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Journal of Autism and Developmental Disorders

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04-01-2021 | Original Paper

DNA Methylation of the Oxytocin Receptor Across Neurodevelopmental Disorders

Auteurs: Michelle T. Siu, Sarah J. Goodman, Isaac Yellan, Darci T. Butcher, Maryam Jangjoo, Daria Grafodatskaya, Rageen Rajendram, Youliang Lou, Rujun Zhang, Chunhua Zhao, Rob Nicolson, Stelios Georgiades, Peter Szatmari, Stephen W. Scherer, Wendy Roberts, Evdokia Anagnostou, Rosanna Weksberg

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 10/2021

Abstract

Many neurodevelopmental disorders (NDDs) share common learning and behavioural impairments, as well as features such as dysregulation of the oxytocin hormone. Here, we examined DNA methylation (DNAm) in the 1st intron of the oxytocin receptor gene, OXTR, in patients with autism spectrum (ASD), attention deficit and hyperactivity (ADHD) and obsessive compulsive (OCD) disorders. DNAm of OXTR was assessed for cohorts of ASD (blood), ADHD (saliva), OCD (saliva), which uncovered sex-specific DNAm differences compared to neurotypical, tissue-matched controls. Individuals with ASD or ADHD exhibiting extreme DNAm values had lower IQ and more social problems, respectively, than those with DNAm within normative ranges. This suggests that OXTR DNAm patterns are altered across NDDs and may be correlated with common clinical outcomes.

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Titel: DNA Methylation of the Oxytocin Receptor Across Neurodevelopmental Disorders
Auteurs: Michelle T. Siu
Sarah J. Goodman
Isaac Yellan
Darci T. Butcher
Maryam Jangjoo
Daria Grafodatskaya
Rageen Rajendram
Youliang Lou
Rujun Zhang
Chunhua Zhao
Rob Nicolson
Stelios Georgiades
Peter Szatmari
Stephen W. Scherer
Wendy Roberts
Evdokia Anagnostou
Rosanna Weksberg
Publicatiedatum: 04-01-2021
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 10/2021
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-020-04792-x

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