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Gepubliceerd in: Journal of Autism and Developmental Disorders 5/2012

01-05-2012 | Original paper

Distinct Plasma Profile of Polar Neutral Amino Acids, Leucine, and Glutamate in Children with Autism Spectrum Disorders

Auteurs: Rabindra Tirouvanziam, Tetyana V. Obukhanych, Julie Laval, Pavel A. Aronov, Robin Libove, Arpita Goswami Banerjee, Karen J. Parker, Ruth O’Hara, Leonard A. Herzenberg, Leonore A. Herzenberg, Antonio Y. Hardan

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 5/2012

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Abstract

The goal of this investigation was to examine plasma amino acid (AA) levels in children with Autism Spectrum Disorders (ASD, N = 27) and neuro-typically developing controls (N = 20). We observed reduced plasma levels of most polar neutral AA and leucine in children with ASD. This AA profile conferred significant post hoc power for discriminating children with ASD from healthy children. Furthermore, statistical correlations suggested the lack of a typical decrease of glutamate and aspartate with age, and a non-typical increase of isoleucine and lysine with age in the ASD group. Findings from this limited prospective study warrant further examination of plasma AA levels in larger cross-sectional and longitudinal cohorts to adequately assess for relationships with developmental and clinical features of ASD.
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Metagegevens
Titel
Distinct Plasma Profile of Polar Neutral Amino Acids, Leucine, and Glutamate in Children with Autism Spectrum Disorders
Auteurs
Rabindra Tirouvanziam
Tetyana V. Obukhanych
Julie Laval
Pavel A. Aronov
Robin Libove
Arpita Goswami Banerjee
Karen J. Parker
Ruth O’Hara
Leonard A. Herzenberg
Leonore A. Herzenberg
Antonio Y. Hardan
Publicatiedatum
01-05-2012
Uitgeverij
Springer US
Gepubliceerd in
Journal of Autism and Developmental Disorders / Uitgave 5/2012
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI
https://doi.org/10.1007/s10803-011-1314-x

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