatrics, 24, 127–130.CrossRefPubMed

Titel: Dose-Response Effects of Long-Acting Liquid Methylphenidate in Children with Attention Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD): A Pilot Study
Auteurs: Soo-Jeong Kim
Sophia Shonka
William P. French
Jennifer Strickland
Lindsey Miller
Mark A. Stein
Publicatiedatum: 05-05-2017
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 8/2017
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-017-3125-1

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