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Journal of Autism and Developmental Disorders

Gepubliceerd in:

01-05-2012 | Original paper

Distinct Plasma Profile of Polar Neutral Amino Acids, Leucine, and Glutamate in Children with Autism Spectrum Disorders

Auteurs: Rabindra Tirouvanziam, Tetyana V. Obukhanych, Julie Laval, Pavel A. Aronov, Robin Libove, Arpita Goswami Banerjee, Karen J. Parker, Ruth O’Hara, Leonard A. Herzenberg, Leonore A. Herzenberg, Antonio Y. Hardan

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 5/2012

Abstract

The goal of this investigation was to examine plasma amino acid (AA) levels in children with Autism Spectrum Disorders (ASD, N = 27) and neuro-typically developing controls (N = 20). We observed reduced plasma levels of most polar neutral AA and leucine in children with ASD. This AA profile conferred significant post hoc power for discriminating children with ASD from healthy children. Furthermore, statistical correlations suggested the lack of a typical decrease of glutamate and aspartate with age, and a non-typical increase of isoleucine and lysine with age in the ASD group. Findings from this limited prospective study warrant further examination of plasma AA levels in larger cross-sectional and longitudinal cohorts to adequately assess for relationships with developmental and clinical features of ASD.

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Adams, J. B., Johansen, L. J., Powell, L. D., Quig, D., & Rubin, R. A. (2011). Gastrointestinal flora and gastrointestinal status in children with autism–comparisons to typical children and correlation with autism severity. BMC Gastroenterology, 11, 22.PubMedCrossRef

Ahearn, W. H., Castine, T., Nault, K., & Green, G. (2001). An assessment of food acceptance in children with autism or pervasive developmental disorder-not otherwise specified. Journal of Autism and Developmental Disorders, 31, 505–511.PubMedCrossRef

Aldred, S., Moore, K. M., Fitzgerald, M., & Waring, R. H. (2003). Plasma amino acid levels in children with autism and their families. Journal of Autism and Developmental Disorders, 33, 93–97.PubMedCrossRef

Altamura, C., Maes, M., Dai, J., & Meltzer, H. Y. (1995). Plasma concentrations of excitatory amino acids, serine, glycine, taurine and histidine in major depression. European Neuropsychopharmacology, 5 (Suppl), 71–75.

Arnold, G. L., Hyman, S. L., Mooney, R. A., & Kirby, R. S. (2003). Plasma amino acids profiles in children with autism: Potential risk of nutritional deficiencies. Journal of Autism and Developmental Disorders, 33, 449–454.PubMedCrossRef

Badawy, A. A., Morgan, C. J., & Turner, J. A. (2008). Application of the Phenomenex EZ: Faasttrade mark amino acid analysis kit for rapid gas-chromatographic determination of concentrations of plasma tryptophan and its brain uptake competitors. Amino Acids, 34, 587–596.PubMedCrossRef

Banks, R. E., Stanley, A. J., Cairns, D. A., Barrett, J. H., Clarke, P., Thompson, D., et al. (2005). Influences of blood sample processing on low-molecular-weight proteome identified by surface-enhanced laser desorption/ionization mass spectrometry. Clinical Chemistry, 51, 1637–1649.PubMedCrossRef

Bellodi, L., Erzegovesi, S., Bianchi, L., Lucini, V., Conca, R., & Lucca, A. (1997). Plasma tryptophan levels and tryptophan/neutral amino acid ratios in obsessive-compulsive patients with and without depression. Psychiatry Research, 69, 9–15.PubMedCrossRef

Blaylock, R. L., & Strunecka, A. (2009). Immune-glutamatergic dysfunction as a central mechanism of the autism spectrum disorders. Current Medicinal Chemistry, 16, 157–170.PubMedCrossRef

Courchesne, E., Carper, R., & Akshoomoff, N. (2003). Evidence of brain overgrowth in the first year of life in autism. JAMA, 290, 337–344.PubMedCrossRef

Courchesne, E., Pierce, K., Schumann, C. M., Redcay, E., Buckwalter, J. A., Kennedy, D. P., et al. (2007). Mapping early brain development in autism. Neuron, 56, 399–413.PubMedCrossRef

Fernell, E., Karagiannakis, A., Edman, G., Bjerkenstedt, L., Wiesel, F. A., & Venizelos, N. (2007). Aberrant amino acid transport in fibroblasts from children with autism. Neuroscience Letters, 418, 82–86.PubMedCrossRef

Finegold, S. M., Dowd, S. E., Gontcharova, V., Liu, C., Henley, K. E., Wolcott, R. D., et al. (2010). Pyrosequencing study of fecal microflora of autistic and control children. Anaerobe, 16, 444–453.PubMedCrossRef

Geschwind, D. H. (2009). Advances in autism. Annual Review of Medicine, 60, 367–380.PubMedCrossRef

