Skip to main content
Top

Tip

Swipe om te navigeren naar een ander artikel

Gepubliceerd in: Journal of Psychopathology and Behavioral Assessment 2/2022

08-01-2022

Disruption in Pavlovian-Instrumental Transfer as a Function of Depression and Anxiety

Auteurs: Allison Metts, Inna Arnaudova, Lindsay Staples-Bradley, Michael Sun, Richard Zinbarg, Robin Nusslock, Kate M. Wassum, Michelle G. Craske

Gepubliceerd in: Journal of Psychopathology and Behavioral Assessment | Uitgave 2/2022

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

Abstract

The Pavlovian-Instrumental Transfer (PIT) paradigm examines probabilistic and reinforcement learning. Disruptions in mechanisms that mediate PIT (i.e., cues not triggering adaptive behaviors) are thought to be contributors to psychopathology, making the study of probabilistic and reinforcement learning clinically relevant. The current study evaluated an appetitive PIT effect and its relationship with symptom dimensions spanning depression and anxiety, with a particular focus on anhedonia. Forty young adults ranging in scores across dimensions of depression and anxiety symptoms completed the PIT paradigm and self-report symptom measures. The PIT paradigm consisted of three phases. The instrumental phase consisted of a contingent association in which participants squeezed a handgrip for monetary reward. The Pavlovian phase established a purely predictive association between three visual stimuli (CS + , CS-, baseline) and presence or absence of monetary reward. In the transfer phase, participants’ responses allowed for examination of whether motivational characteristics of Pavlovian predictors influenced the vigor of their handgrip squeezes (instrumental action), which were formerly independent of Pavlovian associations. Analyses revealed a baseline-reward PIT effect, whereby a reward-associated Pavlovian cue enhanced instrumental responding in the transfer phase. However, there were no significant differences between CS + and CS- or CS- and baseline cues, suggesting a disrupted interaction of Pavlovian and instrumental learning. Further, the appetitive PIT effect captured in this paradigm was not associated with anhedonia, fears, or general distress. Future work should investigate the influence of mood states using more specific appetitive PIT paradigms to further understanding of the implications of disrupted reflexive and instrumental responding.
Voetnoten
1
A modified EPQ-N was used in the present study such that participants responded to items on a 0 (Not at all) to 3 (Very much) Likert scale instead of answering Yes or No.
 
2
In the analyses in which we treated non-response to reward windows as missing (missing data handled with list-wise deletion), we observed a longer response time to CS- (M = 404.213 ms) compared to CS + (M = 393.632 ms). However, this difference did not reach statistical significance level (t(27) = -2.012, p = .054), likely as a result of decreased power.
 
