Introduction
Clinical Characteristics, OCD Symptom Patterns, and Comorbidity in OCD with Autistic Traits
OCD with Autistic Traits and Cognitive Behavioral Therapy Outcomes
Aims
Method
Participants
OCD + AT group (n = 25) | OCD group (n = 232) | p-value | |
---|---|---|---|
Age, M (SD)a | 12.16 (2.79) | 12.86 (2.75) | 0.227 |
Children/adolescents, n/nb | 11/14 | 73/159 | 0.204 |
Boys/girls, n/nb | 18/7* | 107/125 | 0.014 |
ASSQ, M(SD) | |||
Total score | 22.42 (7.89) | 5.53 (4.34) | |
Social difficulties | 9.97 (3.48) | 1.77 (2.12) | |
Motor/tics/OCD | 6.84 (3.80) | 2.34 (1.97) | |
Autistic style | 5.60 (3.46) | 1.41 (1.72) |
Measures
Autism Spectrum Screening Questionnaire (ASSQ)
Children’s Yale–Brown Obsessive–Compulsive Scale (CY-BOCS)
The Clinical Global Impression Scales (CGI)
Kiddie Schedule for Affective Disorders and Schizophrenia –Present and Lifetime Version (K-SADS-PL)
Child Behavior Checklist (CBCL)
Treatment and follow-up
Statistical Analyses
Results
OCD + AT group (n = 25) | OCD group (n = 232) | OR | 95% CI | Exact p-valuea | |
---|---|---|---|---|---|
CGI, M (SD) | 3.64 (0.81) | 3.42 (0.83) | 1.48 | 0.85–2.63 | 0.152 |
CY-BOCS, M (SD) | |||||
Total score | 26.56 (4.58)* | 24.50 (5.13) | 1.09 | 1.00-1.19 | 0.035 |
Compulsion severity | 13.36 (2.60)* | 12.29 (2.67) | 1.18 | 1.00-1.39 | 0.042 |
Obsession severity | 13.20 (2.66) | 12.21 (2.81) | 1.16 | 0.99–1.36 | 0.064 |
Insight | 1.68 (1.28)** | 1.09 (0.93) | 1.79 | 1.16–2.79 | 0.005 |
Avoidance | 2.16 (1.07) | 1.81 (1.05) | 1.53 | 0.98–2.45 | 0.051 |
Indecisiveness | 1.48 (1.26)* | 1.00 (1.09) | 1.46 | 1.00-2.13 | 0.040 |
Pervasive slowness | 2.04 (1.06)*** | 1.05 (1.01) | 2.42 | 1.54–3.95 | < 0.001 |
Pathological doubt | 1.08 (1.22) | 0.96 (1.05) | 1.14 | 0.76–1.69 | 0.547 |
Overvalued responsibility | 0.48 (0.77) | 0.87 (0.99) | 0.65 | 0.35–1.11 | 0.135 |
Age of DSM OCD Onset, M (SD)b | 10.43 (2.95) | 11.69 (3.00) | 0.88 | 0.75–1.01 | 0.067 |
OCD + AT group | OCD group | OR | 95% CI | Exact p-valuea | |
---|---|---|---|---|---|
Anxiety disorders, n (%) | 6 (24.0) | 44 (19.1) | 1.43 | 0.44–4.11 | 0.5848 |
Depressive disorders, n (%) | 1 (4.0) | 9 (3.9) | 1.29 | 0.03–10.81 | 1.000 |
ADHD, n (%) | 9 (36.0)*** | 13 (5.6) | 7.06 | 2.13–23.56 | < 0.001 |
Disruptive behavior disorders, n (%) | 1 (4.0) | 8 (3.5) | 0.97 | 0.02–8.07 | 1.000 |
Tic disorders, n (%) | 14 (56.0)*** | 32 (13.9) | 7.11 | 2.70-19.19 | < 0.001 |
