Top

Quality of Life Research

Gepubliceerd in:

04-03-2019

Does inappropriate prescribing affect elderly patients’ quality of life? A study from a Malaysian tertiary hospital

Auteurs: Muhammad Eid Akkawi, Mohamad Haniki Nik Mohamed, Mohd Aznan Md Aris

Gepubliceerd in: Quality of Life Research | Uitgave 7/2019

Abstract

Purpose

To investigate the association between potentially inappropriate medication (PIM)/potential prescribing omission (PPO) and the health-related quality of life (HRQoL) among community-dwelling hospitalized elderly patients.

Methods

This is a cross-sectional study that took place in a Malaysian tertiary hospital. Patients ≥ 65 years old with at least one medication on admission were recruited. The patients’ prehospitalization medications were reviewed to identify PIMs/PPOs using version 2 of the STOPP/START criteria. HRQoL was assessed using the EuroQol-5 dimensions (EQ-5D) and EuroQol-visual analog scale (EQ-VAS). The association between the presence of PIM/PPO and the patients’ HRQoL was analyzed using Chi-square and Mann–Whitney U tests. Multiple linear regression models were applied to determine the effect of exposure to PIM/PPO on the patients’ HRQoL, adjusting for confounders.

Results

Out of 517 patients who fulfilled the inclusion criteria, 502 patients (97%) accepted to be involved in the study and completed the HRQoL questionnaire. The mean (SD) age was 72.4 (5.9) years. 393 (78.3%) of the patients had problems in at least one EQ-5D dimension with pain/discomfort problem being the most reported complaint. The mean (SD) values of the EQ-5D index and the EQ-VAS were 0.734 (0.214) and 59.6 (14.2), respectively, which are lower than those seen in the general Malaysian population. PIM and PPO were found in 28.5% and 45.6% of the patients, respectively. No significant differences were found in the EQ-5D dimensions, EQ-5D index and EQ-VAS between patients who had PIM/PPO and those who did not. Age, sex, and comorbidities were significantly associated with the patients’ HRQoL.

Conclusion

PIM and PPO are not uncommon among hospitalized elderly patients; however, it does not significantly affect their HRQoL as measured by the EQ-5D-3L instrument.

vorige artikel Comparison of EQ-5D-5L and SPVU-5D for measuring quality of life in patients with venous leg ulcers in an Australian setting

volgende artikel Positive balance: a hierarchical perspective of positive mental health

Nordin Olsson, I., Runnamo, R., & Engfeldt, P. (2011). Medication quality and quality of life in the elderly, a cohort study. Health and Quality of Life Outcomes, 9(1), 95. https://doi.org/10.1186/1477-7525-9-95.CrossRefPubMedCentral

Karimi, M., & Brazier, J. (2016). Health, Health-related quality of life, and quality of life: What is the difference? PharmacoEconomics, 34(7), 645–649. https://doi.org/10.1007/s40273-016-0389-9.CrossRefPubMed

Franic, D. M., & Jiang, J. Z. (2006). Potentially inappropriate drug use and health-related quality of life in the elderly. Pharmacotherapy, 26(6), 768–778. https://doi.org/10.1592/phco.26.6.768.CrossRefPubMed

Kaplan, R. M. (2003). The significance of quality of life in health care. In Quality of life research (Vol. 12, pp. 3–16). Dordrecht: Kluwer Academic Publishers. https://doi.org/10.1023/A:1023547632545.

Rolfes, L., van Hunsel, F., Taxis, K., & van Puijenbroek, E. (2016). The Impact of experiencing adverse drug reactions on the patient’s quality of life: A retrospective cross-sectional study in the Netherlands. Drug Safety, 39(8), 769–776. https://doi.org/10.1007/s40264-016-0422-0.CrossRefPubMedPubMedCentral

OʼConnor, M. N., Gallagher, P., & OʼMahony, D. (2012). Inappropriate prescribing: Criteria, detection and prevention. Drugs & Aging, 29(6), 437–452. https://doi.org/10.2165/11632610-000000000-00000.CrossRef