Hardan, A. Y., Minshew, N. J., Mallikarjuhn, M., & Keshavan, M. S. (2001). Brain volume in autism. Journal of Child Neurology, 16, 421–424.PubMed

Hawkins, R. A., O’kane, R. L., Simpson, I. A., & Vina, J. R. (2006). Structure of the blood-brain barrier and its role in the transport of amino acids. Journal of Nutrition, 136, 218S–226S.PubMed

Hazlett, H. C., Poe, M., Gerig, G., Smith, R. G., Provenzale, J., Ross, A., et al. (2005). Magnetic resonance imaging and head circumference study of brain size in autism: Birth through age 2 years. Archives of General Psychiatry, 62, 1366–1376.PubMedCrossRef

Hyde, R., Taylor, P. M., & Hundal, H. S. (2003). Amino acid transporters: Roles in amino acid sensing and signalling in animal cells. Biochemical Journal, 373, 1–18.PubMedCrossRef

Kaufman, J., Birmaher, B., Brent, D., Rao, U., Flynn, C., Moreci, P., et al. (1997). Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): Initial reliability and validity data. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 980–988.PubMedCrossRef

Lepage, N., Mcdonald, N., Dallaire, L., & Lambert, M. (1997). Age-specific distribution of plasma amino acid concentrations in a healthy pediatric population. Clinical Chemistry, 43, 2397–2402.PubMed

Lord, C., Rutter, M., Goode, S., Heemsbergen, J., Jordan, H., Mawhood, L., et al. (1989). Autism diagnostic observation schedule: A standardized observation of communicative and social behavior. Journal of Autism and Developmental Disorders, 19, 185–212.PubMedCrossRef

Lord, C., Rutter, M., & Le Couteur, A. (1994). Autism diagnostic interview-revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24, 659–685.PubMedCrossRef

Mohabbat, T., & Drew, B. (2008). Simultaneous determination of 33 amino acids and dipeptides in spent cell culture media by gas chromatography-flame ionization detection following liquid and solid phase extraction. Journal of Chromatography B Analytical Technologies in the Biomedical and Life Sciences, 862, 86–92.CrossRef

Moreno-Fuenmayor, H., Borjas, L., Arrieta, A., Valera, V., & Socorro-Candanoza, L. (1996). Plasma excitatory amino acids in autism. Investigation Clinical, 37, 113–128.

Ratajczak, H. V. (2011). Theoretical aspects of autism: Biomarkers–a review. Journal of Immunotoxicology, 8, 80–94.PubMedCrossRef

Rolf, L. H., Haarmann, F. Y., Grotemeyer, K. H., & Kehrer, H. (1993). Serotonin and amino acid content in platelets of autistic children. Acta Psychiatrica Scandinavica, 87, 312–316.PubMedCrossRef

Scholl-Burgi, S., Haberlandt, E., Heinz-Erian, P., Deisenhammer, F., Albrecht, U., Sigl, S. B., et al. (2008). Amino acid cerebrospinal fluid/plasma ratios in children: Influence of age, gender, and antiepileptic medication. Pediatrics, 121, e920–e926.PubMedCrossRef

Schreck, K. A., Williams, K., & Smith, A. F. (2004). A comparison of eating behaviors between children with and without autism. Journal of Autism and Developmental Disorders, 34, 433–438.PubMedCrossRef

Shinohe, A., Hashimoto, K., Nakamura, K., Tsujii, M., Iwata, Y., Tsuchiya, K. J., et al. (2006). Increased serum levels of glutamate in adult patients with autism. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 30, 1472–1477.PubMedCrossRef

Sumiyoshi, T., Anil, A. E., Jin, D., Jayathilake, K., Lee, M., & Meltzer, H. Y. (2004). Plasma glycine and serine levels in schizophrenia compared to normal controls and major depression: Relation to negative symptoms. The International Journal of Neuropsychopharmacology, 7, 1–8.PubMedCrossRef

Tremolizzo, L., Difrancesco, J. C., Rodriguez-Menendez, V., Sirtori, E., Longoni, M., Cassetti, A., et al. (2006). Human platelets express the synaptic markers VGLUT1 and 2 and release glutamate following aggregation. Neuroscience Letters, 404, 262–265.PubMedCrossRef

Titel: Distinct Plasma Profile of Polar Neutral Amino Acids, Leucine, and Glutamate in Children with Autism Spectrum Disorders
Auteurs: Rabindra Tirouvanziam
Tetyana V. Obukhanych
Julie Laval
Pavel A. Aronov
Robin Libove
Arpita Goswami Banerjee
Karen J. Parker
Ruth O’Hara
Leonard A. Herzenberg
Leonore A. Herzenberg
Antonio Y. Hardan
Publicatiedatum: 01-05-2012
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 5/2012
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-011-1314-x

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