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01-06-2010 | Original Article

Divalproex Sodium -ER in Outpatients with Disruptive Behavior Disorders: A Three Month Open Label Study

Auteurs: Kirti Saxena, Linda Mora, Erika Torres, Rebecca Hall, Laura Delizonna, Alex Torres, Hans Steiner

Gepubliceerd in: Child Psychiatry & Human Development | Uitgave 3/2010

Abstract

This aim of this clinical trial was to study the effects of divalproex sodium (DVPX) in reducing Reactive/Affective/ Defensive/ Impulsive Aggression (RADI) in youth with Disruptive Behavior Disorders (DBD) in an outpatient clinic over a period of 3 months. We recruited forty participants with Oppositional Defiant Disorder or Conduct Disorder. Twenty participants received 12 weeks of openly titrated DVPX, whereas twenty participants served as a comparison control group. Primary efficacy measures were the Clinical Global Improvement-Severity (CGI-S) and CGI-C (Change) scales; secondary efficacy measures included standardized measures of aggression. Based on the CGI-S and CGI-C ratings, the DVPX group showed significant improvement by the last observation. Attrition rates were notably high, which is not surprising given the clinical population studied. This study provides further support for the efficacy of DVPX in decreasing RADI aggression in the context of DBD. These results are particularly noteworthy because the sociotherapeutic structures supporting patients in previous trials were not present.

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Steiner H, Remsing L, Work Group on Quality Issues (2007) Practice parameter for the assessment and treatment of children and adolescents with oppositional defiant disorder. J Am Acad Child Adolesc Psychiatry 46:126–141CrossRefPubMed

Daniel F Connor (2002) In: Aggression and antisocial behavior in children and adolescents: research and treatment. Guilford Press, New York, p 480

Steiner H, Cauffman E (1998) Juvenile justice, delinquency, and psychiatry. Child Adolesc Psychiatr Clin N Am 7:653–672PubMed

Crowe SL, Blair RJ (2008) The development of antisocial behavior: what can we learn from functional neuroimaging studies? Dev Psychopathol 4:1145–1159CrossRef

Connor DF, Carlson GA, Chang KD, Daniolos PT, Ferziger R, Findling RL, Hutchinson JG, Malone RP, Halperin JM, Plattner B, Post RM, Reynolds DL, Rogers KM, Saxena K, Steiner H, Stanford/Howard/AACAP Workgroup on Juvenile Impulsivity and Aggression (2006) Juvenile maladaptive aggression: a review of prevention, treatment, and service configuration and a proposed research agenda. J Clin Psychiatry 67:808–820CrossRefPubMed

Campbell M, Small AM, Green WH, Jennings SJ, Perry R, Bennett WG, Anderson L (1984) Behavioral efficacy of haloperidol and lithium carbonate. A comparison in hospitalized aggressive children with conduct disorder. Arch Gen Psychiatry 41:650–656PubMed

Greenhill LL, Solomon M, Pleak R, Ambrosini P (1985) Molindone hydrochloride treatment of hospitalized children with conduct disorder. J Clin Psychiatry 46(82):20–25PubMed

Klein RG (1991) Preliminary results: lithium effects in conduct disorders. In: CME Syllabus and Proceedings Summary of the 144th annual meeting of the American Psychiatric Association, New Orleans. Symposium 2:119–120

Campbell M, Silva RR, Kafantaris V, Locascio JJ, Gonzalez NM, Lee D, Lynch NS (1991) Predictors of side effects associated with lithium administration in children. Psychopharm Bulletin 27:373–380

10.

Campbell M, Adams PB, Small AM, Kafantaris V, Silva RR, Shell J, Perry R, Overall JE (1995) Lithium in hospitalized aggressive children with conduct disorder: a double-blind and placebo-controlled study. J Am Acad Child Adolesc Psychiatry 34:445–453PubMed

11.

Cueva JE, Overall JE, Small AM, Armenteros JL, Perry R, Campbell M (1996) Carbamazepine in aggressive children with conduct disorder: a double-blind and placebo-controlled study. J Am Acad Child Adolesc Psychiatry 35:480–490CrossRefPubMed

12.

Rifkin A, Karajgi B, Dicker R, Perl E, Boppana V, Hasan N, Pollack S (1997) Lithium treatment of conduct disorders in adolescents. Am J Psychiatry 154:554–555PubMed

13.