Hamilton, H., Gallagher, P., Ryan, C., Byrne, S., & O’Mahony, D. (2011). Potentially inappropriate medications defined by STOPP criteria and the risk of adverse drug events in older hospitalized patients. Archives of Internal Medicine, 171(11), 1013–1019. https://doi.org/10.1001/archinternmed.2011.215.CrossRefPubMed

van der Stelt, C. A. K., Windsant-van den Tweel, A. M. A., Egberts, A. C. G., Van den Bemt, P. M. L. A., Leendertse, A. J., Hermens, W. A. J. J., Derijks, H. J. (2016). The association between potentially inappropriate prescribing and medication-related hospital admissions in older patients: A nested case control study. Drug Safety, 39(1), 79–87. https://doi.org/10.1007/s40264-015-0361-1.CrossRefPubMed

Wallace, E., McDowell, R., Bennett, K., Fahey, T., & Smith, S. M. (2017). Impact of potentially inappropriate prescribing on adverse drug events, health related quality of life and emergency hospital attendance in older people attending general practice: A prospective cohort study. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 72(2), 271–277. https://doi.org/10.1093/gerona/glw140.CrossRefPubMed

10.

Meid, A. D., Quinzler, R., Groll, A., Wild, B., Saum, K. U., Schöttker, B., Haefeli, W. E. (2016). Longitudinal evaluation of medication underuse in older outpatients and its association with quality of life. European Journal of Clinical Pharmacology, 72(7), 877–885. https://doi.org/10.1007/s00228-016-2047-8.CrossRefPubMed

11.

Moriarty, F., Bennett, K., Cahir, C., Kenny, R. A., & Fahey, T. (2016). Potentially inappropriate prescribing according to STOPP and START and adverse outcomes in community-dwelling older people: a prospective cohort study. British Journal of Clinical Pharmacology, 82, 849–857. https://doi.org/10.1111/bcp.12995.CrossRefPubMedPubMedCentral

12.

Al Aqqad, S. M. H., Chen, L. L., Shafie, A. A., Hassali, M. A., & Tangiisuran, B. (2014). The use of potentially inappropriate medications and changes in quality of life among older nursing home residents. Clinical Interventions in Aging, 9, 201–207. https://doi.org/10.2147/CIA.S52356.CrossRefPubMed

13.

Lim, L. M., McStea, M., Chung, W. W., Azmi, N. N., Aziz, S. A. A., Alwi, S., Rajasuriar, R. (2017). Prevalence, risk factors and health outcomes associated with polypharmacy among urban community-dwelling older adults in multiethnic Malaysia. PLoS ONE, 12(3), 1–18. https://doi.org/10.1371/journal.pone.0173466.CrossRef

14.

Najjar, M. F., AbdulRazzaq, H. A., Altaie, A. H., Kassab, Y. W., Hassan, Y., & Abd Aziz, N., (2013). Assessment of potentially inappropriate medications and risk of drug-drug interactions among geriatric inpatients in Penang Hospital. International Journal of Clinical Pharmacy (Vol, 35, 911–912.

15.

Population distribution and basic demographic characteristic report. (2011). Retrieved from https://www.dosm.gov.my/v1/index.php?r=column/ctheme&menu_id=L0pheU43NWJwRWVSZklWdzQ4TlhUUT09&bul_id=MDMxdHZjWTk1SjFzTzNkRXYzcVZjdz09.

16.

Naing, L., Winn, T., & Rusli, B. N. (2006). Practical issues in calculating the sample size for prevalence studies. Archives of Orofacial Sciences, 1, 9–14. http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.504.2129&rep=rep1&type=pdf.

17.

Charlson, M., Szatrowski, T. P., Peterson, J., & Gold, J. (1994). Validation of a combined comorbidity index. Journal of Clinical Epidemiology, 47(11), 1245–1251. https://doi.org/10.1016/0895-4356(94)90129-5.CrossRefPubMed

18.

O’Mahony, D., O’Sullivan, D., Byrne, S., O’Connor, M. N., Ryan, C., & Gallagher, P. (2015). STOPP/START criteria for potentially inappropriate prescribing in older people: Version 2. Age and Ageing, 44(2), 213–218. https://doi.org/10.1093/ageing/afu145.CrossRefPubMed

19.

Gnjidic, D., Hilmer, S. N., Blyth, F. M., Naganathan, V., Waite, L., Seibel, M. J., Le Couteur, D. G. (2012). Polypharmacy cutoff and outcomes: Five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes. Journal of Clinical Epidemiology, 65(9), 989–995. https://doi.org/10.1016/j.jclinepi.2012.02.018.CrossRefPubMed

20.