Literatuur
go back to reference American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Author. CrossRef American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Author. CrossRef
go back to reference Di Nardo, P. A., & Barlow, D. H. (1988).  Anxiety disorders interview schedule--revised (ADIS-R). Phobia and Anxiety Disorders Clinic, Center for Stress and Anxiety Disorders, State University of New York at Albany. Di Nardo, P. A., & Barlow, D. H. (1988).  Anxiety disorders interview schedule--revised (ADIS-R). Phobia and Anxiety Disorders Clinic, Center for Stress and Anxiety Disorders, State University of New York at Albany.
go back to reference Eysenck, H. J., & Eysenck, S. B. G. (1975).  Manual of the Eysenck Personality Questionnaire (junior and adult). London, England: Hodder and Stoughton. Eysenck, H. J., & Eysenck, S. B. G. (1975).  Manual of the Eysenck Personality Questionnaire (junior and adult). London, England: Hodder and Stoughton.
go back to reference First, M. B., Williams, J. B., Karg, R. S., & Spitzer, R. L. (2016). SCID-5-CV: Structured clinical interview for DSM-5 disorders: Clinician version. American Psychiatric Association Publishing Washington. First, M. B., Williams, J. B., Karg, R. S., & Spitzer, R. L. (2016). SCID-5-CV: Structured clinical interview for DSM-5 disorders: Clinician version. American Psychiatric Association Publishing Washington.
go back to reference Greenberg, T., Chase, H. W., Almeida, J. R., Stiffler, R., Zevallos, C. R., Aslam, H. A., Deckersbach, T., Weyandt, S., Cooper, C., Toups, M., Carmody, T., Kurian, B., Peltier, S., Adams, P., McInnis, M. G., Oquendo, M. A., McGrath, P. J., Fava, M., Weissman, M., ... & Phillips, M. L. (2015). Moderation of the Relationship Between Reward Expectancy and Prediction Error-Related Ventral Striatal Reactivity by Anhedonia in Unmedicated Major Depressive Disorder: Findings From the EMBARC Study. The American Journal of Psychiatry, 172(9), 881–891. https://​doi.​org/​10.​1176/​appi.​ajp.​2015.​14050594 CrossRefPubMedPubMedCentral Greenberg, T., Chase, H. W., Almeida, J. R., Stiffler, R., Zevallos, C. R., Aslam, H. A., Deckersbach, T., Weyandt, S., Cooper, C., Toups, M., Carmody, T., Kurian, B., Peltier, S., Adams, P., McInnis, M. G., Oquendo, M. A., McGrath, P. J., Fava, M., Weissman, M., ... & Phillips, M. L. (2015). Moderation of the Relationship Between Reward Expectancy and Prediction Error-Related Ventral Striatal Reactivity by Anhedonia in Unmedicated Major Depressive Disorder: Findings From the EMBARC Study. The American Journal of Psychiatry, 172(9), 881–891. https://​doi.​org/​10.​1176/​appi.​ajp.​2015.​14050594 CrossRefPubMedPubMedCentral
go back to reference Rescorla, R.A., and Wagner, A.R. (1972). In Classical Conditioning II: Current Theory and Research, A.H. Black and W.F. Prokasy, eds. (New York: Appleton Century Crofts), pp. 65–99. Rescorla, R.A., and Wagner, A.R. (1972). In Classical Conditioning II: Current Theory and Research, A.H. Black and W.F. Prokasy, eds. (New York: Appleton Century Crofts), pp. 65–99.
go back to reference Stoy, M., Schlagenhauf, F., Sterzer, P., Bermpohl, F., Hägele, C., Suchotzki, K., Schmack, K., Wrase, J., Ricken, R., Knutson, B., Adli, M., Bauer, M., Heinz, A., & Ströhle, A. (2011). Hyporeactivity of ventral striatum towards incentive stimuli in unmedicated depressed patients normalizes after treatment with escitalopram. Journal of Psychopharmacology., 26(5), 677–688. https://​doi.​org/​10.​1016/​s1053-8119(09)71680-5 CrossRefPubMed Stoy, M., Schlagenhauf, F., Sterzer, P., Bermpohl, F., Hägele, C., Suchotzki, K., Schmack, K., Wrase, J., Ricken, R., Knutson, B., Adli, M., Bauer, M., Heinz, A., & Ströhle, A. (2011). Hyporeactivity of ventral striatum towards incentive stimuli in unmedicated depressed patients normalizes after treatment with escitalopram. Journal of Psychopharmacology., 26(5), 677–688. https://​doi.​org/​10.​1016/​s1053-8119(09)71680-5 CrossRefPubMed
go back to reference Vogel, V., Dittrich, M., Horndasch, S., Kratz, O., Moll, G. H., Erim, Y., ... & Steins-Loeber, S. (2020). Pavlovian-to-instrumental transfer in Anorexia Nervosa: A pilot study on conditioned learning and instrumental responding to low-and high-calorie food stimuli. European Journal of Neuroscience, 51(8), 1794–1805. https://​doi.​org/​10.​1111/​ejn.​14592 CrossRef Vogel, V., Dittrich, M., Horndasch, S., Kratz, O., Moll, G. H., Erim, Y., ... & Steins-Loeber, S. (2020). Pavlovian-to-instrumental transfer in Anorexia Nervosa: A pilot study on conditioned learning and instrumental responding to low-and high-calorie food stimuli. European Journal of Neuroscience, 51(8), 1794–1805. https://​doi.​org/​10.​1111/​ejn.​14592 CrossRef
Metagegevens
Titel
Disruption in Pavlovian-Instrumental Transfer as a Function of Depression and Anxiety
Auteurs
Allison Metts
Inna Arnaudova
Lindsay Staples-Bradley
Michael Sun
Richard Zinbarg
Robin Nusslock
Kate M. Wassum
Michelle G. Craske
Publicatiedatum
08-01-2022
Uitgeverij
Springer US
Gepubliceerd in
Journal of Psychopathology and Behavioral Assessment / Uitgave 2/2022
Print ISSN: 0882-2689
Elektronisch ISSN: 1573-3505
DOI
https://doi.org/10.1007/s10862-021-09941-9

Andere artikelen Uitgave 2/2022

Journal of Psychopathology and Behavioral Assessment 2/2022 Naar de uitgave