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17-05-2017 | Original Paper

Differing Developmental Trajectories in Heart Rate Responses to Speech Stimuli in Infants at High and Low Risk for Autism Spectrum Disorder

Auteurs: Katherine L. Perdue, Laura A. Edwards, Helen Tager-Flusberg, Charles A. Nelson

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 8/2017

Abstract

We investigated heart rate (HR) in infants at 3, 6, 9, and 12 months of age, at high (HRA) and low (LRC) familial risk for ASD, to identify potential endophenotypes of ASD risk related to attentional responses. HR was extracted from functional near-infrared spectroscopy recordings while infants listened to speech stimuli. Longitudinal analysis revealed that HRA infants and males generally had lower baseline HR than LRC infants and females. HRA infants showed decreased HR responses to early trials over development, while LRC infants showed increased responses. These findings suggest altered developmental trajectories in physiological responses to speech stimuli over the first year of life, with HRA infants showing less social orienting over time.

vorige artikel Touch Processing and Social Behavior in ASD

volgende artikel Improving Functional Language and Social Motivation with a Parent-Mediated Intervention for Toddlers with Autism Spectrum Disorder

To rule out the possibility that confounding cognitive factors may explain any findings of differing psychological arousal to speech stimuli in HRA infants, we examined available Mullen data, and found that neither verbal nor non-verbal developmental quotients (DQ) were significantly different between HRA and LRC infants (p (verbal DQ, 6 months) = 0.57, p (verbal DQ, 12 months) = 0.22, p (non-verbal DQ, 6 months) = 0.69, p (non-verbal DQ, 12 months) = 0.36) or males and females (p (verbal DQ, 6 months) = 0.71, p (verbal DQ, 12 months) = 0.18, p (non-verbal DQ, 6 months) = 0.92, p (non-verbal DQ, 12 months) = 0.12; see Table 1).

At the time of this manuscript such analyses are not possible (models including gender did not converge) as of the 66 infants who have completed the study and received final clinical judgments, only three females had received an ASD diagnosis.

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Titel: Differing Developmental Trajectories in Heart Rate Responses to Speech Stimuli in Infants at High and Low Risk for Autism Spectrum Disorder
Auteurs: Katherine L. Perdue
Laura A. Edwards
Helen Tager-Flusberg
Charles A. Nelson
Publicatiedatum: 17-05-2017
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 8/2017
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-017-3167-4

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