Rabin, R., & Charro, F., & De (2001). EQ-SD: A measure of health status from the EuroQol Group. Annals of Medicine, 33(5), 337–343. https://doi.org/10.3109/07853890109002087.CrossRefPubMed

21.

Md Yusof, F. A., Goh, A., & Azmi, S. (2012). Estimating an EQ-5D value set for malaysia using time trade-off and visual analogue scale methods. Value in Health, 15(1 SUPPL.), S85–S90. https://doi.org/10.1016/j.jval.2011.11.024.CrossRef

22.

Shafie, A. A., Hassali, M. A., & Liau, S. Y. (2011). A cross-sectional validation study of EQ-5D among the Malaysian adult population. Quality of Life Research, 20(4), 593–600. https://doi.org/10.1007/s11136-010-9774-6.CrossRefPubMed

23.

Wolfs, C. A. G., Dirksen, C. D., Kessels, A., Willems, D. C. M., Verhey, F. R. J., & Severens, J. L. (2007). Performance of the EQ-5D and the EQ-5D+C in elderly patients with cognitive impairments. Health and Quality of Life Outcomes, 5(33). https://doi.org/10.1186/1477-7525-5-33.

24.

Cavrini, G., Broccoli, S., Puccini, A., & Zoli, M. (2012). EQ-5D as a predictor of mortality and hospitalization in elderly people. Quality of Life Research, 21(2), 269–280. https://doi.org/10.1007/s11136-011-9937-0.CrossRefPubMed

25.

Mangen, M. J. J., Bolkenbaas, M., Huijts, S. M., van Werkhoven, C. H., Bonten, M. J. M., & de Wit, G. A. (2017). Quality of life in community-dwelling Dutch elderly measured by EQ-5D-3L. Health and Quality of Life Outcomes, 15(1), 3. https://doi.org/10.1186/s12955-016-0577-5.CrossRefPubMedPubMedCentral

26.

Clemens, S., Begum, N., Harper, C., Whitty, J. A., & Scuffham, P. A. (2014). A comparison of EQ-5D-3L population norms in Queensland, Australia, estimated using utility value sets from Australia, the UK and USA. Quality of Life Research: An International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation, 23(8), 2375–2381. https://doi.org/10.1007/s11136-014-0676-x.CrossRef

27.

König, H. H., Heider, D., Lehnert, T., Riedel-Heller, S. G., Angermeyer, M. C., Matschinger, H., Alonso, J. (2010). Health status of the advanced elderly in six european countries: Results from a representative survey using EQ-5D and SF-12. Health and Quality of Life Outcomes, 8(1), 143. https://doi.org/10.1186/1477-7525-8-143.CrossRefPubMedPubMedCentral

28.

Perneger, T. V., Combescure, C., & Courvoisier, D. S. (2010). General population reference values for the french version of the euroqol EQ-5D health utility instrument. Value in Health, 13(5), 631–635. https://doi.org/10.1111/j.1524-4733.2010.00727.x.CrossRefPubMed

29.

Fu, A. Z., Liu, G. G., & Christensen, D. B. (2004). Inappropriate medication use and health outcomes in the elderly. Journal of the American Geriatrics Society, 52(11), 1934–1939. https://doi.org/10.1111/j.1532-5415.2004.52522.x.CrossRefPubMed

Titel: Does inappropriate prescribing affect elderly patients’ quality of life? A study from a Malaysian tertiary hospital
Auteurs: Muhammad Eid Akkawi
Mohamad Haniki Nik Mohamed
Mohd Aznan Md Aris
Publicatiedatum: 04-03-2019
Uitgeverij: Springer International Publishing
Gepubliceerd in: Quality of Life Research / Uitgave 7/2019
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-019-02153-5

Bohn Stafleu van Loghum

Deel dit onderdeel of sectie (kopieer de link)

Abstract

Purpose

Methods

Results

Conclusion

Log in om toegang te krijgen

Andere artikelen Uitgave 7/2019

Health-related quality of life in Switzerland: normative data for the SF-36v2 questionnaire

Racial/ethnic disparities in health-related quality of life and health status across pre-, early-, and mid-adolescence: a prospective cohort study

Predicting quality of life during and post detention in incarcerated juveniles

Comparative study of PROMISⓇ self-efficacy for managing chronic conditions across chronic neurologic disorders

Comparison of EQ-5D-5L and SPVU-5D for measuring quality of life in patients with venous leg ulcers in an Australian setting

Body dissatisfaction, internalized weight bias and quality of life in young men and women