Klein RG, Abikoff H, Klass E, Ganeles D, Seese LM, Pollack S (1997) Clinical efficacy of methylphenidate in conduct disorder with and without attention deficit hyperactivity disorder. Arch Gen Psychiatry 54:1073–1080PubMed

14.

Malone RP, Bennett DS, Luebbert JF, Rowan AB, Biesecker KA, Blaney BL, Delaney MA (1998) Aggression classification and treatment response. Psychopharmacol Bull 34:41–45PubMed

15.

Donovan SJ, Stewart JW, Nunes EV, Quitkin FM, Parides M, Daniel W, Susser E, Klein DF (2000) Divalproex treatment for youth with explosive temper and mood lability: a double-blind, placebo-controlled crossover design. Am J Psychiatry 157:818–820CrossRefPubMed

16.

Findling RL, McNamara NK, Branicky LA, Schluchter MD, Lemon E, Blumer JL (2000) A double-blind pilot study of risperidone in the treatment of conduct disorder. J Am Acad Child Adolesc Psychiatry 39:509–516CrossRefPubMed

17.

Malone RP, Delaney MA, Lubber JF, Cater J, Campbell M (2000) A double-blind placebo-controlled study of lithium in hospitalized aggressive children and adolescents with conduct disorder. Arch Gen Psychiatry 57:649–654CrossRefPubMed

18.

Connor DF, McLaughlin TJ, Jeffers-Terry M (2008) Randomized controlled pilot study of quetiapine in the treatment of adolescent conduct disorder. J Child Adolesc Psychopharmacol 18:140–156CrossRefPubMed

19.

Donovan SJ, Susser ES, Nunes EV, Stewart JW, Quitkin FM, Klein DF (1997) Divalproex treatment of disruptive adolescent: a report of 10 cases. J Clin Psychiatry 58:12–15PubMed

20.

Schreier HA (1998) Risperidone for young children with mood disorders and aggressive behavior. J Child Adolesc Psychopharmacol 8:49–59CrossRefPubMed

21.

Joshi PT, Hamel L, Joshi A, Capozzoli JA (1998) Use of droperidol in hospitalized children. J Am Acad Child Adolesc Psychiatry 37:228–230PubMedCrossRef

22.

Buitelaar JK (2000) Open-label treatment with risperidone of 26 psychiatrically hospitalized children and adolescents with mixed diagnoses and aggressive behavior. J Child Adolesc Psychopharmacol 10:19–26CrossRefPubMed

23.

Hameer O, Collin K, Ensom MH, Lomax S (2001) Evaluation of droperidol in the acutely agitated child or adolescent. Can J Psychiatry 46(9):864–865PubMed

24.

Armenteros JL, Lewis JE (2002) Citalopram treatment for impulsive aggression in children and adolescents: an open pilot study. J Am Acad Child Adolesc Psychiatry 41:522–529CrossRefPubMed

25.

Steiner H, Petersen ML, Saxena K, Ford S, Matthews Z (2003) Divalproex sodium for the treatment of conduct disorder: a randomized controlled clinical trial. J Clin Psychiatry 64:1183–1191PubMed

26.

Geller B, Zimerman B, Williams M, Bolhofner K, Craney JL, DelBello MP, Soutullo C (2001) Reliability of the Washington University in St. Louis Kiddie Schedule for Affective Disorders and Schizophrenia (WASH-U-KSADS) mania and rapid cycling sections. J Am Acad Child Adolesc Psychiatry 40:450–455CrossRefPubMed

27.

Guy W (1976) ECDEU Manual for Psychopharmacology. In: Publication 76-338. National Institute of Mental Health, US Department of Health, Education and Welfare Press, Washington, pp 113–147, 534–537

28.

Steiner H, Karnik NS (2009). Integrated treatment of aggression in the context of ADHD in children refractory to stimulant monotherapy: a window into the future of child psychopharmacology. Editorial, Am J Psychiatry, 166

Titel: Divalproex Sodium -ER in Outpatients with Disruptive Behavior Disorders: A Three Month Open Label Study
Auteurs: Kirti Saxena
Linda Mora
Erika Torres
Rebecca Hall
Laura Delizonna
Alex Torres
Hans Steiner
Publicatiedatum: 01-06-2010
Uitgeverij: Springer US
Gepubliceerd in: Child Psychiatry & Human Development / Uitgave 3/2010
Print ISSN: 0009-398X
Elektronisch ISSN: 1573-3327
DOI: https://doi.org/10.1007/s10578-009-0167-4

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