OCD + AT | OCD group | OR | 95% CI | Exact p-valuea | |||
---|---|---|---|---|---|---|---|
CBCL raw scores, M(SD) |
n
b
|
n
b
| |||||
Anxious/Depressed | 24 | 11.50 (5.32) | 214 | 7.94 (4.73) | 1.18 | 1.08–1.29 | < 0.001 |
Withdrawn/Depressed | 23 | 6.09 (2.99) | 214 | 3.14 (2.70) | 1.38 | 1.19–1.62 | < 0.001 |
Somatic complaints | 24 | 6.50 (4.01) | 214 | 3.27 (3.05) | 1.30 | 1.15–1.47 | < 0.001 |
Social problems | 23 | 7.38 (3.64) | 213 | 2.28 (2.60) | 1.50 | 1.30–1.76 | < 0.001 |
Thought problems | 23 | 11.04 (5.24) | 213 | 6.84 (3.07) | 1.32 | 1.17–1.50 | < 0.001 |
Attention problems | 23 | 10.09 (4.45) | 211 | 4.17 (3.54) | 1.37 | 1.22–1.56 | < 0.001 |
Rule-breaking behavior | 23 | 4.65 (2.97) | 212 | 1.76 (1.99) | 1.58 | 1.33–1.92 | < 0.001 |
Aggressive behavior | 23 | 15.07 (7.15) | 213 | 5.92 (5.29) | 1.22 | 1.14–1.32 | < 0.001 |
CY-BOCS score in the ≥90th ASSQ percentile groups a | CY-BOCS score in the < 90th ASSQ percentile groups b | ||
---|---|---|---|
M (95% CI) | M (95% CI) | t-value (p-value) | |
ASSQ total score
c
| |||
Baseline | 26.7 (24.8, 28.7) | 24.3 (23.7, 25.0) | 2.29 (0.022) |
Post-treatment | 11.9 (9.1, 14.7) | 10.0 (9.0, 11.0) | 1.27 (0.204) |
1-Year FU | 9.0 (6.8, 11.2) | 8.4 (7.6, 9.2) | 0.49 (0.621) |
2-Years FU | 6.1 (3.9, 8.3) | 6.8 (6.0, 7.6) | -0.61 (0.542) |
3-Years FU | 3.2 (0.5, 5.9) | 5.2 (4.2, 6.2) | -1.39 (0.164) |
ASSQ Social difficulties
| |||
Baseline | 26.7 (24.8, 28.7) | 24.3 (23.7, 25.0) | 2.27 (0.024) |
Post-treatment | 11.3 (8.5, 14.1) | 10.1 (9.1, 11.1) | 0.79 (0.433) |
1-Year FU | 8.6 (6.4, 10.8) | 8.4 (7.7, 9.2) | 0.15 (0.877) |
2-Years FU | 6.0 (3.8, 8.1) | 6.8 (6.0, 7.5) | -0.71 (0.479) |
3-Years FU | 3.3 (0.7, 5.9) | 5.1 (4.1, 6.1) | -1.28 (0.200) |
ASSQ Motor/tics/OCD
| |||
Baseline | 25.8 (24.0, 27.6) | 24.4 (23.7, 25.1) | 1.39 (0.165) |
Post-treatment | 13.5 (11.0, 16.1) | 9.7 (8.8, 10.7) | 2.75 (0.006) |
1-Year FU | 9.8 (7.7, 11.8) | 8.3 (7.5, 9.0) | 1.34 (0.180) |
2-Years FU | 6.0 (3.9, 8.2) | 6.8 (6.0, 7.6) | -0.66 (0.508) |
3-Years FU | 2.3 (-0.5, 5.0) | 5.3 (4.3, 6.3) | -2.06 (0.040) |
ASSQ Autistic style
| |||
Baseline | 25.4 (23.5, 27.2) | 24.5 (23.8, 25.1) | 0.86 (0.387) |
Post-treatment | 11.5 (8.8, 14.2) | 10.0 (9.1, 11.0) | 1.01 (0.315) |
1-Year FU | 8.8 (6.6, 11.0) | 8.4 (7.6, 9.2) | 0.34 (0.734) |
2-Years FU | 6.1 (3.9, 8.3) | 6.8 (6.0, 7.5) | -0.57 (0.572) |
3-Years FU | 3.4 (0.6, 6.2) | 5.1 (4.2, 6.1) | -1.16 (0.246) |